RGD Reference Report - Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.

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Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.
Authors:	Eccles, R Meier, C Jawad, M Weinmullner, R Grassauer, A Prieschl-Grassauer, E
Citation:	Eccles R, etal., Respir Res. 2010 Aug 10;11:108.
RGD ID:	4140458
Pubmed:	PMID:20696083 (View Abstract at PubMed)
PMCID:	PMC2923116 (View Article at PubMed Central)
DOI:	DOI:10.1186/1465-9921-11-108 (Journal Full-text)
BACKGROUND: The common cold, the most prevalent contagious viral disease in humans still lacks a safe and effective antiviral treatment. Iota-Carrageenan is broadly active against respiratory viruses in-vitro and has an excellent safety profile. This study investigated the efficacy and safety of an Iota-Carrageenan nasal spray in patients with common cold symptoms. METHODS: In a randomized, double-blind, placebo-controlled exploratory trial, 35 human subjects suffering from early symptoms of common cold received Iota-Carrageenan (0.12%) in a saline solution three times daily for 4 days, compared to placebo. RESULTS: Administration of Iota-Carrageenan nasal spray reduced the symptoms of common cold (p = 0.046) and the viral load in nasal lavages (p = 0.009) in patients with early symptoms of common cold. Pro-inflammatory mediators FGF-2, Fractalkine, GRO, G-CSF, IL-8, IL-1alpha, IP-10, IL-10, and IFN-alpha2 were reduced in the Iota-Carrageenan group. CONCLUSIONS: Iota-Carrageenan nasal spray appears to be a promising treatment for safe and effective treatment of early symptoms of common cold. Larger trials are indicated to confirm the results.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
CX3CL1	Human	common cold		IDA			RGD
Cx3cl1	Rat	common cold		ISO	CX3CL1 (Homo sapiens)		RGD
Cx3cl1	Mouse	common cold		ISO	CX3CL1 (Homo sapiens)		RGD
IL10	Human	common cold		IDA			RGD
Il10	Rat	common cold		ISO	IL10 (Homo sapiens)		RGD
Il10	Mouse	common cold		ISO	IL10 (Homo sapiens)		RGD

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Genes (Rattus norvegicus)

Cx3cl1 (C-X3-C motif chemokine ligand 1)

Il10 (interleukin 10)

Genes (Mus musculus)

Cx3cl1 (C-X3-C motif chemokine ligand 1)

Il10 (interleukin 10)

Genes (Homo sapiens)

CX3CL1 (C-X3-C motif chemokine ligand 1)

IL10 (interleukin 10)

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Efficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold.