KRAS (KRAS proto-oncogene, GTPase) - Rat Genome Database

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Gene: KRAS (KRAS proto-oncogene, GTPase) Sus scrofa
Analyze
Symbol: KRAS
Name: KRAS proto-oncogene, GTPase
RGD ID: 13855785
Description: ENCODES a protein that exhibits GDP binding (ortholog); GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cytokine-mediated signaling pathway (ortholog); epithelial tube branching involved in lung morphogenesis (ortholog); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN membrane raft (ortholog); mitochondrion (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: GTPase KRas
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl548,508,790 - 48,549,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1548,508,774 - 48,546,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2552,229,592 - 52,270,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
adult hepatocellular carcinoma  (ISO)
anaplastic astrocytoma  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
arteriovenous malformations of the brain  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiofaciocutaneous syndrome 2  (ISO)
cardiomyopathy  (ISO)
Cecal Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
fibrillary astrocytoma  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
myeloid sarcoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 3  (ISO)
oculoectodermal syndrome  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic mucinous cystadenoma  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Penile Neoplasms  (ISO)
pilocytic astrocytoma  (ISO)
plasma cell neoplasm  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
thyroid gland follicular carcinoma  (ISO)
thyroid gland medullary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:33233448   PMID:33638256  


Genomics

Comparative Map Data
KRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl548,508,790 - 48,549,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1548,508,774 - 48,546,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2552,229,592 - 52,270,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1225,205,246 - 25,250,936 (-)EnsemblGRCh38hg38GRCh38
GRCh381225,205,246 - 25,250,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371225,358,180 - 25,403,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,249,447 - 25,295,121 (-)NCBINCBI36hg18NCBI36
Build 341225,249,446 - 25,295,121NCBI
Celera1230,505,144 - 30,550,804 (-)NCBI
Cytogenetic Map12p12.1NCBI
HuRef1225,128,895 - 25,174,493 (-)NCBIHuRef
CHM1_11225,323,336 - 25,368,979 (-)NCBICHM1_1
Kras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,196,144 (-)NCBIGRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBImm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
Kras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24178,185,418 - 178,218,484 (-)NCBImRatBN7.2
Rnor_6.04179,482,562 - 179,515,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4179,486,105 - 179,515,558 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04243,667,912 - 243,696,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44182,869,242 - 182,895,106 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14183,114,365 - 183,140,230 (-)NCBI
Celera4166,708,846 - 166,734,692 (-)NCBICelera
Cytogenetic Map4q44NCBI
Kras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541320,298,824 - 20,328,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541320,298,852 - 20,328,756 (-)NCBIChiLan1.0ChiLan1.0
KRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11263,679,293 - 63,724,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1263,679,293 - 63,724,335 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01261,062,689 - 61,108,524 (+)NCBIMhudiblu_PPA_v0panPan3
KRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12722,261,753 - 22,296,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2722,257,941 - 22,293,369 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,078,345 - 24,117,288 (-)NCBI
ROS_Cfam_1.02722,456,489 - 22,495,435 (+)NCBI
ROS_Cfam_1.0 Ensembl2722,456,012 - 22,495,428 (+)Ensembl
UMICH_Zoey_3.12722,271,689 - 22,310,648 (+)NCBI
UNSW_CanFamBas_1.02722,290,777 - 22,329,504 (+)NCBI
UU_Cfam_GSD_1.02724,245,249 - 24,284,170 (-)NCBI
Kras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494584,156,600 - 84,190,995 (+)NCBI
SpeTri2.0NW_0049365482,078,568 - 2,113,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11124,963,396 - 25,010,747 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1124,973,619 - 25,005,191 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606910,116,447 - 10,163,816 (+)NCBIVero_WHO_p1.0
Kras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475213,809,741 - 13,847,020 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 23 1 3 3
Low 2 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000025989   ⟹   ENSSSCP00000021836
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl548,508,829 - 48,549,346 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042185   ⟹   ENSSSCP00000052259
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl548,508,790 - 48,546,215 (+)Ensembl
RefSeq Acc Id: XM_003126427   ⟹   XP_003126475
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1548,508,774 - 48,546,260 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653151   ⟹   XP_005653208
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1548,508,823 - 48,546,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653152   ⟹   XP_005653209
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1548,508,791 - 48,546,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993780   ⟹   XP_013849234
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1548,508,791 - 48,546,240 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993793   ⟹   XP_013849247
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1548,508,823 - 48,546,240 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003126475   ⟸   XM_003126427
- Peptide Label: isoform X2
- UniProtKB: I3LCQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013849234   ⟸   XM_013993780
- Peptide Label: isoform X1
- UniProtKB: A0A287B854 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005653209   ⟸   XM_005653152
- Peptide Label: isoform X2
- UniProtKB: I3LCQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005653208   ⟸   XM_005653151
- Peptide Label: isoform X1
- UniProtKB: A0A287B854 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013849247   ⟸   XM_013993793
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000021836   ⟸   ENSSSCT00000025989
RefSeq Acc Id: ENSSSCP00000052259   ⟸   ENSSSCT00000042185


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026969 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070024446 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000021836 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000052259 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070041219 UniProtKB/TrEMBL
  ENSSSCP00070041221 UniProtKB/TrEMBL
  ENSSSCP00070041224 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025989 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042185 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070048814 UniProtKB/TrEMBL
  ENSSSCT00070048816 UniProtKB/TrEMBL
  ENSSSCT00070048819 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
KEGG Report ssc:100518251 UniProtKB/TrEMBL
NCBI Gene KRAS ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PROSITE RAS UniProtKB/TrEMBL
SMART RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/TrEMBL
UniProt A0A287B854 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VID5_PIG UniProtKB/TrEMBL
  A0A4X1VIE0_PIG UniProtKB/TrEMBL
  A0A4X1VK18_PIG UniProtKB/TrEMBL
  I3LCQ9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89569 ENTREZGENE