Tmem185b (transmembrane protein 185B) - Rat Genome Database

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Gene: Tmem185b (transmembrane protein 185B) Rattus norvegicus
Analyze
Symbol: Tmem185b
Name: transmembrane protein 185B
RGD ID: 1309602
Description: Predicted to be located in membrane. Orthologous to human TMEM185B (transmembrane protein 185B); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304731; RGD1309602; similar to RIKEN cDNA 2500001K11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,200,329 - 33,203,660 (+)NCBIGRCr8
mRatBN7.21330,647,533 - 30,650,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,647,482 - 30,650,858 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,228,893 - 33,232,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,516,732 - 34,520,065 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,790,854 - 31,794,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,554,621 - 35,557,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,554,964 - 35,556,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01340,669,220 - 40,672,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41332,276,974 - 32,279,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11332,280,108 - 32,281,829 (+)NCBI
Celera1330,543,175 - 30,546,506 (+)NCBICelera
Cytogenetic Map13q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem185b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81333,200,329 - 33,203,660 (+)NCBIGRCr8
mRatBN7.21330,647,533 - 30,650,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1330,647,482 - 30,650,858 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1333,228,893 - 33,232,226 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01334,516,732 - 34,520,065 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01331,790,854 - 31,794,186 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01335,554,621 - 35,557,952 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1335,554,964 - 35,556,016 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01340,669,220 - 40,672,564 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41332,276,974 - 32,279,005 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11332,280,108 - 32,281,829 (+)NCBI
Celera1330,543,175 - 30,546,506 (+)NCBICelera
Cytogenetic Map13q11NCBI
TMEM185B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382120,217,479 - 120,223,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2120,217,479 - 120,223,400 (-)EnsemblGRCh38hg38GRCh38
GRCh372120,975,055 - 120,980,976 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362120,695,324 - 120,697,454 (-)NCBINCBI36Build 36hg18NCBI36
Celera2114,305,701 - 114,307,831 (-)NCBICelera
Cytogenetic Map2q14.2NCBI
HuRef2113,298,822 - 113,304,759 (-)NCBIHuRef
CHM1_12120,979,441 - 120,985,378 (-)NCBICHM1_1
T2T-CHM13v2.02120,652,239 - 120,658,160 (-)NCBIT2T-CHM13v2.0
Tmem185b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391119,453,884 - 119,456,713 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1119,453,890 - 119,456,713 (+)EnsemblGRCm39 Ensembl
GRCm381119,526,154 - 119,528,983 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1119,526,160 - 119,528,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv371121,422,744 - 121,424,803 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361121,353,713 - 121,355,772 (+)NCBIMGSCv36mm8
Celera1122,184,964 - 122,187,094 (+)NCBICelera
Cytogenetic Map1E2.3NCBI
cM Map152.31NCBI
Tmem185b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554599,610,905 - 9,613,405 (+)NCBIChiLan1.0ChiLan1.0
TMEM185B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21322,219,290 - 22,225,355 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B22,238,267 - 22,240,349 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B7,149,925 - 7,155,857 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B120,725,913 - 120,731,687 (-)NCBIpanpan1.1PanPan1.1panPan2
TMEM185B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11929,892,735 - 29,894,526 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1930,149,219 - 30,151,009 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01931,268,313 - 31,270,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1931,268,280 - 31,270,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11929,954,584 - 29,956,373 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01930,123,872 - 30,125,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01931,309,974 - 31,311,768 (+)NCBIUU_Cfam_GSD_1.0
Tmem185b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530391,308,751 - 91,314,210 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646950,303,976 - 50,305,028 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646950,303,513 - 50,306,321 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM185B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1531,141,126 - 31,142,181 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11531,140,283 - 31,146,656 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21536,617,474 - 36,619,775 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM185B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11010,068,817 - 10,070,996 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1010,069,244 - 10,070,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606112,616,649 - 12,619,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem185b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473224,869,529 - 24,872,583 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem185b
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:155
Interacting mature miRNAs:169
Transcripts:ENSRNOT00000072632
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303030Bp327Blood pressure QTL 327arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133039535141184251Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 36 20 19 20 2 5 74 35 39 11 2
Low 2 21 21 21 6 6 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001191668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000072632   ⟹   ENSRNOP00000066393
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1335,554,964 - 35,556,016 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103300   ⟹   ENSRNOP00000088381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1330,647,482 - 30,650,858 (+)Ensembl
RefSeq Acc Id: NM_001191668   ⟹   NP_001178597
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81333,200,329 - 33,203,660 (+)NCBI
mRatBN7.21330,647,533 - 30,650,864 (+)NCBI
Rnor_6.01335,554,621 - 35,557,952 (+)NCBI
Rnor_5.01340,669,220 - 40,672,564 (+)NCBI
Celera1330,543,175 - 30,546,506 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178597 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000088381
  ENSRNOP00000088381.1
RefSeq Acc Id: NP_001178597   ⟸   NM_001191668
- UniProtKB: A0A8I6A9A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066393   ⟸   ENSRNOT00000072632
RefSeq Acc Id: ENSRNOP00000088381   ⟸   ENSRNOT00000103300

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RA52-F1-model_v2 AlphaFold M0RA52 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698763
Promoter ID:EPDNEW_R9287
Type:initiation region
Name:Tmem185b_1
Description:transmembrane protein 185B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01335,554,896 - 35,554,956EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309602 AgrOrtholog
BioCyc Gene G2FUF-18522 BioCyc
Ensembl Genes ENSRNOG00000047257 Ensembl
  ENSRNOG00000067956 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000103300 ENTREZGENE
  ENSRNOT00000103300.1 UniProtKB/TrEMBL
InterPro TM_Fragile-X-F-assoc UniProtKB/TrEMBL
KEGG Report rno:304731 UniProtKB/TrEMBL
NCBI Gene 304731 ENTREZGENE
PANTHER PTHR13568 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 185B UniProtKB/TrEMBL
Pfam Tmemb_185A UniProtKB/TrEMBL
PhenoGen Tmem185b PhenoGen
RatGTEx ENSRNOG00000047257 RatGTEx
  ENSRNOG00000067956 RatGTEx
UniProt A0A8I6A9A9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Tmem185b  transmembrane protein 185B  RGD1309602_predicted  similar to RIKEN cDNA 2500001K11 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1309602_predicted  similar to RIKEN cDNA 2500001K11 (predicted)  LOC304731_predicted    Symbol and Name status set to approved 1331353 APPROVED