Crp (C-reactive protein) - Rat Genome Database

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Gene: Crp (C-reactive protein) Rattus norvegicus
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Symbol: Crp
Name: C-reactive protein
RGD ID: 2411
Description: Enables cholesterol binding activity; identical protein binding activity; and low-density lipoprotein particle binding activity. Involved in several processes, including cellular response to nitric oxide; complement activation, classical pathway; and negative regulation of superoxide anion generation. Located in extracellular space; filopodium; and growth cone. Used to study rheumatoid arthritis. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); iron deficiency anemia; obesity; and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); macular degeneration (multiple); middle cerebral artery infarction; and nephritis (multiple). Orthologous to human CRP (C-reactive protein); PARTICIPATES IN classical complement pathway; interleukin-6 signaling pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,1-dichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, pentraxin-related; C-reactive protein, petaxin related
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Celera1384,770,843 - 84,771,753 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Coronary Syndrome  (ISO)
acute kidney failure  (IEP,ISO)
acute stress disorder  (ISO)
Acute Uveitis  (IEP,ISO)
aggressive periodontitis  (ISO)
Albuminuria  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
antiphospholipid syndrome  (ISO)
anxiety disorder  (ISO)
Arsenic Poisoning  (ISO)
arthritis  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
autoimmune interstitial lung, joint, and kidney disease  (ISO)
Bacteremia  (ISO)
bacterial infectious disease  (ISO)
bacterial meningitis  (ISO)
Behcet's disease  (ISO)
Brain Hypoxia-Ischemia  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
bronchiolitis  (ISO)
Burns  (IEP)
Cardiac Arrhythmias  (ISO)
cardiovascular system disease  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (IEP)
congestive heart failure  (ISO)
Contrast-Induced Nephropathy  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
depressive disorder  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
disease by infectious agent  (ISO)
disease of metabolism  (ISO)
Drug Hypersensitivity Syndrome  (ISO)
end stage renal disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (IDA,ISO)
Experimental Liver Cirrhosis  (IEP)
familial hyperlipidemia  (IEP)
Fever of Unknown Origin  (ISO)
gastrointestinal stromal tumor  (ISO)
heart disease  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
hypertension  (IEP,ISO)
hypertensive retinopathy  (ISO)
Hypertriglyceridemia  (ISO)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inflammatory bowel disease  (ISO)
intermediate coronary syndrome  (ISO)
interstitial cystitis  (ISO)
interstitial nephritis  (ISO)
Intestinal Reperfusion Injury  (IEP)
iron deficiency anemia  (IEP)
juvenile rheumatoid arthritis  (ISO)
Kawasaki disease  (ISO)
kidney failure  (ISO)
Kuhnt-Junius degeneration  (ISO)
Left Ventricular Hypertrophy  (ISO)
leishmaniasis  (ISO)
liver cirrhosis  (ISO)
low tension glaucoma  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
Lymphatic Metastasis  (ISO)
lymphopenia  (ISO)
macular degeneration  (ISO)
malaria  (ISO)
mastoiditis  (ISO)
meningitis  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
Metabolic Syndrome  (ISO)
mevalonic aciduria  (ISO)
middle cerebral artery infarction  (ISO)
mouth disease  (IEP)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IEP)
myocarditis  (ISO)
Neonatal Sepsis  (IEP)
non-arteritic anterior ischemic optic neuropathy  (ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (ISO)
opiate dependence  (ISO)
otitis externa  (ISO)
otitis media  (ISO)
overactive bladder syndrome  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
Pasteurellaceae Infections  (ISO)
pelvic inflammatory disease  (ISO)
periodontitis  (ISO)
pharyngoconjunctival fever  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
polymyalgia rheumatica  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
Postoperative Atrial Fibrillation  (ISO)
Pseudomonas Infections  (IEP,ISO)
psoriasis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
pyelonephritis  (IEP)
renal cell carcinoma  (ISO)
Renal Colic  (ISO)
renal fibrosis  (ISO)
renal hypertension  (IEP)
retinal vein occlusion  (ISO)
rheumatoid arthritis  (IDA,ISO)
secondary hyperparathyroidism  (ISO)
Sepsis  (IEP,ISO)
Serositis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Injuries  (IDA)
status epilepticus  (IEP)
Stevens-Johnson syndrome  (ISO)
systemic lupus erythematosus  (ISO)
temporal arteritis  (ISO)
thrombosis  (ISO)
Tubulointerstitial Nephritis and Uveitis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
uveal melanoma  (ISO)
vestibular neuronitis  (ISO)
visceral leishmaniasis  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (ISO)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
abacavir  (ISO)
acalabrutinib  (ISO)
acetamide  (EXP)
acetic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alclofenac  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
apigenin  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (EXP,ISO)
benidipine  (EXP)
benzbromarone  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bezafibrate  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bivalirudin  (ISO)
boron atom  (EXP)
Botulinum toxin type A  (EXP)
Bromperidol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
candesartan  (ISO)
carbon monoxide  (ISO)
carbon nanotube  (ISO)
carnosine  (EXP,ISO)
carrageenan  (EXP)
carvedilol  (EXP,ISO)
celecoxib  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
colesevelam hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP,ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
cyproterone acetate  (ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
delta-tocotrienol  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
disodium selenite  (ISO)
doxazosin  (ISO)
elemental boron  (EXP)
endosulfan  (EXP)
epoxiconazole  (ISO)
eptifibatide  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
ezetimibe  (ISO)
fenofibrate  (ISO)
flucloxacillin  (ISO)
flunitrazepam  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fosfomycin  (ISO)
fructose  (EXP,ISO)
fumonisin B1  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP)
gestodene  (ISO)
ginsenoside Re  (EXP)
gossypin  (EXP)
heparin  (ISO)
indinavir  (ISO)
indometacin  (EXP)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
levonorgestrel  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
lovastatin  (EXP)
lupeol  (EXP)
medroxyprogesterone acetate  (ISO)
Mesaconitine  (EXP)
metformin  (EXP,ISO)
methotrexate  (ISO)
mevalonic acid  (ISO)
milrinone  (ISO)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
morphine  (ISO)
myricitrin  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nomegestrol  (ISO)
nomegestrol acetate  (ISO)
Nonidet P-40  (ISO)
norgestimate  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
oleic acid  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (EXP)
ozone  (EXP)
p-menthan-3-ol  (EXP)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
Pentoxifylline  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (EXP,ISO)
pirinixic acid  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
rifampicin  (ISO)
rifamycin SV  (ISO)
rivastigmine  (EXP)
rosmarinic acid  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
salvianolic acid B  (EXP,ISO)
SB 203580  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrite  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
superoxide  (EXP)
telmisartan  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thioacetamide  (EXP)
tibolone  (ISO)
titanium dioxide  (ISO)
TMC-120A  (ISO)
triadimefon  (ISO)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (ISO)
withaferin A  (EXP)
wortmannin  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Postoperative atrial fibrillation is not correlated to C-reactive protein. Ahlsson AJ, etal., Ann Thorac Surg. 2007 Apr;83(4):1332-7.
2. Hospitalised patients with Influenza A (H1N1) in the Royal Hospital, Oman: Experience of a tertiary care hospital, July-December 2009. Al-Lawati J, etal., Sultan Qaboos Univ Med J. 2010 Dec;10(3):326-34. Epub 2010 Nov 14.
3. Plasma oxidative and inflammatory markers in patients with idiopathic Parkinson's disease. Andican G, etal., Acta Neurol Belg. 2012 Feb 9.
4. The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion. Angulo JC, etal., Urology. 2010 Aug;76(2):301-6. Epub 2010 Mar 5.
5. The effectiveness of Echinacea extract or composite glucosamine, chondroitin and methyl sulfonyl methane supplements on acute and chronic rheumatoid arthritis rat model. Arafa NM, etal., Toxicol Ind Health. 2011 Dec 15.
6. Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis. Arias-Santiago S, etal., Eur J Dermatol. 2012 Apr 16.
7. C-reactive protein (CRP): An important diagnostic and prognostic tool in nursing-home-associated pneumonia. Arinzon Z, etal., Arch Gerontol Geriatr. 2011 Mar 23.
8. Long-term outcome of tumor necrosis factor alpha antagonist's treatment in pediatric Crohn's disease. Assa A, etal., J Crohns Colitis. 2012 Apr 4.
9. Association between C-reactive protein and generalized anxiety disorder in stable coronary heart disease patients. Bankier B, etal., Eur Heart J. 2008 Sep;29(18):2212-7. doi: 10.1093/eurheartj/ehn326. Epub 2008 Jul 4.
