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Gene: Glrx3 (glutaredoxin 3) Rattus norvegicus

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Symbol:

Glrx3

Name:

glutaredoxin 3

RGD ID:

69414

Description:

Enables protein kinase C binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; cell redox homeostasis; and negative regulation of cardiac muscle hypertrophy. Located in dendrite. Orthologous to human GLRX3 (glutaredoxin 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

glutaredoxin-3; MGC105380; PICOT; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; thioredoxin-like 2; thioredoxin-like protein 2; Txnl2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLRX3 (glutaredoxin 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Glrx3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Glrx3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLRX3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLRX3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Glrx3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GLRX3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GLRX3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Glrx3 (glutaredoxin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PIK3R5 (phosphoinositide-3-kinase regulatory subunit 5)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GLRX3 (glutaredoxin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Glrx3 (glutaredoxin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	glrx3 (glutaredoxin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GRX3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6523	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	glrx-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GRX4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	glrx3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	201,671,410 - 201,701,722 (+)	NCBI		GRCr8
mRatBN7.2	1	192,241,707 - 192,272,012 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	192,241,701 - 192,272,010 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	200,608,856 - 200,638,933 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	207,760,578 - 207,790,565 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	200,434,029 - 200,464,012 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	209,768,696 - 209,799,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	209,768,696 - 209,799,903 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	216,692,884 - 216,724,100 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	197,176,020 - 197,206,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	197,326,013 - 197,356,245 (+)	NCBI
Celera	1	189,946,939 - 189,976,456 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cardiomegaly (ISO)

choreatic disease (ISO)

distal 10q deletion syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

ammonium chloride (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcium atom (EXP)

calcium(0) (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

clobetasol (ISO)

clofibric acid (EXP)

clozapine (ISO)

cocaine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

ethanol (ISO)

finasteride (EXP)

flavonoids (EXP)

flutamide (EXP)

frenolicin B (ISO)

furfural (ISO)

gentamycin (EXP)

glutathione (ISO)

glycidyl methacrylate (ISO)

hyaluronic acid (EXP)

hydrogen peroxide (EXP,ISO)

inulin (ISO)

irinotecan (ISO)

ivermectin (ISO)

lead(0) (ISO)

methimazole (EXP)

microcystin-LR (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nickel atom (ISO)

nitrates (ISO)

ozone (EXP)

paracetamol (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenylephrine (EXP)

quartz (ISO)

reactive oxygen species (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium chloride (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

tamoxifen (EXP,ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

thapsigargin (ISO)

theophylline (ISO)

thioacetamide (EXP)

triptonide (ISO)

trovafloxacin (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

[2Fe-2S] cluster assembly (IEA,ISO,ISS)

cell redox homeostasis (IEA,ISO)

intracellular iron ion homeostasis (IBA,IEA,ISO)

iron-sulfur cluster assembly (IEA,ISO)

negative regulation of cardiac muscle hypertrophy (ISO)

regulation of the force of heart contraction (ISO)

Cellular Component

cell cortex (IEA)

cytoplasm (IEA)

cytosol (IBA,IEA)

dendrite (IDA)

iron-sulfur cluster assembly complex (IEA,ISO)

membrane (IEA)

nucleus (IBA)

Z disc (IEA,ISO)

Molecular Function

identical protein binding (IEA,ISO)

iron-sulfur cluster binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

protein kinase C binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system.	Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9.	Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain.	Witte S, etal., J Biol Chem 2000 Jan 21;275(3):1902-9.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:18258855	PMID:22658674	PMID:23376485	PMID:25416956	PMID:26302480	PMID:27519415

Genomics

Comparative Map Data

Glrx3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	201,671,410 - 201,701,722 (+)	NCBI		GRCr8
mRatBN7.2	1	192,241,707 - 192,272,012 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	192,241,701 - 192,272,010 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	200,608,856 - 200,638,933 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	207,760,578 - 207,790,565 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	200,434,029 - 200,464,012 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	209,768,696 - 209,799,912 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	209,768,696 - 209,799,903 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	216,692,884 - 216,724,100 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	197,176,020 - 197,206,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	197,326,013 - 197,356,245 (+)	NCBI
Celera	1	189,946,939 - 189,976,456 (+)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

GLRX3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	130,136,391 - 130,180,377 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	130,136,391 - 130,184,521 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	131,934,655 - 131,978,641 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	131,824,653 - 131,867,860 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	131,824,671 - 131,872,774	NCBI
Celera	10	125,607,908 - 125,651,111 (+)	NCBI		Celera
Cytogenetic Map	10	q26.3	NCBI
HuRef	10	125,514,535 - 125,558,544 (+)	NCBI		HuRef
CHM1_1	10	132,217,042 - 132,261,052 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	131,065,390 - 131,109,374 (+)	NCBI		T2T-CHM13v2.0

Glrx3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	137,039,302 - 137,071,360 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	137,039,343 - 137,070,323 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	137,437,573 - 137,469,631 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	137,437,614 - 137,468,594 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	144,629,331 - 144,660,277 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	137,275,991 - 137,306,937 (+)	NCBI		MGSCv36	mm8
Celera	7	137,253,536 - 137,284,736 (+)	NCBI		Celera
Cytogenetic Map	7	F4	NCBI
cM Map	7	82.32	NCBI

Glrx3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955477	7,715,257 - 7,752,818 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955477	7,715,257 - 7,748,913 (+)	NCBI	ChiLan1.0	ChiLan1.0

GLRX3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	142,025,459 - 142,134,030 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	142,030,815 - 142,135,466 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	126,730,314 - 126,775,918 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	130,973,022 - 131,019,741 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	130,973,022 - 131,019,742 (+)	Ensembl	panpan1.1		panPan2

GLRX3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	38,724,895 - 38,755,323 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	38,724,941 - 38,755,316 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	38,781,705 - 38,812,290 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	39,360,801 - 39,391,612 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	39,360,806 - 39,391,610 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	38,847,851 - 38,878,212 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	38,836,160 - 38,866,776 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	39,090,506 - 39,121,238 (+)	NCBI		UU_Cfam_GSD_1.0

Glrx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	8,328,180 - 8,354,031 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936486	17,207,309 - 17,233,171 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936486	17,201,838 - 17,233,171 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GLRX3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	139,072,575 - 139,111,249 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	139,072,554 - 139,108,063 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	151,189,259 - 151,224,776 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GLRX3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	122,737,101 - 122,780,001 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	122,737,379 - 122,781,391 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	84,120,319 - 84,163,350 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Glrx3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	16,905,964 - 16,938,048 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	16,906,135 - 16,938,089 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Glrx3
249 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	19
Count of miRNA genes:	15
Interacting mature miRNAs:	19
Transcripts:	ENSRNOT00000022406
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
70160	Bw18	Body weight QTL 18	5.7		body mass (VT:0001259)	body weight (CMO:0000012)	1	144267353	196383668	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1354636	Lmblg1	Limb length QTL 1	6.4		tibia length (VT:0004357)	tibia length (CMO:0000450)	1	151162512	201278233	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
1354634	Kidm12	Kidney mass QTL 12	3.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	1	151162512	201278233	Rat
4889428	Stresp24	Stress response QTL 24		0.05	heart pumping trait (VT:2000009)	absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)	1	155866514	200866514	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
61343	Bp28	Blood pressure QTL 28			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	151646613	196646613	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
61348	Bp30	Blood pressure QTL 30	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	144017057	197814409	Rat
2303622	Vencon6	Ventilatory control QTL 6		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	1	154561505	199561505	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1359018	Hrtrt20	Heart rate QTL 20	3.08		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	185356336	202902618	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
61378	Bp43	Blood pressure QTL 43	22.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	181746937	196383668	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
619614	Bp78	Blood pressure QTL 78		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	169112897	197261052	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
1354620	Kidm19	Kidney mass QTL 19	4		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	201278233	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
1354618	Kidm15	Kidney mass QTL 15	5		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	1	156677124	201278233	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
6480780	Insul18	Insulin level QTL 18	4.11		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	189607473	200611765	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1354602	Bw35	Body weight QTL 35	12.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	201278233	Rat
631670	Iddm10	Insulin dependent diabetes mellitus QTL 10	1.9		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	174133260	196383668	Rat

Markers in Region

BE117517

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	1	q41	UniSTS

BE113509

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	201,691,007 - 201,691,179 (+)	Marker Load Pipeline
mRatBN7.2	1	192,261,295 - 192,261,467 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	209,789,194 - 209,789,365	NCBI	Rnor6.0
Rnor_5.0	1	216,713,382 - 216,713,553	UniSTS	Rnor5.0
RGSC_v3.4	1	197,195,535 - 197,195,706	UniSTS	RGSC3.4
Celera	1	189,965,796 - 189,965,967	UniSTS
RH 3.4 Map	1	1420.6	UniSTS
Cytogenetic Map	1	q41	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_032614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF118651	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216152	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000022406 ⟹ ENSRNOP00000022406

