Asah1 (N-acylsphingosine amidohydrolase 1) - Rat Genome Database

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Gene: Asah1 (N-acylsphingosine amidohydrolase 1) Mus musculus
Analyze
Symbol: Asah1
Name: N-acylsphingosine amidohydrolase 1
RGD ID: 1551184
MGI Page MGI
Description: Enables N-acylsphingosine amidohydrolase activity. Involved in cellular response to tumor necrosis factor; regulation of programmed necrotic cell death; and sphingolipid metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study Farber lipogranulomatosis. Human ortholog(s) of this gene implicated in Farber lipogranulomatosis; sphingolipidosis; and spinal muscular atrophy with progressive myoclonic epilepsy. Orthologous to human ASAH1 (N-acylsphingosine amidohydrolase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 2310081N20Rik; AC; ACDase; acid CDase; acid ceramidase; acylsphingosine deacylase; AL022942; Asah; AU044555; N-acylethanolamine hydrolase ASAH1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,793,683 - 41,850,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,793,234 - 41,827,810 (-)EnsemblGRCm39 Ensembl
GRCm38841,340,646 - 41,397,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl841,340,197 - 41,374,773 (-)EnsemblGRCm38mm10GRCm38
MGSCv37842,425,997 - 42,460,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,839,482 - 42,873,444 (-)NCBIMGSCv36mm8
Celera843,964,022 - 43,997,069 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
cyproconazole  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disopyramide  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (EXP)
erythromycin A  (ISO)
ethanol  (EXP,ISO)
etoposide  (ISO)
fenamidone  (EXP)
fenfluramine  (ISO)
flavonoids  (ISO)
flecainide  (ISO)
fluoxetine  (ISO)
folic acid  (EXP)
gamma-linolenic acid  (ISO)
genistein  (ISO)
gentamycin  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
imipramine  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
metronidazole  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
neomycin  (ISO)
nickel sulfate  (ISO)
ofloxacin  (ISO)
ouabain  (ISO)
ozone  (EXP,ISO)
p-toluidine  (ISO)
paracetamol  (ISO)
perhexiline  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sertraline  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
sotalol  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (ISO)
thioridazine  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
Yessotoxin  (ISO)
zearalenone  (ISO)
zimeldine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
early endosome  (ISO)
endoplasmic reticulum  (ISO)
extracellular space  (ISO,ISS)
lysosome  (ISO,ISS)
membrane  (IEA)
nucleus  (IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ceramide level  (IAGP)
abnormal chemokine secretion  (IAGP)
abnormal circulating chemokine level  (IAGP)
abnormal circulating cytokine level  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal endochondral bone ossification  (IAGP)
abnormal enzyme/coenzyme activity  (IAGP)
abnormal gait  (IAGP)
abnormal knee joint morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymph node morphology  (IAGP)
abnormal lysosome morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pulmonary alveolus morphology  (IAGP)
abnormal sphingomyelin level  (IAGP)
abnormal thymus morphology  (IAGP)
astrocytosis  (IAGP)
cachexia  (IAGP)
centrally nucleated skeletal muscle fibers  (IAGP)
decreased B cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased long bone epiphyseal plate size  (IAGP)
decreased lymphocyte cell number  (IAGP)
decreased mean corpuscular hemoglobin  (IAGP)
decreased mean corpuscular volume  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
dilated brain ventricle  (IAGP)
dystrophic muscle  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged thymus  (IAGP)
hepatic necrosis  (IAGP)
hydrocephaly  (IAGP)
increased blood urea nitrogen level  (IAGP)
increased ceramide level  (IAGP)
increased circulating alanine transaminase level  (IAGP)
increased circulating aspartate transaminase level  (IAGP)
increased circulating creatine kinase level  (IAGP)
increased circulating CXCL10 level  (IAGP)
increased circulating interleukin-12b level  (IAGP)
increased circulating lactate dehydrogenase level  (IAGP)
increased eosinophil cell number  (IAGP)
increased erythrocyte cell number  (IAGP)
increased granulocyte number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased hemoglobin content  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased macrophage derived foam cell number  (IAGP)
increased monocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased sphingosine level  (IAGP)
increased spleen weight  (IAGP)
lethargy  (IAGP)
limb grasping  (IAGP)
liver fibrosis  (IAGP)
lung inflammation  (IAGP)
pale liver  (IAGP)
pale spleen  (IAGP)
penis prolapse  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
pulmonary alveolar edema  (IAGP)
scoliosis  (IAGP)
skeletal muscle fiber atrophy  (IAGP)
small ovary  (IAGP)
weight loss  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Molecular analysis of acid ceramidase deficiency in patients with Farber disease. Bar J, etal., Hum Mutat 2001 Mar;17(3):199-209.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Insertional mutagenesis of the mouse acid ceramidase gene leads to early embryonic lethality in homozygotes and progressive lipid storage disease in heterozygotes. Li CM, etal., Genomics 2002 Feb;79(2):218-24.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. MGD IEA MGD IEA
