Gene: Asah1 (N-acylsphingosine amidohydrolase 1) Rattus norvegicus
Analyze
Symbol:
Asah1
Name:
N-acylsphingosine amidohydrolase 1
Description:
Predicted to have N-acylsphingosine amidohydrolase activity; nuclear receptor binding activity; and transcription corepressor activity. Involved in lung development and response to organic substance. Predicted to localize to the extracellular space; lysosome; and nucleus. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis and sphingolipidosis. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1); PARTICIPATES IN ceramide signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
AC; ACDase; acid CDase; acid ceramidase; acylsphingosine deacylase; Asah; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase (acid ceramidase); N-acylsphingosine amidohydrolase (acid ceramidase) 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ASAH1 (N-acylsphingosine amidohydrolase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Asah1 (N-acylsphingosine amidohydrolase 1) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Asah1 (N-acylsphingosine amidohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ASAH1 (N-acylsphingosine amidohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ASAH1 (N-acylsphingosine amidohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Asah1 (N-acylsphingosine amidohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ASAH1 (N-acylsphingosine amidohydrolase 1) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ASAH1 (N-acylsphingosine amidohydrolase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Asah1 (N-acylsphingosine amidohydrolase 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
asah1a (N-acylsphingosine amidohydrolase (acid ceramidase) 1a)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
asah1b (N-acylsphingosine amidohydrolase (acid ceramidase) 1b)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
asah-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
asah-2
Alliance
DIOPT (Ensembl Compara, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 16 53,998,604 - 54,030,006 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 16 53,712,315 - 53,743,717 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 16 54,279,253 - 54,311,084 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 16 54,279,327 - 54,311,158 (+) NCBI Celera 16 48,861,616 - 48,893,051 (+) NCBI Celera Cytogenetic Map 16 q12.1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
benign epilepsy with centrotemporal spikes ISO RGD:734135 8554872 ClinVar Annotator: match by term: Rolandic epilepsy ClinVar PMID:29358611 benign epilepsy with centrotemporal spikes ISO RGD:734135 8554872 ClinVar Annotator: match by term: Rolandic epilepsy ClinVar PMID:26467025 , PMID:29358611 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber disease ClinVar PMID:26467025 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:25741868 , PMID:26467025 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:24033266 more ... Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:26467025 , PMID:29358611 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:11241842 , PMID:25741868 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:29358611 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber disease ClinVar PMID:24033266 , PMID:24164096 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber disease ClinVar PMID:24033266 , PMID:25741868 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:25741868 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by term: Farber's lipogranulomatosis ClinVar PMID:24614645 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:10610716 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:23707712 , PMID:9128814 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:23707712 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:16951918 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:8955159 Farber lipogranulomatosis ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:228000 ClinVar PMID:11241842 Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by term: Jankovic Rivera syndrome ClinVar PMID:22703880 , PMID:25741868 Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by term: Jankovic Rivera syndrome ClinVar PMID:29358611 Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by term: Jankovic Rivera syndrome ClinVar PMID:22703880 more ... Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by term: Jankovic Rivera syndrome ClinVar PMID:25326635 , PMID:25741868 Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by term: Jankovic Rivera syndrome ClinVar Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:159950 ClinVar PMID:24164096 Jankovic Rivera Syndrome ISO RGD:734135 8554872 ClinVar Annotator: match by OMIM:159950 ClinVar PMID:22703880 Keloid ISO RGD:734135 8554872 ClinVar Annotator: match by term: Keloid formation ClinVar PMID:28905881
