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Gene: Trp53 (transformation related protein 53) Mus musculus
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Symbol: Trp53
Name: transformation related protein 53
Description: This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bbl; bfy; bhy; cellular tumor antigen p53; mutant p53; p44; p53; p53 cellular tumor antigen; Tp53; tumor suppressor p53; tumor supressor p53
Orthologs:
Homo sapiens (human) : TP53 (tumor protein p53)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tp53 (tumor protein p53)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tp53 (tumor protein p53)
Pan paniscus (bonobo/pygmy chimpanzee) : TP53 (tumor protein p53)
Canis lupus familiaris (dog) : TP53 (tumor protein p53)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tp53 (tumor protein p53)
Sus scrofa (pig) : TP53 (tumor protein p53)
more info ...
Related Pseudogenes: Trp53-ps  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381169,580,359 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBImm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11 B3NCBI
cM Map1142.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model