10. Prolonged C1 inhibitor administration improves local healing of burn wounds and reduces myocardial inflammation in a rat burn wound model. Begieneman MP, etal., J Burn Care Res. 2012 Jul;33(4):544-51.
11. The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in rats. Bekyarova G, etal., Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):299-303.
12. Promotion of beta-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease. Bi BT, etal., Neurochem Int. 2012 Feb;60(3):257-66. Epub 2011 Dec 19.
13. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Biljak VR, etal., Platelets. 2011 Apr 20.
14. Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritis. Breda L, etal., Clin Res Cardiol. 2012 Aug 11.
15. Effects of topical indomethacin, bromfenac and nepafenac on lipopolysaccharide-induced ocular inflammation. Bucolo C, etal., J Pharm Pharmacol. 2014 Jul;66(7):954-60. doi: 10.1111/jphp.12224. Epub 2014 Feb 12.
16. Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model. Cai Y, etal., J Antimicrob Chemother. 2009 Sep;64(3):563-6. Epub 2009 Jun 26.
17. Accuracy of white blood cell count, C-reactive protein, interleukin-6 and tumor necrosis factor alpha for diagnosing late neonatal sepsis. Caldas JP, etal., J Pediatr (Rio J). 2008 Nov-Dec;84(6):536-42. doi: doi:10.2223/JPED.1838.
18. Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis. Carlucci F, etal., Arthritis Rheum. 2010 Jan;62(1):245-9.
19. Early proinflammatory cytokines and C-reactive protein trends as predictors of outcome in invasive Aspergillosis. Chai L, etal., J Infect Dis. 2010 Nov 1;202(9):1454-62. doi: 10.1086/656527.
20. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
21. Augmented nitric oxide generation in neutrophils: oxidative and pro-inflammatory implications in hypertension. Chatterjee M, etal., Free Radic Res. 2009 Dec;43(12):1195-204.
22. [Promoting effect of granulocyto-colony stimulating factor on neovascularization in rats with myocardial infarction]. Chen T, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Oct;24(10):1239-43.
23. Molecular and clinical characteristics of adenoviral infections in Taiwanese children in 2004-2005. Cheng CC, etal., Eur J Pediatr. 2008 Jun;167(6):633-40. Epub 2007 Sep 18.
24. Inflammatory gene polymorphisms and susceptibility to kawasaki disease and its arterial sequelae. Cheung YF, etal., Pediatrics. 2008 Sep;122(3):e608-14. doi: 10.1542/peds.2008-0646. Epub 2008 Aug 18.
25. Mastoiditis diagnosed by clinical symptoms and imaging studies in children: disease spectrum and evolving diagnostic challenges. Chien JH, etal., J Microbiol Immunol Infect. 2012 Oct;45(5):377-81. doi: 10.1016/j.jmii.2011.12.008. Epub 2012 May 9.
26. Malignant otitis externa: an Australian case series. Chin R, etal., Surgeon. 2012 Oct;10(5):273-7. doi: 10.1016/j.surge.2011.09.004. Epub 2011 Oct 26.
27. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Chung MK, etal., Circulation. 2001 Dec 11;104(24):2886-91.
28. Elevation of serum c-reactive protein in patients with OAB and IC/BPS implies chronic inflammation in the urinary bladder. Chung SD, etal., Neurourol Urodyn. 2011 Mar;30(3):417-20. doi: 10.1002/nau.20938. Epub 2011 Jan 31.
29. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. Clayton KB, etal., J Neurosci. 2012 Jan 25;32(4):1453-66.
30. The association of low-grade systemic inflammation with hypertensive retinopathy. Coban E, etal., Clin Exp Hypertens. 2010;32(8):528-31. doi: 10.3109/10641963.2010.496519.
31. Inflammation reduces HDL protection against primary cardiac risk. Corsetti JP, etal., Eur J Clin Invest. 2010 Jun;40(6):483-9. doi: 10.1111/j.1365-2362.2010.02287.x. Epub 2010 Apr 14.
32. Role of thrombocytosis in diagnosis of giant cell arteritis and differentiation of arteritic from non-arteritic anterior ischemic optic neuropathy. Costello F, etal., Eur J Ophthalmol. 2004 May-Jun;14(3):245-57.
33. Complement activation in patients with COVID-19: A novel therapeutic target. Cugno M, etal., J Allergy Clin Immunol. 2020 May 14. pii: S0091-6749(20)30650-3. doi: 10.1016/j.jaci.2020.05.006.
34. [Assess the impact of concentrations of inflammatory markers IL-6, CRP in the presence of albuminuria in patients with type 2 diabetes]. Czyzewska J, etal., Pol Merkur Lekarski. 2012 Feb;32(188):98-102.
35. Exercise Training and Antioxidants: Effects on Rat Heart Tissue Exposed to Lead Acetate. Dabidi Roshan V, etal., Int J Toxicol. 2011 Mar 4.
36. C-reactive protein and atrial fibrillation in idiopathic dilated cardiomyopathy. Dai S, etal., Clin Cardiol. 2009 Sep;32(9):E45-50. doi: 10.1002/clc.20430.
37. Isolation and characterization of C-reactive protein and serum amyloid P component in the rat. de Beer FC, etal., Immunology. 1982 Jan;45(1):55-70.
38. Selection of Symptomatic Patients With Crohn's Disease for Abdominopelvic Computed Tomography: Role of Serum C-Reactive Protein. Desmond AN, etal., Can Assoc Radiol J. 2012 Mar 14.
39. Rat C-reactive protein activates the autologous complement system. Diaz Padilla N, etal., Immunology. 2003 Aug;109(4):564-71.
40. Retinal vein occlusion: C-reactive protein and arterial hypertension. Dodson PM and Shine B, Acta Ophthalmol (Copenh). 1984 Feb;62(1):123-30.
41. Iron deficiency and renal development in the newborn rat. Drake KA, etal., Pediatr Res. 2009 Dec;66(6):619-24.
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48. Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. Faddah LM, etal., BMC Complement Altern Med. 2012 May 2;12:60.
49. Nitric oxide-induced expression of C-reactive protein in islet cells as a very early marker for islet stress in the rat pancreas. Fehsel K, etal., Nitric Oxide. 1997 Jun;1(3):254-62.
50. Complement factor H Y402H and C-reactive protein polymorphism and photodynamic therapy response in age-related macular degeneration. Feng X, etal., Ophthalmology. 2009 Oct;116(10):1908-12.e1. doi: 10.1016/j.ophtha.2009.03.011. Epub 2009 Aug 18.
51. Autoantibodies against C-reactive protein: clinical associations in systemic lupus erythematosus and primary antiphospholipid syndrome. Figueredo MA, etal., J Rheumatol. 2006 Oct;33(10):1980-6.
52. C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes. Forte L, etal., Int J Cardiol. 2011 Oct 6;152(1):7-12. doi: 10.1016/j.ijcard.2011.05.062. Epub 2011 Jul 26.
53. Effect of antibacterial cathelicidin peptide CAP18/LL-37 on sepsis in neonatal rats. Fukumoto K, etal., Pediatr Surg Int. 2005 Jan;21(1):20-4. doi: 10.1007/s00383-004-1256-x.
54. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. Gao Y, etal., J Med Virol. 2020 Jul;92(7):791-796. doi: 10.1002/jmv.25770. Epub 2020 Apr 10.
55. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
56. Serum markers of inflammation and oxidative stress in chronic opium (Taryak) smokers. Ghazavi A, etal., Immunol Lett. 2013 Jun;153(1-2):22-6. doi: 10.1016/j.imlet.2013.07.001. Epub 2013 Jul 12.
57. Effect of a high-fat diet on the hepatic expression of nuclear receptors and their target genes: relevance to drug disposition. Ghoneim RH, etal., Br J Nutr. 2015 Feb 14;113(3):507-16. doi: 10.1017/S0007114514003717. Epub 2015 Jan 23.
58. Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. Gill R, etal., J Cereb Blood Flow Metab. 2004 Nov;24(11):1214-8.
59. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
60. C-reactive protein levels do not correlate with retinal artery occlusion but with atherosclerosis. Goldenberg-Cohen N, etal., Eye (Lond). 2009 Apr;23(4):785-90. doi: 10.1038/eye.2008.159. Epub 2008 Jun 6.
61. Serum biomarkers of aging in the Brown Norway rat. Gordon CJ, etal., Exp Gerontol. 2011 Nov;46(11):953-7. Epub 2011 Jul 28.
62. Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats. Guan H, etal., Clin Chem. 2009 Feb;55(2):274-84. doi: 10.1373/clinchem.2008.115857. Epub 2008 Dec 4.
63. Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. Hall JC, etal., J Neurochem. 2012 Jun;121(5):738-50. doi: 10.1111/j.1471-4159.2012.07726.x. Epub 2012 Apr 12.
64. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
65. Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy. Holtman L, etal., Epilepsia. 2013 Apr;54(4):589-95. doi: 10.1111/epi.12112. Epub 2013 Feb 8.
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67. Systemic inflammation and innate immune response in patients with previous anterior uveitis. Huhtinen M, etal., Br J Ophthalmol. 2002 Apr;86(4):412-7.
68. C-reactive protein and uric Acid levels in patients with psoriasis. Isha, etal., Indian J Clin Biochem. 2011 Jul;26(3):309-11. doi: 10.1007/s12291-011-0132-4. Epub 2011 May 4.
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70. Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus. Jin C, etal., Clin Chim Acta. 2009 Oct;408(1-2):45-9. Epub 2009 Jul 15.
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120. GOA pipeline RGD automated data pipeline
121. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
122. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
123. Comprehensive gene review and curation RGD comprehensive gene curation
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128. Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein. Saxena U, etal., Biochem Biophys Res Commun. 1986 Nov 26;141(1):151-7.
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135. Up-regulation of PPARgamma, heat shock protein-27 and -72 by naringin attenuates insulin resistance, beta-cell dysfunction, hepatic steatosis and kidney damage in a rat model of type 2 diabetes. Sharma AK, etal., Br J Nutr. 2011 Dec;106(11):1713-23. Epub 2011 Jun 21.
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138. Long-term ethanol consumption initiates atherosclerosis in rat aorta through inflammatory stress and endothelial dysfunction. Shirpoor A, etal., Vascul Pharmacol. 2012 Sep;57(2-4):72-7. Epub 2012 Apr 12.
139. Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus. Sjowall C, etal., Arthritis Res Ther. 2004;6(2):R87-94. Epub 2003 Dec 5.
140. High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation. Sjowall C, etal., Hum Immunol. 2012 Apr;73(4):382-8. Epub 2012 Feb 1.
141. Association of posttraumatic stress disorder with low-grade elevation of C-reactive protein: evidence from the general population. Spitzer C, etal., J Psychiatr Res. 2010 Jan;44(1):15-21. doi: 10.1016/j.jpsychires.2009.06.002. Epub 2009 Jul 22.
142. Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients. Steffens S, etal., BMC Cancer. 2012 Sep 8;12(1):399.
143. Elevated C-reactive protein levels may be a predictor of persistent unfavourable symptoms in patients with mild traumatic brain injury: a preliminary study. Su SH, etal., Brain Behav Immun. 2014 May;38:111-7. doi: 10.1016/j.bbi.2014.01.009. Epub 2014 Jan 21.
144. The effects of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in rat allograft adventitial inflammation and allograft arteriosclerosis. Sun H, etal., Transplant Proc. 2009 Nov;41(9):3909-12.
145. C-reactive protein predicts response to infliximab in patients with chronic sarcoidosis. Sweiss NJ, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(1):49-56.
146. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Szalai AJ, etal., Genes Immun. 2002 Feb;3(1):14-9.
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Additional References at PubMed
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Genomics

Comparative Map Data
Crp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,694,062 - 87,695,978 (+)NCBIGRCr8
mRatBN7.21385,135,384 - 85,175,178 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1385,124,977 - 85,175,178 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,664,967 - 87,666,915 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01389,065,246 - 89,067,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01386,249,976 - 86,251,928 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01391,080,448 - 91,081,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,599,418 - 95,600,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,702,243 - 88,703,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,891,058 - 88,892,928 (+)NCBI
Celera1384,770,843 - 84,771,753 (+)NCBICelera
Cytogenetic Map13q24NCBI
CRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381159,712,289 - 159,714,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1159,712,289 - 159,714,589 (-)EnsemblGRCh38hg38GRCh38
GRCh371159,682,079 - 159,684,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361157,948,703 - 157,951,003 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,495,152 - 156,497,452NCBI
Celera1132,750,525 - 132,752,817 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,038,539 - 131,040,831 (-)NCBIHuRef
CHM1_11161,076,594 - 161,078,894 (-)NCBICHM1_1
T2T-CHM13v2.01158,849,333 - 158,851,633 (-)NCBIT2T-CHM13v2.0
Crp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,525,623 - 172,527,533 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,525,622 - 172,660,598 (+)EnsemblGRCm39 Ensembl
GRCm381172,698,056 - 172,699,966 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,698,055 - 172,833,031 (+)EnsemblGRCm38mm10GRCm38
MGSCv371174,628,187 - 174,630,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,534,741 - 174,536,635 (+)NCBIMGSCv36mm8
Celera1175,548,254 - 175,550,142 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map180.13NCBI
CRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2190,140,428 - 90,143,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,880,463 - 89,883,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,062,102 - 135,064,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11138,858,353 - 138,860,652 (-)NCBIpanpan1.1PanPan1.1panPan2
CRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,396,787 - 22,398,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,396,263 - 22,399,166 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,473,724 - 22,475,116 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,519,785 - 22,521,176 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,519,714 - 22,522,146 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,286,369 - 22,287,757 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,818,770 - 22,820,163 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03823,230,160 - 23,231,548 (+)NCBIUU_Cfam_GSD_1.0
Crp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050585,866,551 - 5,870,192 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740883,272 - 890,606 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936740885,855 - 888,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,793,350 - 90,805,218 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,793,361 - 90,801,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,764,964 - 98,772,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1204,232,262 - 4,235,826 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl204,232,913 - 4,235,377 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660383,340,251 - 3,342,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,531,571 - 1,533,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,531,555 - 1,533,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crp
456 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:74
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000000058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
Crp  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21385,162,863 - 85,163,015 (+)MAPPERmRatBN7.2
Rnor_6.01391,081,476 - 91,081,627NCBIRnor6.0
Rnor_5.01395,600,446 - 95,600,597UniSTSRnor5.0
RGSC_v3.41388,703,271 - 88,703,422UniSTSRGSC3.4
Celera1384,771,871 - 84,772,022UniSTS
Cytogenetic Map13q24UniSTS
AU048742  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14q11UniSTS
Cytogenetic Map13q27UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY310153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY318961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY321324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY325232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH755429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI986631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ438897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000000058   ⟹   ENSRNOP00000000058
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,124,977 - 85,163,634 (+)Ensembl
Rnor_6.0 Ensembl1391,080,341 - 91,081,629 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091089   ⟹   ENSRNOP00000074751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1385,135,399 - 85,175,178 (+)Ensembl