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. Mouse MP Annotation Import Pipeline RGD automated import pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:9653654   PMID:10349636   PMID:10610717   PMID:10922068   PMID:10974027   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12815059   PMID:12904583  
PMID:14610273   PMID:14681479   PMID:15489334   PMID:16026583   PMID:16141072   PMID:16141073   PMID:16500425   PMID:16602821   PMID:17264167   PMID:17881906   PMID:18195024   PMID:18799693  
PMID:20211931   PMID:21267068   PMID:21335555   PMID:21487040   PMID:21873635   PMID:22854249   PMID:22927646   PMID:23096701   PMID:23681708   PMID:23770692   PMID:25682603   PMID:26190650  
PMID:27915031   PMID:28342444   PMID:28552668   PMID:29044125   PMID:29167126   PMID:29259036   PMID:29379059   PMID:29908121   PMID:30077007   PMID:30472209   PMID:31647995   PMID:31835809  
PMID:32015399   PMID:32165633   PMID:32194052   PMID:32325033   PMID:32817366   PMID:33139382   PMID:33221496   PMID:34321999   PMID:36094170   PMID:36302466   PMID:36426850   PMID:36638912  
PMID:37231125   PMID:38919612  


Genomics

Comparative Map Data
Asah1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39841,793,683 - 41,850,681 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl841,793,234 - 41,827,810 (-)EnsemblGRCm39 Ensembl
GRCm38841,340,646 - 41,397,644 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl841,340,197 - 41,374,773 (-)EnsemblGRCm38mm10GRCm38
MGSCv37842,425,997 - 42,460,051 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36842,839,482 - 42,873,444 (-)NCBIMGSCv36mm8
Celera843,964,022 - 43,997,069 (-)NCBICelera
Cytogenetic Map8A4NCBI
cM Map823.89NCBI
ASAH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38818,055,992 - 18,084,961 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl818,055,992 - 18,084,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37817,913,501 - 17,942,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36817,958,214 - 17,986,787 (-)NCBINCBI36Build 36hg18NCBI36
Build 34817,958,220 - 17,985,900NCBI
Celera816,879,836 - 16,908,397 (-)NCBICelera
Cytogenetic Map8p22NCBI
HuRef816,458,203 - 16,486,822 (-)NCBIHuRef
CHM1_1818,115,374 - 18,143,960 (-)NCBICHM1_1
T2T-CHM13v2.0818,323,470 - 18,352,414 (-)NCBIT2T-CHM13v2.0
Asah1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81657,669,927 - 57,701,349 (+)NCBIGRCr8
mRatBN7.21650,966,404 - 50,997,827 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1650,966,229 - 51,008,233 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1656,286,045 - 56,317,559 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01659,685,411 - 59,716,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01654,919,980 - 54,951,496 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01653,998,604 - 54,030,006 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1653,998,560 - 54,040,836 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01653,712,315 - 53,743,717 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41654,279,253 - 54,311,084 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11654,279,327 - 54,311,158 (+)NCBI
Celera1648,861,616 - 48,893,051 (+)NCBICelera
Cytogenetic Map16q12.1NCBI
Asah1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555521,623,738 - 1,659,086 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555521,623,263 - 1,660,285 (+)NCBIChiLan1.0ChiLan1.0
ASAH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2736,528,846 - 36,557,133 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1812,254,484 - 12,282,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0817,272,632 - 17,300,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1814,226,156 - 14,254,155 (-)NCBIpanpan1.1PanPan1.1panPan2
ASAH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11641,297,215 - 41,335,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1641,297,809 - 41,323,078 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1641,806,175 - 41,854,360 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01643,355,806 - 43,404,107 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1643,355,801 - 43,404,134 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11641,448,325 - 41,495,377 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01641,993,731 - 42,041,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01642,187,013 - 42,233,873 (-)NCBIUU_Cfam_GSD_1.0
Asah1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494337,949,337 - 38,005,322 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936554104,229 - 141,512 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936554104,666 - 141,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASAH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl175,712,058 - 5,758,821 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1175,712,048 - 5,749,811 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2176,296,192 - 6,333,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASAH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1816,151,974 - 16,181,726 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl816,151,247 - 16,181,155 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605226,094,678 - 26,124,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asah1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476921,112,851 - 21,138,831 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476921,112,705 - 21,140,004 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asah1
