RGD Reference Report - NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. - Rat Genome Database

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NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics.

Authors: Clayton, KB  Podlesniy, P  Figueiro-Silva, J  Lopez-Domenech, G  Benitez, L  Enguita, M  Abad, MA  Soriano, E  Trullas, R 
Citation: Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
RGD ID: 6903322
Pubmed: PMID:22279230   (View Abstract at PubMed)
PMCID: PMC6796267   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.4604-11.2012   (Journal Full-text)

In cultured cerebellar granule neurons, low neuronal activity triggers the intrinsic program of apoptosis, which requires protein synthesis-dependent BAX translocation to mitochondria, a process that may underlie neuronal damage in neurodegeneration. However, the mechanisms that link neuronal activity with the induction of the mitochondrial program of apoptosis remain unclear. Neuronal pentraxin 1 (NP1) is a pro-apoptotic protein induced by low neuronal activity that is increased in damaged neurites in Alzheimer's disease-affected brains. Here we report that NP1 facilitates the accumulation of BAX in mitochondria and regulates mitochondrial dynamics during apoptosis in rat and mouse cerebellar granule neurons in culture. Reduction of neuronal activity increases NP1 protein levels in mitochondria and contributes to mitochondrial fragmentation in a Bax-dependent manner. In addition, NP1 is involved in mitochondrial transport in healthy neurons. These results show that NP1 is targeted to mitochondria acting upstream of BAX and uncover a novel function for NP1 in the regulation of mitochondrial dynamics and trafficking during apoptotic neurodegeneration.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Nptx1Ratcellular response to potassium ion  IDA  RGD 
Nptx1Ratmitochondrial fragmentation involved in apoptotic process  IMP  RGD 
Nptx1Ratmitochondrial transport  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nptx1  (neuronal pentraxin 1)

Objects referenced in this article
Gene Crp C-reactive protein Rattus norvegicus

Additional Information