Cx3cl1 (C-X3-C motif chemokine ligand 1) - Rat Genome Database

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Gene: Cx3cl1 (C-X3-C motif chemokine ligand 1) Heterocephalus glaber
Analyze
Symbol: Cx3cl1
Name: C-X3-C motif chemokine ligand 1
RGD ID: 18926098
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine activity (ortholog); CX3C chemokine receptor binding (ortholog); INVOLVED IN angiogenesis involved in wound healing (ortholog); autocrine signaling (ortholog); cell adhesion (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); allergic disease (ortholog); anti-basement membrane glomerulonephritis (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fractalkine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,677,709 - 28,689,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute pancreatitis  (ISO)
allergic disease  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
Bardet-Biedl syndrome  (ISO)
borna disease  (ISO)
Chromosome 16q12 Duplication Syndrome  (ISO)
chronic fatigue syndrome  (ISO)
Chronic Mesangial Proliferative Glomerulonephritis  (ISO)
common cold  (ISO)
Cor pulmonale  (ISO)
Cranial Nerve Injuries  (ISO)
cystitis  (ISO)
dermatomyositis  (ISO)
developmental and epileptic encephalopathy  (ISO)
early infantile epileptic encephalopathy  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
glomerulonephritis  (ISO)
Hearing Loss  (ISO)
hepatopulmonary syndrome  (ISO)
Hyperalgesia  (ISO)
Intervertebral Disc Displacement  (ISO)
ischemia  (ISO)
Legionnaires' disease  (ISO)
lung disease  (ISO)
Microscopic Polyangiitis  (ISO)
Myocardial Ischemia  (ISO)
myocarditis  (ISO)
nephrosis  (ISO)
Paramyxoviridae Infections  (ISO)
Parkinsonism  (ISO)
Periapical Diseases  (ISO)
pneumonia  (ISO)
polyarteritis nodosa  (ISO)
polymyositis  (ISO)
portal hypertension  (ISO)
prion disease  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary embolism  (ISO)
pulmonary emphysema  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (ISO)
uveitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis involved in wound healing  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (IEA)
autocrine signaling  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell-cell adhesion  (ISO)
cellular response to tumor necrosis factor  (ISO)
chemokine-mediated signaling pathway  (IEA)
chemotaxis  (ISO)
cytokine-mediated signaling pathway  (ISO)
eosinophil chemotaxis  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
immune response  (IEA)
inflammatory response  (IEA)
inhibitory postsynaptic potential  (ISO)
integrin activation  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lymphocyte chemotaxis  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of glutamate receptor signaling pathway  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vasoconstriction  (ISO)
neuron cellular homeostasis  (ISO)
neutrophil chemotaxis  (ISO)
positive chemotaxis  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of calcium-independent cell-cell adhesion  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta1 production  (ISO)
regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cx3cl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,677,709 - 28,689,122 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CX3CL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,372,490 - 57,385,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1657,372,477 - 57,385,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,406,402 - 57,418,956 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,963,915 - 55,976,457 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,963,914 - 55,976,455NCBI
Celera1641,906,410 - 41,918,956 (+)NCBICelera
Cytogenetic Map16q21NCBI
HuRef1643,274,294 - 43,286,836 (+)NCBIHuRef
CHM1_11658,814,629 - 58,827,168 (+)NCBICHM1_1
T2T-CHM13v2.01663,167,607 - 63,180,165 (+)NCBIT2T-CHM13v2.0
Cx3cl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,498,808 - 95,509,055 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,498,637 - 95,509,055 (+)EnsemblGRCm39 Ensembl
GRCm38894,772,180 - 94,782,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,772,009 - 94,782,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,296,080 - 97,306,327 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,661,355 - 97,671,556 (+)NCBIMGSCv36mm8
Celera899,100,414 - 99,110,655 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.79NCBI
Cx3cl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,233,326 - 10,244,856 (-)NCBIGRCr8
mRatBN7.21910,227,337 - 10,237,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,227,340 - 10,236,833 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,190,578 - 10,200,058 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01910,957,425 - 10,966,906 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,244,371 - 10,253,854 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01910,644,267 - 10,654,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,638,466 - 10,647,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,666,940 - 10,676,424 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,671,765 - 10,681,250 (-)NCBI
Celera1910,113,300 - 10,122,786 (-)NCBICelera
Cytogenetic Map19p13NCBI
Cx3cl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBIChiLan1.0ChiLan1.0
CX3CL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,840,670 - 66,853,297 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,761,444 - 72,774,073 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,646,447 - 37,659,078 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,779,065 - 56,791,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,779,065 - 56,791,760 (+)Ensemblpanpan1.1panPan2
CX3CL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,022,794 - 59,032,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,022,794 - 59,032,095 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,652,232 - 55,661,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,561,127 - 59,570,437 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,559,167 - 59,570,279 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,392,704 - 56,402,005 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,400,382 - 57,409,687 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,293,678 - 58,302,979 (-)NCBIUU_Cfam_GSD_1.0
Cx3cl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,134,360 - 50,145,250 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,443,733 - 9,455,062 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,443,851 - 9,454,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CX3CL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,304,118 - 17,315,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103233058
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,310,711 - 43,323,533 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,310,753 - 43,323,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604732,993,345 - 33,006,077 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015070   ⟹   ENSHGLP00000014920
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474628,677,709 - 28,689,122 (-)Ensembl
RefSeq Acc Id: XM_004843169   ⟹   XP_004843226
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004843226 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00654 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014920
RefSeq Acc Id: XP_004843226   ⟸   XM_004843169
- UniProtKB: G5AUE3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014920   ⟸   ENSHGLT00000015070


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010666 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015070 ENTREZGENE
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
NCBI Gene Cx3cl1 ENTREZGENE
PANTHER FRACTALKINE UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS FRACTALKINE UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL
UniProt G5AUE3 ENTREZGENE, UniProtKB/TrEMBL