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	192,241,701 - 192,272,010 (+)	Ensembl
Rnor_6.0 Ensembl	1	209,768,696 - 209,799,903 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083316 ⟹ ENSRNOP00000073509

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	192,241,765 - 192,272,010 (+)	Ensembl
Rnor_6.0 Ensembl	1	209,769,282 - 209,799,903 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107315 ⟹ ENSRNOP00000079546

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	192,241,701 - 192,269,832 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109827 ⟹ ENSRNOP00000091412

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	192,250,032 - 192,269,832 (+)	Ensembl

RefSeq Acc Id:

NM_032614 ⟹ NP_116003

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	201,671,494 - 201,701,722 (+)	NCBI
mRatBN7.2	1	192,241,781 - 192,272,010 (+)	NCBI
Rnor_6.0	1	209,768,696 - 209,799,908 (+)	NCBI
Rnor_5.0	1	216,692,884 - 216,724,100 (+)	NCBI
RGSC_v3.4	1	197,176,020 - 197,206,249 (+)	RGD
Celera	1	189,946,939 - 189,976,456 (+)	RGD

Sequence:

show sequence

GGCAGCATGGCGGCGGGGGCGGCTGAAGCAGCCGAGGCGGCCGTGGCAGTGGTGGAAGTCGGCT
CTGCCCGGCAGTTTGAGGAGCTACTGCGCCTCAAAACCAAGTCACTCCTTGTGGTCCATTTCTG
GGCGCCATGGGCTCCACAGTGTGTACAGATGAACGATGTCATGGCAGAGTTAGCTAAAGAGCAT
CCTCATGTTTCATTTGTGAAGCTGGAAGCCGAAGCTGTTCCTGAAGTATCTGAAAAATATGAAA
TTAGTTCTGTTCCCACCTTCCTGTTCTTCAAGAATTCTCAGAAAGTCGACCGGTTAGATGGTGC
ACATGCCCCAGAGTTGACCAAAAAAGTCCAGCGACACGTGTCTAGTGGATCCTTTCCTCCTAGT
ACTAATGAACATGTTAAAGAAGATCTCAACCTTCGCCTGAAAAAGCTGACTCACGCTGCCCCCT
GCATGCTCTTCATGAAGGGAACACCTCAGGAACCACGCTGTGGTTTTAGCAAGCAGATGGTGGA
AATCCTTCACAAACACAATATTCAGTTCAGCAGTTTTGATATCTTCTCAGATGAAGAAGTTCGA
CAGGGGCTCAAAACATACTCTAATTGGCCCACCTATCCTCAGCTCTATGTTTCTGGAGAGCTCA
TAGGAGGACTTGACATAATTAAGGAGCTGGAAGCATCAGAAGAACTAGATACAATTTGTCCCAA
AGCACCCAAGTTAGAGGAAAGGCTCAAAGTGCTGACCAATAAAGCTTCTGTGATGCTCTTTATG
AAAGGAAACAAACAGGAAGCAAAATGTGGATTCAGCAAACAAATTCTGGAAATACTGAATAGTA
CTGGGGTTGAATATGAGACTTTTGATATACTGGAGGATGAAGAAGTGCGTCAGGGATTAAAAAC
GTTCTCAAATTGGCCAACCTACCCTCAGCTGTATGTGAGAGGGGATCTTGTTGGAGGACTGGAT
ATTGTCAAGGAACTGAAAGACAACGGTGAATTGCTACCTATACTGAAGGGAGAAAATTAGTGAA
CGTTAAGCACGGTGTCCAAGGACTGCAAGAAGTATTTAGTTATCGTGGAATAGTTGATGACTTG
GTCCTGCGAAGTGGACTGAGAGTAGAAATGCGACATAGTCAGCTGTGCTCAATGTGCTTCACAA
AGTTGTGCTGAAAAAAACATATGTTACATTTTCCATGAAGCATAGAAGGCAATAAACTCCAGAT
TCAGCTAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039088750 ⟹ XP_038944678

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	201,671,985 - 201,701,722 (+)	NCBI
mRatBN7.2	1	192,242,356 - 192,272,012 (+)	NCBI

RefSeq Acc Id:

XM_039088751 ⟹ XP_038944679

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	201,671,410 - 201,701,722 (+)	NCBI
mRatBN7.2	1	192,241,707 - 192,272,004 (+)	NCBI

RefSeq Acc Id:

