NTN5 (netrin 5) - Rat Genome Database

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Gene: NTN5 (netrin 5) Homo sapiens
Analyze
Symbol: NTN5
Name: netrin 5
RGD ID: 1606977
HGNC Page HGNC:25208
Description: Predicted to be involved in neurogenesis. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: netrin-1-like protein; netrin-5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,661,407 - 48,673,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,661,407 - 48,673,081 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,164,664 - 49,176,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,856,476 - 53,868,076 (-)NCBINCBI36Build 36hg18NCBI36
Celera1946,029,521 - 46,042,362 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,544,064 - 45,555,139 (-)NCBIHuRef
CHM1_11949,166,555 - 49,177,886 (-)NCBICHM1_1
T2T-CHM13v2.01951,655,875 - 51,667,423 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21873635   PMID:21926972   PMID:26858598   PMID:33961781  


Genomics

Comparative Map Data
NTN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,661,407 - 48,673,017 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,661,407 - 48,673,081 (-)EnsemblGRCh38hg38GRCh38
GRCh371949,164,664 - 49,176,274 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361953,856,476 - 53,868,076 (-)NCBINCBI36Build 36hg18NCBI36
Celera1946,029,521 - 46,042,362 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,544,064 - 45,555,139 (-)NCBIHuRef
CHM1_11949,166,555 - 49,177,886 (-)NCBICHM1_1
T2T-CHM13v2.01951,655,875 - 51,667,423 (-)NCBIT2T-CHM13v2.0
Ntn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,333,519 - 45,343,980 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,333,446 - 45,343,980 (+)EnsemblGRCm39 Ensembl
GRCm38745,684,022 - 45,694,556 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,684,022 - 45,694,556 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,939,784 - 52,949,924 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,552,456 - 45,562,596 (+)NCBIMGSCv36mm8
Celera741,146,895 - 41,157,130 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.43NCBI
Ntn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,293,408 - 105,302,163 (+)NCBIGRCr8
mRatBN7.2196,156,948 - 96,165,997 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,156,985 - 96,165,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,542,413 - 101,550,924 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,015,111 - 110,023,622 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,305,490 - 103,314,001 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,668,354 - 101,678,117 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,669,086 - 101,677,596 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,746,540 - 102,756,952 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,154,919 - 96,163,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera190,410,184 - 90,418,695 (+)NCBICelera
Cytogenetic Map1q22NCBI
Ntn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,892,982 - 1,901,759 (+)NCBIChiLan1.0ChiLan1.0
NTN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,766,415 - 54,777,583 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,692,752 - 56,703,813 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,662,734 - 45,678,300 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,255,122 - 54,258,753 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,255,392 - 54,263,552 (-)Ensemblpanpan1.1panPan2
NTN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,651,495 - 107,653,904 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,647,674 - 107,655,020 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1107,169,268 - 107,176,769 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01108,175,428 - 108,178,402 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11107,838,241 - 107,845,744 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,485,538 - 107,493,041 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,324,848 - 108,327,822 (+)NCBIUU_Cfam_GSD_1.0
Ntn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,077,178 - 21,089,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,697,616 - 2,703,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,697,359 - 2,706,962 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,006,665 - 54,017,166 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,006,662 - 54,019,282 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,753,999 - 49,766,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NTN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1641,910,275 - 41,917,958 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607321,781,347 - 21,791,504 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ntn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,219,259 - 5,225,653 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,217,001 - 5,225,930 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NTN5
56 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.32-13.33(chr19:46658791-49050450)x3 copy number gain See cases [RCV000052913] Chr19:46658791..49050450 [GRCh38]
Chr19:47162048..49553707 [GRCh37]
Chr19:51853888..54245519 [NCBI36]
Chr19:19q13.32-13.33
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43
pathogenic
GRCh38/hg38 19q13.33(chr19:48577651-48839042)x3 copy number gain See cases [RCV000135686] Chr19:48577651..48839042 [GRCh38]
Chr19:49080908..49342299 [GRCh37]
Chr19:53772720..54034111 [NCBI36]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.595C>T (p.Arg199Trp) single nucleotide variant Inborn genetic diseases [RCV003269564] Chr19:48670392 [GRCh38]
Chr19:49173649 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1055C>T (p.Ser352Leu) single nucleotide variant Inborn genetic diseases [RCV003240347] Chr19:48663513 [GRCh38]
Chr19:49166770 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1081C>T (p.Arg361Trp) single nucleotide variant Inborn genetic diseases [RCV003297840] Chr19:48663487 [GRCh38]
Chr19:49166744 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.947G>A (p.Arg316His) single nucleotide variant Inborn genetic diseases [RCV003297704] Chr19:48664166 [GRCh38]
Chr19:49167423 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic|uncertain significance
NM_145807.4(NTN5):c.904G>A (p.Gly302Ser) single nucleotide variant Inborn genetic diseases [RCV003299512] Chr19:48664209 [GRCh38]
Chr19:49167466 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q13.33(chr19:49169554-49388064)x3 copy number gain not provided [RCV000684074] Chr19:49169554..49388064 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43
pathogenic
NM_145807.4(NTN5):c.820+50C>T single nucleotide variant not provided [RCV001679955] Chr19:48664529 [GRCh38]
Chr19:49167786 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.820+57G>A single nucleotide variant not provided [RCV001534267] Chr19:48664522 [GRCh38]
Chr19:49167779 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q11-13.33(chr19:28271106-49213832)x3 copy number gain not provided [RCV000845733] Chr19:28271106..49213832 [GRCh37]
Chr19:19q11-13.33
pathogenic
GRCh37/hg19 19q13.33(chr19:48119589-49595956)x3 copy number gain not provided [RCV000848800] Chr19:48119589..49595956 [GRCh37]
Chr19:19q13.33
uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42
pathogenic
NM_145807.4(NTN5):c.632-206G>A single nucleotide variant not provided [RCV001609197] Chr19:48664973 [GRCh38]
Chr19:49168230 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.651C>T (p.His217=) single nucleotide variant not provided [RCV001656563] Chr19:48664748 [GRCh38]
Chr19:49168005 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.573G>A (p.Pro191=) single nucleotide variant not provided [RCV001641073] Chr19:48670414 [GRCh38]
Chr19:49173671 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.820+58G>T single nucleotide variant not provided [RCV001685769] Chr19:48664521 [GRCh38]
Chr19:49167778 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.1025-75C>T single nucleotide variant not provided [RCV001617711] Chr19:48663618 [GRCh38]
Chr19:49166875 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.632-158A>G single nucleotide variant not provided [RCV001707322] Chr19:48664925 [GRCh38]
Chr19:49168182 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.*194A>G single nucleotide variant not provided [RCV001667953] Chr19:48661483 [GRCh38]
Chr19:49164740 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.971-62G>T single nucleotide variant not provided [RCV001679019] Chr19:48663876 [GRCh38]
Chr19:49167133 [GRCh37]
Chr19:19q13.33
benign
NM_145807.4(NTN5):c.970+39C>T single nucleotide variant not provided [RCV001684986] Chr19:48664104 [GRCh38]
Chr19:49167361 [GRCh37]
Chr19:19q13.33
benign
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42
not provided
GRCh37/hg19 19q13.33(chr19:48854319-49430535)x3 copy number gain not provided [RCV001259943] Chr19:48854319..49430535 [GRCh37]
Chr19:19q13.33
likely pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43
pathogenic
NC_000019.9:g.(?_48618906)_(50921204_?)dup duplication Developmental and epileptic encephalopathy, 12 [RCV001939968]|not provided [RCV001916178] Chr19:48618906..50921204 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.425T>C (p.Phe142Ser) single nucleotide variant Inborn genetic diseases [RCV002685137] Chr19:48670562 [GRCh38]
Chr19:49173819 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.514C>A (p.Pro172Thr) single nucleotide variant Inborn genetic diseases [RCV002993423] Chr19:48670473 [GRCh38]
Chr19:49173730 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.611G>A (p.Arg204Gln) single nucleotide variant Inborn genetic diseases [RCV002973264] Chr19:48670376 [GRCh38]
Chr19:49173633 [GRCh37]
Chr19:19q13.33
likely benign
NM_145807.4(NTN5):c.1132G>A (p.Glu378Lys) single nucleotide variant Inborn genetic diseases [RCV002684475] Chr19:48662015 [GRCh38]
Chr19:49165272 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1012G>A (p.Ala338Thr) single nucleotide variant Inborn genetic diseases [RCV002772568] Chr19:48663773 [GRCh38]
Chr19:49167030 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.520C>T (p.Arg174Cys) single nucleotide variant Inborn genetic diseases [RCV002970429] Chr19:48670467 [GRCh38]
Chr19:49173724 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1418G>A (p.Gly473Glu) single nucleotide variant Inborn genetic diseases [RCV002973917] Chr19:48661729 [GRCh38]
Chr19:49164986 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.947G>T (p.Arg316Leu) single nucleotide variant Inborn genetic diseases [RCV002906433] Chr19:48664166 [GRCh38]
Chr19:49167423 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.919C>T (p.Arg307Cys) single nucleotide variant Inborn genetic diseases [RCV002973427] Chr19:48664194 [GRCh38]
Chr19:49167451 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.404C>A (p.Ala135Asp) single nucleotide variant Inborn genetic diseases [RCV002849335] Chr19:48670583 [GRCh38]
Chr19:49173840 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1405G>A (p.Glu469Lys) single nucleotide variant Inborn genetic diseases [RCV002978159] Chr19:48661742 [GRCh38]
Chr19:49164999 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.159C>A (p.Asn53Lys) single nucleotide variant Inborn genetic diseases [RCV002951589] Chr19:48670828 [GRCh38]
Chr19:49174085 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.487G>A (p.Ala163Thr) single nucleotide variant Inborn genetic diseases [RCV002693000] Chr19:48670500 [GRCh38]
Chr19:49173757 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.867G>C (p.Gln289His) single nucleotide variant Inborn genetic diseases [RCV003000605] Chr19:48664246 [GRCh38]
Chr19:49167503 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.958A>C (p.Met320Leu) single nucleotide variant Inborn genetic diseases [RCV002798398] Chr19:48664155 [GRCh38]
Chr19:49167412 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.656G>A (p.Arg219Gln) single nucleotide variant Inborn genetic diseases [RCV002955956] Chr19:48664743 [GRCh38]
Chr19:49168000 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.115G>C (p.Val39Leu) single nucleotide variant Inborn genetic diseases [RCV002985160] Chr19:48670872 [GRCh38]
Chr19:49174129 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1204G>A (p.Val402Met) single nucleotide variant Inborn genetic diseases [RCV002965901] Chr19:48661943 [GRCh38]
Chr19:49165200 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1271A>G (p.Gln424Arg) single nucleotide variant Inborn genetic diseases [RCV002674031] Chr19:48661876 [GRCh38]
Chr19:49165133 [GRCh37]
Chr19:19q13.33
likely benign
NM_145807.4(NTN5):c.682T>C (p.Phe228Leu) single nucleotide variant Inborn genetic diseases [RCV002809343] Chr19:48664717 [GRCh38]
Chr19:49167974 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.536A>C (p.His179Pro) single nucleotide variant Inborn genetic diseases [RCV002702638] Chr19:48670451 [GRCh38]
Chr19:49173708 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1312G>A (p.Asp438Asn) single nucleotide variant Inborn genetic diseases [RCV002936535] Chr19:48661835 [GRCh38]
Chr19:49165092 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.659G>A (p.Arg220His) single nucleotide variant Inborn genetic diseases [RCV002940269] Chr19:48664740 [GRCh38]
Chr19:49167997 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.663C>G (p.Cys221Trp) single nucleotide variant Inborn genetic diseases [RCV002964443] Chr19:48664736 [GRCh38]
Chr19:49167993 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.721C>T (p.Arg241Trp) single nucleotide variant Inborn genetic diseases [RCV002921762] Chr19:48664678 [GRCh38]