4986 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:727
Count of miRNA genes:452
Interacting mature miRNAs:533
Transcripts:ENSMUST00000034000, ENSMUST00000110417, ENSMUST00000126561, ENSMUST00000131796, ENSMUST00000143057
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301139Lmr10_mleishmaniasis resistance 10 (mouse)Not determined83532109757797633Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
11049577Lmr10b_mleishmaniasis resistance 10b (mouse)83532109757797633Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3250657271740637Mouse
11049578Lmr10c_mleishmaniasis resistance 10c (mouse)83532109757797633Mouse
11041902Lmr10a_mleishmaniasis resistance 10a (mouse)83532109757797633Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83663015493455280Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3250657271740637Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
10043990Hbnr12_mHeligmosomoides bakeri nematode resistance 12 (mouse)Not determined83327701651290537Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3250657271740637Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837867154110326632Mouse
10043974Obq30_mobesity QTL 30 (mouse)Not determined82658332260583322Mouse
1301196Mnif1_mmacronutrient intake (mouse)Not determined83510993045305872Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
13524525Bodwtq7_mbody wweight QTL 7 (mouse)82824955647027681Mouse
1301936Trigq2_mtriglyceride QTL 2 (mouse)Not determined83429039768290537Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83250657271740637Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)84016229795416226Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse

Markers in Region
AU044555  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38841,340,697 - 41,340,804UniSTSGRCm38
MGSCv37842,426,051 - 42,426,158UniSTSGRCm37
Celera843,964,076 - 43,964,183UniSTS
Cytogenetic Map8A4UniSTS
Whitehead/MRC_RH8493.92UniSTS
RH125381  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38841,341,062 - 41,341,353UniSTSGRCm38
MGSCv37842,426,416 - 42,426,707UniSTSGRCm37
Celera843,964,458 - 43,964,749UniSTS
Cytogenetic Map8A4UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017312536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030243253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC144926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF157500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF352179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK034204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW124297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY028080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY160973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000034000   ⟹   ENSMUSP00000034000
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,793,234 - 41,827,810 (-)Ensembl
GRCm38.p6 Ensembl841,340,197 - 41,374,773 (-)Ensembl
Ensembl Acc Id: ENSMUST00000110417   ⟹   ENSMUSP00000106047
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,799,217 - 41,827,672 (-)Ensembl
GRCm38.p6 Ensembl841,346,180 - 41,374,635 (-)Ensembl
Ensembl Acc Id: ENSMUST00000126561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,793,698 - 41,803,074 (-)Ensembl
GRCm38.p6 Ensembl841,340,661 - 41,350,037 (-)Ensembl
Ensembl Acc Id: ENSMUST00000131796
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,794,347 - 41,796,893 (-)Ensembl
GRCm38.p6 Ensembl841,341,310 - 41,343,856 (-)Ensembl
Ensembl Acc Id: ENSMUST00000143057   ⟹   ENSMUSP00000117362
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl841,807,064 - 41,827,810 (-)Ensembl
GRCm38.p6 Ensembl841,354,027 - 41,374,773 (-)Ensembl
RefSeq Acc Id: NM_019734   ⟹   NP_062708
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,827,734 (-)NCBI
GRCm38841,340,646 - 41,374,697 (-)NCBI
MGSCv37842,425,997 - 42,460,051 (-)RGD
Celera843,964,022 - 43,997,069 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017312527   ⟹   XP_017168016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312528   ⟹   XP_017168017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312530   ⟹   XP_017168019
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312531   ⟹   XP_017168020
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312532   ⟹   XP_017168021
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312533   ⟹   XP_017168022
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312534   ⟹   XP_017168023
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312535   ⟹   XP_017168024
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017312536   ⟹   XP_017168025
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030243253   ⟹   XP_030099113
