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Gene: Actn1 (actinin, alpha 1) Rattus norvegicus
Symbol: Actn1
Name: actinin, alpha 1
RGD ID: 70907
Description: Exhibits cytoskeletal regulatory protein binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; focal adhesion assembly; and platelet formation. Localizes to several cellular components, including cytoskeleton; dendritic spine; and nucleus. Colocalizes with cortical actin cytoskeleton and stress fiber. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 15. Orthologous to human ACTN1 (actinin alpha 1); PARTICIPATES IN E-cadherin signaling pathway; syndecan signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (R)-adrenaline; 1-naphthyl isothiocyanate; 2,6-dinitrotoluene.
Type: protein-coding
Also known as: alpha-actinin cytoskeletal isoform; alpha-actinin-1; F-actin cross-linking protein; non-muscle alpha-actinin 1; non-muscle alpha-actinin-1
Homo sapiens (human) : ACTN1 (actinin alpha 1)  HGNC  Alliance
Mus musculus (house mouse) : Actn1 (actinin, alpha 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn1 (actinin alpha 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN1 (actinin alpha 1)
Canis lupus familiaris (dog) : ACTN1 (actinin alpha 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn1 (actinin alpha 1)
Sus scrofa (pig) : ACTN1 (actinin alpha 1)
Chlorocebus sabaeus (African green monkey) : ACTN1 (actinin alpha 1)
Heterocephalus glaber (naked mole-rat) : Actn1 (actinin alpha 1)
more info ...
Allele / Splice: Actn1_v3   Actn1_v2   Actn1_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16103,192,048 - 103,286,329NCBI
Celera697,355,796 - 97,450,012 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Actn1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70907
Created: 2002-07-09
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.