Per2 (period circadian regulator 2) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Per2 (period circadian regulator 2) Rattus norvegicus
Symbol: Per2
Name: period circadian regulator 2
RGD ID: 61945
Description: Predicted to enable several functions, including enzyme binding activity; nucleic acid binding activity; and transcription corepressor binding activity. Involved in circadian rhythm and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 1. Orthologous to human PER2 (period circadian regulator 2); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
Previously known as: circadian clock protein PERIOD 2; period circadian clock 2; period circadian protein homolog 2; period homolog 2; period homolog 2 (Drosophila); rPER2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Celera989,548,336 - 89,590,505 (-)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acamprosate  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chrysene  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethyl maleate  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
Erionite  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glycine betaine  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
linsidomine  (ISO)
manganese(II) chloride  (EXP)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
milrinone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
plumbagin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
sevoflurane  (EXP)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
styrene  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
torcetrapib  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
trovafloxacin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zalcitabine  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO)
perinuclear region of cytoplasm  (ISO)


References - curated
# Reference Title Reference Citation
1. Requirement of mammalian Timeless for circadian rhythmicity. Barnes JW, etal., Science 2003 Oct 17;302(5644):439-42.
2. Role of the circadian clock gene Per2 in adaptation to cold temperature. Chappuis S, etal., Mol Metab. 2013 May 10;2(3):184-93. doi: 10.1016/j.molmet.2013.05.002. eCollection 2013.
3. Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light. Dardente H, etal., Brain Res 2002 Dec 27;958(2):261-71.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system. Hamaguchi H, etal., Biochem J. 2004 Aug 15;382(Pt 1):43-50.
7. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. Hirota T, etal., J Biol Chem 2002 Nov 15;277(46):44244-51.
8. Dec1 and Dec2 are regulators of the mammalian molecular clock. Honma S, etal., Nature 2002 Oct 24;419(6909):841-4.
9. A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation. Kawamoto T, etal., Biochem Biophys Res Commun. 2004 Jan 2;313(1):117-24.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein. Miyazaki K, etal., Mol Cell Biol 2001 Oct;21(19):6651-9.
12. Indication of circadian oscillations in the rat pancreas. Muhlbauer E, etal., FEBS Lett. 2004 Apr 23;564(1-2):91-6.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. Ohsaki K, etal., J Biochem. 2008 Nov;144(5):609-18. doi: 10.1093/jb/mvn112. Epub 2008 Sep 8.
15. Antiphase circadian expression between BMAL1 and period homologue mRNA in the suprachiasmatic nucleus and peripheral tissues of rats. Oishi K, etal., Biochem Biophys Res Commun. 1998 Dec 18;253(2):199-203.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. Sakamoto K, etal., J Biol Chem 1998 Oct 16;273(42):27039-42.
21. Molecular characterization and nuclear localization of rat timeless-like gene product. Sakamoto S, etal., Biochem Biophys Res Commun. 2000 Dec 9;279(1):131-8.
22. Serotonin inhibits glutamate- but not PACAP-induced per gene expression in the rat suprachiasmatic nucleus at night. Sanggaard KM, etal., Eur J Neurosci 2003 Mar;17(6):1245-52.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Toh KL, etal., Science. 2001 Feb 9;291(5506):1040-3.
25. Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Yuferov V, etal., Synapse 2003 Jun 15;48(4):157-69.