Rnor_6.0 Ensembl1391,054,974 - 91,093,713 (+)Ensembl
RefSeq Acc Id: NM_017096   ⟹   NP_058792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,694,062 - 87,695,978 (+)NCBI
mRatBN7.21385,161,724 - 85,163,640 (+)NCBI
Rnor_6.01391,080,448 - 91,081,358 (+)NCBI
Rnor_5.01395,599,418 - 95,600,328 (+)NCBI
RGSC_v3.41388,702,243 - 88,703,153 (+)RGD
Celera1384,770,843 - 84,771,753 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058792 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40964 (Get FASTA)   NCBI Sequence Viewer  
  AAH91157 (Get FASTA)   NCBI Sequence Viewer  
  AAP78761 (Get FASTA)   NCBI Sequence Viewer  
  AAP85372 (Get FASTA)   NCBI Sequence Viewer  
  AAP86250 (Get FASTA)   NCBI Sequence Viewer  
  AAP86256 (Get FASTA)   NCBI Sequence Viewer  
  AAP92597 (Get FASTA)   NCBI Sequence Viewer  
  AAP92619 (Get FASTA)   NCBI Sequence Viewer  
  AAP92633 (Get FASTA)   NCBI Sequence Viewer  
  AFA37850 (Get FASTA)   NCBI Sequence Viewer  
  AFA37851 (Get FASTA)   NCBI Sequence Viewer  
  AFA37852 (Get FASTA)   NCBI Sequence Viewer  
  AFA37853 (Get FASTA)   NCBI Sequence Viewer  
  AFA37854 (Get FASTA)   NCBI Sequence Viewer  
  AFA37855 (Get FASTA)   NCBI Sequence Viewer  
  AFA37856 (Get FASTA)   NCBI Sequence Viewer  
  AFA37857 (Get FASTA)   NCBI Sequence Viewer  
  AFA37858 (Get FASTA)   NCBI Sequence Viewer  
  AFA37859 (Get FASTA)   NCBI Sequence Viewer  
  AFA37860 (Get FASTA)   NCBI Sequence Viewer  
  AFA37861 (Get FASTA)   NCBI Sequence Viewer  
  AFA37862 (Get FASTA)   NCBI Sequence Viewer  
  AFA37863 (Get FASTA)   NCBI Sequence Viewer  
  AFA37864 (Get FASTA)   NCBI Sequence Viewer  
  AFA37865 (Get FASTA)   NCBI Sequence Viewer  
  AFA37866 (Get FASTA)   NCBI Sequence Viewer  
  AFA37867 (Get FASTA)   NCBI Sequence Viewer  
  AFA37868 (Get FASTA)   NCBI Sequence Viewer  
  AFA37869 (Get FASTA)   NCBI Sequence Viewer  
  CBW53726 (Get FASTA)   NCBI Sequence Viewer  
  CBY88722 (Get FASTA)   NCBI Sequence Viewer  
  EDL94725 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000058.4
  ENSRNOP00000074751.2
GenBank Protein P48199 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058792   ⟸   NM_017096
- Peptide Label: precursor
- UniProtKB: Q5BK94 (UniProtKB/Swiss-Prot),   P48199 (UniProtKB/Swiss-Prot),   H6X2W5 (UniProtKB/TrEMBL),   H6X2V1 (UniProtKB/TrEMBL),   H6X2V8 (UniProtKB/TrEMBL),   H6X2W3 (UniProtKB/TrEMBL),   H6X2W4 (UniProtKB/TrEMBL),   H6X2X0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000058   ⟸   ENSRNOT00000000058
Ensembl Acc Id: ENSRNOP00000074751   ⟸   ENSRNOT00000091089
Protein Domains
Pentraxin (PTX)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P48199-F1-model_v2 AlphaFold P48199 1-230 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699031
Promoter ID:EPDNEW_R9556
Type:multiple initiation site
Name:Crp_1
Description:C-reactive protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01391,080,367 - 91,080,427EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2411 AgrOrtholog
BioCyc Gene G2FUF-17296 BioCyc
Ensembl Genes ENSRNOG00000000053 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000058.7 UniProtKB/TrEMBL
  ENSRNOT00000091089.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7368286 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINE-1_ORF2_RT/EN UniProtKB/TrEMBL
  Pentaxin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pentraxin-related UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pentraxin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25419 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108726 IMAGE-MGC_LOAD
NCBI Gene 25419 ENTREZGENE
PANTHER C-REACTIVE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-REACTIVE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN UniProtKB/TrEMBL
Pfam Pentaxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRP RGD
PhenoGen Crp PhenoGen
PRINTS PENTAXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PTX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000053 RatGTEx
SMART PTX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2PYP2_RAT UniProtKB/TrEMBL
  CRP_RAT UniProtKB/Swiss-Prot
  H6X2V1 ENTREZGENE, UniProtKB/TrEMBL
  H6X2V2_RAT UniProtKB/TrEMBL
  H6X2V3_RAT UniProtKB/TrEMBL
  H6X2V4_RAT UniProtKB/TrEMBL
  H6X2V7_RAT UniProtKB/TrEMBL
  H6X2V8 ENTREZGENE, UniProtKB/TrEMBL
  H6X2V9_RAT UniProtKB/TrEMBL
  H6X2W0_RAT UniProtKB/TrEMBL
  H6X2W1_RAT UniProtKB/TrEMBL
  H6X2W2_RAT UniProtKB/TrEMBL
  H6X2W3 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W4 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W5 ENTREZGENE, UniProtKB/TrEMBL
  H6X2W6_RAT UniProtKB/TrEMBL
  H6X2W7_RAT UniProtKB/TrEMBL
  H6X2X0 ENTREZGENE, UniProtKB/TrEMBL
  P48199 ENTREZGENE
  Q5BK94 ENTREZGENE
  Q63133_RAT UniProtKB/TrEMBL
  Q7TMA9_RAT UniProtKB/TrEMBL
UniProt Secondary A0A0G2K8V5 UniProtKB/TrEMBL
  Q5BK94 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-24 Crp  C-reactive protein  Crp  C-reactive protein, pentraxin-related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Crp  C-reactive protein, pentraxin-related      Name updated 1299863 APPROVED
2002-06-10 Crp  C-reactive protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein glycoprotein that exists as a covalently-linked dimer 1298812