Imported Annotations - CTD
atrial fibrillation ISO RGD:734135 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29892015 , PMID:30061737 Experimental Liver Cirrhosis ISO RGD:734135 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25380136 lipid storage disease ISO RGD:734135 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:15342952 , PMID:16919414 Imported Annotations - OMIM
Farber lipogranulomatosis ISO RGD:734135 7240710 OMIM Jankovic Rivera Syndrome ISO RGD:734135 7240710 OMIM
1,1-dichloroethene increases expression ISO RGD:1551184 6480464 vinylidene chloride results in increased expression of ASAH1 mRNA CTD PMID:26682919 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expression ISO RGD:734135 6480464 chlorcyclizine results in increased expression of ASAH1 mRNA CTD PMID:15342952 1-naphthyl isothiocyanate increases expression EXP 6480464 1-Naphthylisothiocyanate results in increased expression of ASAH1 mRNA CTD PMID:25380136 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of ASAH1 mRNA CTD PMID:16174780 17alpha-ethynylestradiol increases expression ISO RGD:1551184 6480464 Ethinyl Estradiol results in increased expression of ASAH1 mRNA CTD PMID:17942748 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:734135 6480464 Dihydrotestosterone results in increased expression of ASAH1 mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ASAH1 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:734135 6480464 Tetrachlorodibenzodioxin results in decreased expression of ASAH1 mRNA CTD PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551184 6480464 Tetrachlorodibenzodioxin affects the expression of ASAH1 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of ASAH1 mRNA CTD PMID:21346803 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of ASAH1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression EXP 6480464 4, 4'-diaminodiphenylmethane results in increased expression of ASAH1 mRNA CTD PMID:25380136 5-fluorouracil affects response to substance ISO RGD:734135 6480464 ASAH1 protein affects the susceptibility to Fluorouracil CTD PMID:16217747 5-fluorouracil multiple interactions ISO RGD:734135 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of ASAH1 mRNA] CTD PMID:15016801 7,12-dimethyltetraphene affects expression ISO RGD:1551184 6480464 9 more ... CTD PMID:21785161 8'-apo-beta,psi-caroten-8'-al increases expression ISO RGD:734135 6480464 apocarotenal results in increased expression of ASAH1 mRNA CTD PMID:17034753 all-trans-retinoic acid increases expression ISO RGD:734135 6480464 Tretinoin results in increased expression of ASAH1 mRNA CTD PMID:21934132 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of ASAH1 mRNA CTD PMID:19224547 amiodarone increases expression ISO RGD:734135 6480464 Amiodarone results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17567588 amitriptyline increases expression ISO RGD:734135 6480464 Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952 more ... ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of ASAH1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:1551184 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of ASAH1 mRNA CTD PMID:23650126 benzo[a]pyrene increases mutagenesis ISO RGD:734135 6480464 Benzo(a)pyrene results in increased mutagenesis of ASAH1 gene CTD PMID:25435355 benzo[a]pyrene affects expression ISO RGD:1551184 6480464 Benzo(a)pyrene affects the expression of ASAH1 mRNA CTD PMID:22342234 benzo[a]pyrene increases expression ISO RGD:1551184 6480464 Benzo(a)pyrene results in increased expression of ASAH1 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I increases expression ISO RGD:734135 6480464 7 more ... CTD PMID:20382639 beta-carotene increases expression ISO RGD:734135 6480464 beta Carotene results in increased expression of ASAH1 mRNA CTD PMID:17034753 bisphenol A decreases expression ISO RGD:734135 6480464 bisphenol A results in decreased expression of ASAH1 mRNA CTD PMID:19371625 bisphenol A decreases methylation ISO RGD:734135 6480464 bisphenol A results in decreased methylation of ASAH1 gene CTD PMID:28582417 bisphenol A increases expression ISO RGD:734135 6480464 bisphenol