Additional References at PubMed
PMID:9989497   PMID:11395012   PMID:11889036   PMID:12710990   PMID:12738229   PMID:12843397   PMID:14593213   PMID:14645221   PMID:14701732   PMID:15193530   PMID:15689618   PMID:15792371  
PMID:15860628   PMID:15864751   PMID:16580135   PMID:16595674   PMID:16675517   PMID:16678973   PMID:16923124   PMID:17310242   PMID:17404161   PMID:17544223   PMID:17915197   PMID:17986006  
PMID:18208549   PMID:18511208   PMID:18810660   PMID:18817849   PMID:19036829   PMID:19103603   PMID:19122877   PMID:19217292   PMID:19222559   PMID:19402751   PMID:19559014   PMID:19605937  
PMID:19740747   PMID:19887760   PMID:19917250   PMID:20096750   PMID:20159955   PMID:20205554   PMID:20424134   PMID:20589906   PMID:20738730   PMID:20962226   PMID:21035761   PMID:21063915  
PMID:21076970   PMID:21182399   PMID:21363938   PMID:21484443   PMID:21547532   PMID:21613214   PMID:21621196   PMID:21680841   PMID:21767615   PMID:21768648   PMID:21775066   PMID:21952132  
PMID:22170608   PMID:22208286   PMID:22274616   PMID:22381761   PMID:22504074   PMID:22767893   PMID:23106436   PMID:23167790   PMID:23418588   PMID:23738784   PMID:23785138   PMID:23850797  
PMID:23850969   PMID:23864491   PMID:23977055   PMID:24124556   PMID:24133102   PMID:24268780   PMID:24413057   PMID:24549704   PMID:24619734   PMID:24737000   PMID:25068868   PMID:25669688  
PMID:25760074   PMID:26213916   PMID:26271538   PMID:26656624   PMID:26892296   PMID:26901093   PMID:27362940   PMID:27365111   PMID:27999821   PMID:28423013   PMID:29165002   PMID:29894471  
PMID:30627637   PMID:31822134   PMID:32777474   PMID:32964673   PMID:37338051  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2992,007,289 - 92,049,551 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,434,053 - 100,476,216 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,569,813 - 105,611,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,933,398 - 103,975,592 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,555,154 - 98,597,362 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,231,202 - 98,273,371 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,645,342 - 90,687,509 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,850,110 - 90,892,278 (-)NCBI
Celera989,548,336 - 89,590,505 (-)NCBICelera
Cytogenetic Map9q36NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382238,244,044 - 238,300,065 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,244,044 - 238,290,102 (-)EnsemblGRCh38hg38GRCh38
GRCh372239,152,685 - 239,197,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,817,418 - 238,861,946 (-)NCBINCBI36Build 36hg18NCBI36
Build 342238,934,685 - 238,979,092NCBI
Celera2232,865,233 - 232,909,762 (-)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,943,837 - 230,988,232 (-)NCBIHuRef
CHM1_12239,158,528 - 239,203,056 (-)NCBICHM1_1
T2T-CHM13v2.02238,733,782 - 238,779,869 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39191,343,699 - 91,387,028 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,343,704 - 91,387,046 (-)EnsemblGRCm39 Ensembl
GRCm38191,415,977 - 91,459,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,415,982 - 91,459,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,312,559 - 93,355,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,246,388 - 93,289,702 (-)NCBIMGSCv36mm8
Celera194,353,350 - 94,396,834 (-)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.13NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049555422,338,099 - 2,371,274 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,331,547 - 2,369,011 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12B140,891,847 - 140,936,401 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,477,021 - 125,521,577 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,328,122 - 244,371,040 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,328,122 - 244,371,040 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12548,716,499 - 48,761,617 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,717,173 - 48,758,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,211,912 - 49,257,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,102,140 - 49,147,315 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,102,151 - 49,143,375 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,977,242 - 49,022,398 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,765,877 - 48,806,293 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,998,242 - 49,043,270 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405303190,676,406 - 190,718,243 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525221,510 - 263,295 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525221,601 - 263,284 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl15137,793,422 - 137,837,070 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,793,419 - 137,837,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,264,819 - 152,284,153 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.110124,270,917 - 124,316,031 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,269,543 - 124,315,904 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,104,175 - 75,149,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248473,361,170 - 3,390,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,359,174 - 3,399,584 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Per2
138 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:281
Count of miRNA genes:174
