Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | allergic disease | | ISO | RGD:735910 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21625544 | Experimental Diabetes Mellitus | | ISO | RGD:735910 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:20388520 | Myocardial Ischemia | | ISO | RGD:735910 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:16214533 | pneumonia | | ISO | RGD:735910 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:21625544 | Prostatic Neoplasms | | ISO | RGD:735910 | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:17199135 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Small airway obstruction in severe pulmonary arterial hypertension correlates with increased airway CD8+ T-cells and fractalkine expression. | Ars C, etal., Eur Respir J. 2009 Dec;34(6):1494-6. |
| 2. | Delta chemokine (fractalkine)--a novel mediator of pulmonary arterial hypertension in children undergoing cardiac surgery. | Avni T, etal., Cytokine. 2010 Dec;52(3):143-5. |
| 3. | Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats. | Bachstetter AD, etal., Neurobiol Aging. 2011 Nov;32(11):2030-44. doi: 10.1016/j.neurobiolaging.2009.11.022. Epub 2009 Dec 16. |
| 4. | Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-regulation in a Rat Model of Chronic Stress. | Bradesi S, etal., Gastroenterology. 2008 Dec 24. |
| 5. | Chronic neuroinflammation and cognitive impairment following transient global cerebral ischemia: role of fractalkine/CX3CR1 signaling. | Briones TL, etal., J Neuroinflammation. 2014 Jan 22;11:13. doi: 10.1186/1742-2094-11-13. |
| 6. | Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. | Chandrasekar B, etal., Biochem J. 2003 Jul 15;373(Pt 2):547-58. doi: 10.1042/BJ20030207. |
| 7. | Expression of CX3CL1/fractalkine by mesangial cells in vitro and in acute anti-Thy1 glomerulonephritis in rats. | Chen YM, etal., Nephrol Dial Transplant. 2003 Dec;18(12):2505-14. |
| 8. | Expression of fractalkine (CX3CL1) and its receptor in endotoxin-induced uveitis. | Chu L, etal., Ophthalmic Res. 2009;42(3):160-6. Epub 2009 Jul 31. |
| 9. | Infiltration of macrophages through the atrial endocardium of inflammation-induced rats: contribution of fractalkine. | Date T, etal., Circ J. 2009 May;73(5):932-7. Epub 2009 Mar 12. |
| 10. | Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold. | Eccles R, etal., Respir Res. 2010 Aug 10;11:108. |
| 11. | Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation. | Echigo T, etal., J Allergy Clin Immunol. 2004 May;113(5):940-8. |
| 12. | Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. | Fang IM, etal., Mol Vis. 2005 Jul 1;11:443-51. |
| 13. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 14. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 15. | Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. | Harrison JK, etal., Proc Natl Acad Sci U S A 1998 Sep 1;95(18):10896-901. |
| 16. | Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis. | Hasegawa M, etal., Ann Rheum Dis. 2005 Jan;64(1):21-8. |
| 17. | Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. | Heinisch S and Kirby LG, Neuroscience. 2009 Dec 15;164(3):1210-23. Epub 2009 Sep 10. |
| 18. | Pulmonary infection of mice with human metapneumovirus induces local cytotoxic T-cell and immunoregulatory cytokine responses similar to those seen with human respiratory syncytial virus. | Herd KA, etal., J Gen Virol. 2010 May;91(Pt 5):1302-10. Epub 2010 Jan 6. |
| 19. | Fractalkine upregulates inflammation through CX3CR1 and the Jak-Stat pathway in severe acute pancreatitis rat model. | Huang LY, etal., Inflammation. 2012 Jun;35(3):1023-30. doi: 10.1007/s10753-011-9406-5. |
| 20. | Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. | Hughes PM, etal., Glia. 2002 Mar 15;37(4):314-27. |
| 21. | Fractalkine expression and the recruitment of CX3CR1+ cells in the prolonged mesangial proliferative glomerulonephritis. | Ito Y, etal., Kidney Int. 2002 Jun;61(6):2044-57. |
| 22. | Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. | Ji JF, etal., Stem Cells. 2004;22(3):415-27. |