A results in increased expression of ASAH1 mRNA CTD PMID:29275510 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of ASAH1 gene CTD PMID:28505145 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of ASAH1 mRNA CTD PMID:25181051 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of ASAH1 promoter CTD PMID:22457795 carbamazepine affects expression ISO RGD:734135 6480464 Carbamazepine affects the expression of ASAH1 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1551184 6480464 Nanotubes, Carbon results in increased expression of ASAH1 mRNA CTD PMID:25554681 carbon nanotube decreases expression ISO RGD:1551184 6480464 Nanotubes, Carbon results in decreased expression of ASAH1 mRNA CTD PMID:25620056 chlorpromazine increases expression ISO RGD:734135 6480464 Chlorpromazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 cisplatin multiple interactions ISO RGD:734135 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of ASAH1 mRNA CTD PMID:27392435 clarithromycin increases expression ISO RGD:734135 6480464 Clarithromycin results in increased expression of ASAH1 mRNA CTD PMID:15342952 clofibrate increases expression ISO RGD:1551184 6480464 Clofibrate results in increased expression of ASAH1 mRNA CTD PMID:25270620 clozapine increases expression ISO RGD:734135 6480464 Clozapine results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17175557 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of ASAH1 protein CTD PMID:24386269 copper(II) sulfate decreases expression ISO RGD:734135 6480464 Copper Sulfate results in decreased expression of ASAH1 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:734135 6480464 Cyclosporine results in decreased expression of ASAH1 mRNA CTD PMID:25562108 cyproconazole increases expression ISO RGD:1551184 6480464 cyproconazole results in increased expression of ASAH1 mRNA CTD PMID:22334560 dicrotophos decreases expression ISO RGD:734135 6480464 dicrotophos results in decreased expression of ASAH1 mRNA CTD PMID:28302478 disopyramide increases expression ISO RGD:734135 6480464 Disopyramide results in increased expression of ASAH1 mRNA CTD PMID:15342952 dorsomorphin multiple interactions ISO RGD:734135 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA CTD PMID:27188386 epoxiconazole increases expression ISO RGD:1551184 6480464 epoxiconazole results in increased expression of ASAH1 mRNA CTD PMID:22334560 erythromycin A increases expression ISO RGD:734135 6480464 Erythromycin results in increased expression of ASAH1 mRNA CTD PMID:17175557 ethanol multiple interactions EXP 6480464 [Fish Oils co-treated with Ethanol] results in increased expression of ASAH1 mRNA CTD PMID:17347304 ethanol affects splicing ISO RGD:1551184 6480464 Ethanol affects the splicing of ASAH1 mRNA CTD PMID:30319688 etoposide affects response to substance ISO RGD:734135 6480464 ASAH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 fenamidone increases expression ISO RGD:1551184 6480464 fenamidone results in increased expression of ASAH1 mRNA CTD PMID:27029645 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of ASAH1 mRNA CTD PMID:18035473 flecainide increases expression ISO RGD:734135 6480464 Flecainide results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17175557 fluoxetine increases expression ISO RGD:734135 6480464 Fluoxetine results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17567588 gamma-linolenic acid increases expression ISO RGD:734135 6480464 gamma-Linolenic Acid results in increased expression of ASAH1 mRNA CTD PMID:20664735 genistein decreases expression ISO RGD:734135 6480464 Genistein results in decreased expression of ASAH1 mRNA CTD PMID:19371625 imipramine increases expression ISO RGD:734135 6480464 Imipramine results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17567588 lead diacetate increases expression ISO RGD:1551184 6480464 lead acetate results in increased expression of ASAH1 mRNA CTD PMID:21829687 lead(0) affects expression ISO RGD:734135 6480464 Lead affects the expression of ASAH1 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:734135 6480464 Lead affects the expression of ASAH1 mRNA CTD PMID:28903495 methapyrilene increases expression EXP 6480464 Methapyrilene results in increased expression of ASAH1 mRNA CTD PMID:28935588 methapyrilene increases expression ISO RGD:734135 6480464 Methapyrilene results in increased expression of ASAH1 mRNA CTD PMID:28935588 methyl methanesulfonate increases expression ISO RGD:734135 6480464 Methyl Methanesulfonate results in increased expression