Kras (KRAS proto-oncogene, GTPase) - Rat Genome Database

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Gene: Kras (KRAS proto-oncogene, GTPase) Heterocephalus glaber
Analyze
Symbol: Kras
Name: KRAS proto-oncogene, GTPase
RGD ID: 18920028
Description: ENCODES a protein that exhibits GDP binding (ortholog); GMP binding (ortholog); identical protein binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); cardiac muscle cell proliferation (ortholog); cell population proliferation (ortholog); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; colorectal cancer pathway; endometrial cancer pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTPase KRas; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475213,809,775 - 13,844,166 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475213,809,741 - 13,847,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
anaplastic astrocytoma  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
arteriovenous malformations of the brain  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Capillary Malformation-Arteriovenous Malformation 1  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiofaciocutaneous syndrome 2  (ISO)
cardiomyopathy  (ISO)
Cecal Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Hyperplasia without Atypia  (ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Sarcoma  (ISO)
Familial Pancreatic Carcinoma  (ISO)
fibrillary astrocytoma  (ISO)
follicular thyroid carcinoma  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
hereditary diffuse gastric cancer  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (ISO)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
juvenile myelomonocytic leukemia  (ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Klatskin's tumor  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
Lung Reperfusion Injury  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
Lynch syndrome  (ISO)
malignant astrocytoma  (ISO)
medullary thyroid carcinoma  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
multiple myeloma  (ISO)
muscular atrophy  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (ISO)
myeloid sarcoma  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 3  (ISO)
oculoectodermal syndrome  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic mucinous cystadenoma  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Penile Neoplasms  (ISO)
pilocytic astrocytoma  (ISO)
plasma cell neoplasm  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
teratoma  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
Vascular Malformations  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
cardiac muscle cell proliferation  (ISO)
cell population proliferation  (IEA,ISO)
cytokine-mediated signaling pathway  (ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
female pregnancy  (ISO)
forebrain astrocyte development  (IEA,ISO)
gene expression  (IEA,ISO)
glial cell proliferation  (IEA,ISO)
homeostasis of number of cells within a tissue  (IEA,ISO)
liver development  (ISO)
myoblast proliferation  (ISO)
negative regulation of epithelial cell differentiation  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of cellular senescence  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glial cell proliferation  (IEA,ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nitric-oxide synthase activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of Rac protein signal transduction  (IEA,ISO)
Rac protein signal transduction  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of synaptic transmission, GABAergic  (IEA,ISO)
response to glucocorticoid  (ISO)
response to gravity  (ISO)
response to isolation stress  (ISO)
response to mineralocorticoid  (ISO)
signal transduction  (IEA)
skeletal muscle cell differentiation  (IEA,ISO)
striated muscle cell differentiation  (IEA,ISO)
type I pneumocyte differentiation  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475213,809,775 - 13,844,166 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475213,809,741 - 13,847,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,205,246 - 25,250,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,205,246 - 25,250,936 (-)EnsemblGRCh38hg38GRCh38
GRCh371225,358,180 - 25,403,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,249,447 - 25,295,121 (-)NCBINCBI36Build 36hg18NCBI36
Build 341225,249,446 - 25,295,121NCBI
Celera1230,505,144 - 30,550,804 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1225,128,895 - 25,174,493 (-)NCBIHuRef
CHM1_11225,323,336 - 25,368,979 (-)NCBICHM1_1
T2T-CHM13v2.01225,076,496 - 25,122,152 (-)NCBIT2T-CHM13v2.0
Kras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,197,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)EnsemblGRCm39 Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBIMGSCv36mm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
Kras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84179,916,255 - 179,949,613 (-)NCBIGRCr8
mRatBN7.24178,185,418 - 178,218,484 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4184,490,327 - 184,516,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,274,827 - 180,300,720 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04178,895,248 - 178,921,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04179,482,562 - 179,515,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4179,486,105 - 179,515,558 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04243,667,912 - 243,696,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44182,869,242 - 182,895,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14183,114,365 - 183,140,230 (-)NCBI
Celera4166,708,846 - 166,734,692 (-)NCBICelera
Cytogenetic Map4q44NCBI
Kras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541320,298,824 - 20,328,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541320,298,852 - 20,328,756 (-)NCBIChiLan1.0ChiLan1.0
KRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21071,565,722 - 71,611,563 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11271,562,118 - 71,607,959 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01261,062,689 - 61,108,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11263,679,293 - 63,724,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1263,679,293 - 63,724,335 (+)Ensemblpanpan1.1panPan2
KRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12722,261,753 - 22,296,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2722,257,941 - 22,293,369 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,078,345 - 24,117,288 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02722,456,489 - 22,495,435 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2722,456,012 - 22,495,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12722,271,689 - 22,310,648 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02722,290,777 - 22,329,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02724,245,249 - 24,284,170 (-)NCBIUU_Cfam_GSD_1.0
Kras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494584,156,600 - 84,190,995 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365482,079,036 - 2,110,523 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365482,078,568 - 2,113,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl548,508,811 - 48,549,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1548,508,774 - 48,546,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2552,229,592 - 52,270,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11124,963,396 - 25,010,747 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1124,973,619 - 25,005,191 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606910,116,447 - 10,163,816 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000012407   ⟹   ENSHGLP00000012273
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475213,809,775 - 13,839,856 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000012408   ⟹   ENSHGLP00000012274
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475213,809,779 - 13,842,781 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000012409   ⟹   ENSHGLP00000012275
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475213,809,971 - 13,844,166 (+)Ensembl
RefSeq Acc Id: XM_004845743   ⟹   XP_004845800
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475213,809,922 - 13,847,020 (+)NCBI
RefSeq Acc Id: XM_013072557   ⟹   XP_012928011
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475213,809,915 - 13,847,020 (+)NCBI
RefSeq Acc Id: XM_013072558   ⟹   XP_012928012
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475213,809,741 - 13,847,020 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004845800 (Get FASTA)   NCBI Sequence Viewer  
  XP_012928011 (Get FASTA)   NCBI Sequence Viewer  
  XP_012928012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB11462 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000012273
  ENSHGLP00000012274
  ENSHGLP00000012275
  ENSHGLP00100011647
GenBank Protein JAO02696 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012928012   ⟸   XM_013072558
- Peptide Label: isoform X1
- UniProtKB: G5BQA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012928011   ⟸   XM_013072557
- Peptide Label: isoform X1
- UniProtKB: G5BQA1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845800   ⟸   XM_004845743
- Peptide Label: isoform X2
Ensembl Acc Id: ENSHGLP00000012274   ⟸   ENSHGLT00000012408
Ensembl Acc Id: ENSHGLP00000012273   ⟸   ENSHGLT00000012407
Ensembl Acc Id: ENSHGLP00000012275   ⟸   ENSHGLT00000012409


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008775 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100008637 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000012407 ENTREZGENE
  ENSHGLT00000012408 UniProtKB/TrEMBL
  ENSHGLT00000012409 ENTREZGENE
  ENSHGLT00100011783 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
NCBI Gene Kras ENTREZGENE
PANTHER GTPASE KRAS UniProtKB/TrEMBL
  PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt G5BQA1 ENTREZGENE, UniProtKB/TrEMBL