Trp53 (transformation related protein 53) - Rat Genome Database

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Gene: Trp53 (transformation related protein 53) Mus musculus
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Symbol: Trp53
Name: transformation related protein 53
RGD ID: 11440
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to radiation; intrinsic apoptotic signaling pathway; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including mitochondrion organization; negative regulation of cellular metabolic process; and regulation of apoptotic process. Located in several cellular components, including chromosome; cytosol; and mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study several diseases, including CHARGE syndrome; Li-Fraumeni syndrome; bone cancer (multiple); diffuse large B-cell lymphoma; and endometrial cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bbl; bfy; bhy; cellular tumor antigen p53; ME-delta123p53; mutant p53; p4; p44; p5; p53; p53 cellular tumor antigen; Tp53; tumor suppressor p53; tumor supressor p53
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Trp53-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,471,174 - 69,482,699 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,471,185 - 69,482,699 (+)Ensembl
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBImm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model