| 23. | Expression of the chemokine fractalkine (FKN/CX3CL1) by podocytes in normal and proteinuric rat kidney glomerulus. | Katsuyama K, etal., Nephron Exp Nephrol. 2009;113(2):e45-56. Epub 2009 Jul 10. |
| 24. | Involvement of fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. | Kikuchi T, etal., Infect Immun. 2005 Sep;73(9):5350-7. |
| 25. | Fractalkine and its receptor, CX3CR1, upregulation in streptozotocin-induced diabetic kidneys. | Kikuchi Y, etal., Nephron Exp Nephrol. 2004;97(1):e17-25. |
| 26. | Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome. | Landi A, etal., Cytokine. 2016 Feb;78:27-36. doi: 10.1016/j.cyto.2015.11.018. Epub 2015 Nov 28. |
| 27. | The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the beta1 integrin subunit. | Lauro C, etal., J Immunol. 2006 Dec 1;177(11):7599-606. |
| 28. | [Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease] | Li L, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Apr;30(4):373-5. |
| 29. | Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. | Limatola C, etal., J Neuroimmunol. 2005 Sep;166(1-2):19-28. doi: 10.1016/j.jneuroim.2005.03.023. |
| 30. | Spinal changes associated with mechanical hypersensitivity in a model of Guillain-Barre syndrome. | Luongo L, etal., Neurosci Lett. 2008 May 30;437(2):98-102. Epub 2008 Apr 10. |
| 31. | Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. | Lyons A, etal., J Neurochem. 2009 Sep;110(5):1547-56. doi: 10.1111/j.1471-4159.2009.06253.x. Epub 2009 Jul 15. |
| 32. | Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. | Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8. |
| 33. | CX3CL1 up-regulation is associated with recruitment of CX3CR1+ mononuclear phagocytes and T lymphocytes in the lungs during cigarette smoke-induced emphysema. | McComb JG, etal., Am J Pathol. 2008 Oct;173(4):949-61. Epub 2008 Sep 4. |
| 34. | Gut-brain chemokine changes in portal hypertensive rats. | Merino J, etal., Dig Dis Sci. 2011 Aug;56(8):2309-17. doi: 10.1007/s10620-011-1625-y. Epub 2011 Feb 24. |
| 35. | Interaction between CX3CL1 and CX3CR1 regulates vasculitis induced by immune complex deposition. | Morimura S, etal., Am J Pathol. 2013 May;182(5):1640-7. doi: 10.1016/j.ajpath.2013.01.023. Epub 2013 Mar 5. |
| 36. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 37. | Changes in spinal cord expression of fractalkine and its receptor in a rat model of disc herniation by autologous nucleus pulposus. | Park HW, etal., Spine (Phila Pa 1976). 2011 Jan 8. |
| 38. | Fractalkine-induced smooth muscle cell proliferation in pulmonary hypertension. | Perros F, etal., Eur Respir J. 2007 May;29(5):937-43. Epub 2006 Dec 20. |
| 39. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 40. | Upregulation of chemokine receptor gene expression in brains of Borna disease virus (BDV)-infected rats in the absence and presence of inflammation. | Rauer M, etal., J Neurovirol. 2002 Jan;8(3):168-79. |
| 41. | GOA pipeline | RGD automated data pipeline |
| 42. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 43. | The CX3C chemokine fractalkine in allergic asthma and rhinitis. | Rimaniol AC, etal., J Allergy Clin Immunol. 2003 Dec;112(6):1139-46. |
| 44. | A multilevel screening strategy defines a molecular fingerprint of proregenerative olfactory ensheathing cells and identifies SCARB2, a protein that improves regenerative sprouting of injured sensory spinal axons. | Roet KC, etal., J Neurosci. 2013 Jul 3;33(27):11116-35. doi: 10.1523/JNEUROSCI.1002-13.2013. |
| 45. | Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. | Ruth JH, etal., Arthritis Rheum. 2001 Jul;44(7):1568-81. |
| 46. | Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. | Ryu J, etal., Cardiovasc Res. 2008 May 1;78(2):333-40. Epub 2007 Nov 11. |
| 47. | Novel role of the membrane-bound chemokine fractalkine in platelet activation and adhesion. | Schafer A, etal., Blood. 2004 Jan 15;103(2):407-12. Epub 2003 Sep 11. |
| 48. | Neuronal expression of fractalkine in the presence and absence of inflammation. | Schwaeble WJ, etal., FEBS Lett 1998 Nov 20;439(3):203-7. |
| 49. | NEW evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. | Shan S, etal., Neurobiol Aging. 2009 Apr 14. |
