Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) - Rat Genome Database

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Gene: Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) Rattus norvegicus
Analyze
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
RGD ID: 1359266
Description: Involved in positive regulation of apoptotic process. Predicted to be located in cytosol and nucleus. Predicted to be part of Bcl-2 family protein complex. Predicted to be active in mitochondrion. Orthologous to human PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1); PARTICIPATES IN intrinsic apoptotic pathway; p53 signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Noxa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Celera1858,105,912 - 58,109,899 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-O-methylguanine  (ISO)
9,10-phenanthroquinone  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aurin  (ISO)
baicalein  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzyl bromide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carboplatin  (ISO)
celecoxib  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chloromethylisothiazolinone  (ISO)
chloroprene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloromethane  (ISO)
diclofenac  (ISO)
dihydroartemisinin  (ISO)
dimethyl sulfate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
Dodecyl gallate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (ISO)
fenvalerate  (ISO)
flubendazole  (ISO)
flusilazole  (ISO)
flutamide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP,ISO)
glucose  (ISO)
glutaraldehyde  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
ionomycin  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
melatonin  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
motexafin gadolinium  (ISO)
N(6)-dimethylallyladenine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
Nutlin-3  (ISO)
o-xylene  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
pevonedistat  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
promethazine  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
ruthenium atom  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
torcetrapib  (ISO)
triacsin C  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
venetoclax  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
cellular response to glucose starvation  (ISO)
cellular response to hypoxia  (ISO)
defense response to virus  (ISO)
DNA damage response  (ISO)
fibroblast apoptotic process  (IEA,ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of mitochondrial membrane potential  (IEA,ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
positive regulation of establishment of protein localization to mitochondrion  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
proteasomal protein catabolic process  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
release of cytochrome c from mitochondria  (IEA,ISO)
response to dsRNA  (ISO)
response to UV  (IEA,ISO)
response to X-ray  (IEA,ISO)
T cell homeostasis  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Ji X, etal., Front Biosci. 2007 Jan 1;12:1737-47.
4. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
5. Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. Onoue S, etal., FEBS J. 2008 Nov;275(22):5542-51.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling. Zhang G, etal., J Biol Chem. 2008 Sep 5;283(36):24343-58. Epub 2008 Jul 9.
Additional References at PubMed
PMID:10807576   PMID:12879012   PMID:12952892   PMID:14500711   PMID:14500851   PMID:14651853   PMID:14699081   PMID:15102863   PMID:15703398   PMID:15705586   PMID:15901672   PMID:16407291  
PMID:17024184   PMID:17289999   PMID:17599062   PMID:18411339   PMID:19052818   PMID:20810912   PMID:21145489   PMID:21454712   PMID:21525171   PMID:21660051   PMID:22785021   PMID:28131915  
PMID:37580530  


Genomics

Comparative Map Data
Pmaip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Celera1858,105,912 - 58,109,899 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
PMAIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,899,996 - 59,904,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,899,996 - 59,904,305 (+)EnsemblGRCh38hg38GRCh38
GRCh371857,567,228 - 57,571,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,718,172 - 55,722,518 (+)NCBINCBI36Build 36hg18NCBI36
Build 341855,718,216 - 55,722,517NCBI
Celera1854,285,254 - 54,289,600 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,276,682 - 54,281,028 (+)NCBIHuRef
CHM1_11857,562,830 - 57,567,176 (+)NCBICHM1_1
T2T-CHM13v2.01860,102,671 - 60,106,980 (+)NCBIT2T-CHM13v2.0
Pmaip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,591,675 - 66,598,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,591,604 - 66,598,636 (+)EnsemblGRCm39 Ensembl
GRCm381866,458,604 - 66,465,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,458,533 - 66,465,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371866,618,258 - 66,625,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,583,973 - 66,590,927 (+)NCBIMGSCv36mm8
Celera1867,745,077 - 67,752,031 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.52NCBI
Pmaip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540244,005,517 - 44,010,722 (+)NCBIChiLan1.0ChiLan1.0
LOC100979315
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21777,437,419 - 77,441,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,130,031 - 63,134,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,286,590 - 53,290,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,611,098 - 56,615,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1856,611,098 - 56,615,449 (+)Ensemblpanpan1.1panPan2
PMAIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,469,793 - 16,472,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,469,793 - 16,472,910 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,446,017 - 17,449,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,340,520 - 16,344,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,340,520 - 16,344,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,376,897 - 16,380,246 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,303,869 - 16,307,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,558,934 - 16,562,268 (-)NCBIUU_Cfam_GSD_1.0
Pmaip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494429,746,960 - 29,747,884 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364974,985,995 - 4,986,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMAIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,182,887 - 161,188,164 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11161,184,458 - 161,188,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,853,630 - 178,857,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PMAIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11819,861,182 - 19,865,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,862,743 - 19,865,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660605,737,434 - 5,741,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pmaip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pmaip1
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:127
Count of miRNA genes:103
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000025362
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61360EaeyExperimental allergic encephalomyelitis QTL y3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)184698893960377753Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)185971241776477814Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 8 1
Low 1 43 37 29 29 8 10 66 35 40 11 8
Below cutoff 12 12 12 1

Sequence


RefSeq Acc Id: ENSRNOT00000025362   ⟹   ENSRNOP00000025361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)Ensembl
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)Ensembl
RefSeq Acc Id: NM_001008385   ⟹   NP_001008386
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81862,255,970 - 62,262,384 (+)NCBI
mRatBN7.21859,986,020 - 59,992,434 (+)NCBI
Rnor_6.01862,174,850 - 62,178,837 (+)NCBI
Rnor_5.01861,365,056 - 61,369,043 (+)NCBI
RGSC_v3.41862,914,845 - 62,918,832 (+)RGD
Celera1858,105,912 - 58,109,899 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008386 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV51955 (Get FASTA)   NCBI Sequence Viewer  
  EDM14710 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025361
  ENSRNOP00000025361.2
  ENSRNOP00055014437
GenBank Protein Q5U777 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008386   ⟸   NM_001008385
- UniProtKB: Q5U777 (UniProtKB/Swiss-Prot),   A6IXS9 (UniProtKB/TrEMBL),   A0A8L2UK23 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025361   ⟸   ENSRNOT00000025362

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U777-F1-model_v2 AlphaFold Q5U777 1-105 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700839
Promoter ID:EPDNEW_R11361
Type:single initiation site
Name:Pmaip1_1
Description:phorbol-12-myristate-13-acetate-induced protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01862,174,683 - 62,174,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359266 AgrOrtholog
BioCyc Gene G2FUF-7188 BioCyc
Ensembl Genes ENSRNOG00000018770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055010597 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025362 ENTREZGENE
  ENSRNOT00000025362.4 UniProtKB/TrEMBL
  ENSRNOT00055017933 UniProtKB/Swiss-Prot
InterPro Noxa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:492821 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 492821 ENTREZGENE
PANTHER PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PMAIP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pmaip1 PhenoGen
RatGTEx ENSRNOG00000018770 RatGTEx
  ENSRNOG00055010597 RatGTEx
UniProt A0A8L2UK23 ENTREZGENE, UniProtKB/TrEMBL
  A6IXS9 ENTREZGENE, UniProtKB/TrEMBL
  APR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-17 Pmaip1  phorbol-12-myristate-13-acetate-induced protein 1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Pmaip1  phorbol-12-myristate-13-acetate-induced protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL