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Gene: Msh6 (mutS homolog 6) Rattus norvegicus
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Symbol: Msh6
Name: mutS homolog 6
RGD ID: 2322311
Description: Predicted to contribute to several functions, including DNA binding activity; MutLalpha complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including DNA metabolic process; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic hypermutation of immunoglobulin genes. Predicted to localize to Golgi apparatus; cytosol; and nucleus. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 5. Orthologous to human MSH6 (mutS homolog 6); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH amphetamine; N-ethyl-N-nitrosourea; sodium arsenite.
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA mismatch repair protein Msh6; LOC100360342; mutS homolog 6 (E. coli); rCG61559-like
Orthologs:
Homo sapiens (human) : MSH6 (mutS homolog 6)  HGNC  Alliance
Mus musculus (house mouse) : Msh6 (mutS homolog 6)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msh6 (mutS homolog 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MSH6 (mutS homolog 6)
Canis lupus familiaris (dog) : MSH6 (mutS homolog 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msh6 (mutS homolog 6)
Sus scrofa (pig) : MSH6 (mutS homolog 6)
Chlorocebus sabaeus (African green monkey) : MSH6 (mutS homolog 6)
Heterocephalus glaber (naked mole-rat) : Msh6 (mutS homolog 6)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0611,644,565 - 11,662,389 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl611,644,578 - 11,662,499 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0621,616,672 - 21,634,338 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4611,525,292 - 11,542,592 (+)NCBIRGSC3.4rn4RGSC3.4
Celera66,326,162 - 6,343,370 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)