Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: KRAS (KRAS proto-oncogene, GTPase) Homo sapiens
Analyze
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
Description: Exhibits identical protein binding activity. Involved in positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of protein stability. Localizes to cytoplasm and extrinsic component of cytoplasmic side of plasma membrane. Implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Biomarker of carcinoma (multiple) and malignant glioma (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 'C-K-RAS; C-K-RAS; c-Ki-ras; c-Ki-ras2; c-Kirsten-ras protein; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; CFC2; GTPase KRas; K-Ras; K-Ras 2; K-ras p21 protein; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral proto-oncogene; Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog; KRAS1; KRAS2; NS; NS3; OES; oncogene KRAS2; PR310 c-K-ras oncogene; RALD; RASK2; transforming protein p21; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Orthologs:
Mus musculus (house mouse) : Kras (Kirsten rat sarcoma viral oncogene homolog)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kras (KRAS proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kras (KRAS proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : KRAS (KRAS proto-oncogene, GTPase)
Canis lupus familiaris (dog) : KRAS (KRAS proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kras (KRAS proto-oncogene, GTPase)
Sus scrofa (pig) : KRAS (KRAS proto-oncogene, GTPase)
Chlorocebus sabaeus (African green monkey) : KRAS (KRAS proto-oncogene, GTPase)
Heterocephalus glaber (naked mole-rat) : Kras (KRAS proto-oncogene, GTPase)
more info ...
Related Pseudogenes: KRASP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1225,205,246 - 25,250,936 (-)EnsemblGRCh38hg38GRCh38
GRCh381225,205,246 - 25,250,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371225,358,180 - 25,403,870 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,249,447 - 25,295,121 (-)NCBINCBI36hg18NCBI36
Build 341225,249,446 - 25,295,121NCBI
Celera1230,505,144 - 30,550,804 (-)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1225,128,895 - 25,174,493 (-)NCBIHuRef
CHM1_11225,322,879 - 25,368,990 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data