Chr19:49167935 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.299G>A (p.Gly100Asp) single nucleotide variant Inborn genetic diseases [RCV002832473] Chr19:48670688 [GRCh38]
Chr19:49173945 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.410A>G (p.His137Arg) single nucleotide variant Inborn genetic diseases [RCV002900795] Chr19:48670577 [GRCh38]
Chr19:49173834 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.242G>A (p.Arg81His) single nucleotide variant Inborn genetic diseases [RCV002648767] Chr19:48670745 [GRCh38]
Chr19:49174002 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.521G>A (p.Arg174His) single nucleotide variant Inborn genetic diseases [RCV002656523] Chr19:48670466 [GRCh38]
Chr19:49173723 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.821C>T (p.Ala274Val) single nucleotide variant Inborn genetic diseases [RCV002657426] Chr19:48664292 [GRCh38]
Chr19:49167549 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1234C>T (p.Pro412Ser) single nucleotide variant Inborn genetic diseases [RCV002723641] Chr19:48661913 [GRCh38]
Chr19:49165170 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.542C>G (p.Thr181Ser) single nucleotide variant Inborn genetic diseases [RCV003186237] Chr19:48670445 [GRCh38]
Chr19:49173702 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1180G>A (p.Val394Ile) single nucleotide variant Inborn genetic diseases [RCV003183874] Chr19:48661967 [GRCh38]
Chr19:49165224 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.977C>G (p.Pro326Arg) single nucleotide variant Inborn genetic diseases [RCV003175420] Chr19:48663808 [GRCh38]
Chr19:49167065 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.439G>A (p.Gly147Arg) single nucleotide variant Inborn genetic diseases [RCV003195858] Chr19:48670548 [GRCh38]
Chr19:49173805 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.572C>T (p.Pro191Leu) single nucleotide variant Inborn genetic diseases [RCV003218847] Chr19:48670415 [GRCh38]
Chr19:49173672 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.632C>T (p.Pro211Leu) single nucleotide variant Inborn genetic diseases [RCV003209899] Chr19:48664767 [GRCh38]
Chr19:49168024 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1268T>G (p.Leu423Arg) single nucleotide variant Inborn genetic diseases [RCV003210458] Chr19:48661879 [GRCh38]
Chr19:49165136 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.701G>A (p.Arg234Gln) single nucleotide variant Inborn genetic diseases [RCV003214578] Chr19:48664698 [GRCh38]
Chr19:49167955 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.84C>G (p.Phe28Leu) single nucleotide variant Inborn genetic diseases [RCV003376426] Chr19:48670903 [GRCh38]
Chr19:49174160 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.386C>G (p.Pro129Arg) single nucleotide variant Inborn genetic diseases [RCV003364678] Chr19:48670601 [GRCh38]
Chr19:49173858 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.332G>C (p.Trp111Ser) single nucleotide variant Inborn genetic diseases [RCV003370427] Chr19:48670655 [GRCh38]
Chr19:49173912 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.805C>A (p.Arg269Ser) single nucleotide variant Inborn genetic diseases [RCV003373931] Chr19:48664594 [GRCh38]
Chr19:49167851 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.544A>G (p.Thr182Ala) single nucleotide variant Inborn genetic diseases [RCV003354099] Chr19:48670443 [GRCh38]
Chr19:49173700 [GRCh37]
Chr19:19q13.33
uncertain significance
NM_145807.4(NTN5):c.1416C>T (p.Ala472=) single nucleotide variant not provided [RCV003425309] Chr19:48661731 [GRCh38]
Chr19:49164988 [GRCh37]
Chr19:19q13.33
likely benign
NM_145807.4(NTN5):c.1247T>G (p.Leu416Arg) single nucleotide variant not provided [RCV003425310] Chr19:48661900 [GRCh38]
Chr19:49165157 [GRCh37]
Chr19:19q13.33
likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:858
Count of miRNA genes:570
Interacting mature miRNAs:623
Transcripts:ENST00000270235, ENST00000596844, ENST00000600468
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S1361  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map12q24UniSTS
Cytogenetic Map20q13.32UniSTS
Cytogenetic Map12q13.2UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map1q44UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map17p13.2UniSTS
Cytogenetic MapXq21.1UniSTS
Cytogenetic Map2q21.1UniSTS
Cytogenetic Map19p13.11UniSTS
Cytogenetic Map19q13.33UniSTS
Cytogenetic Map1p35.3UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map22q11.2UniSTS
Cytogenetic Map2q37.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map6p21.1-p12.1UniSTS
Cytogenetic Map1q21.3UniSTS
Cytogenetic Map1q42.12UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map4q22.1UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map3q25.33UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map11q13.2UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map19p13.13UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map12q12UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map1q32.1UniSTS
Cytogenetic Map5p13.1UniSTS
Cytogenetic MapXq24UniSTS
Cytogenetic Map9q34UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map5q22.2UniSTS
Cytogenetic Map1p31UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map1q21.2UniSTS
Cytogenetic Map20q13.2UniSTS
Cytogenetic Map19q13.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map6p21.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic Map5q33.1UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map7p22.3UniSTS
Cytogenetic Map4p16.3UniSTS
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map17q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2 124 2 2 96 1 64 31 1
Low 1697 1219 1109 245 693 100 2968 783 3431 194 1269 1253 153 811 1672
Below cutoff 717 1737 464 352 987 339 1325 1354 177 199 96 293 17 392 1071 4

Sequence


RefSeq Acc Id: ENST00000270235   ⟹   ENSP00000270235
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,661,407 - 48,673,017 (-)Ensembl
RefSeq Acc Id: ENST00000596844   ⟹   ENSP00000469490
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,661,965 - 48,673,081 (-)Ensembl
RefSeq Acc Id: ENST00000600468
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1948,662,475 - 48,673,027 (-)Ensembl
RefSeq Acc Id: NM_145807   ⟹   NP_665806
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,661,407 - 48,673,017 (-)NCBI
GRCh371949,164,664 - 49,176,264 (-)RGD
Build 361953,856,476 - 53,868,076 (-)NCBI Archive
Celera1946,029,521 - 46,042,362 (-)RGD
HuRef1945,544,064 - 45,555,139 (-)ENTREZGENE
CHM1_11949,166,555 - 49,177,960 (-)NCBI
T2T-CHM13v2.01951,655,875 - 51,667,423 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011526443   ⟹   XP_011524745
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,661,984 - 48,671,797 (-)NCBI
Sequence:
RefSeq Acc Id: XM_054319787   ⟹   XP_054175762
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01951,656,452 - 51,666,203 (-)NCBI
RefSeq Acc Id: NP_665806   ⟸   NM_145807
- Peptide Label: precursor
- UniProtKB: Q8N4X9 (UniProtKB/Swiss-Prot),   Q8WU63 (UniProtKB/Swiss-Prot),   Q8WTR8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011524745   ⟸   XM_011526443
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000469490   ⟸   ENST00000596844
RefSeq Acc Id: ENSP00000270235   ⟸   ENST00000270235
RefSeq Acc Id: XP_054175762   ⟸   XM_054319787
- Peptide Label: isoform X1
Protein Domains
Laminin EGF-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8WTR8-F1-model_v2 AlphaFold Q8WTR8 1-489 view protein structure

Promoters
RGD ID:13204999
Promoter ID:EPDNEW_H26079
Type:multiple initiation site
Name:NTN5_1
Description:netrin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381948,673,267 - 48,673,327EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:25208 AgrOrtholog
COSMIC NTN5 COSMIC
Ensembl Genes ENSG00000142233 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000270235 ENTREZGENE
  ENST00000270235.11 UniProtKB/Swiss-Prot
  ENST00000596844.5 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  Tie2 ligand-binding domain superfamily UniProtKB/Swiss-Prot
GTEx ENSG00000142233 GTEx
HGNC ID HGNC:25208 ENTREZGENE
Human Proteome Map NTN5 Human Proteome Map
InterPro Laminin_EGF UniProtKB/Swiss-Prot
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:126147 UniProtKB/Swiss-Prot
NCBI Gene 126147 ENTREZGENE
PANTHER NETRIN 5 UniProtKB/Swiss-Prot
  NETRIN/LAMININ-RELATED UniProtKB/Swiss-Prot
Pfam Laminin_EGF UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot
PharmGKB PA164724232 PharmGKB
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_LAM_1 UniProtKB/Swiss-Prot
  EGF_LAM_2 UniProtKB/Swiss-Prot
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART C345C UniProtKB/Swiss-Prot
  EGF_Lam UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0QXZ9_HUMAN UniProtKB/TrEMBL
  NET5_HUMAN UniProtKB/Swiss-Prot
  Q8N4X9 ENTREZGENE
  Q8WTR8 ENTREZGENE
  Q8WU63 ENTREZGENE
UniProt Secondary Q8N4X9 UniProtKB/Swiss-Prot
  Q8WU63 UniProtKB/Swiss-Prot