Kras (Kirsten rat sarcoma viral oncogene homolog) - Rat Genome Database

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Gene: Kras (Kirsten rat sarcoma viral oncogene homolog) Mus musculus
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Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
RGD ID: 1550157
MGI Page MGI
Description: Exhibits GTPase activity. Involved in several processes, including endocrine signaling; forebrain astrocyte development; and modulation of chemical synaptic transmission. Localizes to membrane. Is expressed in several structures, including brain; early embryo; eye; genitourinary system; and gut. Used to study several diseases, including Noonan syndrome 3; carcinoma (multiple); juvenile myelomonocytic leukemia; lung cancer; and prostate cancer. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); arteriovenous malformations of the brain; cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; endometrial cancer pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (trichloromethyl)benzene; 1,1-dichloroethene; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI929937; c-K-ras; c-Ki-ras; GTPase KRas; K-; K-ras; K-Ras 2; Ki; Ki-ras; Kirsten rat sarcoma oncogene 2, expressed; Kr; Kra; Kras-2; Kras2; MGC7141; p21 protein; p21B; ras; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396145,162,425 - 145,196,144 (-)NCBIGRCm39mm39
GRCm39 Ensembl6145,162,425 - 145,195,965 (-)Ensembl
GRCm386145,216,699 - 145,250,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6145,216,699 - 145,250,239 (-)EnsemblGRCm38mm10GRCm38
MGSCv376145,165,219 - 145,198,751 (-)NCBIGRCm37mm9NCBIm37
MGSCv366145,173,866 - 145,207,390 (-)NCBImm8
Celera6148,290,985 - 148,324,546 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
adult hepatocellular carcinoma  (ISO)
anaplastic astrocytoma  (ISO)
anemia  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
arteriovenous malformations of the brain  (ISO)
autoimmune lymphoproliferative syndrome type 4  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bladder urothelial carcinoma  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiofaciocutaneous syndrome 2  (ISO)
cardiomyopathy  (IMP)
Cecal Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (IDA,ISO)
Costello syndrome  (ISO)
dilated cardiomyopathy  (IDA)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IEA,ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Experimental Sarcoma  (ISO)
fibrillary astrocytoma  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (IMP,ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary diffuse gastric cancer  (ISO)
high grade glioma  (IMP,ISO)
hypertension  (IDA)
intellectual disability  (ISO)
intrahepatic cholangiocarcinoma  (IEA,ISO)
juvenile myelomonocytic leukemia  (IEA,ISO)
juvenile rheumatoid arthritis  (ISO)
Kidney Neoplasms  (ISO)
Leukocytosis  (ISO)
linear nevus sebaceous syndrome  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (IEA,ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (ISO)
malignant astrocytoma  (IGI,ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myeloid neoplasm  (IMP)
myeloid sarcoma  (ISO)
Neoplasm Metastasis  (IEP,ISO)
Neoplastic Cell Transformation  (ISO)
neuroblastoma  (ISO)
Noonan syndrome  (IMP,ISO)
Noonan syndrome 3  (IEA,ISO)
oculoectodermal syndrome  (ISO)
Ovarian Neoplasms  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (IEA,ISO,ISS)
pancreatic ductal carcinoma  (ISO)
pancreatic mucinous cystadenoma  (ISO)
Paraproteinemias  (ISO)
Parasitic Liver Diseases  (ISO)
Penile Neoplasms  (ISO)
pilocytic astrocytoma  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
prostate cancer  (IEA)
prostate carcinoma in situ  (IAGP)
Prostatic Neoplasms  (IAGP,ISO)
RASopathy  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
renal fibrosis  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin melanoma  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-cell acute lymphoblastic leukemia  (IMP)
thyroid gland follicular carcinoma  (ISO)
thyroid gland medullary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(trichloromethyl)benzene  (EXP)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropyrene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2-Bis(bromomethyl)propane-1,3-diol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Methylchrysene  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
Benz[j]aceanthrylene  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
ceruletide  (EXP)
chloroethene  (EXP,ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
chymostatin  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
