Gene: Fbln5 (fibulin 5) Rattus norvegicus
Analyze
Symbol:
Fbln5
Name:
fibulin 5
Description:
Predicted to have integrin binding activity; protein C-terminus binding activity; and protein homodimerization activity. Involved in regulation of cell growth. Localizes to the extracellular space. Predicted to colocalize with the elastic fiber. Human ortholog(s) of this gene implicated in age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5); INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 3,3',4,4',5-pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
dance; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF repeat-containing protein; EVEC; FIBL-5; fibulin-5
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
FBLN5 (fibulin 5) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther
Mus musculus (house mouse):
Fbln5 (fibulin 5) HGNC
OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Fbln5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
FBLN5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
FBLN5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Fbln5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
FBLN5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
FBLN5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Fbln5 (fibulin 5) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
EFEMP2 (EGF containing fibulin extracellular matrix protein 2) HGNC
OrthoDB
Alliance orthologs 3
Homo sapiens (human):
FBLN5 (fibulin 5)
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Mus musculus (house mouse):
Fbln5 (fibulin 5)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Danio rerio (zebrafish):
fbln5 (fibulin 5)
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 125,644,797 - 125,723,957 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 125,644,804 - 125,723,944 (-) Ensembl Rnor_5.0 6 134,856,694 - 134,935,853 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 126,018,541 - 126,098,234 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 126,022,288 - 126,102,052 (-) NCBI Celera 6 118,399,373 - 118,476,665 (-) NCBI Celera Cytogenetic Map 6 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 3 ClinVar PMID:21576112 more ... Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 3 ClinVar PMID:21576112 , PMID:28492532 Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 3 ClinVar PMID:15269314 more ... Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 3 ClinVar PMID:25741868 Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 3 ClinVar Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:608895 ClinVar PMID:21576112 Age Related Macular Degeneration 3 ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:608895 ClinVar PMID:15269314 , PMID:21576112 autosomal dominant cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis laxa, autosomal dominant ClinVar PMID:12618961 autosomal dominant cutis laxa 1 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis laxa, autosomal dominant 1 ClinVar PMID:12618961 autosomal dominant cutis laxa 2 ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis laxa, autosomal dominant 2 ClinVar autosomal dominant cutis laxa 2 ISO RGD:736145 8554872 ClinVar Annotator: match by This custom term has been created by RGD curators. ClinVar PMID:12618961 autosomal recessive cutis laxa type IA ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:219100 ClinVar PMID:16374472 , PMID:20599547 autosomal recessive cutis laxa type IA ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:219100 ClinVar PMID:18185537 , PMID:22829427 autosomal recessive cutis laxa type IA ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:219100 ClinVar autosomal recessive cutis laxa type IA ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:219100 ClinVar PMID:12189163 more ... autosomal recessive cutis laxa type IA ISO RGD:736145 8554872 ClinVar Annotator: match by OMIM:219100 ClinVar PMID:22829427 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:28492532 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:21576112 , PMID:28492532 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:24033266 , PMID:28492532 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:24033266 , PMID:25741868 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:24033266 cutis