CX3CL1 (C-X3-C motif chemokine ligand 1) - Rat Genome Database
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Gene: CX3CL1 (C-X3-C motif chemokine ligand 1) Sus scrofa
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Symbol: CX3CL1
Name: C-X3-C motif chemokine ligand 1
RGD ID: 13857824
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); chemokine activity (ortholog); CX3C chemokine receptor binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in wound healing (ortholog); autocrine signaling (ortholog); ASSOCIATED WITH acute pancreatitis (ortholog); allergic disease (ortholog); anti-basement membrane glomerulonephritis (ortholog); FOUND IN cell body (ortholog); cell projection (ortholog); cell surface (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Also known as: chemokine (C-X3-C motif) ligand 1; LOW QUALITY PROTEIN: fractalkine
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,304,118 - 17,315,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis involved in wound healing  (ISO)
autocrine signaling  (ISO)
cell adhesion  (ISO)
cell chemotaxis  (ISO)
cell-cell adhesion  (ISO)
chemokine-mediated signaling pathway  (ISO)
chemotaxis  (ISO)
cytokine-mediated signaling pathway  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
inhibitory postsynaptic potential  (ISO)
integrin activation  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
lymphocyte chemotaxis  (ISO)
macrophage chemotaxis  (ISO)
microglial cell activation  (ISO)
microglial cell proliferation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of glutamate receptor signaling pathway  (ISO)
negative regulation of hippocampal neuron apoptotic process  (ISO)
negative regulation of interleukin-1 alpha production  (ISO)
negative regulation of microglial cell activation  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vasoconstriction  (ISO)
neuron cellular homeostasis  (ISO)
neutrophil chemotaxis  (ISO)
platelet activation  (ISO)
positive chemotaxis  (ISO)
positive regulation of actin filament bundle assembly  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of calcium-independent cell-cell adhesion  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of I-kappaB phosphorylation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of microglial cell migration  (ISO)
positive regulation of neuroblast proliferation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta1 production  (ISO)
regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
response to hypoxia  (ISO)
response to ischemia  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:32661265  


Genomics

Comparative Map Data
CX3CL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,304,118 - 17,315,820 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CX3CL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1657,372,477 - 57,385,044 (+)EnsemblGRCh38hg38GRCh38
GRCh381657,372,490 - 57,385,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371657,406,414 - 57,418,956 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,963,915 - 55,976,457 (+)NCBINCBI36hg18NCBI36
Build 341655,963,914 - 55,976,455NCBI
Celera1641,906,410 - 41,918,956 (+)NCBI
Cytogenetic Map16q21NCBI
HuRef1643,274,294 - 43,286,836 (+)NCBIHuRef
CHM1_11658,814,588 - 58,827,172 (+)NCBICHM1_1
Cx3cl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,498,808 - 95,509,055 (+)NCBIGRCm39mm39
GRCm38894,772,180 - 94,782,427 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,772,009 - 94,782,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,296,080 - 97,306,327 (+)NCBIGRCm37mm9NCBIm37
MGSCv36897,661,355 - 97,671,556 (+)NCBImm8
Celera899,100,414 - 99,110,655 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.79NCBI
Cx3cl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01910,644,267 - 10,654,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,644,244 - 10,653,800 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,638,466 - 10,647,951 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,666,940 - 10,676,424 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11910,671,765 - 10,681,250 (-)NCBI
Celera1910,113,300 - 10,122,786 (-)NCBICelera
Cytogenetic Map19p13NCBI
Cx3cl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543315,023,050 - 15,034,711 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543315,023,272 - 15,034,650 (+)NCBIChiLan1.0ChiLan1.0
CX3CL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11656,779,065 - 56,791,760 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,779,065 - 56,791,760 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01637,646,447 - 37,659,078 (+)NCBIMhudiblu_PPA_v0panPan3
CX3CL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl259,022,794 - 59,032,095 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1259,022,794 - 59,032,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cx3cl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364759,443,851 - 9,454,715 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103233058
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl543,310,753 - 43,323,529 (+)Ensembl
ChlSab1.1543,310,711 - 43,323,533 (+)NCBI
Cx3cl1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474628,677,956 - 28,688,638 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021093908   ⟹   XP_020949567
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1619,312,351 - 19,324,439 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020949567 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABJ97544 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020949567   ⟸   XM_021093908
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene CX3CL1 ENTREZGENE
UniProt A0FEV8_PIG UniProtKB/TrEMBL