cumene  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
Cyclopenta[cd]pyrene  (EXP)
dabrafenib  (ISO)
dextran sulfate  (EXP)
dibenzo[a,l]pyrene  (EXP)
dichlorine  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
farnesyl diphosphate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
GDP  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
GTP  (ISO)
guanosine  (ISO)
haloperidol  (ISO)
hydroquinone  (ISO)
hydroxyurea  (EXP)
ionomycin  (ISO)
irbesartan  (EXP,ISO)
isoprenaline  (EXP)
isoprene  (EXP)
isotretinoin  (ISO)
kainic acid  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
lipopolysaccharide  (EXP)
losartan  (ISO)
lovastatin  (EXP,ISO)
Manumycin A  (ISO)
MeIQx  (ISO)
mercury dibromide  (ISO)
metformin  (ISO)
methohexital  (ISO)
methotrexate  (ISO)
monosodium L-glutamate  (ISO)
N,N-bis(2-hydroxypropyl)nitrosamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nicotinic acid  (EXP)
ochratoxin A  (ISO)
oxirane  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
PD 0325901  (EXP,ISO)
pemetrexed  (ISO)
pentobarbital  (ISO)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picrotoxin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
Rebamipide  (ISO)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
SB 431542  (ISO)
secobarbital  (ISO)
selumetinib  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
styrene  (EXP)
sulfur dioxide  (ISO)
sulindac  (ISO)
tacrolimus hydrate  (EXP)
Tanshinone I  (ISO)
Temsirolimus  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
Tetranitromethane  (EXP)
thiamylal  (ISO)
thimerosal  (ISO)
tiazofurine  (ISO)
tipifarnib  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
trimetrexate  (ISO)
Triptolide  (ISO)
triptonide  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vemurafenib  (ISO)
vinyl carbamate  (EXP)
zearalenone  (EXP)
zidovudine  (EXP)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte morphology  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell physiology  (IAGP)
abnormal brain development  (IAGP)
abnormal branching involved in lung morphogenesis  (IAGP)
abnormal bronchiole morphology  (IAGP)
abnormal bronchoalveolar duct junction morphology  (IAGP)
abnormal bronchus epithelium morphology  (IAGP)
abnormal bronchus morphology  (IAGP)
abnormal cardiovascular system physiology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell proliferation  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal CNS glial cell morphology  (IAGP)
abnormal colon goblet cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal common lymphocyte progenitor cell morphology  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cone electrophysiology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal cystic duct morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal DNA repair  (IAGP)
abnormal duodenum morphology  (IAGP)
abnormal ear position  (IAGP)
abnormal embryonic erythrocyte morphology  (IAGP)
abnormal embryonic erythropoiesis  (IAGP)
abnormal embryonic hematopoiesis  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal enterocyte proliferation  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal exocrine pancreas morphology  (IAGP)
abnormal extrahepatic bile duct morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal facial morphology  (IAGP)
abnormal fetal cardiomyocyte proliferation  (IAGP)
abnormal fibroblast proliferation  (IAGP)
abnormal gallbladder morphology  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hematopoietic system morphology/development  (IAGP)
abnormal hepatic portal vein morphology  (IAGP)
abnormal hepatic portal vein thrombosis  (IAGP)
abnormal hepatobiliary system morphology  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal goblet cell morphology  (IAGP)
abnormal intestine morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lacrimal gland development  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lung adenoma incidence  (IAGP)
abnormal lung development  (IAGP)
abnormal lung epithelium morphology  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal metabolism  (IAGP)
abnormal metastatic potential  (IAGP)
abnormal mismatch repair  (IAGP)
abnormal myeloid leukocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal ovary morphology  (IAGP)
abnormal pancreas development  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal pancreatic duct morphology  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal prostate gland morphology  (IAGP)
abnormal prostate gland physiology  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal rod electrophysiology  (IAGP)