of ASAH1 mRNA CTD PMID:23649840 mitomycin C affects response to substance ISO RGD:734135 6480464 ASAH1 protein affects the susceptibility to Mitomycin CTD PMID:16217747 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of ASAH1 mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression EXP 6480464 Dimethylnitrosamine results in increased expression of ASAH1 mRNA CTD PMID:25380136 nickel sulfate decreases expression ISO RGD:734135 6480464 nickel sulfate results in decreased expression of ASAH1 mRNA CTD PMID:16780908 ofloxacin increases expression ISO RGD:734135 6480464 Ofloxacin results in increased expression of ASAH1 mRNA CTD PMID:17175557 ouabain affects expression ISO RGD:734135 6480464 Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 p-toluidine increases expression EXP 6480464 4-toluidine results in increased expression of ASAH1 mRNA CTD PMID:27638505 paracetamol increases expression ISO RGD:734135 6480464 Acetaminophen results in increased expression of ASAH1 mRNA CTD PMID:22230336 perhexiline increases expression ISO RGD:734135 6480464 Perhexiline results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17175557 phenylmercury acetate increases expression ISO RGD:734135 6480464 Phenylmercuric Acetate results in increased expression of ASAH1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:734135 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA CTD PMID:27188386 propiconazole increases expression ISO RGD:1551184 6480464 propiconazole results in increased expression of ASAH1 mRNA CTD PMID:22334560 protein kinase inhibitor multiple interactions ISO RGD:734135 6480464 Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in decreased expression of ASAH1 mRNA] CTD PMID:28003376 quercetin increases expression ISO RGD:734135 6480464 Quercetin results in increased expression of ASAH1 mRNA CTD PMID:21632981 resveratrol decreases expression ISO RGD:734135 6480464 resveratrol results in decreased expression of ASAH1 mRNA CTD PMID:19371625 rotenone increases expression ISO RGD:1551184 6480464 Rotenone results in increased expression of ASAH1 mRNA CTD PMID:23186747 SB 431542 multiple interactions ISO RGD:734135 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASAH1 mRNA CTD PMID:27188386 sertraline increases expression ISO RGD:734135 6480464 Sertraline results in increased expression of ASAH1 mRNA CTD PMID:15342952 sodium arsenite affects expression ISO RGD:734135 6480464 sodium arsenite affects the expression of ASAH1 mRNA CTD PMID:20816728 sodium fluoride decreases expression ISO RGD:1551184 6480464 Sodium Fluoride results in decreased expression of ASAH1 protein CTD PMID:28918527 sotalol increases expression ISO RGD:734135 6480464 Sotalol results in increased expression of ASAH1 mRNA CTD PMID:17175557 sulindac sulfide decreases expression ISO RGD:734135 6480464 sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 tamoxifen increases expression ISO RGD:734135 6480464 Tamoxifen results in increased expression of ASAH1 mRNA CTD PMID:15342952 more ... thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of ASAH1 mRNA CTD PMID:23411599 thioridazine increases expression ISO RGD:734135 6480464 Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 titanium dioxide increases expression ISO RGD:1551184 6480464 titanium dioxide results in increased expression of ASAH1 mRNA CTD PMID:23409001 valproic acid affects expression ISO RGD:734135 6480464 Valproic Acid affects the expression of ASAH1 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:734135 6480464 Valproic Acid results in increased expression of ASAH1 mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:734135 6480464 Valproic Acid results in decreased methylation of ASAH1 gene CTD PMID:29154799 zearalenone decreases expression ISO RGD:734135 6480464 Zearalenone results in decreased expression of ASAH1 mRNA CTD PMID:19371625 zimeldine increases expression ISO RGD:734135 6480464 Zimeldine results in increased expression of ASAH1 mRNA CTD PMID:15342952 , PMID:17175557
