Kras (Kirsten rat sarcoma viral oncogene homolog) - Rat Genome Database

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Gene: Kras (Kirsten rat sarcoma viral oncogene homolog) Mus musculus
Analyze
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
RGD ID: 1550157
MGI Page MGI
Description: Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI929937; c-K-ras; c-Ki-ras; GTPase KRas; K-; K-ras; K-Ras 2; Ki; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kr; Kra; Kras-2; Kras2; MGC7141; p21 protein; p21B; ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,197,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)EnsemblGRCm39 Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBIMGSCv36mm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
KrasMouseAcute Experimental Pancreatitis  ISOKras (Rattus norvegicus)11062095 RGD 
KrasMouseacute lymphoblastic leukemia  ISOKRAS (Homo sapiens)11060148 RGD 
KrasMouseacute lymphoblastic leukemia disease_progressionISOKRAS (Homo sapiens)11060149 RGD 
KrasMouseacute myeloid leukemia  ISOKRAS (Homo sapiens)11060151 RGD 
KrasMouseacute myeloid leukemia  ISOKRAS (Homo sapiens)1600469OMIM:601626RGD 
KrasMouseanaplastic astrocytoma  ISOKRAS (Homo sapiens)13702872mRNA:decreased expression:brainRGD 
KrasMousebreast cancer  ISOKRAS (Homo sapiens)2314909 RGD 
KrasMouseBreast Neoplasms  ISOKRAS (Homo sapiens)1600466human breast adenocarcinoma cell line and OMIM:114480RGD 
KrasMousebronchiolo-alveolar adenocarcinoma  IMP 11075076DNA:mutations:cds:RGD 
KrasMousecardiofaciocutaneous syndrome  ISOKRAS (Homo sapiens)1600471DNA:missense mutations:CDS:p.G60R and p.D153V (human)RGD 
KrasMousecardiomyopathy no_associationIMP 11568677 RGD 
KrasMousecolorectal cancer disease_progressionISOKRAS (Homo sapiens)14398748DNA:missense mutations:cds:p.GLY12ASP more ...RGD 
KrasMouseColorectal Neoplasms  ISOKRAS (Homo sapiens)11060146DNA:missense mutations: :p.G12C more ...RGD 
KrasMouseColorectal Neoplasms  IDA 11568690 RGD 
KrasMousedilated cardiomyopathy  IDA 1581757 RGD 
KrasMouseendometrial adenocarcinoma  ISOKras (Rattus norvegicus)1600499DNA:point mutation:CDS:p.G12D more ...RGD 
KrasMouseendometrial hyperplasia  ISOKRAS (Homo sapiens)2314912 RGD 
KrasMouseEndometrial Neoplasms  ISOKRAS (Homo sapiens)4143515 RGD 
KrasMouseEndometrial Neoplasms  ISOKRAS (Homo sapiens)2314907 RGD 
KrasMouseEndometrioid Carcinomas  ISOKRAS (Homo sapiens)2314910associated with Ovarian NeoplasmsRGD 
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Original Reference(s)
KrasMouseacute myeloid leukemia  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMousearteriovenous malformations of the brain  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMousearteriovenous malformations of the brain  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMouseautoimmune lymphoproliferative syndrome type 4  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMousebreast adenocarcinoma  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Breast adenocarcinoma and somaticClinVarPMID:15696205 more ...
KrasMousebreast cancer  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Breast cancer and somaticClinVarPMID:15696205 more ...
KrasMouseBreast Cancer, Familial  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cancer of breastClinVarPMID:12110640 more ...
KrasMouseBreast Cancer, Familial  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cancer of breastClinVarPMID:12110640 more ...
KrasMouseBreast Cancer, Familial  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMouseBreast Cancer, Familial  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12110640 more ...
KrasMouseCapillary Malformation-Arteriovenous Malformation 1  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Capillary malformation-arteriovenous malformation 1ClinVarPMID:12720172 more ...
KrasMousecardiofaciocutaneous syndrome  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16474404 more ...
KrasMousecardiofaciocutaneous syndrome 1  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 1ClinVarPMID:17056636 more ...
KrasMousecardiofaciocutaneous syndrome 2  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Cardiofaciocutaneous syndrome 2ClinVarPMID:12110640 more ...
KrasMousechronic myelogenous leukemia, BCR-ABL1 positive  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Chronic myelogenous leukemia and BCR-ABL1 positiveClinVarPMID:15696205 more ...
KrasMouseEncephalocraniocutaneous Lipomatosis  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Encephalocraniocutaneous lipomatosisClinVarPMID:12720172 more ...
KrasMouseendometrial carcinoma  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial carcinomaClinVarPMID:11745231 more ...
KrasMouseEndometrial Hyperplasia without Atypia  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial hyperplasia without atypiaClinVarPMID:12720172 more ...
KrasMouseEndometrial Intraepithelial Neoplasia  ISOKRAS (Homo sapiens)8554872ClinVar Annotator: match by term: Atypical endometrial hyperplasiaClinVarPMID:12720172 more ...