abnormal skin sebaceous gland morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal survival  (IAGP)
abnormal systemic arterial blood pressure  (IAGP)
abnormal translation  (IAGP)
abnormal tumor incidence  (IAGP)
abnormal tumor morphology  (IAGP)
absent lacrimal glands  (IAGP)
absent Paneth cells  (IAGP)
absent visceral yolk sac blood islands  (IAGP)
absent vitelline blood vessels  (IAGP)
anemia  (IAGP)
anisopoikilocytosis  (IAGP)
ascites  (IAGP)
bile duct hyperplasia  (IAGP)
bronchial epithelial hyperplasia  (IAGP)
bronchiolar epithelial hyperplasia  (IAGP)
cachexia  (IAGP)
cardiac fibrosis  (IAGP)
cellular necrosis  (IAGP)
cholestasis  (IAGP)
chromosomal instability  (IAGP)
chromosome breakage  (IAGP)
chylous ascites  (IAGP)
conotruncal ridge hyperplasia  (IAGP)
decreased a-wave amplitude  (IAGP)
decreased B cell number  (IAGP)
decreased b-wave amplitude  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased cardiac muscle contractility  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating estradiol level  (IAGP)
decreased circulating progesterone level  (IAGP)
decreased circulating thyroid-stimulating hormone level  (IAGP)
decreased classified tumor incidence  (IAGP)
decreased cranium length  (IAGP)
decreased double-negative T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased glutamic acid level  (IAGP)
decreased hematocrit  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased incidence of induced tumors  (IAGP)
decreased incidence of tumors by chemical induction  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased lung tumor incidence  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased lymphoma incidence  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased metastatic potential  (IAGP)
decreased ovarian tumor incidence  (IAGP)
decreased skin tumor incidence  (IAGP)
decreased survivor rate  (IAGP)
decreased T cell number  (IAGP)
decreased tumor growth/size  (IAGP)
decreased tumor incidence  (IAGP)
decreased tumor latency  (IAGP)
dilated bile duct  (IAGP)
dilated cardiomyopathy  (IAGP)
dilated gallbladder  (IAGP)
dilated heart  (IAGP)
dilated pancreatic duct  (IAGP)
dilated respiratory conducting tubes  (IAGP)
disorganized pancreatic islets  (IAGP)
distended abdomen  (IAGP)
distended pericardium  (IAGP)
double outlet right ventricle  (IAGP)
early cellular replicative senescence  (IAGP)
edema  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged heart  (IAGP)
enlarged liver  (IAGP)
enlarged lung  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pancreas  (IAGP)
enlarged pancreatic islets  (IAGP)
enlarged sebaceous gland  (IAGP)
enlarged spleen  (IAGP)
enlarged thyroid gland  (IAGP)
epidermal hyperplasia  (IAGP)
excessive folding of visceral yolk sac  (IAGP)
exocrine pancreas atrophy  (IAGP)
exocrine pancreatic insufficiency  (IAGP)
extramedullary hematopoiesis  (IAGP)
fetal growth retardation  (IAGP)
flattened snout  (IAGP)
Harderian gland hyperplasia  (IAGP)
heart hyperplasia  (IAGP)
hemoperitoneum  (IAGP)
hemorrhage  (IAGP)
hemorrhagic ascites  (IAGP)
hepatic necrosis  (IAGP)
hepatosplenomegaly  (IAGP)
hunched posture  (IAGP)
hydrops fetalis  (IAGP)
hyperpigmentation  (IAGP)
hypertension  (IAGP)
impaired branching involved in bronchus morphogenesis  (IAGP)
impaired branching involved in terminal bronchiole morphogenesis  (IAGP)
impaired granulosa cell differentiation  (IAGP)
increased adenocarcinoma incidence  (IAGP)
increased adenoma incidence  (IAGP)
increased apoptosis  (IAGP)
increased B cell number  (IAGP)
increased basophil cell number  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cardiac output  (IAGP)
increased cell proliferation  (IAGP)
increased cellular sensitivity to oxidative stress  (IAGP)
increased cholangiocarcinoma incidence  (IAGP)
increased circulating erythropoietin level  (IAGP)
increased circulating follicle stimulating hormone level  (IAGP)
increased circulating luteinizing hormone level  (IAGP)
increased classified tumor incidence  (IAGP)
increased colon adenoma incidence  (IAGP)
increased cranium height  (IAGP)
increased cranium width  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased dendritic cell number  (IAGP)
increased embryonic neuroepithelium apoptosis  (IAGP)
increased embryonic tissue cell apoptosis  (IAGP)
increased endometrial carcinoma incidence  (IAGP)
increased eosinophil cell number  (IAGP)
increased esophageal papilloma incidence  (IAGP)
increased facial tumor incidence  (IAGP)
increased fibroblast proliferation  (IAGP)
increased fibrosarcoma incidence  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased granulocyte monocyte progenitor cell number  (IAGP)
