Slc35a2 (solute carrier family 35 member A2) - Rat Genome Database

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Gene: Slc35a2 (solute carrier family 35 member A2) Rattus norvegicus
Analyze
Symbol: Slc35a2
Name: solute carrier family 35 member A2
RGD ID: 2293497
Description: Predicted to enable UDP-galactose transmembrane transporter activity. Predicted to be involved in UDP-galactose transmembrane transport. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIm. Orthologous to human SLC35A2 (solute carrier family 35 member A2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Soman.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC188623; solute carrier family 35 (UDP-galactose transporter), member A2; solute carrier family 35, member A2; UDP-galactose translocator
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,280,072 - 17,288,928 (-)NCBIGRCr8
mRatBN7.2X14,608,145 - 14,616,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,608,055 - 14,616,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,421,690 - 19,430,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,652,888 - 20,661,421 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,918,058 - 16,926,591 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,453,184 - 15,461,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,453,186 - 15,461,713 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,234,419 - 16,243,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,642,694 - 26,651,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,692,902 - 14,701,423 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:10578063   PMID:12477932   PMID:21918738  


Genomics

Comparative Map Data
Slc35a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,280,072 - 17,288,928 (-)NCBIGRCr8
mRatBN7.2X14,608,145 - 14,616,937 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,608,055 - 14,616,678 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,421,690 - 19,430,223 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,652,888 - 20,661,421 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,918,058 - 16,926,591 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,453,184 - 15,461,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,453,186 - 15,461,713 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,234,419 - 16,243,248 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,642,694 - 26,651,223 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,692,902 - 14,701,423 (-)NCBICelera
Cytogenetic MapXq12NCBI
SLC35A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,903,183 - 48,911,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,903,180 - 48,911,958 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,760,460 - 48,769,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,645,403 - 48,654,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,516,706 - 48,525,165NCBI
CeleraX52,894,294 - 52,903,071 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,416,492 - 46,425,389 (-)NCBIHuRef
CHM1_1X48,791,601 - 48,800,377 (-)NCBICHM1_1
T2T-CHM13v2.0X48,313,659 - 48,322,434 (-)NCBIT2T-CHM13v2.0
Slc35a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,750,189 - 7,760,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,750,267 - 7,760,731 (+)EnsemblGRCm39 Ensembl
GRCm38X7,883,921 - 7,894,492 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,884,028 - 7,894,492 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,461,370 - 7,471,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,041,203 - 7,051,364 (+)NCBIMGSCv36mm8
CeleraX3,575,406 - 3,585,656 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.56NCBI
Slc35a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543434,405 - 443,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543434,265 - 443,460 (-)NCBIChiLan1.0ChiLan1.0
SLC35A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,392,307 - 50,400,854 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,395,823 - 50,405,546 (-)NCBINHGRI_mPanPan1
PanPan1.1 EnsemblX49,058,622 - 49,067,821 (-)Ensemblpanpan1.1panPan2
SLC35A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,060,568 - 42,071,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,052,781 - 42,071,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,437,676 - 16,446,449 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,196,798 - 42,207,560 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,186,311 - 42,207,558 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,184,671 - 42,193,444 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,172,953 - 42,181,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,267,160 - 42,275,933 (-)NCBIUU_Cfam_GSD_1.0
Slc35a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,589,680 - 34,598,671 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721830,042 - 838,866 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721830,067 - 838,783 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC35A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,981,802 - 42,992,081 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,981,801 - 42,992,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,820,828 - 47,831,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC35A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,020,241 - 46,030,205 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,017,681 - 46,030,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,505,352 - 11,516,839 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc35a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893684,481 - 694,130 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893684,307 - 694,113 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc35a2
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:295
Count of miRNA genes:187
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000063952
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat

Markers in Region
RH129124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,608,605 - 14,608,806 (+)MAPPERmRatBN7.2
Rnor_6.0X15,453,645 - 15,453,845NCBIRnor6.0
Rnor_5.0X16,234,880 - 16,235,080UniSTSRnor5.0
RGSC_v3.4X26,643,155 - 26,643,355UniSTSRGSC3.4
CeleraX14,693,363 - 14,693,563UniSTS
RH 3.4 MapX142.6UniSTS
Cytogenetic MapXq13UniSTS
RH129463  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21878,340,697 - 78,340,885 (-)MAPPERmRatBN7.2
mRatBN7.2X14,607,753 - 14,607,946 (+)MAPPERmRatBN7.2
Rnor_6.0X15,452,793 - 15,452,985NCBIRnor6.0
Rnor_5.0X16,234,028 - 16,234,220UniSTSRnor5.0
RGSC_v3.4X26,642,303 - 26,642,495UniSTSRGSC3.4
CeleraX14,692,511 - 14,692,703UniSTS
RH 3.4 Map8433.8UniSTS
Cytogenetic MapXq13UniSTS
UniSTS:547084  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,609,390 - 14,610,337 (+)MAPPERmRatBN7.2
Rnor_6.0X15,454,430 - 15,455,376NCBIRnor6.0
Rnor_5.0X16,235,665 - 16,236,611UniSTSRnor5.0
CeleraX14,694,148 - 14,695,094UniSTS
Cytogenetic MapXq13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 36 24 17 24 74 32 34 11
Low 23 21 17 2 17 8 11 3 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063952   ⟹   ENSRNOP00000061970
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,608,055 - 14,616,678 (-)Ensembl
Rnor_6.0 EnsemblX15,453,186 - 15,461,713 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096381   ⟹   ENSRNOP00000079603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,608,920 - 14,616,678 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100331   ⟹   ENSRNOP00000088418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,608,588 - 14,615,891 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115934   ⟹   ENSRNOP00000077125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,608,588 - 14,616,662 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118297   ⟹   ENSRNOP00000094158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,608,588 - 14,616,662 (-)Ensembl
RefSeq Acc Id: NM_001127642   ⟹   NP_001121114
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,280,076 - 17,288,613 (-)NCBI
mRatBN7.2X14,608,149 - 14,616,686 (-)NCBI
Rnor_6.0X15,453,184 - 15,461,713 (-)NCBI
Rnor_5.0X16,234,419 - 16,243,248 (-)NCBI
RGSC_v3.4X26,642,694 - 26,651,223 (-)RGD
CeleraX14,692,902 - 14,701,423 (-)RGD
Sequence:
RefSeq Acc Id: XM_039099384   ⟹   XP_038955312
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X17,280,072 - 17,288,928 (-)NCBI
mRatBN7.2X14,608,145 - 14,616,937 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001121114   ⟸   NM_001127642
- UniProtKB: F7FFH4 (UniProtKB/TrEMBL),   A6KP68 (UniProtKB/TrEMBL),   A0A8I5Y5Y5 (UniProtKB/TrEMBL),   B2RYK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061970   ⟸   ENSRNOT00000063952
RefSeq Acc Id: XP_038955312   ⟸   XM_039099384
- Peptide Label: isoform X1
- UniProtKB: A0A8I5Y5Y5 (UniProtKB/TrEMBL),   B2RYK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088418   ⟸   ENSRNOT00000100331
RefSeq Acc Id: ENSRNOP00000079603   ⟸   ENSRNOT00000096381
RefSeq Acc Id: ENSRNOP00000094158   ⟸   ENSRNOT00000118297
RefSeq Acc Id: ENSRNOP00000077125   ⟸   ENSRNOT00000115934

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYK5-F1-model_v2 AlphaFold B2RYK5 1-392 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701741
Promoter ID:EPDNEW_R12263
Type:multiple initiation site
Name:Slc35a2_1
Description:solute carrier family 35 member A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,461,708 - 15,461,768EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2293497 AgrOrtholog
BioCyc Gene G2FUF-2927 BioCyc
Ensembl Genes ENSRNOG00000024801 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063952 ENTREZGENE
  ENSRNOT00000063952.2 UniProtKB/TrEMBL
  ENSRNOT00000096381.1 UniProtKB/TrEMBL
  ENSRNOT00000100331.1 UniProtKB/TrEMBL
  ENSRNOT00000115934.1 UniProtKB/TrEMBL
  ENSRNOT00000118297.1 UniProtKB/TrEMBL
InterPro Nuc_sug_transpt UniProtKB/TrEMBL
KEGG Report rno:100158233 UniProtKB/TrEMBL
NCBI Gene 100158233 ENTREZGENE
PANTHER Nuc_sug_transpt UniProtKB/TrEMBL
  UDP-GALACTOSE TRANSLOCATOR UniProtKB/TrEMBL
Pfam Nuc_sug_transp UniProtKB/TrEMBL
PharmGKB SLC35A2 RGD
PhenoGen Slc35a2 PhenoGen
PIRSF UDP-gal_transpt UniProtKB/TrEMBL
RatGTEx ENSRNOG00000024801 RatGTEx
Superfamily-SCOP Multidrug resistance efflux transporter EmrE UniProtKB/TrEMBL
UniProt A0A8I5Y5Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A9D7_RAT UniProtKB/TrEMBL
  A0A8I6ALI9_RAT UniProtKB/TrEMBL
  A0A8I6G5I8_RAT UniProtKB/TrEMBL
  A6KP68 ENTREZGENE, UniProtKB/TrEMBL
  B2RYK5 ENTREZGENE, UniProtKB/TrEMBL
  F7FFH4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc35a2  solute carrier family 35 member A2  Slc35a2  solute carrier family 35 (UDP-galactose transporter), member A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-30 Slc35a2  solute carrier family 35, member A2      Symbol and Name status set to provisional 70820 PROVISIONAL