KrasMouseepidermal nevus  ISOKRAS (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12720172 more ...
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Original Reference(s)
KrasMouseacute myeloid leukemia  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
KrasMouseadenocarcinoma  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11745231 more ...
KrasMouseadenoma  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8761429 more ...
KrasMouseanemia  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27725143
KrasMouseangiosarcoma  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10930038 more ...
KrasMouseAnimal Disease Models  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26390243 more ...
KrasMousearteriovenous malformations of the brain  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
KrasMouseBreast Neoplasms  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
KrasMouseCarcinogenesis  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26595770 and PMID:29247004
KrasMousecarcinoma  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10545420 and PMID:20565773
KrasMousecardiofaciocutaneous syndrome  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17703371
KrasMouseCecal Neoplasms  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14688030
KrasMousecholangiocarcinoma  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8968066 and PMID:22561520
KrasMouseColonic Neoplasms  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10813127 more ...
KrasMouseColorectal Neoplasms  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20565773 more ...
KrasMouseCostello syndrome  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17468812 and PMID:17703371
KrasMousedisease of cellular proliferation  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10673434 and PMID:26595770
KrasMouseDisease Progression  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30654191
KrasMouseendometriosis  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23284138
KrasMouseExperimental Liver Neoplasms  ISOKRAS (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8603461
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Original Reference(s)
KrasMousearteriovenous malformations of the brain  IAGP 13592920OMIM:108010MouseDO 
KrasMouseendometriosis  IAGP 13592920OMIM:131200MouseDO 
KrasMouseintrahepatic cholangiocarcinoma  IAGP 13592920 MouseDO 
KrasMousejuvenile myelomonocytic leukemia  IAGP 13592920OMIM:607785MouseDO 
KrasMouselung cancer  IAGP 13592920OMIM:211980 more ...MouseDO 
KrasMouseNoonan syndrome 3  IAGP 13592920OMIM:609942MouseDO 
KrasMousepancreatic carcinoma  IAGP 13592920OMIM:260350MouseDO 
KrasMouseprostate cancer  IAGP 13592920OMIM:176807 more ...MouseDO 

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Original Reference(s)
KrasMouse(S)-colchicine multiple interactionsEXP 6480464Colchicine inhibits the reaction [Carbon Tetrachloride results in increased expression of KRAS protein]CTDPMID:38348705
KrasMouse(S)-naringenin multiple interactionsISOKRAS (Homo sapiens)6480464[naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNACTDPMID:36235125
KrasMouse(trichloromethyl)benzene increases mutagenesisEXP 6480464benzotrichloride results in increased mutagenesis of KRAS geneCTDPMID:8508514
KrasMouse1,1-dichloroethene increases expressionEXP 6480464vinylidene chloride results in increased expression of KRAS mRNACTDPMID:26682919
KrasMouse1,2-dimethylhydrazine affects expressionEXP 64804641 and 2-Dimethylhydrazine affects the expression of KRAS mRNACTDPMID:22206623
KrasMouse1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KRAS mRNACTDPMID:22206623
KrasMouse1-nitropyrene increases mutagenesisEXP 64804641-nitropyrene results in increased mutagenesis of KRAS geneCTDPMID:10396879 more ...
KrasMouse1-nitropyrene multiple interactionsEXP 6480464[1-nitropyrene co-treated with KC 400] results in increased mutagenesis of KRAS gene more ...CTDPMID:10396879 more ...
KrasMouse17alpha-ethynylestradiol multiple interactionsEXP 6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRAS mRNACTDPMID:17942748
KrasMouse17alpha-ethynylestradiol increases expressionISOKras (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of KRAS mRNACTDPMID:29097150
KrasMouse17beta-estradiol decreases expressionISOKRAS (Homo sapiens)6480464Estradiol results in decreased expression of KRAS mRNACTDPMID:16474171
KrasMouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of KRAS mRNACTDPMID:39298647
KrasMouse17beta-estradiol increases expressionISOKRAS (Homo sapiens)6480464Estradiol results in increased expression of KRAS mRNACTDPMID:23094148
KrasMouse2,2-Bis(bromomethyl)propane-1,3-diol increases mutagenesisEXP 64804642 more ...CTDPMID:14713543
KrasMouse2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKRAS (Homo sapiens)6480464Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of KRAS mRNA]CTDPMID:11007951
KrasMouse2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOKras (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in decreased expression of KRAS mRNACTDPMID:33387578
KrasMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKras (Rattus norvegicus)6480464Tetrachlorodibenzodioxin results in increased expression of KRAS mRNACTDPMID:32109520
KrasMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of KRAS mRNACTDPMID:21570461
KrasMouse2,3,7,8-tetrachlorodibenzodioxine increases expressionISOKRAS (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of KRAS mRNACTDPMID:11007951 more ...