Biological Process cellular response to tumor necrosis factor ISS UniProtKB:Q9WV54 1600115 GO_REF:0000024 UniProt GO_REF:0000024 cellular response to tumor necrosis factor ISO RGD:1551184 1624291 (MGI:MGI:6275115, PMID:10974027) RGD MGI:MGI:6275115 , PMID:10974027 cellular response to tumor necrosis factor IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 ceramide biosynthetic process IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 ceramide biosynthetic process ISO RGD:734135 1624291 (PMID:12764132), (PMID:12815059) RGD PMID:12764132 , PMID:12815059 ceramide biosynthetic process ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ceramide catabolic process IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 ceramide catabolic process ISO RGD:1551184 1624291 (MGI:MGI:1267186 more ... RGD MGI:MGI:1267186 more ... ceramide catabolic process ISO RGD:734135 1624291 (PMID:10610716), (PMID:12815059) RGD PMID:10610716 , PMID:12815059 ceramide catabolic process ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ceramide catabolic process IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 keratinocyte differentiation ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 keratinocyte differentiation ISO RGD:734135 1624291 (PMID:17713573) RGD PMID:17713573 keratinocyte differentiation IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 lung development IDA 1599262 RGD negative regulation of nucleic acid-templated transcription ISO RGD:734135 1624291 (PMID:22927646) RGD PMID:22927646 regulation of programmed necrotic cell death ISS UniProtKB:Q9WV54 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of programmed necrotic cell death ISO RGD:1551184 1624291 (MGI:MGI:6275115, PMID:10974027) RGD MGI:MGI:6275115 , PMID:10974027 regulation of programmed necrotic cell death IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of steroid biosynthetic process ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 regulation of steroid biosynthetic process ISO RGD:734135 1624291 (PMID:22261821), (PMID:22927646) RGD PMID:22261821 , PMID:22927646 regulation of steroid biosynthetic process IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to organic substance IDA 1599260 RGD sphingosine biosynthetic process ISO RGD:1551184 1624291 (MGI:MGI:1267186, PMID:9653654) RGD MGI:MGI:1267186 , PMID:9653654 sphingosine biosynthetic process ISO RGD:734135 1624291 (PMID:10610716), (PMID:12815059) RGD PMID:10610716 , PMID:12815059 sphingosine biosynthetic process ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 sphingosine biosynthetic process IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 sphingosine biosynthetic process IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cellular_component ND 1598407 01/2007: no relevant rat data RGD early endosome NOT ISO RGD:734135 1624291 (PMID:12764132) RGD PMID:12764132 endoplasmic reticulum NOT ISO RGD:734135 1624291 (PMID:12764132) RGD PMID:12764132 extracellular space IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space ISO RGD:734135 1624291 (PMID:11451951), (PMID:25645918), (PMID:7744740) RGD PMID:11451951 more ... extracellular space ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lysosome IEA UniProtKB-SubCell:SL-0158 1600115 GO_REF:0000040 UniProt GO_REF:0000040 lysosome ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 lysosome ISO RGD:734135 1624291 (PMID:12764132) RGD PMID:12764132 nucleus IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:1551184 1624291 (MGI:MGI:5444795, PMID:22927646) RGD MGI:MGI:5444795 , PMID:22927646 nucleus ISO RGD:734135 1624291 (PMID:22927646) RGD PMID:22927646 Molecular Function ceramidase activity IEA EC:3.5.1.23 1600115 GO_REF:0000003 UniProt GO_REF:0000003 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IBA PANTHER:PTN002005634 , UniProtKB:Q02083 13792537 PMID:21873635 GO_Central hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO RGD:734135 1624291 (PMID:15655246) RGD PMID:15655246 molecular_function ND 1598407 01/2007: no relevant rat data RGD N-acylsphingosine amidohydrolase activity ISO RGD:1551184 1624291 (MGI:MGI:1267186, PMID:9653654) RGD MGI:MGI:1267186 , PMID:9653654 N-acylsphingosine amidohydrolase activity ISO RGD:734135 1624291 (PMID:10610716), (PMID:11451951), (PMID:12764132), (PMID:12815059), (PMID:7744740) RGD PMID:10610716 more ... N-acylsphingosine amidohydrolase activity ISS UniProtKB:Q13510 1600115 GO_REF:0000024 UniProt GO_REF:0000024 N-acylsphingosine amidohydrolase activity IEA UniProtKB:Q13510 , ensembl:ENSP000003711521600115 GO_REF:0000107 Ensembl GO_REF:0000107 N-acylsphingosine amidohydrolase activity IBA MGI:MGI:1277124 more ... 13792537 PMID:21873635 GO_Central N-acylsphingosine amidohydrolase activity IEA UniProtKB:Q9WV54 , ensembl:ENSMUSP000000340001600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear receptor binding ISO RGD:734135 1624291 UniProtKB:Q13285 (PMID:22927646) RGD PMID:22927646 transcription corepressor activity ISO RGD:734135 1624291 (PMID:22927646) RGD PMID:22927646
Gene-Chemical Interaction Annotations