laxa ISO RGD:736145 8554872 ClinVar Annotator: match by term: Cutis Laxa, Dominant/Recessive ClinVar PMID:16374472 , PMID:20599547 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:24033266 , PMID:25741868 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:24033266 , PMID:28492532 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:21576112 , PMID:28492532 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:28492532 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:16374472 , PMID:20599547 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:21576112 macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar macular degeneration ISO RGD:736145 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:24033266 spinal muscular atrophy ISO RGD:736145 8554872 ClinVar Annotator: match by term: Proximal spinal muscular atrophy ClinVar
Imported Annotations - CTD
adult respiratory distress syndrome ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25070658 autosomal dominant cutis laxa ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD Autosomal Recessive Cutis Laxa ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 congestive heart failure ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 Emphysema ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 Prostatic Neoplasms ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17929269 pulmonary hypertension ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 respiratory failure ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 Respiratory Tract Infections ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 vascular disease ISO RGD:736145 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12189163 Imported Annotations - MGI
cutis laxa ISS RGD:736146 13592920 OMIM:123700 more ... MouseDO Imported Annotations - OMIM
Age Related Macular Degeneration 3 ISO RGD:736145 7240710 OMIM autosomal dominant cutis laxa 2 ISO RGD:736145 7240710 OMIM autosomal recessive cutis laxa type IA ISO RGD:736145 7240710 OMIM
1,1-dichloroethene decreases expression ISO RGD:736146 6480464 vinylidene chloride results in decreased expression of FBLN5 mRNA CTD PMID:26682919 17alpha-ethynylestradiol affects expression ISO RGD:736146 6480464 Ethinyl Estradiol affects the expression of FBLN5 mRNA CTD PMID:17555576 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of FBLN5 mRNA CTD PMID:15576828 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of FBLN5 mRNA CTD PMID:17108234 17beta-estradiol multiple interactions ISO RGD:736145 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of FBLN5 mRNA CTD PMID:30165855 2,2',5,5'-tetrachlorobiphenyl increases expression EXP 6480464 2 more ... CTD PMID:23829299 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:20959002 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of FBLN5 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:736146 6480464 4, 4'-diaminodiphenylmethane results in increased expression of FBLN5 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:736146 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of FBLN5 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol increases expression ISO RGD:736146 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of FBLN5 mRNA CTD PMID:30951980 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of FBLN5 mRNA CTD PMID:24780913 aflatoxin B1 increases methylation ISO RGD:736145 6480464 Aflatoxin B1 results in increased methylation of FBLN5 gene CTD PMID:27153756 all-trans-retinoic acid multiple interactions ISO RGD:736146 6480464 [bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of FBLN5 mRNA more ... CTD PMID:30951980 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of FBLN5 mRNA CTD PMID:16483693 aristolochic acid multiple interactions EXP 6480464 [aristolochic acid I co-treated with aristolochic acid II] results in increased expression of FBLN5 mRNA CTD PMID:23912714 arsenous acid increases expression ISO RGD:736145 6480464 Arsenic Trioxide results in increased expression of FBLN5 mRNA CTD PMID:15761015 benzo[a]pyrene decreases expression ISO RGD:736146 6480464 Benzo(a)pyrene results in decreased expression of FBLN5 mRNA CTD PMID:20713471 benzo[a]pyrene increases expression ISO RGD:736146 6480464 Benzo(a)pyrene results in increased expression