| 50. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
| 51. | Greater fractalkine expression in mesenteric arteries of female spontaneously hypertensive rats compared with males. | Sullivan JC, etal., Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1080-8. Epub 2009 Feb 6. |
| 52. | [Effects of aspirin on CX3CL1 and CX3CR1 in acute pulmonary embolism rats]. | Sun C, etal., Zhonghua Yi Xue Za Zhi. 2013 Jan 1;93(1):69-72. |
| 53. | Inhibition of the Activation and Recruitment of Microglia-Like Cells Protects Against Neomycin-Induced Ototoxicity. | Sun S, etal., Mol Neurobiol. 2014 May 1. |
| 54. | CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin. | Sunnemark D, etal., J Neuroinflammation. 2005 Jul 29;2:17. |
| 55. | Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity. | Suzuki F, etal., Arthritis Res Ther. 2012 Mar 6;14(2):R48. doi: 10.1186/ar3761. |
| 56. | Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. | Tarozzo G, etal., Eur J Neurosci. 2002 May;15(10):1663-8. |
| 57. | Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. | Verge GM, etal., Eur J Neurosci 2004 Sep;20(5):1150-60. |
| 58. | Expression of CX3CL1 and its receptor, CX3CR1, in the development of periapical lesions. | Wang L, etal., Int Endod J. 2014 Mar;47(3):271-9. doi: 10.1111/iej.12143. Epub 2013 Jul 6. |
| 59. | [Effect of Shenqi Fuzheng injection on fractalkine expression in lung tissue of rats with lipopolysaccharide-induced acute lung injury]. | Wang L, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Jan;27(1):55-9. |
| 60. | Gabapentin reduces CX3CL1 signaling and blocks spinal microglial activation in monoarthritic rats. | Yang JL, etal., Mol Brain. 2012 May 30;5:18. doi: 10.1186/1756-6606-5-18. |
| 61. | The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus. | Yeo SI, etal., J Neuroimmunol. 2011 May;234(1-2):93-102. doi: 10.1016/j.jneuroim.2011.03.005. Epub 2011 Apr 8. |
| 62. | Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. | Yoshida T, etal., Cardiovasc Res. 2005 Nov 1;68(2):278-88. Epub 2005 Jul 12. |
| 63. | Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis. | Yuridullah R, etal., Auton Neurosci. 2006 Jun 30;126-127:380-9. Epub 2006 May 2. |
| 64. | The role of CX(3)CL1/CX(3)CR1 in pulmonary angiogenesis and intravascular monocyte accumulation in rat experimental hepatopulmonary syndrome. | Zhang J, etal., J Hepatol. 2012 Oct;57(4):752-8. doi: 10.1016/j.jhep.2012.05.014. Epub 2012 May 29. |
| 65. | [The change of fractalkine in lung tissue of rat with hypoxic pulmonary hypertension]. | Zheng BX, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 Mar;39(2):227-30. |
| 66. | Fractalkine and CX3CR1 are involved in the migration of intravenously grafted human bone marrow stromal cells toward ischemic brain lesion in rats. | Zhu J, etal., Brain Res. 2009 Sep 1;1287:173-83. Epub 2009 Jun 27. |
| 67. | Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. | Zujovic V, etal., Glia. 2000 Feb 15;29(4):305-15. |
Additional References at PubMed
| PMID:9177350 | PMID:10187784 | PMID:10415068 | PMID:10869418 | PMID:10899174 | PMID:11777952 | PMID:12125082 | PMID:12631113 | PMID:12714508 | PMID:12815711 | PMID:12837921 | PMID:15111313 |
| PMID:15321787 | PMID:15525271 | PMID:15993821 | PMID:16234287 | PMID:16272359 | PMID:16413026 | PMID:16980051 | PMID:17174525 | PMID:17430890 | PMID:17953351 | PMID:17971299 | PMID:18097059 |
| PMID:18292196 | PMID:18322241 | PMID:18971423 | PMID:19422292 | PMID:19474321 | PMID:21829356 | PMID:21840883 | PMID:22387113 | PMID:22435508 | PMID:22536384 | PMID:22871113 | PMID:23125415 |
| PMID:23147224 | PMID:23361876 | PMID:23400803 | PMID:23718544 | PMID:23776243 | PMID:23897050 | PMID:23953563 | PMID:23968561 | PMID:24036597 | PMID:24175290 | PMID:24294368 | PMID:24603149 |
| PMID:24731444 | PMID:25195598 | PMID:25435433 | PMID:25494456 | PMID:25559502 | PMID:25768734 | PMID:27209190 | PMID:27923568 | PMID:28612258 | PMID:28849713 | PMID:29313211 | PMID:30248434 |
| PMID:32127397 | PMID:32152663 | PMID:32664639 | PMID:32664984 | PMID:32692220 | PMID:32819407 | PMID:33969675 | PMID:35382731 |
Genomics