increased granulocyte number  (IAGP)
increased granulosa cell tumor incidence  (IAGP)
increased hair follicle cell proliferation  (IAGP)
increased hamartoma incidence  (IAGP)
increased hemangiosarcoma incidence  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemolymphoid system tumor incidence  (IAGP)
increased hepatocellular carcinoma incidence  (IAGP)
increased hepatocyte apoptosis  (IAGP)
increased IgG level  (IAGP)
increased IgM level  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenocarcinoma incidence  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased lip tumor incidence  (IAGP)
increased liver tumor incidence  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung carcinoma incidence  (IAGP)
increased lung large cell carcinoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lung squamous cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased lung weight  (IAGP)
increased lymphoblastic lymphoma incidence  (IAGP)
increased lymphoma incidence  (IAGP)
increased macrophage cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased mesothelioma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased monocyte cell number  (IAGP)
increased mouth tumor incidence  (IAGP)
increased myeloid cell number  (IAGP)
increased myeloid cell number in bone marrow  (IAGP)
increased myocardial fiber number  (IAGP)
increased neurofibroma incidence  (IAGP)
increased neurofibrosarcoma incidence  (IAGP)
increased neuron apoptosis  (IAGP)
increased neutrophil cell number  (IAGP)
increased oral papilloma incidence  (IAGP)
increased organ/body region tumor incidence  (IAGP)
increased osteosarcoma incidence  (IAGP)
increased ovary tumor incidence  (IAGP)
increased pancreas adenoma incidence  (IAGP)
increased pancreas apoptosis  (IAGP)
increased pancreas tumor incidence  (IAGP)
increased pancreas weight  (IAGP)
increased pancreatic acinar cell carcinoma incidence  (IAGP)
increased pancreatic ductal adenocarcinoma incidence  (IAGP)
increased pancreatic intraepithelial neoplasia incidence  (IAGP)
increased papilloma incidence  (IAGP)
increased pituitary adenoma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased regulatory T cell number  (IAGP)
increased sarcoma incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin squamous cell carcinoma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased spindle cell carcinoma incidence  (IAGP)
increased spleen red pulp amount  (IAGP)
increased splenocyte proliferation  (IAGP)
increased squamous cell carcinoma incidence  (IAGP)
increased stomach tumor incidence  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased T cell derived lymphoma incidence  (IAGP)
increased T cell number  (IAGP)
increased teratocarcinoma incidence  (IAGP)
increased testis tumor incidence  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroxine level  (IAGP)
increased trichoepithelioma incidence  (IAGP)
increased tumor growth/size  (IAGP)
increased tumor incidence  (IAGP)
increased tumor latency  (IAGP)
increased type II pneumocyte number  (IAGP)
increased urinary bladder carcinoma incidence  (IAGP)
intestinal obstruction  (IAGP)
jaundice  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
liver hypoplasia  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
lymphedema  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
no abnormal phenotype detected  (IAGP)
ocular hypertelorism  (IAGP)
oxidative stress  (IAGP)
pale liver  (IAGP)
pale yolk sac  (IAGP)
pallor  (IAGP)
pancreas cysts  (IAGP)
pancreas hyperplasia  (IAGP)
pancreas inflammation  (IAGP)
pancreatic acinar-to-ductal metaplasia  (IAGP)
paralysis  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
perinatal lethality, incomplete penetrance  (IAGP)
polychromatophilia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
prostate gland hyperplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
reticulocytosis  (IAGP)
ruffled hair  (IAGP)
sebaceous gland hyperplasia  (IAGP)
seminiferous tubule degeneration  (IAGP)
short tail  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small heart  (IAGP)
small liver  (IAGP)
spleen vascular congestion  (IAGP)
squamous metaplasia of bulbourethral gland  (IAGP)
squamous metaplasia of urethral gland  (IAGP)
stomach mucosa hyperplasia  (IAGP)
submandibular gland hyperplasia  (IAGP)
tachypnea  (IAGP)
thick aortic valve  (IAGP)
thick epidermis  (IAGP)
thick pulmonary interalveolar septum  (IAGP)
thin myocardium  (IAGP)
thin ventricular wall  (IAGP)
thrombocytopenia  (IAGP)
thymus atrophy  (IAGP)
triangular face  (IAGP)
uterus adenomyosis  (IAGP)
ventricular septal defect  (IAGP)
weight loss  (IAGP)
References