KrasMouse2,3,7,8-tetrachlorodibenzodioxine affects expressionISOKRAS (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of KRAS mRNACTDPMID:22298810

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Biological Process
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Original Reference(s)
KrasMouseactin cytoskeleton organization acts_upstream_of_or_withinIGIMGI:973062290270 PMID:15665300MGIPMID:15665300
KrasMousecardiac muscle cell proliferation  ISOKras (Rattus norvegicus)9068941 RGDPMID:2447874 and REF_RGD_ID:151665807
KrasMousecell population proliferation acts_upstream_ofIGIMGI:973062290270 PMID:15665300MGIPMID:15665300
KrasMousecytokine-mediated signaling pathway involved_inISOKras (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
KrasMousecytokine-mediated signaling pathway  ISOKras (Rattus norvegicus)9068941 RGDPMID:14576830 and REF_RGD_ID:1600488
KrasMouseepithelial tube branching involved in lung morphogenesis acts_upstream_of_or_withinIDA 2290270 PMID:24058167MGIPMID:24058167
KrasMouseepithelial tube branching involved in lung morphogenesis acts_upstream_of_or_withinIGIMGI:983712290270 PMID:24058167MGIPMID:24058167
KrasMousefemale pregnancy  ISOKras (Rattus norvegicus)9068941 RGDPMID:1570348 and REF_RGD_ID:11570399
KrasMouseforebrain astrocyte development acts_upstream_of_or_withinIMPMGI:24299482290270 PMID:22577135MGIPMID:22577135
KrasMousegene expression acts_upstream_of_or_withinIMP 2290270 PMID:29191600MGIPMID:29191600
KrasMouseglial cell proliferation acts_upstream_ofIGIMGI:973062290270 PMID:15665300MGIPMID:15665300
KrasMousehomeostasis of number of cells within a tissue acts_upstream_of_or_withinIGIMGI:995112290270 PMID:24675817MGIPMID:24675817
KrasMouseinsulin-like growth factor receptor signaling pathway involved_inISOUniProtKB:P011162290270 PMID:33302159MGIPMID:33302159
KrasMouseliver development  ISOKras (Rattus norvegicus)9068941 RGDPMID:1526114 and REF_RGD_ID:11060153
KrasMousemyoblast proliferation  ISOKras (Rattus norvegicus)9068941 RGDPMID:2425941 and REF_RGD_ID:151667421
KrasMousenegative regulation of epithelial cell differentiation acts_upstream_of_or_withinIDA 2290270 PMID:24058167MGIPMID:24058167
KrasMousenegative regulation of neuron apoptotic process acts_upstream_of_or_withinIGIMGI:96224 and MGI:973062290270 PMID:10845775MGIPMID:10845775
KrasMouseneuron apoptotic process acts_upstream_ofIGIMGI:96224 and MGI:973062290270 PMID:10845775MGIPMID:10845775
KrasMousepositive regulation of cellular senescence  ISOKras (Rattus norvegicus)9068941 RGDPMID:17706954 and REF_RGD_ID:11060281
KrasMousepositive regulation of cellular senescence involved_inISOKras (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
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Cellular Component
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Original Reference(s)
KrasMousecytoplasm located_inISOUniProtKB:P011162290270 GO_CentralGO_REF:0000119
KrasMousecytoplasm located_inISSUniProtKB:P011162290270 UniProtGO_REF:0000024
KrasMousecytoplasmic side of plasma membrane located_inISOUniProtKB:P011162290270 GO_CentralGO_REF:0000119
KrasMousecytoplasmic side of plasma membrane located_inISSUniProtKB:P011162290270 UniProtGO_REF:0000024
KrasMouseendomembrane system located_inIEAUniProtKB-SubCell:SL-01472290270 UniProtGO_REF:0000044
KrasMousemembrane located_inIDA 2290270 PMID:10085069MGIPMID:10085069
KrasMousemembrane located_inIGIMGI:18885942290270 PMID:14966563MGIPMID:14966563
KrasMouseplasma membrane is_active_inIBAPANTHER:PTN000631348 more ...2290270 GO_CentralGO_REF:0000033
KrasMouseplasma membrane located_inTAS 2290270 ReactomeReactome:R-MMU-9029152 more ...