of FBLN5 mRNA CTD PMID:22610609 benzo[e]pyrene increases methylation ISO RGD:736145 6480464 benzo(e)pyrene results in increased methylation of FBLN5 intron CTD PMID:30157460 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN5 mRNA CTD PMID:18164116 bis(2-ethylhexyl) phthalate increases expression ISO RGD:736145 6480464 Diethylhexyl Phthalate results in increased expression of FBLN5 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FBLN5 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol A increases expression ISO RGD:736146 6480464 bisphenol A results in increased expression of FBLN5 mRNA CTD PMID:30951980 bisphenol A multiple interactions ISO RGD:736146 6480464 [bisphenol A co-treated with Tretinoin] results in decreased expression of FBLN5 mRNA CTD PMID:30951980 bisphenol A increases expression ISO RGD:736145 6480464 bisphenol A results in increased expression of FBLN5 mRNA CTD PMID:29275510 bisphenol F multiple interactions ISO RGD:736146 6480464 [bisphenol F co-treated with Tretinoin] results in decreased expression of FBLN5 mRNA CTD PMID:30951980 bisphenol F increases expression ISO RGD:736146 6480464 bisphenol F results in increased expression of FBLN5 mRNA CTD PMID:30951980 bortezomib decreases expression ISO RGD:736145 6480464 Bortezomib results in decreased expression of FBLN5 mRNA CTD PMID:20977926 butanal increases expression ISO RGD:736145 6480464 butyraldehyde results in increased expression of FBLN5 mRNA CTD PMID:26079696 cadmium atom multiple interactions ISO RGD:736145 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FBLN5 mRNA CTD PMID:29741670 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of FBLN5 mRNA CTD PMID:25993096 cadmium dichloride multiple interactions ISO RGD:736145 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of FBLN5 mRNA CTD PMID:29741670 cadmium dichloride increases expression ISO RGD:736145 6480464 Cadmium Chloride results in increased expression of FBLN5 mRNA CTD PMID:26314618 carbon nanotube decreases expression ISO RGD:736146 6480464 Nanotubes, Carbon analog results in decreased expression of FBLN5 mRNA, Nanotubes, Carbon results in decreased expression of FBLN5 mRNA CTD PMID:25554681 , PMID:25620056 carmustine decreases expression EXP 6480464 Carmustine results in decreased expression of FBLN5 mRNA CTD PMID:16005536 choline multiple interactions ISO RGD:736146 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA CTD PMID:20938992 ciguatoxin CTX1B affects expression ISO RGD:736146 6480464 Ciguatoxins affects the expression of FBLN5 mRNA CTD PMID:18353800 cisplatin increases expression ISO RGD:736145 6480464 Cisplatin results in increased expression of FBLN5 mRNA CTD PMID:27392435 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of FBLN5 mRNA CTD PMID:24386269 copper atom multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA, [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 copper(0) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA, [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 dexamethasone decreases expression ISO RGD:736146 6480464 Dexamethasone results in decreased expression of FBLN5 mRNA CTD PMID:25056791 dextran sulfate multiple interactions ISO RGD:736146 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of FBLN5 mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:736145 6480464 Arsenic Trioxide results in increased expression of FBLN5 mRNA CTD PMID:15761015 dioxygen increases expression ISO RGD:736145 6480464 Oxygen deficiency results in increased expression of FBLN5 mRNA CTD PMID:26516004 dorsomorphin multiple interactions ISO RGD:736145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:736145 6480464 Doxorubicin results in decreased expression of FBLN5 mRNA CTD PMID:29803840 elemental selenium increases expression ISO RGD:736145 6480464 Selenium results in increased expression of FBLN5 mRNA CTD PMID:19244175 entinostat increases expression ISO RGD:736145 6480464 entinostat results in increased expression of FBLN5 mRNA CTD PMID:27188386 ethanol multiple interactions ISO RGD:736146 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of FBLN5 mRNA CTD PMID:30517762 ethanol affects expression ISO RGD:736146 6480464 Ethanol affects the expression of FBLN5 mRNA CTD PMID:30319688 folic acid multiple interactions ISO RGD:736146 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA CTD PMID:20938992 furan increases expression EXP 6480464 furan results in increased expression of FBLN5 mRNA CTD PMID:27387713 L-methionine multiple interactions ISO RGD:736146 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FBLN5 mRNA CTD PMID:20938992 lead(0) affects expression ISO RGD:736145 6480464 Lead affects the expression of FBLN5 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:736145 6480464 Lead affects the expression of FBLN5 mRNA CTD PMID:28903495 methapyrilene increases methylation ISO RGD:736145 6480464 Methapyrilene results in increased methylation of FBLN5 intron CTD PMID:30157460 methotrexate decreases expression EXP 6480464 Methotrexate results in decreased expression of FBLN5 mRNA CTD PMID:16005536 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN5 mRNA CTD PMID:18164116 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of FBLN5 mRNA CTD PMID:22110744 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of FBLN5 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:736146 6480464 Acetaminophen affects the expression of FBLN5 mRNA CTD PMID:17562736 pentanal increases expression ISO RGD:736145 6480464 pentanal results in increased expression of FBLN5 mRNA CTD PMID:26079696 phenylmercury acetate increases expression ISO RGD:736145 6480464 Phenylmercuric Acetate results in increased expression of FBLN5 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:736145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA CTD PMID:27188386 phosgene affects expression ISO RGD:736146 6480464 Phosgene affects the expression of FBLN5 mRNA CTD PMID:16300373 potassium dichromate increases expression ISO RGD:736146 6480464 Potassium Dichromate results in increased expression of FBLN5 mRNA CTD PMID:23608068 progesterone increases expression ISO RGD:736145 6480464 Progesterone results in increased expression of FBLN5 mRNA CTD PMID:21795739 propanal increases expression ISO RGD:736145 6480464 propionaldehyde results in increased expression of FBLN5 mRNA CTD PMID:26079696 resveratrol increases expression ISO RGD:736145 6480464 resveratrol results in increased expression of FBLN5 mRNA CTD PMID:25888808 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of FBLN5 mRNA CTD PMID:28374803 SB 431542 multiple interactions ISO RGD:736145 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FBLN5 mRNA CTD PMID:27188386 selenium atom increases expression ISO RGD:736145 6480464 Selenium results in increased expression of FBLN5 mRNA CTD PMID:19244175 silicon dioxide decreases expression ISO RGD:736145 6480464 Silicon Dioxide analog results in decreased expression of FBLN5 mRNA CTD PMID:25895662 silver atom decreases expression ISO RGD:736146 6480464 Silver results in decreased expression of FBLN5 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:736146 6480464 Silver results in decreased expression of FBLN5 mRNA CTD PMID:27131904 sodium arsenite affects methylation ISO RGD:736145 6480464 sodium arsenite affects the methylation of FBLN5 gene CTD PMID:28589171 Soman increases expression EXP 6480464 Soman results in increased expression of FBLN5 mRNA CTD PMID:19281266 sunitinib decreases expression ISO RGD:736145 6480464 Sunitinib results in decreased expression of FBLN5 mRNA CTD PMID:31533062 tamoxifen affects expression ISO RGD:736146 6480464 Tamoxifen affects the expression of FBLN5 mRNA CTD PMID:17555576 tetrachloromethane increases expression ISO RGD:736146 6480464 Carbon Tetrachloride results in increased expression of FBLN5 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions ISO RGD:736146 6480464 [Carbon Tetrachloride co-treated with Ethanol] results in increased expression of FBLN5 mRNA CTD PMID:30517762 tetrathiomolybdate(2-) multiple interactions EXP 6480464 [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 mRNA, [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of FBLN5 protein CTD PMID:22276220 tioguanine decreases expression EXP 6480464 Thioguanine results in decreased expression of FBLN5 mRNA CTD PMID:16005536 titanium dioxide decreases expression ISO RGD:736146 6480464 titanium dioxide results in decreased expression of FBLN5 mRNA CTD PMID:23557971 , PMID:27760801 titanium dioxide multiple interactions ISO RGD:736146 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of FBLN5 mRNA CTD PMID:29950665 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of FBLN5 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of FBLN5 mRNA CTD PMID:25729387 triclosan increases expression ISO RGD:736145 6480464 Triclosan results in increased expression of FBLN5 mRNA CTD PMID:30510588 troglitazone decreases expression ISO RGD:736146 6480464 troglitazone results in decreased expression of FBLN5 mRNA CTD PMID:28973697 troglitazone increases expression ISO RGD:736146 6480464 troglitazone results in increased expression of FBLN5 mRNA CTD PMID:28973697 urethane decreases expression ISO RGD:736146 6480464 Urethane results in decreased expression of FBLN5 mRNA CTD PMID:16289808 valproic acid increases expression ISO RGD:736145 6480464 Valproic Acid results in increased expression of FBLN5 mRNA CTD PMID:23179753 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of FBLN5 mRNA CTD PMID:29427782 valproic acid increases methylation ISO RGD:736145 6480464 Valproic Acid results in increased methylation of FBLN5 gene CTD PMID:29154799 zoledronic acid increases expression ISO RGD:736145 6480464 zoledronic acid results in increased expression of FBLN5 mRNA CTD PMID:24714768
Biological Process cell adhesion IEA UniProtKB-KW:KW-0130 1600115 GO_REF:0000037 UniProt GO_REF:0000037 elastic fiber assembly ISO RGD:736146 1624291 (MGI:MGI:2681470 more ... RGD MGI:MGI:2681470 more ... elastic fiber assembly IBA MGI:MGI:1346091 more ... 13792537 PMID:21873635 GO_Central elastic fiber assembly ISS UniProtKB:Q9WVH9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 elastic fiber assembly ISS UniProtKB:Q9UBX5 1600115 GO_REF:0000024 UniProt GO_REF:0000024 elastic fiber assembly ISO RGD:736145 1624291 (PMID:17035250) RGD PMID:17035250 extracellular matrix organization ISO RGD:736146 1624291 (MGI:MGI:3807344, PMID:18757743) RGD MGI:MGI:3807344 , PMID:18757743 intramembranous bone growth IEA UniProtKB:Q9WVH9 , ensembl:ENSMUSP000000216031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of angiogenesis IEA UniProtKB:Q9WVH9 , ensembl:ENSMUSP000000216031600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q9WVH9 , ensembl:ENSMUSP000000216031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of osteoblast proliferation IEA UniProtKB:Q9WVH9 , ensembl:ENSMUSP000000216031600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q9WVH9 , ensembl:ENSMUSP000000216031600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein localization to cell surface ISO RGD:736146 1624291 (MGI:MGI:3610795, PMID:15528465) RGD MGI:MGI:3610795 , PMID:15528465 regulation of cell growth IEP 632806 RGD regulation of removal of superoxide radicals ISO RGD:736146 1624291 (MGI:MGI:3610795, PMID:15528465) RGD MGI:MGI:3610795 , PMID:15528465 secretion ISO RGD:736145 1624291 (PMID:20599547) RGD PMID:20599547 Cellular Component collagen-containing extracellular matrix ISO RGD:736145 1624291 (PMID:17035250) RGD PMID:17035250 collagen-containing extracellular matrix colocalizes_with ISO RGD:736146 1624291 (MGI:MGI:3610795, PMID:15528465) RGD MGI:MGI:3610795 , PMID:15528465 collagen-containing extracellular matrix ISS UniProtKB:Q9UBX5 1600115 GO_REF:0000024 UniProt GO_REF:0000024 elastic fiber colocalizes_with ISO RGD:736146 1624291 (MGI:MGI:2681471, PMID:11805834) RGD MGI:MGI:2681471 , PMID:11805834 extracellular space IDA 69830 RGD Molecular Function calcium ion binding IEA InterPro:IPR001881 , InterPro:IPR018097 1600115 GO_REF:0000002 InterPro GO_REF:0000002 integrin binding ISO RGD:736146 1624291 (MGI:MGI:2681470, PMID:11805835) RGD MGI:MGI:2681470 , PMID:11805835 integrin binding ISS UniProtKB:Q9WVH9 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein binding IPI UniProtKB:P15502 1300318 PMID:11805834 BHF-UCL protein binding ISO RGD:736145 1624291 UniProtKB:O95967 more ... RGD PMID:15790312 more ... protein C-terminus binding ISO RGD:736145 1624291 UniProtKB:P08294 (PMID:15528465) RGD PMID:15528465 protein homodimerization activity ISO RGD:736145 1624291 (PMID:19617354), (PMID:20007835) RGD PMID:19617354 , PMID:20007835 protein homodimerization activity ISS UniProtKB:Q9UBX5 1600115 GO_REF:0000024 UniProt GO_REF:0000024
Gene-Chemical Interaction Annotations