Interacting mature miRNAs:220
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,035,203 - 92,035,384 (+)MAPPERmRatBN7.2
Rnor_6.0998,583,068 - 98,583,248NCBIRnor6.0
Rnor_5.0998,259,116 - 98,259,296UniSTSRnor5.0
RGSC_v3.4990,673,254 - 90,673,434UniSTSRGSC3.4
Celera989,576,250 - 89,576,430UniSTS
Cytogenetic Map9q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,034,821 - 92,034,960 (+)MAPPERmRatBN7.2
Rnor_6.0998,582,686 - 98,582,824NCBIRnor6.0
Rnor_5.0998,258,734 - 98,258,872UniSTSRnor5.0
RGSC_v3.4990,672,872 - 90,673,010UniSTSRGSC3.4
Celera989,575,868 - 89,576,006UniSTS
RH 3.4 Map9785.49UniSTS
Cytogenetic Map9q36UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2992,008,649 - 92,009,153 (+)MAPPERmRatBN7.2
Rnor_6.0998,556,510 - 98,557,013NCBIRnor6.0
Rnor_5.0998,232,558 - 98,233,061UniSTSRnor5.0
RGSC_v3.4990,646,696 - 90,647,199UniSTSRGSC3.4
Celera989,549,690 - 89,550,193UniSTS
Cytogenetic Map9q36UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 18 9 3 3 3 3 46 15 17 6
Low 25 48 38 16 38 8 8 28 20 24 5 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000027506   ⟹   ENSRNOP00000027507
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)Ensembl
Rnor_6.0 Ensembl998,555,169 - 98,597,359 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109112   ⟹   ENSRNOP00000077245
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl992,007,296 - 92,049,459 (-)Ensembl
RefSeq Acc Id: NM_031678   ⟹   NP_113866
Rat AssemblyChrPosition (strand)Source
mRatBN7.2992,007,296 - 92,049,459 (-)NCBI
Rnor_6.0998,555,156 - 98,597,323 (-)NCBI
Rnor_5.0998,231,202 - 98,273,371 (-)NCBI
RGSC_v3.4990,645,342 - 90,687,509 (-)RGD
Celera989,548,336 - 89,590,505 (-)RGD
RefSeq Acc Id: XM_006245476   ⟹   XP_006245538
Rat AssemblyChrPosition (strand)Source
mRatBN7.2992,007,289 - 92,049,353 (-)NCBI
Rnor_6.0998,555,154 - 98,597,225 (-)NCBI
Rnor_5.0998,231,202 - 98,273,371 (-)NCBI
RefSeq Acc Id: XM_017596618   ⟹   XP_017452107
Rat AssemblyChrPosition (strand)Source
mRatBN7.2992,007,289 - 92,049,551 (-)NCBI
Rnor_6.0998,555,154 - 98,597,362 (-)NCBI
RefSeq Acc Id: XM_039084159   ⟹   XP_038940087
Rat AssemblyChrPosition (strand)Source
mRatBN7.2992,007,289 - 92,049,551 (-)NCBI
RefSeq Acc Id: XM_039084160   ⟹   XP_038940088
Rat AssemblyChrPosition (strand)Source
mRatBN7.2992,007,289 - 92,029,049 (-)NCBI
RefSeq Acc Id: NP_113866   ⟸   NM_031678
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245538   ⟸   XM_006245476
- Peptide Label: isoform X1
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017452107   ⟸   XM_017596618
- Peptide Label: isoform X1
- UniProtKB: Q9Z301 (UniProtKB/Swiss-Prot),   A6JQS5 (UniProtKB/TrEMBL),   A0A8I5Y7B9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027507   ⟸   ENSRNOT00000027506
RefSeq Acc Id: XP_038940087   ⟸   XM_039084159
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y7B9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940088   ⟸   XM_039084160
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000077245   ⟸   ENSRNOT00000109112
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z301-F1-model_v2 AlphaFold Q9Z301 1-1257 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696861
Promoter ID:EPDNEW_R7386
Type:initiation region
Description:period circadian regulator 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,597,372 - 98,597,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61945 AgrOrtholog
BioCyc Gene G2FUF-26713 BioCyc
Ensembl Genes ENSRNOG00000020254 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009603 UniProtKB/Swiss-Prot
  ENSRNOG00060009201 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027506 ENTREZGENE
  ENSRNOT00000027506.6 UniProtKB/Swiss-Prot
  ENSRNOT00000109112.1 UniProtKB/TrEMBL
  ENSRNOT00055016243 UniProtKB/Swiss-Prot
  ENSRNOT00060015508 UniProtKB/Swiss-Prot
Gene3D-CATH PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per1-3_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_circadian-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAS_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Per3-like_PAS-A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Period_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Per2 PhenoGen
PROSITE PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020254 RatGTEx
  ENSRNOG00055009603 RatGTEx
  ENSRNOG00060009201 RatGTEx
SMART PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231261

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Per2  period circadian regulator 2  Per2  period circadian clock 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-02 Per2  period circadian clock 2  Per2  period homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Per2  period homolog 2 (Drosophila)    period homolog 2   Name updated 1299863 APPROVED
2002-06-10 Per2  period homolog 2       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a nucleus localization signal in the central domain; has PAS domians near the N-terminal which can interact with and regulate the activity of PAS domain transcriptional factors, such as CLOCK and BMAL 61691
gene_domains contains a nucleus localization signal in the central domain; has PAS domians near the N-terminal which can interact with and regulate the activity of PAS domain transcriptional factors, such as CLOCK and BMAL 69505
gene_domains contains PAS (PER-ARNT-SIM) domains near the N-terminus which regulate PAS domain transcriptional factors 631232
gene_process controls circadian rhythms 61691
gene_process controls circadian rhythms 631232