KrasMouseplasma membrane located_inISOUniProtKB:P011162290270 GO_CentralGO_REF:0000119
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Molecular Function
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KrasMouseG protein activity enablesIEAEC:3.6.5.22290270 UniProtGO_REF:0000003
KrasMouseGDP binding  ISOKras (Rattus norvegicus)9068941 RGDPMID:12594205 and REF_RGD_ID:1581766
KrasMouseGDP binding enablesISOKras (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
KrasMouseGDP binding enablesIBAPANTHER:PTN000631348 more ...2290270 GO_CentralGO_REF:0000033
KrasMouseGMP binding  ISOKras (Rattus norvegicus)9068941 RGDPMID:12594205 and REF_RGD_ID:1581766
KrasMouseGMP binding enablesISOKras (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
KrasMouseGTP binding enablesIBAPANTHER:PTN000631348 more ...2290270 GO_CentralGO_REF:0000033
KrasMouseGTP binding enablesIEAUniProtKB-KW:KW-03422290270 UniProtGO_REF:0000043
KrasMouseGTPase activity enablesIGIMGI:973062290270 PMID:15665300MGIPMID:15665300
KrasMouseGTPase activity enablesTAS 2290270 PMID:10498879MGIPMID:10498879
KrasMouseGTPase activity enablesISOUniProtKB:P011162290270 GO_CentralGO_REF:0000119
KrasMouseGTPase activity enablesIBAPANTHER:PTN000631348 more ...2290270 GO_CentralGO_REF:0000033
KrasMouseidentical protein binding enablesISOUniProtKB:P011162290270 GO_CentralGO_REF:0000119
KrasMouseLRR domain binding  ISOKras (Rattus norvegicus)9068941 RGDPMID:12594205 and REF_RGD_ID:1581766
KrasMouseLRR domain binding enablesISOKras (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
KrasMouseprotein binding enablesIPIUniProtKB:Q80UQ22290270 PMID:17404571UniProtPMID:17404571
KrasMouseprotein binding enablesIPIUniProtKB:Q99N572290270 PMID:15102471IntActPMID:15102471
KrasMouseprotein binding enablesIPIUniProtKB:P040492290270 PMID:17229891 and PMID:19164755IntActPMID:17229891 and PMID:19164755
KrasMouseprotein binding enablesIPIUniProtKB:Q012792290270 PMID:22975374IntActPMID:22975374
KrasMouseprotein-containing complex binding enablesISOUniProtKB:P011162290270 PMID:23209302MGIPMID:23209302
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Imported Annotations - SMPDB

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KrasMouseFc epsilon receptor mediated signaling pathway  ISOKRAS (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

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KrasMouseacute myeloid leukemia pathway  IEA 6907045 KEGGmmu:05221
KrasMousealdosterone signaling pathway   IEA 6907045 KEGGmmu:04960
KrasMouseB cell receptor signaling pathway  IEA 6907045 KEGGmmu:04662
KrasMouseceramide signaling pathway  IEA 6907045 KEGGmmu:05212
KrasMousechronic myeloid leukemia pathway  IEA 6907045 KEGGmmu:05220
KrasMousecolorectal cancer pathway   IEA 6907045 KEGGmmu:05210
KrasMouseendometrial cancer pathway   IEA 6907045 KEGGmmu:05213
KrasMouseepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGmmu:04012
KrasMouseglioma pathway  IEA 6907045 KEGGmmu:05214
KrasMousegonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGmmu:04912
KrasMousehepatitis C pathway  IEA 6907045 KEGGmmu:05160
KrasMouseinsulin signaling pathway   IEA 6907045 KEGGmmu:04910
KrasMouselong term depression  IEA 6907045 KEGGmmu:04730
KrasMouselong term potentiation  IEA 6907045 KEGGmmu:04720
KrasMousemelanoma pathway  IEA 6907045 KEGGmmu:05218
KrasMousemitogen activated protein kinase signaling pathway   IEA 6907045 KEGGmmu:04010
KrasMouseneurotrophic factor signaling pathway  IEA 6907045 KEGGmmu:04722
KrasMousenon-small cell lung carcinoma pathway   IEA 6907045 KEGGmmu:05223
KrasMousepancreatic cancer pathway   IEA 6907045 KEGGmmu:05212
KrasMouseprostate cancer pathway   IEA 6907045 KEGGmmu:05215
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Source
Original Reference(s)
KrasMouseabnormal astrocyte morphology  IAGP 5509061 MGIPMID:18371380
KrasMouseabnormal atrioventricular valve morphology  IAGP 5509061 MGIPMID:17369402
KrasMouseabnormal blood cell morphology/development  IAGP 5509061 MGIPMID:20233966
KrasMouseabnormal bone marrow cell physiology  IAGP 5509061 MGIPMID:25359213
KrasMouseabnormal brain development  IAGP 5509061 MGIPMID:15093544
KrasMouseabnormal brain development  IAGP 5509061 MGIPMID:18371380
KrasMouseabnormal brain vasculature morphology  IAGP 5509061 MGIPMID:32552404
KrasMouseabnormal branching involved in lung morphogenesis  IAGP 5509061 MGIPMID:17369402
KrasMouseabnormal bronchiole morphology  IAGP 5509061 MGIPMID:19151761
KrasMouseabnormal bronchiole morphology  IAGP 5509061 MGIPMID:18493606
KrasMouseabnormal bronchoalveolar duct junction morphology  IAGP 5509061 MGIPMID:22411819
KrasMouseabnormal bronchus epithelium morphology  IAGP 5509061 MGIPMID:17369402
KrasMouseabnormal bronchus morphology  IAGP 5509061 MGIPMID:17369402
KrasMouseabnormal bronchus morphology  IAGP 5509061 MGIPMID:18493606
KrasMouseabnormal cardiovascular system physiology  IAGP 5509061 MGIPMID:17369402
KrasMouseabnormal cell cycle  IAGP 5509061 MGIPMID:20308544
KrasMouseabnormal cell morphology  IAGP 5509061 MGIPMID:17476360
KrasMouseabnormal cell proliferation  IAGP 5509061 MGIPMID:12957286
KrasMouseabnormal centrosome morphology  IAGP 5509061 MGIPMID:17607363
KrasMouseabnormal CNS glial cell morphology  IAGP 5509061 MGIPMID:18371380
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Reference Title
Reference Citation
1. GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma. Abel TW, etal., Mol Cancer Res. 2009 May;7(5):645-53. doi: 10.1158/1541-7786.MCR-08-0477. Epub 2009 May 12.
2. Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Ahrendt SA, etal., Cancer. 2001 Sep 15;92(6):1525-30.
3. Association in the expression of Kirsten-ras oncogene and the major histocompatibility complex class I antigens in fibrosarcoma tumor cell variants exhibiting different metastatic capabilities. Alon Y, etal., Cancer Res. 1987 May 15;47(10):2553-7.
4. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
5. Biochemical characterization of a novel KRAS insertion mutation from a human leukemia. Bollag G, etal., J Biol Chem. 1996 Dec 20;271(51):32491-4.
6. Activation of RAS family genes in urothelial carcinoma. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
7. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. Cai B, etal., J Pineal Res. 2016 Aug;61(1):82-95. doi: 10.1111/jpi.12331. Epub 2016 Apr 29.
8. K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors. Calvert RJ, etal., Cancer Lett. 1996 Dec 3;109(1-2):1-7.
9. The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease. Calvisi DF, etal., Int J Cancer. 2009 Jun 16.
10. ZFP36 protects lungs from intestinal I/R-induced injury and fibrosis through the CREBBP/p53/p21/Bax pathway. Cao Y, etal., Cell Death Dis. 2021 Jul 8;12(7):685. doi: 10.1038/s41419-021-03950-y.
11. Mutant KRAS, chromosomal instability and prognosis in colorectal cancer. Castagnola P and Giaretti W, Biochim Biophys Acta. 2005 Nov 25;1756(2):115-25. Epub 2005 Jul 13.
12. Mutational analysis of KRAS, BRAF, and TP53 genes of ovarian serous carcinomas in Korean women. Cho YH, etal., Yonsei Med J. 2009 Apr 30;50(2):266-72.
13. Myocardial KRAS(G12D) expression does not cause cardiomyopathy in mice. Dalin MG, etal., Cardiovasc Res. 2014 Feb 1;101(2):229-35. doi: 10.1093/cvr/cvt260. Epub 2013 Nov 20.
14. Wild type Kirsten rat sarcoma is a novel microRNA-622-regulated therapeutic target for hepatocellular carcinoma and contributes to sorafenib resistance. Dietrich P, etal., Gut. 2018 Jul;67(7):1328-1341. doi: 10.1136/gutjnl-2017-315402. Epub 2017 Dec 23.
15. Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma. Dobrzycka B, etal., Folia Histochem Cytobiol. 2009;47(1):65-8.
16. Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer. Dobrzycka B, etal., Int J Cancer. 2009 Dec 3.
17. MiR-193a-3p is an Important Tumour Suppressor in Lung Cancer and Directly Targets KRAS. Fan Q, etal., Cell Physiol Biochem. 2017;44(4):1311-1324. doi: 10.1159/000485491. Epub 2017 Nov 29.
18. Comprehensive analysis of genomic alterations of Chinese hilar cholangiocarcinoma patients. Feng F, etal., Int J Clin Oncol. 2021 Apr;26(4):717-727. doi: 10.1007/s10147-020-01846-z. Epub 2021 Jan 2.
19. Involvement of Gpr125 in the myeloid sarcoma formation induced by cooperating MLL/AF10(OM-LZ) and oncogenic KRAS in a mouse bone marrow transplantation model. Fu JF, etal., Int J Cancer. 2013 Oct 15;133(8):1792-802. doi: 10.1002/ijc.28195. Epub 2013 May 7.
20. Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression. Fujikura K, etal., Histopathology. 2017 Oct;71(4):591-600. doi: 10.1111/his.13271. Epub 2017 Aug 2.
