Cdc37 (cell division cycle 37, HSP90 cochaperone) - Rat Genome Database

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Gene: Cdc37 (cell division cycle 37, HSP90 cochaperone) Rattus norvegicus
Analyze
Symbol: Cdc37
Name: cell division cycle 37, HSP90 cochaperone
RGD ID: 71006
Description: Enables protein kinase binding activity; protein-folding chaperone binding activity; and transcription corepressor binding activity. Predicted to be involved in several processes, including positive regulation of type 2 mitophagy; protein stabilization; and regulation of macromolecule metabolic process. Predicted to act upstream of or within regulation of type I interferon-mediated signaling pathway and regulation of type II interferon-mediated signaling pathway. Located in ruffle membrane. Part of protein-containing complex. Orthologous to human CDC37 (cell division cycle 37, HSP90 cochaperone); PARTICIPATES IN protein kinase C (PKC) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CDC37 (cell division cycle 37 S. cerevisiae homolog); cell division cycle 37; cell division cycle 37 homolog; cell division cycle 37 homolog (S. cerevisiae); hsp90 chaperone protein kinase-targeting subunit; hsp90 co-chaperone Cdc37; p50Cdc37
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,954,292 - 27,966,935 (-)NCBIGRCr8
mRatBN7.2819,677,400 - 19,690,761 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,671,938 - 19,690,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,697,528 - 23,710,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,995,388 - 22,008,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,907,795 - 19,920,433 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,160,922 - 22,173,797 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,154,067 - 22,173,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,217,096 - 22,229,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,164,150 - 20,176,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,164,149 - 20,176,763 (-)NCBI
Celera821,072,564 - 21,085,065 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdc37Ratfamilial hypercholesterolemia  ISOCDC37 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial hypercholesterolemiaClinVarPMID:20809525 more ...
Cdc37Ratimmunodeficiency 35  ISOCDC37 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 35ClinVarPMID:22402565 more ...

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdc37Rat1,2-dimethylhydrazine affects expressionISOCdc37 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of CDC37 mRNACTDPMID:22206623
Cdc37Rat14-Deoxy-11,12-didehydroandrographolide decreases expressionISOCDC37 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in decreased expression of CDC37 mRNACTDPMID:22101062
Cdc37Rat17alpha-ethynylestradiol affects expressionISOCdc37 (Mus musculus)6480464Ethinyl Estradiol affects the expression of CDC37 mRNACTDPMID:17555576
Cdc37Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of CDC37 mRNACTDPMID:16174780
Cdc37Rat17alpha-ethynylestradiol multiple interactionsISOCdc37 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC37 mRNACTDPMID:17942748
Cdc37Rat17alpha-ethynylestradiol increases expressionISOCdc37 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of CDC37 mRNACTDPMID:16174780 and PMID:17942748
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCDC37 (Homo sapiens)6480464geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of CDC37 protein] and Tetrachlorodibenzodioxin promotes the reaction [CDC37 protein binds to SRC protein]CTDPMID:17223712
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOCdc37 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of CDC37 mRNACTDPMID:21570461
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOCdc37 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of CDC37 mRNACTDPMID:16960034 and PMID:17942748
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of CDC37 mRNACTDPMID:16960034 and PMID:33387578
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOCdc37 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDC37 mRNACTDPMID:17942748
Cdc37Rat2,3,7,8-tetrachlorodibenzodioxine affects localizationISOCDC37 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the localization of CDC37 proteinCTDPMID:17223712
Cdc37Rat2,4,6-tribromophenol decreases expressionISOCDC37 (Homo sapiens)64804642 more ...CTDPMID:31675489
Cdc37Rat2,6-dimethoxyphenol multiple interactionsISOCDC37 (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in decreased expression of CDC37 proteinCTDPMID:38598786
Cdc37Rat2-acetamidofluorene multiple interactionsEXP 6480464[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 mRNA and [2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of CDC37 proteinCTDPMID:16317707
Cdc37Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOCDC37 (Homo sapiens)6480464tetrabromobisphenol A results in decreased expression of CDC37 proteinCTDPMID:31675489
Cdc37Rat4,4'-sulfonyldiphenol increases expressionISOCdc37 (Mus musculus)6480464bisphenol S results in increased expression of CDC37 mRNACTDPMID:39298647
Cdc37Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of CDC37 mRNACTDPMID:36041667
Cdc37Rat4,4'-sulfonyldiphenol affects expressionISOCDC37 (Homo sapiens)6480464bisphenol S affects the expression of CDC37 proteinCTDPMID:31945527
Cdc37Ratacetylsalicylic acid decreases expressionISOCDC37 (Homo sapiens)6480464Aspirin results in decreased expression of CDC37 mRNACTDPMID:15928584

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Biological Process
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Cellular Component
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdc37Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Cdc37Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Cdc37Ratcytoplasm is_active_inIBAMGI:109531 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc37Ratcytoplasm located_inISOCDC37 (Homo sapiens)1624291 RGDGO_REF:0000054
Cdc37Ratcytoplasm located_inIEAUniRule:UR0019037691600115GO_REF:0000104UniProtGO_REF:0000104
Cdc37Ratcytosol located_inISOCDC37 (Homo sapiens)1624291 RGDGO_REF:0000052
Cdc37Ratcytosol located_inISOCdc37 (Mus musculus)1624291 PMID:17189825RGDPMID:17189825
Cdc37RatHSP90-CDC37 chaperone complex part_ofISOCdc37 (Mus musculus)1624291 PMID:21855797RGDPMID:21855797
Cdc37RatHSP90-CDC37 chaperone complex part_ofISOCDC37 (Homo sapiens)1624291 PMID:21855797RGDPMID:21855797
Cdc37Ratprotein folding chaperone complex part_ofISOCDC37 (Homo sapiens)1624291 PMID:29127155RGDPMID:29127155
Cdc37Ratprotein-containing complex  IDA 5131523 RGD 
Cdc37Ratruffle membrane  IDA 5131523 RGD 
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Molecular Function
1 to 20 of 22 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdc37Ratheat shock protein binding enablesISOCDC37 (Homo sapiens)1624291UniProtKB:P07900 and PMID:9660753RGDPMID:9660753
Cdc37Ratheat shock protein binding enablesIBAMGI:109531 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc37Ratheat shock protein binding enablesIEAUniRule:UR0019037691600115GO_REF:0000104UniProtGO_REF:0000104
Cdc37RatHsp90 protein binding enablesISOCdc37 (Mus musculus)1624291 PMID:17189825RGDPMID:17189825
Cdc37Ratkinase binding enablesISOCDC37 (Homo sapiens)1624291UniProtKB:O70405 and PMID:21855797RGDPMID:21855797
Cdc37Ratkinase binding enablesISOCdc37 (Mus musculus)1624291UniProtKB:O70405 and PMID:21855797RGDPMID:21855797
Cdc37Ratmitogen-activated protein kinase kinase kinase binding  IPIRAF1 (Homo sapiens)5131523 RGD 
Cdc37Ratprotein binding enablesISOCDC37 (Homo sapiens)1624291UniProtKB:A6NEM1 more ...RGDPMID:11036079 more ...
Cdc37Ratprotein binding enablesIPIUniProtKB:P0C86512790637PMID:23428871UniProt 
Cdc37Ratprotein binding enablesISOCdc37 (Mus musculus)1624291UniProtKB:Q9WVS8 and PMID:23428871RGDPMID:23428871
Cdc37Ratprotein kinase B binding  IPIAkt1 (Mus musculus)5131523 RGD 
Cdc37Ratprotein kinase binding  IPICdk4 (Mus musculus)5131523 RGD 
Cdc37Ratprotein kinase binding enablesIEAUniRule:UR0019037691600115GO_REF:0000104UniProtGO_REF:0000104
Cdc37Ratprotein kinase binding enablesIEAInterPro:IPR0138551600115GO_REF:0000002InterProGO_REF:0000002
Cdc37Ratprotein kinase regulator activity contributes_toISOCdc37 (Mus musculus)1624291 PMID:21855797RGDPMID:21855797
Cdc37Ratprotein-folding chaperone binding  IPIHSP90AA1 (Homo sapiens)5131523 RGD 
Cdc37Ratprotein-folding chaperone binding enablesIEAUniRule:UR0019037691600115GO_REF:0000104UniProtGO_REF:0000104
Cdc37Ratprotein-folding chaperone binding enablesIBAPANTHER:PTN000980613 and Cdc37 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Cdc37Ratscaffold protein binding enablesISOCDC37 (Homo sapiens)1624291UniProtKB:Q61097 and PMID:10409742RGDPMID:10409742
Cdc37Rattranscription corepressor binding  IPIRb1 (Rattus norvegicus)9698454protein C-terminus bindingRGD 
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Cdc37Ratprotein kinase C (PKC) signaling pathway   ISOCDC37 (Homo sapiens)5131489 RGD 

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#
Reference Title
Reference Citation
1. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Erazo T, etal., Mol Cell Biol. 2013 Apr;33(8):1671-86. doi: 10.1128/MCB.01246-12. Epub 2013 Feb 19.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene Data Set MGD Curation, June 12, 2002
5. CK2 binds, phosphorylates, and regulates its pivotal substrate Cdc37, an Hsp90-cochaperone. Miyata Y and Nishida E, Mol Cell Biochem. 2005 Jun;274(1-2):171-9.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Protein kinase C: poised to signal. Newton AC Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E395-402. Epub 2009 Nov 24.
8. Interaction of rat Cdc37-related protein with retinoblastoma gene product. Ozaki T and Sakiyama S, DNA Cell Biol. 1996 Nov;15(11):975-9.
9. Molecular cloning and cell cycle-dependent expression of a novel gene that is homologous to cdc37. Ozaki T, etal., DNA Cell Biol 1995 Dec;14(12):1017-23.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:9660753   PMID:10409742   PMID:12489981   PMID:15082798   PMID:15489334   PMID:16280321   PMID:17189825   PMID:17349580   PMID:18566753   PMID:19091746   PMID:20458337   PMID:21855797  
PMID:25002582   PMID:26362850   PMID:29127155   PMID:29687307   PMID:30053369   PMID:36920636  



Cdc37
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,954,292 - 27,966,935 (-)NCBIGRCr8
mRatBN7.2819,677,400 - 19,690,761 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,671,938 - 19,690,809 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,697,528 - 23,710,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,995,388 - 22,008,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,907,795 - 19,920,433 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,160,922 - 22,173,797 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,154,067 - 22,173,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,217,096 - 22,229,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,164,150 - 20,176,763 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,164,149 - 20,176,763 (-)NCBI
Celera821,072,564 - 21,085,065 (-)NCBICelera
Cytogenetic Map8q13NCBI
CDC37
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,391,133 - 10,403,542 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,391,090 - 10,420,121 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,501,809 - 10,514,218 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,362,809 - 10,375,271 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,362,808 - 10,375,271NCBI
Celera1910,396,515 - 10,408,977 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,081,863 - 10,094,337 (-)NCBIHuRef
CHM1_11910,502,536 - 10,515,003 (-)NCBICHM1_1
T2T-CHM13v2.01910,517,575 - 10,529,998 (-)NCBIT2T-CHM13v2.0
Cdc37
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,050,727 - 21,061,230 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,044,518 - 21,061,278 (-)EnsemblGRCm39 Ensembl
GRCm38921,139,431 - 21,149,934 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,133,222 - 21,149,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,942,985 - 20,954,350 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,888,943 - 20,900,308 (-)NCBIMGSCv36mm8
Celera918,407,255 - 18,418,620 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.72NCBI
Cdc37
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,641,236 - 1,651,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,642,467 - 1,651,288 (-)NCBIChiLan1.0ChiLan1.0
CDC37
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,309,229 - 15,322,930 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,307,842 - 14,321,343 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,942,644 - 9,955,112 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,606,246 - 10,618,702 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,606,246 - 10,618,702 (-)Ensemblpanpan1.1panPan2
CDC37
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,727,702 - 50,738,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,727,749 - 50,736,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,598,319 - 50,608,815 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,249,729 - 51,260,450 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,249,761 - 51,260,446 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,456,068 - 50,466,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,885,097 - 50,895,593 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,125,770 - 51,136,267 (+)NCBIUU_Cfam_GSD_1.0
Cdc37
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,633,499 - 209,643,541 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659711,117 - 721,260 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659711,165 - 721,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC37
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,201,579 - 69,225,994 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,202,695 - 69,212,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,534,504 - 69,544,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC37
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,427,220 - 9,439,469 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,427,191 - 9,439,913 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,563,853 - 10,576,327 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc37
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,521,272 - 2,535,475 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,523,761 - 2,533,387 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Cdc37
51 total Variants

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:64
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000042314
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat

1 to 10 of 23 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000042314   ⟹   ENSRNOP00000051248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,678,121 - 19,690,739 (-)Ensembl
Rnor_6.0 Ensembl822,160,922 - 22,173,797 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079949   ⟹   ENSRNOP00000072578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,671,938 - 19,690,809 (-)Ensembl
Rnor_6.0 Ensembl822,154,067 - 22,173,804 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112085   ⟹   ENSRNOP00000076743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,678,121 - 19,690,809 (-)Ensembl
RefSeq Acc Id: NM_053743   ⟹   NP_446195
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,954,294 - 27,966,930 (-)NCBI
mRatBN7.2819,678,123 - 19,690,759 (-)NCBI
Rnor_6.0822,160,922 - 22,173,797 (-)NCBI
Rnor_5.0822,217,096 - 22,229,971 (-)NCBI
RGSC_v3.4820,164,150 - 20,176,763 (-)RGD
Celera821,072,564 - 21,085,065 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080700   ⟹   XP_038936628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8827,954,292 - 27,966,935 (-)NCBI
mRatBN7.2819,677,400 - 19,690,761 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_446195 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936628 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61720 (Get FASTA)   NCBI Sequence Viewer  
  BAA05618 (Get FASTA)   NCBI Sequence Viewer  
  BAC54286 (Get FASTA)   NCBI Sequence Viewer  
  EDL78319 (Get FASTA)   NCBI Sequence Viewer  
  EDL78320 (Get FASTA)   NCBI Sequence Viewer  
  EDL78321 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051248
  ENSRNOP00000076743
GenBank Protein Q63692 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_446195   ⟸   NM_053743
- UniProtKB: Q63692 (UniProtKB/Swiss-Prot),   Q8CH95 (UniProtKB/Swiss-Prot),   A0A140TAG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072578   ⟸   ENSRNOT00000079949
Ensembl Acc Id: ENSRNOP00000051248   ⟸   ENSRNOT00000042314
RefSeq Acc Id: XP_038936628   ⟸   XM_039080700
- Peptide Label: isoform X1
- UniProtKB: A0A140TAG9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000076743   ⟸   ENSRNOT00000112085
Cdc37 C-terminal   Cdc37 Hsp90 binding   Cdc37 N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q63692-F1-model_v2 AlphaFold Q63692 1-379 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695776
Promoter ID:EPDNEW_R6300
Type:initiation region
Name:Cdc37_1
Description:cell division cycle 37
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,173,776 - 22,173,836EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31434 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000033426 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042314 ENTREZGENE
  ENSRNOT00000112085 ENTREZGENE
Gene3D-CATH 1.20.58.610 UniProtKB/Swiss-Prot
  6.10.140.250 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598479 IMAGE-MGC_LOAD
InterPro Cdc37 UniProtKB/Swiss-Prot
  Cdc37_C UniProtKB/Swiss-Prot
  Cdc37_Hsp90-bd UniProtKB/Swiss-Prot
  Cdc37_Hsp90-bd_sf UniProtKB/Swiss-Prot
  Cdc37_N_dom UniProtKB/Swiss-Prot
KEGG Report rno:114562 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72349 IMAGE-MGC_LOAD
NCBI Gene 114562 ENTREZGENE
PANTHER HSP90 CO-CHAPERONE CDC37 UniProtKB/Swiss-Prot
  PTHR12800 UniProtKB/Swiss-Prot
Pfam CDC37_C UniProtKB/Swiss-Prot
  CDC37_M UniProtKB/Swiss-Prot
  CDC37_N UniProtKB/Swiss-Prot
PhenoGen Cdc37 PhenoGen
RatGTEx ENSRNOG00000033426 RatGTEx
SMART CDC37_C UniProtKB/Swiss-Prot
  CDC37_M UniProtKB/Swiss-Prot
  CDC37_N UniProtKB/Swiss-Prot
Superfamily-SCOP Hsp90 co-chaperone CDC37 UniProtKB/Swiss-Prot
UniProt A0A0G2K3C1_RAT UniProtKB/TrEMBL
  A0A140TAG9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y0C0_RAT UniProtKB/TrEMBL
  A6JNP5_RAT UniProtKB/TrEMBL
  A6JNP6_RAT UniProtKB/TrEMBL
  A6JNP7_RAT UniProtKB/TrEMBL
  CDC37_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CH95 ENTREZGENE
UniProt Secondary Q8CH95 UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-28 Cdc37  cell division cycle 37, HSP90 cochaperone  Cdc37  cell division cycle 37  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-23 Cdc37  cell division cycle 37  Cdc37  cell division cycle 37 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Cdc37  cell division cycle 37 homolog (S. cerevisiae)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_homology has similarity to S. cerevisiae cdc37 70676