RGD Reference Report - Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis. - Rat Genome Database

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Elevated serum levels of soluble CX3CL1 in patients with microscopic polyangiitis.

Authors: Matsunawa, M  Odai, T  Wakabayashi, K  Isozaki, T  Yajima, N  Miwa, Y  Nohtomi, K  Takeuchi, H  Kasama, T 
Citation: Matsunawa M, etal., Clin Exp Rheumatol. 2009 Jan-Feb;27(1):72-8.
RGD ID: 9491765
Pubmed: PMID:19327232   (View Abstract at PubMed)

OBJECTIVES: To test the hypothesis that CX3CL1 contributes to the pathogenesis of microscopic polyangiitis. METHODS: Serum samples from 18 patients with microscopic polyangiitis (MPA), who fulfilled the revised criteria of the American College of Rheumatology (ACR), were collected during both the newly diagnosed, untreated active disease states and inactive disease states. Also serum was from patients with large vessel vasculitis (LVV), including giant cell arteritis (n=4) and Takayasu arteritis (n=3), and from 52 healthy individuals. Soluble (s)CX3CL1 levels in serum were measured using an enzyme-linked immunosorbent assay. Disease activity was assessed using Birmingham vasculitis activity scores (BVAS). Expression of CX3CR1 was examined by flow cytometry. RESULTS: Serum sCX3CL1 levels were significantly higher in MPA patients than in either LVV group or healthy individuals. The elevated sCX3CL1 levels seen in MPA patients correlated positively with BVAS, as well as with CRP levels and ESR, and similarly increased expression of cell-surface CX3CR1 was seen on peripheral blood CD4 and CD8 T cells from patients with MPA. Notably, sCX3CL1 levels and CX3CR1 expression were diminished during clinical remission following treatment. CONCLUSION: Our findings suggest that CX3CL1 may be involved in the pathogenesis of MPA, and may serve as a useful serologic marker of disease activity in systemic vasculitis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Microscopic Polyangiitis severityIEP 9491765protein:increased expression:serumRGD 
Microscopic Polyangiitis  IEP 9491765protein:increased expression:blood and T cellRGD 
Microscopic Polyangiitis severityISOCX3CL1 (Homo sapiens)9491765; 9491765protein:increased expression:serumRGD 
Microscopic Polyangiitis  ISOCX3CR1 (Homo sapiens)9491765; 9491765protein:increased expression:blood and T cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Mus musculus)
Cx3cl1  (C-X3-C motif chemokine ligand 1)
Cx3cr1  (C-X3-C motif chemokine receptor 1)

Genes (Homo sapiens)
CX3CL1  (C-X3-C motif chemokine ligand 1)
CX3CR1  (C-X3-C motif chemokine receptor 1)


Additional Information