XM_063272117 ⟹ XP_063128187

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	201,687,294 - 201,701,722 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_116003	(Get FASTA)	NCBI Sequence Viewer
	XP_038944678	(Get FASTA)	NCBI Sequence Viewer
	XP_038944679	(Get FASTA)	NCBI Sequence Viewer
	XP_063128187	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF28843	(Get FASTA)	NCBI Sequence Viewer
	AAH86381	(Get FASTA)	NCBI Sequence Viewer
	EDM11816	(Get FASTA)	NCBI Sequence Viewer
	EDM11817	(Get FASTA)	NCBI Sequence Viewer
	EDM11818	(Get FASTA)	NCBI Sequence Viewer
	EDM11819	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000022406
	ENSRNOP00000022406.5
	ENSRNOP00000073509
GenBank Protein	Q9JLZ1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_116003 ⟸ NM_032614

- UniProtKB:

Q5RK11 (UniProtKB/Swiss-Prot), Q9JLZ1 (UniProtKB/Swiss-Prot), A6HX85 (UniProtKB/TrEMBL), A0A8I6AG27 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAGAAEAAEAAVAVVEVGSARQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPH
VSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGSFPPSTN
EHVKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQG
LKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKG
NKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIV
KELKDNGELLPILKGEN

hide sequence

Ensembl Acc Id:

ENSRNOP00000022406 ⟸ ENSRNOT00000022406

Ensembl Acc Id:

ENSRNOP00000073509 ⟸ ENSRNOT00000083316

RefSeq Acc Id:	XP_038944679 ⟸ XM_039088751
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038944678 ⟸ XM_039088750
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K5P8 (UniProtKB/TrEMBL), A0A8I5ZN19 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000079546 ⟸ ENSRNOT00000107315

Ensembl Acc Id:

ENSRNOP00000091412 ⟸ ENSRNOT00000109827

RefSeq Acc Id:	XP_063128187 ⟸ XM_063272117
- Peptide Label:	isoform X3
- UniProtKB:	A6HX87 (UniProtKB/TrEMBL), A6HX86 (UniProtKB/TrEMBL)

Protein Domains

Glutaredoxin Thioredoxin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9JLZ1-F1-model_v2	AlphaFold	Q9JLZ1	1-337	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690498

Promoter ID:

EPDNEW_R1023

Type:

initiation region

Name:

Glrx3_1

Description:

glutaredoxin 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	209,768,688 - 209,768,748	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69414	AgrOrtholog
BioCyc Gene	G2FUF-57120	BioCyc
Ensembl Genes	ENSRNOG00000016227	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022406	ENTREZGENE
	ENSRNOT00000022406.7	UniProtKB/Swiss-Prot
	ENSRNOT00000083316	ENTREZGENE
Gene3D-CATH	Glutaredoxin	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7301390	IMAGE-MGC_LOAD
InterPro	Glutaredoxin	UniProtKB/Swiss-Prot
	GRX_PICOT-like	UniProtKB/Swiss-Prot
	Monothiol_GRX-rel	UniProtKB/Swiss-Prot
	Thioredoxin-like_sf	UniProtKB/Swiss-Prot
	Thioredoxin_domain	UniProtKB/Swiss-Prot
KEGG Report	rno:58815	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105380	IMAGE-MGC_LOAD
NCBI Gene	58815	ENTREZGENE
PANTHER	GLUTAREDOXIN-3	UniProtKB/Swiss-Prot
	PTHR10293	UniProtKB/Swiss-Prot
Pfam	Glutaredoxin	UniProtKB/Swiss-Prot
	Thioredoxin	UniProtKB/Swiss-Prot
PhenoGen	Glrx3	PhenoGen
PROSITE	GLUTAREDOXIN_2	UniProtKB/Swiss-Prot
	THIOREDOXIN_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000016227	RatGTEx
Superfamily-SCOP	SSF52833	UniProtKB/Swiss-Prot
TIGR	TC204832
UniProt	A0A0G2K5P8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZN19	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AG27	ENTREZGENE, UniProtKB/TrEMBL
	A6HX85	ENTREZGENE, UniProtKB/TrEMBL
	A6HX86	ENTREZGENE, UniProtKB/TrEMBL
	A6HX87	ENTREZGENE, UniProtKB/TrEMBL
	GLRX3_RAT	UniProtKB/Swiss-Prot
	Q5RK11	ENTREZGENE
	Q9JLZ1	ENTREZGENE
UniProt Secondary	Q5RK11	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-18	Glrx3	glutaredoxin 3	Txnl2	thioredoxin-like 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Txnl2	thioredoxin-like 2			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains an N-terminal thioredoxin homology domain and two tandem repeats of a novel domain	69393

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD