Nptx1 (neuronal pentraxin 1) - Rat Genome Database

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Gene: Nptx1 (neuronal pentraxin 1) Rattus norvegicus
Analyze
Symbol: Nptx1
Name: neuronal pentraxin 1
RGD ID: 628894
Description: Predicted to enable metal ion binding activity. Involved in several processes, including mitochondrial fragmentation involved in apoptotic process; neurotransmitter receptor localization to postsynaptic specialization membrane; and postsynaptic density assembly. Is active in glutamatergic synapse and synaptic cleft. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human NPTX1 (neuronal pentraxin 1); INTERACTS WITH (S)-colchicine; 1,2,4-trimethylbenzene; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 47 kDa taipoxin-binding protein; LOC360249; neuronal pentraxin I; neuronal pentraxin-1; NP-I; NP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,309,578 - 105,318,829 (-)NCBIGRCr8
mRatBN7.210104,811,107 - 104,820,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,914,282 - 109,923,567 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,377,316 - 109,386,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,731,702 - 104,740,953 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,682,637 - 108,691,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,286,989 - 108,295,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,918,661 - 108,927,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10103,356,568 - 103,365,489 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-colchicine  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
dichloroacetic acid  (ISO)
diiodine  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
hydrogen peroxide  (ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methylisothiazolinone  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodiethylamine  (ISO)
naphthalenes  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
PCB138  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
propanal  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triptonide  (ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
2. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Farhy-Tselnicker I, etal., Neuron. 2017 Oct 11;96(2):428-445.e13. doi: 10.1016/j.neuron.2017.09.053.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Schlimgen AK, etal., Neuron 1995 Mar;14(3):519-26.
9. Modulation of Neuronal Pentraxin 1 Expression in Rat Pancreatic beta-Cells Submitted to Chronic Glucotoxic Stress. Schvartz D, etal., Mol Cell Proteomics. 2012 Aug;11(8):244-54. Epub 2012 Mar 16.
Additional References at PubMed
PMID:10748068   PMID:15115814   PMID:16763034   PMID:22956834   PMID:27986928   PMID:32357304   PMID:34142698  


Genomics

Comparative Map Data
Nptx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810105,309,578 - 105,318,829 (-)NCBIGRCr8
mRatBN7.210104,811,107 - 104,820,358 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10109,914,282 - 109,923,567 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010109,377,316 - 109,386,601 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010104,731,702 - 104,740,953 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010108,682,637 - 108,691,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010108,286,989 - 108,295,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410108,918,661 - 108,927,616 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera10103,356,568 - 103,365,489 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
NPTX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381780,466,834 - 80,476,607 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1780,466,834 - 80,477,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371778,440,634 - 78,450,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361776,055,228 - 76,064,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 341776,055,227 - 76,064,999NCBI
Celera1775,069,005 - 75,078,529 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1773,878,650 - 73,888,424 (-)NCBIHuRef
CHM1_11778,526,902 - 78,536,673 (-)NCBICHM1_1
T2T-CHM13v2.01781,368,723 - 81,378,497 (-)NCBIT2T-CHM13v2.0
Nptx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911119,429,545 - 119,438,646 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11119,429,545 - 119,438,579 (-)EnsemblGRCm39 Ensembl
GRCm3811119,538,719 - 119,547,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11119,538,719 - 119,547,753 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711119,400,033 - 119,409,134 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611119,355,462 - 119,363,915 (-)NCBIMGSCv36mm8
Celera11131,286,494 - 131,295,595 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1183.95NCBI
Nptx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555062,447,109 - 2,456,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555062,447,429 - 2,456,612 (+)NCBIChiLan1.0ChiLan1.0
NPTX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,048,221 - 97,057,994 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117101,948,062 - 101,957,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01774,896,150 - 74,905,917 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11780,629,443 - 80,638,376 (-)NCBIpanpan1.1PanPan1.1panPan2
NPTX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.191,388,728 - 1,398,115 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl91,388,407 - 1,399,390 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha92,006,248 - 2,015,635 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.091,998,099 - 2,007,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl91,998,127 - 2,007,488 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.192,021,740 - 2,031,119 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.092,147,267 - 2,156,623 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.092,228,148 - 2,237,541 (+)NCBIUU_Cfam_GSD_1.0
Nptx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056022,027,566 - 2,038,459 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365944,373,473 - 4,384,461 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365944,373,500 - 4,384,394 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPTX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl122,036,810 - 2,046,193 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1122,036,727 - 2,046,202 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,938,606 - 1,948,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NPTX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11672,438,728 - 72,449,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1672,439,482 - 72,449,139 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607743,751,846 - 43,761,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nptx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248019,628,882 - 9,637,859 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248019,628,878 - 9,637,869 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nptx1
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000005067
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat

Markers in Region
Nptx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,811,149 - 104,811,263 (+)MAPPERmRatBN7.2
Rnor_6.010108,682,384 - 108,682,497NCBIRnor6.0
Rnor_5.010108,286,736 - 108,286,849UniSTSRnor5.0
RGSC_v3.410108,918,408 - 108,918,521UniSTSRGSC3.4
Celera10103,356,315 - 103,356,428UniSTS
Cytogenetic Map10q32.3UniSTS
RH143293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210104,811,580 - 104,811,721 (+)MAPPERmRatBN7.2
Rnor_6.010108,682,815 - 108,682,955NCBIRnor6.0
Rnor_5.010108,287,167 - 108,287,307UniSTSRnor5.0
RGSC_v3.410108,918,839 - 108,918,979UniSTSRGSC3.4
Celera10103,356,746 - 103,356,886UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 45 113 62 61 30 25 30 6 185 93 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000005067   ⟹   ENSRNOP00000005067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10104,811,403 - 104,820,367 (-)Ensembl
Rnor_6.0 Ensembl10108,682,638 - 108,691,367 (-)Ensembl
RefSeq Acc Id: NM_153735   ⟹   NP_714957
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810105,309,578 - 105,318,829 (-)NCBI
mRatBN7.210104,811,107 - 104,820,358 (-)NCBI
Rnor_6.010108,682,637 - 108,691,592 (-)NCBI
Rnor_5.010108,286,989 - 108,295,944 (-)NCBI
RGSC_v3.410108,918,661 - 108,927,616 (-)RGD
Celera10103,356,568 - 103,365,489 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_714957 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM06797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005067
  ENSRNOP00000005067.6
  ENSRNOP00055045272
  ENSRNOP00060040038
  ENSRNOP00065004836
GenBank Protein P47971 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_714957   ⟸   NM_153735
- Peptide Label: precursor
- UniProtKB: P47971 (UniProtKB/Swiss-Prot),   A6HL92 (UniProtKB/TrEMBL),   A0A0H2UHC1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005067   ⟸   ENSRNOT00000005067
Protein Domains
Pentraxin (PTX)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47971-F1-model_v2 AlphaFold P47971 1-432 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628894 AgrOrtholog
BioCyc Gene G2FUF-22477 BioCyc
Ensembl Genes ENSRNOG00000003741 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055031635 UniProtKB/Swiss-Prot
  ENSRNOG00060027723 UniProtKB/Swiss-Prot
  ENSRNOG00065004839 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005067 UniProtKB/TrEMBL
  ENSRNOT00000005067.7 UniProtKB/Swiss-Prot
  ENSRNOT00055054777 UniProtKB/Swiss-Prot
  ENSRNOT00060048114 UniProtKB/Swiss-Prot
  ENSRNOT00065007023 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuronal_Pentraxin_Related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pentaxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pentraxin-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:266777 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 266777 ENTREZGENE
PANTHER NEURONAL PENTRAXIN-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PENTRAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pentaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nptx1 PhenoGen
PRINTS PENTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PTX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003741 RatGTEx
  ENSRNOG00055031635 RatGTEx
  ENSRNOG00060027723 RatGTEx
  ENSRNOG00065004839 RatGTEx
SMART PTX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UHC1 ENTREZGENE, UniProtKB/TrEMBL
  A6HL92 ENTREZGENE, UniProtKB/TrEMBL
  NPTX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Nptx1  neuronal pentraxin 1  Nptx1  neuronal pentraxin I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-19 Nptx1  neuronal pentraxin I  Nptx1  neuronal pentraxin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Nptx1  neuronal pentraxin 1  Nptx1_predicted  neuronal pentraxin 1 (predicted)  Data merged from RGD:1310581 737654 APPROVED
2005-01-20 Nptx1  neuronal pentraxin 1      Symbol and Name status set to approved 1299863 APPROVED
2005-01-12 Nptx1_predicted  neuronal pentraxin 1 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-02-27 Nptx1  neuronal pentraxin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neurons of cerebellum, hippocampus, and cerebral cortex 729007