References - curated
1. Abel TW, etal., Mol Cancer Res. 2009 May;7(5):645-53. doi: 10.1158/1541-7786.MCR-08-0477. Epub 2009 May 12.
2. Ahrendt SA, etal., Cancer. 2001 Sep 15;92(6):1525-30.
3. Alon Y, etal., Cancer Res. 1987 May 15;47(10):2553-7.
4. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
5. Bollag G, etal., J Biol Chem. 1996 Dec 20;271(51):32491-4.
6. Boulalas I, etal., J Urol. 2009 May;181(5):2312-9. Epub 2009 Mar 19.
7. Calvert RJ, etal., Cancer Lett. 1996 Dec 3;109(1-2):1-7.
8. Castagnola P and Giaretti W, Biochim Biophys Acta. 2005 Nov 25;1756(2):115-25. Epub 2005 Jul 13.
9. Cho YH, etal., Yonsei Med J. 2009 Apr 30;50(2):266-72.
10. Dalin MG, etal., Cardiovasc Res. 2014 Feb 1;101(2):229-35. doi: 10.1093/cvr/cvt260. Epub 2013 Nov 20.
11. Dietrich P, etal., Gut. 2018 Jul;67(7):1328-1341. doi: 10.1136/gutjnl-2017-315402. Epub 2017 Dec 23.
12. Dobrzycka B, etal., Folia Histochem Cytobiol. 2009;47(1):65-8.
13. Dobrzycka B, etal., Int J Cancer. 2009 Dec 3.
14. Fu JF, etal., Int J Cancer. 2013 Oct 15;133(8):1792-802. doi: 10.1002/ijc.28195. Epub 2013 May 7.
15. Fujikura K, etal., Histopathology. 2017 Oct;71(4):591-600. doi: 10.1111/his.13271. Epub 2017 Aug 2.
16. Geyer JT, etal., Am J Surg Pathol. 2009 Aug;33(8):1157-63.
17. Gormally E, etal., Cancer Res. 2006 Jul 1;66(13):6871-6.
18. Grimmond SM, etal., Urol Res. 1992;20(2):121-6.
19. Haferlach C, etal., Leukemia. 2011 May;25(5):874-7. doi: 10.1038/leu.2011.5. Epub 2011 Feb 1.
20. Hernandez-Porras I, etal., Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400. doi: 10.1073/pnas.1418126111. Epub 2014 Oct 30.
21. Holmen SL and Williams BO, Cancer Res. 2005 Sep 15;65(18):8250-5. doi: 10.1158/0008-5472.CAN-05-1173.
22. Hong HH, etal., Toxicol Pathol. 2015 Aug;43(6):872-82. doi: 10.1177/0192623315581192. Epub 2015 Jun 9.
23. Jones S, etal., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4.
24. Kamai T, etal., BJU Int. 2001 Dec;88(9):960-6.
25. Kong G, etal., J Biol Chem. 2013 Jun 21;288(25):18219-27. doi: 10.1074/jbc.M113.475376. Epub 2013 May 14.
26. Kozma SC, etal., Nucleic Acids Res. 1987 Aug 11;15(15):5963-71.
27. Lahti SJ, etal., J Vasc Interv Radiol. 2015 Aug;26(8):1102-11. doi: 10.1016/j.jvir.2015.05.032.
28. Lee KH, etal., Cancer. 1995 Jun 15;75(12):2794-801.
29. Li Z, etal., J Int Med Res. 2012;40(4):1589-98. doi: 10.1177/147323001204000439.
30. Liang MC, etal., Oncogene. 2010 Mar 18;29(11):1588-97. doi: 10.1038/onc.2009.452. Epub 2009 Dec 7.
31. Lymbouridou R, etal., Eur J Cancer. 2009 May;45(7):1294-303. doi: 10.1016/j.ejca.2008.12.028. Epub 2009 Jan 27.
32. Lyubynska N, etal., Sci Transl Med. 2011 Mar 30;3(76):76ra27. doi: 10.1126/scitranslmed.3001069.
33. Malinowska-Ozdowy K, etal., Leukemia. 2015 Aug;29(8):1656-67. doi: 10.1038/leu.2015.107. Epub 2015 Apr 28.
34. Mammas IN, etal., Gynecol Oncol. 2004 Mar;92(3):941-8.
35. Margonis GA, etal., J Surg Oncol. 2016 Sep;114(3):361-7. doi: 10.1002/jso.24319. Epub 2016 Jun 6.
36. MGD data from the GO Consortium
37. MGD IEA
38. Muñoz DM, etal., Glia. 2013 Nov;61(11):1862-72. doi: 10.1002/glia.22563. Epub 2013 Aug 30.
39. Niihori T, etal., Nat Genet. 2006 Mar;38(3):294-6. Epub 2006 Feb 12.
40. Ohigashi H, etal., Arch Surg. 2000 Dec;135(12):1450-5.
41. OMIM Disease Annotation Pipeline
42. Ortega MM, etal., Leuk Lymphoma. 2006 Feb;47(2):285-9.
43. Ouerhani S, etal., Mol Biol Rep. 2013 Jun;40(6):4109-14. doi: 10.1007/s11033-013-2512-8. Epub 2013 May 3.
44. Paulsson K, etal., Genes Chromosomes Cancer. 2008 Jan;47(1):26-33.
45. Pearson HB, etal., Cancer Res. 2009 Jan 1;69(1):94-101.
46. Pipeline to import KEGG annotations from KEGG into RGD
47. Pipeline to import SMPDB annotations from SMPDB into RGD
48. Potenza N, etal., EMBO Rep. 2005 May;6(5):432-7.
49. Przygodzki RM, etal., Hum Pathol. 1996 Sep;27(9):975-9.
50. RGD automated import pipeline
51. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. RGD automated import pipeline for gene-chemical interactions
53. Robertson S, etal., Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.
54. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
55. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
56. Sarfati P, etal., Digestion. 1996 Nov-Dec;57(6):453-63.
57. Saud SM, etal., Carcinogenesis. 2014 Dec;35(12):2778-86. doi: 10.1093/carcin/bgu209. Epub 2014 Oct 3.
58. Schubbert S, etal., Nat Genet. 2006 Mar;38(3):331-6. Epub 2006 Feb 12.
59. Serenari M, etal., Dig Surg. 2018;35(4):303-310. doi: 10.1159/000471930. Epub 2017 Oct 14.
60. Sharma MK, etal., Neurology. 2005 Oct 25;65(8):1335-6.
61. Soman NR and Wogan GN, Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):2045-9.
62. Stockand JD and Meszaros JG, Am J Physiol Heart Circ Physiol 2003 Jan;284(1):H176-84.
63. Szpirer J, etal., Somat Cell Mol Genet 1985 Jan;11(1):93-7.
64. Tanoguchi K, etal., Tohoku J Exp Med. 1999 Oct;189(2):87-93.
65. Tsujioka H, etal., Int J Gynecol Cancer. 2009 Aug;19(6):1052-6.
66. Vaziri ND and Liang K, Am J Physiol Renal Physiol. 2004 Nov;287(5):F1038-43. Epub 2004 Jul 27.
67. Wang JH, etal., Am J Pathol. 2012 Jan;180(1):82-90. doi: 10.1016/j.ajpath.2011.09.036. Epub 2011 Nov 7.
68. Wang XF, etal., J Cancer Res Clin Oncol. 2012 Apr;138(4):573-84. doi: 10.1007/s00432-011-1114-x. Epub 2011 Dec 30.
69. Warden CH, etal., Genomics 1993 Nov;18(2):295-307.
70. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9.
71. Zenker M, etal., J Med Genet. 2007 Feb;44(2):131-5. Epub 2006 Oct 20.
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