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
GRCm38841,340,646 - 41,397,644 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153730   ⟹   XP_036009623
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39841,793,683 - 41,850,681 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062708 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168016 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168017 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168019 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168020 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168021 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168022 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168023 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168024 (Get FASTA)   NCBI Sequence Viewer  
  XP_017168025 (Get FASTA)   NCBI Sequence Viewer  
  XP_030099113 (Get FASTA)   NCBI Sequence Viewer  
  XP_036009623 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD39551 (Get FASTA)   NCBI Sequence Viewer  
  AAH03204 (Get FASTA)   NCBI Sequence Viewer  
  AAK21979 (Get FASTA)   NCBI Sequence Viewer  
  AAK39512 (Get FASTA)   NCBI Sequence Viewer  
  BAC35884 (Get FASTA)   NCBI Sequence Viewer  
  BAC36053 (Get FASTA)   NCBI Sequence Viewer  
  BAC36980 (Get FASTA)   NCBI Sequence Viewer  
  BAC41166 (Get FASTA)   NCBI Sequence Viewer  
  BAE30433 (Get FASTA)   NCBI Sequence Viewer  
  BAE31111 (Get FASTA)   NCBI Sequence Viewer  
  BAE31879 (Get FASTA)   NCBI Sequence Viewer  
  BAE35181 (Get FASTA)   NCBI Sequence Viewer  
  BAE38998 (Get FASTA)   NCBI Sequence Viewer  
  EDL35519 (Get FASTA)   NCBI Sequence Viewer  
  EDL35520 (Get FASTA)   NCBI Sequence Viewer  
  EDL35521 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000034000
  ENSMUSP00000034000.9
  ENSMUSP00000106047.3
  ENSMUSP00000117362.2
GenBank Protein Q9WV54 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062708   ⟸   NM_019734
- Peptide Label: preproprotein
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168023   ⟸   XM_017312534
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168022   ⟸   XM_017312533
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168024   ⟸   XM_017312535
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168025   ⟸   XM_017312536
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017168021   ⟸   XM_017312532
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168019   ⟸   XM_017312530
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168017   ⟸   XM_017312528
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168016   ⟸   XM_017312527
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017168020   ⟸   XM_017312531
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL),   Q78P93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099113   ⟸   XM_030243253
- Peptide Label: isoform X1
- UniProtKB: Q9WV54 (UniProtKB/Swiss-Prot),   Q78P93 (UniProtKB/TrEMBL),   Q3TWT5 (UniProtKB/TrEMBL),   Q3U646 (UniProtKB/TrEMBL),   Q3U8A7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000106047   ⟸   ENSMUST00000110417
Ensembl Acc Id: ENSMUSP00000117362   ⟸   ENSMUST00000143057
Ensembl Acc Id: ENSMUSP00000034000   ⟸   ENSMUST00000034000
RefSeq Acc Id: XP_036009623   ⟸   XM_036153730
- Peptide Label: isoform X2
Protein Domains
Acid ceramidase N-terminal   Choloylglycine hydrolase/NAAA C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WV54-F1-model_v2 AlphaFold Q9WV54 1-394 view protein structure

Promoters
RGD ID:8666965
Promoter ID:EPDNEW_M11513
Type:initiation region
Name:Asah1_1
Description:Mus musculus N-acylsphingosine amidohydrolase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38841,374,618 - 41,374,678EPDNEW
RGD ID:6842794
Promoter ID:MM_KWN:54259
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000110417,   OTTMUST00000054076,   OTTMUST00000054077,   UC009LNV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36842,459,861 - 42,460,361 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277124 AgrOrtholog
Ensembl Genes ENSMUSG00000031591 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034000 ENTREZGENE
  ENSMUST00000034000.15 UniProtKB/Swiss-Prot
  ENSMUST00000110417.8 UniProtKB/TrEMBL
  ENSMUST00000143057.2 UniProtKB/TrEMBL
Gene3D-CATH Penicillin V Acylase, Chain A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Acid_ceramidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acid_ceramidase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBAH/NAAA_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11886 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1277124 ENTREZGENE
NCBI Gene 11886 ENTREZGENE
PANTHER ACID AMIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACID CERAMIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBAH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAAA-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asah1 PhenoGen
PIRSF Acid_ceramidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ASAH1_MOUSE UniProtKB/Swiss-Prot
  D3Z015_MOUSE UniProtKB/TrEMBL
  D3Z505_MOUSE UniProtKB/TrEMBL
  Q3TWT5 ENTREZGENE, UniProtKB/TrEMBL
  Q3U646 ENTREZGENE, UniProtKB/TrEMBL
  Q3U8A7 ENTREZGENE, UniProtKB/TrEMBL
  Q78P93 ENTREZGENE, UniProtKB/TrEMBL
  Q9WV54 ENTREZGENE