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Gene: Trp53 (transformation related protein 53) Mus musculus
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Symbol: Trp53
Name: transformation related protein 53
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; MDM2/MDM4 family protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signal transduction; negative regulation of cellular metabolic process; and regulation of programmed cell death. Localizes to several cellular components, including chromosome; cytosol; and mitochondrial matrix. Predicted to colocalize with nuclear body and transcription factor TFIID complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study several diseases, including CHARGE syndrome; Li-Fraumeni syndrome; bone cancer (multiple); diffuse large B-cell lymphoma; and endometrial cancer. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bbl; bfy; bhy; cellular tumor antigen p53; ME-delta123p53; mutant p53; p44; p53; p53 cellular tumor antigen; Tp53; tumor suppressor p53; tumor supressor p53
Orthologs:
Homo sapiens (human) : TP53 (tumor protein p53)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tp53 (tumor protein p53)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53 (tumor protein p53)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53 (tumor protein p53)
Canis lupus familiaris (dog) : TP53 (tumor protein p53)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53 (tumor protein p53)
Sus scrofa (pig) : TP53 (tumor protein p53)
Chlorocebus sabaeus (African green monkey) : TP53 (tumor protein p53)
Heterocephalus glaber (naked mole-rat) : Tp53 (tumor protein p53)
more info ...
Related Pseudogenes: Trp53-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)EnsemblGRCm38mm10GRCm38
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBImm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model