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PMID:228288   PMID:1352876   PMID:1354597   PMID:1499088   PMID:1507224   PMID:1572642   PMID:1586998   PMID:1617215   PMID:1673105   PMID:1684952   PMID:1686731   PMID:1738193  
PMID:1754390   PMID:1889815   PMID:1914521   PMID:2114387   PMID:2193291   PMID:2341153   PMID:2613230   PMID:2878419   PMID:2891865   PMID:3003402   PMID:3022995   PMID:3279541  
PMID:3416641   PMID:3614201   PMID:3692486   PMID:3865197   PMID:4006517   PMID:4006913   PMID:6265801   PMID:6304530   PMID:6320193   PMID:6364482   PMID:6474169   PMID:6546797  
PMID:6641714   PMID:6690234   PMID:7590978   PMID:7594541   PMID:7607686   PMID:7688967   PMID:7767966   PMID:7776260   PMID:7813906   PMID:7873877   PMID:7894154   PMID:7894156  
PMID:8081710   PMID:8095010   PMID:8152802   PMID:8301128   PMID:8324828   PMID:8499946   PMID:8575777   PMID:8598575   PMID:8661067   PMID:8662936   PMID:8666392   PMID:8944028  
PMID:9011744   PMID:9076683   PMID:9119363   PMID:9133601   PMID:9230199   PMID:9294608   PMID:9321475   PMID:9321483   PMID:9334313   PMID:9337390   PMID:9337410   PMID:9362444  
PMID:9371744   PMID:9466889   PMID:9514948   PMID:9615230   PMID:9657861   PMID:9659579   PMID:9659582   PMID:9696043   PMID:9744549   PMID:9952298   PMID:10085069   PMID:10349636  
PMID:10413402   PMID:10498879   PMID:10845775   PMID:10871846   PMID:10917603   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11293323   PMID:11323676   PMID:11360188  
PMID:11528387   PMID:11641780   PMID:11713472   PMID:11751630   PMID:11751631   PMID:11793011   PMID:11867530   PMID:12106604   PMID:12231543   PMID:12354753   PMID:12391845   PMID:12466851  
PMID:12477808   PMID:12477932   PMID:12545163   PMID:12727809   PMID:12727811   PMID:12805379   PMID:12810665   PMID:12907238   PMID:12957286   PMID:12963544   PMID:14517344   PMID:14583591  
1 to 10 of 183 rows



Kras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,197,631 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)EnsemblGRCm39 Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBIMGSCv36mm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
KRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381225,205,246 - 25,250,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1225,205,246 - 25,250,936 (-)EnsemblGRCh38hg38GRCh38
GRCh371225,358,180 - 25,403,863 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361225,249,447 - 25,295,121 (-)NCBINCBI36Build 36hg18NCBI36
Build 341225,249,446 - 25,295,121NCBI
Celera1230,505,144 - 30,550,804 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1225,128,895 - 25,174,493 (-)NCBIHuRef
CHM1_11225,323,336 - 25,368,979 (-)NCBICHM1_1
T2T-CHM13v2.01225,076,496 - 25,122,152 (-)NCBIT2T-CHM13v2.0
Kras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84179,916,255 - 179,949,613 (-)NCBIGRCr8
mRatBN7.24178,185,418 - 178,218,484 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx4184,490,327 - 184,516,219 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04180,274,827 - 180,300,720 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04178,895,248 - 178,921,140 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04179,482,562 - 179,515,483 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4179,486,105 - 179,515,558 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04243,667,912 - 243,696,325 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44182,869,242 - 182,895,106 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14183,114,365 - 183,140,230 (-)NCBI
Celera4166,708,846 - 166,734,692 (-)NCBICelera
Cytogenetic Map4q44NCBI
Kras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541320,298,824 - 20,328,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541320,298,852 - 20,328,756 (-)NCBIChiLan1.0ChiLan1.0
KRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21071,565,722 - 71,611,563 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11271,562,118 - 71,607,959 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01261,062,689 - 61,108,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11263,679,293 - 63,724,335 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1263,679,293 - 63,724,335 (+)Ensemblpanpan1.1panPan2
KRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12722,261,753 - 22,296,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2722,257,941 - 22,293,369 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2724,078,345 - 24,117,288 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02722,456,489 - 22,495,435 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2722,456,012 - 22,495,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12722,271,689 - 22,310,648 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02722,290,777 - 22,329,504 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02724,245,249 - 24,284,170 (-)NCBIUU_Cfam_GSD_1.0
Kras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494584,156,600 - 84,190,995 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365482,079,036 - 2,110,523 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365482,078,568 - 2,113,877 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl548,508,811 - 48,549,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1548,508,774 - 48,546,260 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2552,229,592 - 52,270,153 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11124,963,396 - 25,010,747 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1124,973,619 - 25,005,191 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606910,116,447 - 10,163,816 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475213,809,775 - 13,844,166 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475213,809,741 - 13,847,020 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Kras
1299 total Variants

Predicted Target Of
Summary Value
Count of predictions:1616
Count of miRNA genes:678
Interacting mature miRNAs:858
Transcripts:ENSMUST00000032399, ENSMUST00000111710, ENSMUST00000123972, ENSMUST00000149314, ENSMUST00000155145, ENSMUST00000156486
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142079Skmw15_mskeletal muscle weight 15 (mouse)Not determined6116829851149588044Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11252138Clas1_mcarcinogen-induced lung adenoma susceptibility 1 (mouse)6112246918146954059Mouse
10449437Pas15_mpulmonary adenoma susceptibility 15 (mouse)6128180868149588044Mouse
10449436Pas17_mpulmonary adenoma susceptibility 17 (mouse)6124334273145601739Mouse
10449435Pas18_mpulmonary adenoma susceptibility 18 (mouse)6145162425145195965Mouse
1301658Radpf3_mradiation pulmonary fibrosis 3 (mouse)Not determined6115219814146330736Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4140980Mvwf2_mmodifier of von Willebrand factor 2 (mouse)Not determined114345693145601739Mouse
4141617Ncilt_mnuclear cytoplasmic invaginations in lung tumors (mouse)Not determined145162425145195965Mouse

1 to 10 of 43 rows
D6Mit57  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,235,142 - 145,235,338UniSTSGRCm38
MGSCv376145,183,662 - 145,183,858UniSTSGRCm37
Celera6148,309,449 - 148,309,647UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.1UniSTS
Whitehead Genetic662.3UniSTS
Whitehead/MRC_RH61458.33UniSTS
Whitehead_YAC6 UniSTS
AI929937  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,218,279 - 145,218,427UniSTSGRCm38
MGSCv376145,166,799 - 145,166,947UniSTSGRCm37
Celera6148,292,569 - 148,292,717UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Whitehead/MRC_RH61458.43UniSTS
PMC316567P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,797 - 145,247,199UniSTSGRCm38
MGSCv376145,195,317 - 145,195,719UniSTSGRCm37
Celera6148,321,118 - 148,321,520UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,377 - 145,246,552UniSTSGRCm38
MGSCv376145,194,897 - 145,195,072UniSTSGRCm37
Celera6148,320,698 - 148,320,873UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,472 - 145,246,805UniSTSGRCm38
MGSCv376145,194,992 - 145,195,325UniSTSGRCm37
Celera6148,320,793 - 148,321,126UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,687 - 145,246,818UniSTSGRCm38
MGSCv376145,195,207 - 145,195,338UniSTSGRCm37
Celera6148,321,008 - 148,321,139UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,928 - 145,247,108UniSTSGRCm38
MGSCv376145,195,448 - 145,195,628UniSTSGRCm37
Celera6148,321,249 - 148,321,429UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,246,264 - 145,246,548UniSTSGRCm38
MGSCv376145,194,784 - 145,195,068UniSTSGRCm37
Celera6148,320,585 - 148,320,869UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,219,570 - 145,219,680UniSTSGRCm38
MGSCv376145,168,090 - 145,168,200UniSTSGRCm37
Celera6148,293,870 - 148,293,980UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,220,057 - 145,220,250UniSTSGRCm38
MGSCv376145,168,577 - 145,168,770UniSTSGRCm37
Celera6148,294,361 - 148,294,554UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386145,219,521 - 145,219,688UniSTSGRCm38
MGSCv376145,168,041 - 145,168,208UniSTSGRCm37
Celera6148,293,821 - 148,293,988UniSTS
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS
Kras  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6G2UniSTS
cM Map671.2UniSTS






1 to 30 of 37 rows
RefSeq Transcripts NM_001403240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403245 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001403246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_175368 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC157091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY487807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC010202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC119495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU207316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU458742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JC006855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S39586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U76425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U76426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 37 rows

Ensembl Acc Id: ENSMUST00000032399   ⟹   ENSMUSP00000032399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)Ensembl
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111710   ⟹   ENSMUSP00000107339
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,165,971 - 145,195,903 (-)Ensembl
GRCm38.p6 Ensembl6145,220,245 - 145,250,177 (-)Ensembl
Ensembl Acc Id: ENSMUST00000123972
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,165,706 - 145,176,550 (-)Ensembl
GRCm38.p6 Ensembl6145,219,980 - 145,230,824 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149314
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,166,336 - 145,171,283 (-)Ensembl
GRCm38.p6 Ensembl6145,220,610 - 145,225,557 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155145   ⟹   ENSMUSP00000118251
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,192,430 - 145,195,928 (-)Ensembl
GRCm38.p6 Ensembl6145,246,704 - 145,250,202 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156486   ⟹   ENSMUSP00000119414
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,166,023 - 145,195,896 (-)Ensembl
GRCm38.p6 Ensembl6145,220,297 - 145,250,170 (-)Ensembl
Ensembl Acc Id: ENSMUST00000203147   ⟹   ENSMUSP00000145294
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6145,165,947 - 145,195,965 (-)Ensembl
GRCm38.p6 Ensembl6145,220,221 - 145,250,239 (-)Ensembl
RefSeq Acc Id: NM_001403240   ⟹   NP_001390169
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,197,631 (-)NCBI
RefSeq Acc Id: NM_001403241   ⟹   NP_001390170
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NM_001403242   ⟹   NP_001390171
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NM_001403243   ⟹   NP_001390172
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NM_001403244   ⟹   NP_001390173
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,197,631 (-)NCBI
RefSeq Acc Id: NM_001403245   ⟹   NP_001390174
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NM_001403246   ⟹   NP_001390175
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NM_021284   ⟹   NP_067259
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
GRCm386145,216,699 - 145,250,231 (-)NCBI
MGSCv376145,165,219 - 145,198,751 (-)RGD
Celera6148,290,985 - 148,324,546 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_175367
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: NR_175368
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,429 - 145,195,965 (-)NCBI
RefSeq Acc Id: XM_006506919   ⟹   XP_006506982
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396145,162,425 - 145,196,069 (-)NCBI
GRCm386145,216,699 - 145,250,141 (-)NCBI
Sequence:
1 to 30 of 30 rows
Protein RefSeqs NP_001390169 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390170 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390171 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390172 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390173 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390174 (Get FASTA)   NCBI Sequence Viewer  
  NP_001390175 (Get FASTA)   NCBI Sequence Viewer  
  NP_067259 (Get FASTA)   NCBI Sequence Viewer  
  XP_006506982 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40037 (Get FASTA)   NCBI Sequence Viewer  
  AAH04642 (Get FASTA)   NCBI Sequence Viewer  
  AAH10202 (Get FASTA)   NCBI Sequence Viewer  
  AAI19496 (Get FASTA)   NCBI Sequence Viewer  
  AAI41052 (Get FASTA)   NCBI Sequence Viewer  
  AAO46052 (Get FASTA)   NCBI Sequence Viewer  
  AAS58056 (Get FASTA)   NCBI Sequence Viewer  
  BAE33023 (Get FASTA)   NCBI Sequence Viewer  
  BAE37609 (Get FASTA)   NCBI Sequence Viewer  
  CAA25160 (Get FASTA)   NCBI Sequence Viewer  
  CAA26295 (Get FASTA)   NCBI Sequence Viewer  
  CAA26296 (Get FASTA)   NCBI Sequence Viewer  
  CAA33897 (Get FASTA)   NCBI Sequence Viewer  
  CDL93478 (Get FASTA)   NCBI Sequence Viewer  
  EDL10686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000032399
  ENSMUSP00000032399.6
  ENSMUSP00000107339
  ENSMUSP00000107339.2
  ENSMUSP00000145294
GenBank Protein P32883 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 30 rows
1 to 5 of 14 rows
1 to 5 of 14 rows
RefSeq Acc Id: NP_067259   ⟸   NM_021284
- Peptide Label: isoform 1
- UniProtKB: Q5J7N1 (UniProtKB/TrEMBL),   Q3U2W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006506982   ⟸   XM_006506919
- Peptide Label: isoform X2
- UniProtKB: Q3U2W7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000107339   ⟸   ENSMUST00000111710
Ensembl Acc Id: ENSMUSP00000145294   ⟸   ENSMUST00000203147
Ensembl Acc Id: ENSMUSP00000032399   ⟸   ENSMUST00000032399

Name Modeler Protein Id AA Range Protein Structure
AF-P32883-F1-model_v2 AlphaFold P32883 1-189 view protein structure

RGD ID:6839546
Promoter ID:MM_KWN:48206
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:ENSMUST00000032397,   ENSMUST00000111709,   OTTMUST00000052666,   OTTMUST00000053353,   OTTMUST00000053356,   UC009ERI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366145,198,499 - 145,198,999 (-)MPROMDB
RGD ID:6891488
Promoter ID:EPDNEW_M9195
Type:initiation region
Name:Kras_1
Description:Mus musculus Kirsten rat sarcoma viral oncogene homolog , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386145,250,231 - 145,250,291EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000030265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000032399 ENTREZGENE
  ENSMUST00000032399.12 UniProtKB/Swiss-Prot
  ENSMUST00000111710 ENTREZGENE
  ENSMUST00000111710.8 UniProtKB/Swiss-Prot
  ENSMUST00000203147 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot
KEGG Report mmu:16653 UniProtKB/Swiss-Prot
MGD MGI:96680 ENTREZGENE
NCBI Gene 16653 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PharmGKB KRAS RGD
PhenoGen Kras PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAS UniProtKB/Swiss-Prot
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2JGP4 ENTREZGENE
  A0A0N4SVY1 ENTREZGENE, UniProtKB/TrEMBL
  B2KGV5_MOUSE UniProtKB/TrEMBL
  E9Q8V2_MOUSE UniProtKB/TrEMBL
  P04200 ENTREZGENE
  P08643 ENTREZGENE
  P32883 ENTREZGENE
  Q0VDV7 ENTREZGENE, UniProtKB/TrEMBL
  Q3U2W7 ENTREZGENE, UniProtKB/TrEMBL
  Q5J7N1 ENTREZGENE, UniProtKB/TrEMBL
  RASK_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P04200 UniProtKB/Swiss-Prot
  P08643 UniProtKB/Swiss-Prot
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-05 Kras  Kirsten rat sarcoma viral oncogene homolog    v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED