Asah1 (N-acylsphingosine amidohydrolase 1) - Rat Genome Database

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Gene: Asah1 (N-acylsphingosine amidohydrolase 1) Rattus norvegicus
Analyze
Symbol: Asah1
Name: N-acylsphingosine amidohydrolase 1
RGD ID: 621568
Description: Predicted to enable N-acylsphingosine amidohydrolase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in lung development. Predicted to be located in extracellular space; lysosome; and nucleus. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1); PARTICIPATES IN ceramide signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AC; ACDase; acid CDase; acid ceramidase; acylsphingosine deacylase; Asah; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase); N-acylsphingosine amidohydrolase (acid ceramidase) 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81657,669,927 - 57,701,349 (+)NCBIGRCr8
mRatBN7.21650,966,404 - 50,997,827 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1650,966,229 - 51,008,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1656,286,045 - 56,317,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01659,685,411 - 59,716,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01654,919,980 - 54,951,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01653,998,604 - 54,030,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1653,998,560 - 54,040,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01653,712,315 - 53,743,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,279,253 - 54,311,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,279,327 - 54,311,158 (+)NCBI
Celera1648,861,616 - 48,893,051 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
ampicillin  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disopyramide  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenfluramine  (ISO)
flavonoids  (EXP)
flecainide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
metronidazole  (EXP)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
neomycin  (EXP)
nickel sulfate  (ISO)
ofloxacin  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perhexiline  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sotalol  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
Yessotoxin  (ISO)
zearalenone  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Bar J, etal., Hum Mutat 2001 Mar;17(3):199-209.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Design, synthesis and activity as acid ceramidase inhibitors of 2-oxooctanoyl and N-oleoylethanolamine analogues. Grijalvo S, etal., Chem Phys Lipids. 2006 Oct;144(1):69-84. Epub 2006 Aug 7.
5. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Li CM, etal., Genomics 2002 Feb;79(2):218-24.
6. Sphingomyelin metabolism is developmentally regulated in rat lung. Longo CA, etal., Am J Respir Cell Mol Biol. 1997 May;16(5):605-12.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7744740   PMID:9653654   PMID:10610716   PMID:10974027   PMID:11451951   PMID:12764132   PMID:12815059   PMID:15655246   PMID:17713573   PMID:19056867   PMID:22206666   PMID:22261821  
PMID:22927646   PMID:23376485   PMID:23533145   PMID:23770692   PMID:25645918  


Genomics

Comparative Map Data
Asah1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81657,669,927 - 57,701,349 (+)NCBIGRCr8
mRatBN7.21650,966,404 - 50,997,827 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1650,966,229 - 51,008,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1656,286,045 - 56,317,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01659,685,411 - 59,716,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01654,919,980 - 54,951,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01653,998,604 - 54,030,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1653,998,560 - 54,040,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01653,712,315 - 53,743,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,279,253 - 54,311,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,279,327 - 54,311,158 (+)NCBI
Celera1648,861,616 - 48,893,051 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
ASAH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38818,055,992 - 18,084,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl818,055,992 - 18,084,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37817,913,501 - 17,942,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36817,958,214 - 17,986,787 (-)NCBINCBI36Build 36hg18NCBI36
Build 34817,958,220 - 17,985,900NCBI
Celera816,879,836 - 16,908,397 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef816,458,203 - 16,486,822 (-)NCBIHuRef
CHM1_1818,115,374 - 18,143,960 (-)NCBICHM1_1
T2T-CHM13v2.0818,323,470 - 18,352,414 (-)NCBIT2T-CHM13v2.0
Asah1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,793,683 - 41,850,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,793,234 - 41,827,810 (-)EnsemblGRCm39 Ensembl
GRCm38841,340,646 - 41,397,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl841,340,197 - 41,374,773 (-)EnsemblGRCm38mm10GRCm38
MGSCv37842,425,997 - 42,460,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,839,482 - 42,873,444 (-)NCBIMGSCv36mm8
Celera843,964,022 - 43,997,069 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
Asah1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555521,623,738 - 1,659,086 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555521,623,263 - 1,660,285 (+)NCBIChiLan1.0ChiLan1.0
ASAH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2736,528,846 - 36,557,133 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1812,254,484 - 12,282,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0817,272,632 - 17,300,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1814,226,156 - 14,254,155 (-)NCBIpanpan1.1PanPan1.1panPan2
ASAH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11641,297,215 - 41,335,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1641,297,809 - 41,323,078 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1641,806,175 - 41,854,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01643,355,806 - 43,404,107 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1643,355,801 - 43,404,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11641,448,325 - 41,495,377 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01641,993,731 - 42,041,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01642,187,013 - 42,233,873 (-)NCBIUU_Cfam_GSD_1.0
Asah1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494337,949,337 - 38,005,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936554104,229 - 141,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936554104,666 - 141,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASAH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,712,058 - 5,758,821 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,712,048 - 5,749,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2176,296,192 - 6,333,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASAH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1816,151,974 - 16,181,726 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl816,151,247 - 16,181,155 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605226,094,678 - 26,124,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asah1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476921,112,851 - 21,138,831 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476921,112,705 - 21,140,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asah1
54 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:99
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000013463
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH144085  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21650,988,361 - 50,988,616 (+)MAPPERmRatBN7.2
Rnor_6.01654,020,542 - 54,020,796NCBIRnor6.0
Rnor_5.01653,734,253 - 53,734,507UniSTSRnor5.0
RGSC_v3.41654,301,620 - 54,301,874UniSTSRGSC3.4
Celera1648,883,679 - 48,883,933UniSTS
RH 3.4 Map16523.9UniSTS
Cytogenetic Map16q12.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013463   ⟹   ENSRNOP00000013463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1650,966,372 - 50,997,839 (+)Ensembl
Rnor_6.0 Ensembl1653,998,604 - 54,030,005 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077188   ⟹   ENSRNOP00000074724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1650,966,229 - 51,008,233 (+)Ensembl
Rnor_6.0 Ensembl1653,998,560 - 54,040,836 (+)Ensembl
RefSeq Acc Id: NM_053407   ⟹   NP_445859
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81657,669,927 - 57,701,349 (+)NCBI
mRatBN7.21650,966,404 - 50,997,827 (+)NCBI
Rnor_6.01653,998,604 - 54,030,006 (+)NCBI
Rnor_5.01653,712,315 - 53,743,717 (+)NCBI
RGSC_v3.41654,279,253 - 54,311,084 (+)RGD
Celera1648,861,616 - 48,893,051 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_445859 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG43956 (Get FASTA)   NCBI Sequence Viewer  
  AAH61540 (Get FASTA)   NCBI Sequence Viewer  
  EDL78835 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013463.5
  ENSRNOP00000074724.1
  ENSRNOP00055015589
  ENSRNOP00060009152
  ENSRNOP00065002934
GenBank Protein Q6P7S1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445859   ⟸   NM_053407
- Peptide Label: precursor
- UniProtKB: Q9EQJ6 (UniProtKB/Swiss-Prot),   Q6P7S1 (UniProtKB/Swiss-Prot),   A0A8L2Q768 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074724   ⟸   ENSRNOT00000077188
Ensembl Acc Id: ENSRNOP00000013463   ⟸   ENSRNOT00000013463
Protein Domains
Acid ceramidase N-terminal   Choloylglycine hydrolase/NAAA C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7S1-F1-model_v2 AlphaFold Q6P7S1 1-394 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700117
Promoter ID:EPDNEW_R10638
Type:initiation region
Name:Asah1_1
Description:N-acylsphingosine amidohydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01653,998,576 - 53,998,636EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621568 AgrOrtholog
BioCyc Gene G2FUF-11260 BioCyc
Ensembl Genes ENSRNOG00000010034 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055011396 UniProtKB/Swiss-Prot
  ENSRNOG00060007372 UniProtKB/Swiss-Prot
  ENSRNOG00065002941 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013463.5 UniProtKB/TrEMBL
  ENSRNOT00000077188.2 UniProtKB/TrEMBL
  ENSRNOT00055019344 UniProtKB/Swiss-Prot
  ENSRNOT00060012135 UniProtKB/Swiss-Prot
  ENSRNOT00065004114 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919949 IMAGE-MGC_LOAD
InterPro Acid_ceramidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acid_ceramidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBAH/NAAA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84431 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72746 IMAGE-MGC_LOAD
NCBI Gene 84431 ENTREZGENE
PANTHER ACID AMIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACID CERAMIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAAA-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asah1 PhenoGen
PIRSF Acid_ceramidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010034 RatGTEx
  ENSRNOG00055011396 RatGTEx
  ENSRNOG00060007372 RatGTEx
  ENSRNOG00065002941 RatGTEx
UniProt A0A0G2K8T0_RAT UniProtKB/TrEMBL
  A0A8L2Q768 ENTREZGENE, UniProtKB/TrEMBL
  A6JPT7_RAT UniProtKB/TrEMBL
  ASAH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9EQJ6 ENTREZGENE
UniProt Secondary Q9EQJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Asah1  N-acylsphingosine amidohydrolase 1  Asah1  N-acylsphingosine amidohydrolase (acid ceramidase) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Asah1  N-acylsphingosine amidohydrolase (acid ceramidase) 1  Asah1  N-acylsphingosine amidohydrolase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Asah1  N-acylsphingosine amidohydrolase 1  Asah  N-acylsphingosine amidohydrolase (acid ceramidase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Asah  N-acylsphingosine amidohydrolase (acid ceramidase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease deficiency of the human homolog causes Farber disease, a lipid storage disorder 634631