ACTN1 (actinin alpha 1) - Rat Genome Database

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Gene: ACTN1 (actinin alpha 1) Pan paniscus
Analyze
Symbol: ACTN1
Name: actinin alpha 1
RGD ID: 11744247
Description: ENCODES a protein that exhibits cytoskeletal regulatory protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN platelet activation (ortholog); platelet aggregation (ortholog); PARTICIPATES IN E-cadherin signaling pathway; syndecan signaling pathway; ASSOCIATED WITH Diabetic Nephropathies (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-actinin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,460,390 - 49,565,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,335,694 - 68,440,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ACTN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01449,460,390 - 49,565,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11468,335,694 - 68,440,836 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)Ensemblpanpan1.1panPan2
ACTN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381468,874,128 - 68,979,302 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1468,874,128 - 68,979,440 (-)EnsemblGRCh38hg38GRCh38
GRCh371469,340,845 - 69,446,019 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361468,410,793 - 68,515,709 (-)NCBINCBI36Build 36hg18NCBI36
Build 341468,410,792 - 68,515,709NCBI
Celera1449,401,716 - 49,506,993 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1449,510,917 - 49,616,121 (-)NCBIHuRef
CHM1_11469,279,215 - 69,384,488 (-)NCBICHM1_1
T2T-CHM13v2.01463,083,135 - 63,188,360 (-)NCBIT2T-CHM13v2.0
Actn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391280,214,316 - 80,307,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1280,214,321 - 80,307,145 (-)EnsemblGRCm39 Ensembl
GRCm381280,167,542 - 80,260,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1280,167,547 - 80,260,371 (-)EnsemblGRCm38mm10GRCm38
MGSCv371281,268,529 - 81,361,358 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361281,086,387 - 81,179,156 (-)NCBIMGSCv36mm8
Celera1281,632,311 - 81,725,181 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1236.49NCBI
Actn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86104,731,485 - 104,826,312 (-)NCBIGRCr8
mRatBN7.2698,998,553 - 99,093,334 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl698,998,556 - 99,093,251 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx699,420,854 - 99,515,776 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0699,719,945 - 99,814,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0699,099,910 - 99,194,634 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06103,376,557 - 103,470,497 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6103,375,799 - 103,470,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,056,248 - 116,149,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46103,188,593 - 103,282,873 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16103,192,048 - 103,286,329NCBI
Celera697,355,796 - 97,450,012 (-)NCBICelera
Cytogenetic Map6q24NCBI
Actn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554661,388,507 - 1,480,282 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554661,388,507 - 1,480,990 (+)NCBIChiLan1.0ChiLan1.0
ACTN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1842,714,806 - 42,808,318 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl842,712,142 - 42,808,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha842,404,474 - 42,497,710 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0842,945,028 - 43,038,491 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl842,945,037 - 43,038,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1842,559,338 - 42,652,710 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0842,634,268 - 42,727,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0842,993,500 - 43,086,762 (-)NCBIUU_Cfam_GSD_1.0
Actn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864061,974,520 - 62,067,210 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649512,124,443 - 12,217,242 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649512,124,489 - 12,217,223 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl792,550,007 - 92,644,842 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1792,550,132 - 92,644,842 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2798,863,871 - 98,874,025 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12446,089,989 - 46,196,897 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2446,085,751 - 46,196,886 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605334,323,625 - 34,430,616 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Actn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473432,097,671 - 32,192,729 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473432,097,364 - 32,190,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000051212   ⟹   ENSPPAP00000028365
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1468,335,694 - 68,440,836 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051217   ⟹   ENSPPAP00000028370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1468,335,694 - 68,440,565 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000051222   ⟹   ENSPPAP00000028375
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1468,335,697 - 68,440,565 (-)Ensembl
RefSeq Acc Id: XM_003824085   ⟹   XP_003824133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,691 (-)NCBI
NHGRI_mPanPan11469,207,296 - 69,313,200 (-)NCBI
Mhudiblu_PPA_v01449,460,390 - 49,565,982 (-)NCBI
PanPan1.11468,335,697 - 68,440,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003824086   ⟹   XP_003824134
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,582 (-)NCBI
NHGRI_mPanPan11469,207,296 - 69,312,921 (-)NCBI
Mhudiblu_PPA_v01449,460,569 - 49,565,959 (-)NCBI
PanPan1.11468,335,694 - 68,440,565 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003824087   ⟹   XP_003824135
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,372 (-)NCBI
NHGRI_mPanPan11469,207,296 - 69,312,920 (-)NCBI
Mhudiblu_PPA_v01449,460,390 - 49,565,959 (-)NCBI
PanPan1.11468,335,694 - 68,440,836 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034937714   ⟹   XP_034793605
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,582 (-)NCBI
NHGRI_mPanPan11469,207,296 - 69,312,923 (-)NCBI
Mhudiblu_PPA_v01449,461,127 - 49,565,986 (-)NCBI
RefSeq Acc Id: XM_055097732   ⟹   XP_054953707
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,995,107 - 70,096,582 (-)NCBI
NHGRI_mPanPan11469,211,621 - 69,312,947 (-)NCBI
RefSeq Acc Id: XM_055097733   ⟹   XP_054953708
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,486 (-)NCBI
NHGRI_mPanPan11469,207,296 - 69,312,922 (-)NCBI
RefSeq Acc Id: XM_063596262   ⟹   XP_063452332
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21569,990,975 - 70,096,582 (-)NCBI
RefSeq Acc Id: XP_003824135   ⟸   XM_003824087
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BFF0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003824134   ⟸   XM_003824086
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BFF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003824133   ⟸   XM_003824085
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BFG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034793605   ⟸   XM_034937714
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000028370   ⟸   ENSPPAT00000051217
RefSeq Acc Id: ENSPPAP00000028365   ⟸   ENSPPAT00000051212
RefSeq Acc Id: ENSPPAP00000028375   ⟸   ENSPPAT00000051222
RefSeq Acc Id: XP_054953708   ⟸   XM_055097733
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054953707   ⟸   XM_055097732
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063452332   ⟸   XM_063596262
- Peptide Label: isoform X7
Protein Domains
Calponin-homology (CH)   EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037190 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051212.1 UniProtKB/TrEMBL
  ENSPPAT00000051217.1 UniProtKB/TrEMBL
  ENSPPAT00000051222.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.58.60 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report pps:100979183 UniProtKB/TrEMBL
NCBI Gene ACTN1 ENTREZGENE
PANTHER ALPHA-ACTININ-1 UniProtKB/TrEMBL
  SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN UniProtKB/TrEMBL
Pfam EF-hand_6 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  efhand_Ca_insen UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP Spectrin repeat UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A2R9BFF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BFG1 ENTREZGENE, UniProtKB/TrEMBL