Ppbp (pro-platelet basic protein) - Rat Genome Database

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Gene: Ppbp (pro-platelet basic protein) Rattus norvegicus
Analyze
Symbol: Ppbp
Name: pro-platelet basic protein
RGD ID: 70548
Description: Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in positive regulation of granulocyte chemotaxis. Predicted to be located in platelet alpha granule. Predicted to be active in extracellular space. Biomarker of acute myocardial infarction and hypospadias. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to human PPBP (pro-platelet basic protein); PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH acetamide; acrylamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chemokine (C-X-C motif) ligand 7; Cxcl7; Nap-2; neutrophil activating peptide-2; platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,586,495 - 17,587,299 (-)NCBIGRCr8
mRatBN7.21417,302,326 - 17,303,130 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,302,326 - 17,303,130 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,302,459 - 17,303,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,621,380 - 18,622,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,313,684 - 17,314,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,852,433 - 18,853,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,851,954 - 18,853,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,762,075 - 18,762,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,816,434 - 18,817,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,816,433 - 18,817,238 (-)NCBI
Celera1416,678,302 - 16,679,106 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-nitroquinoline N-oxide  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
ADP  (ISO)
amlodipine  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
cobalt atom  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dimercaprol  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
eugenol  (ISO)
fenvalerate  (EXP)
genistein  (ISO)
graphene oxide  (ISO)
heparin  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nortriptyline  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paroxetine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
poly(styrene)  (ISO)
rotenone  (EXP)
sertraline  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (ISO)
testosterone  (ISO)
Thrombin  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
verapamil  (ISO)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neutrophil-activating peptide-2 in patients with pulmonary edema from congestive heart failure or ARDS. Cohen AB, etal., Am J Physiol. 1993 May;264(5 Pt 1):L490-5. doi: 10.1152/ajplung.1993.264.5.L490.
2. Molecular cloning and characterization of a novel rat CXC chemokine, rPBP, the homologue of human and mouse PBP. Fu WX, etal., Cytokine. 2004 Apr 7;26(1):37-43. doi: 10.1016/j.cyto.2003.12.007.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Novel TIA biomarkers identified by mass spectrometry-based proteomics. George PM, etal., Int J Stroke. 2015 Dec;10(8):1204-11. doi: 10.1111/ijs.12603. Epub 2015 Aug 26.
5. The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi. Ghasemzadeh M, etal., Blood. 2013 May 30;121(22):4555-66. doi: 10.1182/blood-2012-09-459636. Epub 2013 Apr 2.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. The CXCL7/CXCR1/2 axis is a key driver in the growth of clear cell renal cell carcinoma. Grépin R, etal., Cancer Res. 2014 Feb 1;74(3):873-83. doi: 10.1158/0008-5472.CAN-13-1267. Epub 2013 Dec 12.
8. Hypothermia-induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model. Horioka K, etal., J Thromb Haemost. 2019 Oct;17(10):1762-1771. doi: 10.1111/jth.14555. Epub 2019 Jul 17.
9. Di-n-butyl phthalate induces oversecretion of vascular endothelium-derived NAP-2 and promotes epithelial-mesenchymal transition of urothelial cells in newborn hypospadias rats. Hua S, etal., Ecotoxicol Environ Saf. 2023 May;256:114892. doi: 10.1016/j.ecoenv.2023.114892. Epub 2023 Apr 12.
10. PPBP gene as a biomarker for coronary heart disease risk in postmenopausal Thai women. Mansanguan C and Maneerat Y, PeerJ. 2022 Jun 17;10:e13615. doi: 10.7717/peerj.13615. eCollection 2022.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Isolation and characterization of mouse homolog of the neutrophil activating peptide-2. Oda M, etal., Biochem Biophys Res Commun 2002 Jan 18;290(2):865-8.
13. Elevated expression of platelet-derived chemokines in patients with antiphospholipid syndrome. Patsouras MD, etal., J Autoimmun. 2015 Dec;65:30-7. doi: 10.1016/j.jaut.2015.08.001. Epub 2015 Aug 15.
14. Platelet activation in chronic cocaine users: effect of short term abstinence. Pereira J, etal., Platelets. 2011;22(8):596-601. doi: 10.3109/09537104.2011.578181. Epub 2011 Aug 2.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation. Smith C, etal., J Am Coll Cardiol. 2006 Oct 17;48(8):1591-9. doi: 10.1016/j.jacc.2006.06.060. Epub 2006 Sep 27.
21. Platelet factor 4 and β-thromboglobulin mRNAs in circulating microparticles of trauma patients as diagnostic markers for deep vein thrombosis. Su Y, etal., J Thromb Thrombolysis. 2020 Oct;50(3):525-532. doi: 10.1007/s11239-020-02124-5.
22. Effects of pesticide seed treatments on Rhizobium japonicum and its symbiotic relationship with soybean. Tu CM Bull Environ Contam Toxicol 1977 Aug;18(2):190-9.
23. rLj-RGD3, a novel recombinant toxin protein from Lampetra japonica, prevents coronary thrombosis-induced acute myocardial infarction by inhibiting platelet functions in rats. Wang S, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):240-245. doi: 10.1016/j.bbrc.2018.02.021. Epub 2018 Feb 3.
24. Plasma NAP-2 levels are associated with critical limb ischemia in peripheral arterial disease patients. Wang X, etal., Exp Biol Med (Maywood). 2019 Jan;244(1):22-27. doi: 10.1177/1535370218823684. Epub 2019 Jan 12.
25. Plasma beta-thromboglobulin and platelet factor 4 concentrations in patients with atrial fibrillation. Yamauchi K, etal., Jpn Heart J. 1986 Jul;27(4):481-7. doi: 10.1536/ihj.27.481.
26. [Changes of platelet rheological behavior and the interventional effects of ulinastatin in rats with high-voltage electrical burns]. Zhang QF, etal., Zhonghua Shao Shang Za Zhi. 2017 Dec 20;33(12):744-749. doi: 10.3760/cma.j.issn.1009-2587.2017.12.005.
27. Mining biomarkers in human sera using proteomic tools. Zhang R, etal., Proteomics. 2004 Jan;4(1):244-56.
28. Neutrophil-activating Peptide 2 as a Novel Modulator of Fibrin Clot Properties in Patients with Atrial Fibrillation. Ząbczyk M, etal., Transl Stroke Res. 2023 Jun 9:1-11. doi: 10.1007/s12975-023-01165-1.
Additional References at PubMed
PMID:10877842  


Genomics

Comparative Map Data
Ppbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,586,495 - 17,587,299 (-)NCBIGRCr8
mRatBN7.21417,302,326 - 17,303,130 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,302,326 - 17,303,130 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,302,459 - 17,303,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,621,380 - 18,622,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,313,684 - 17,314,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,852,433 - 18,853,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,851,954 - 18,853,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,762,075 - 18,762,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,816,434 - 18,817,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,816,433 - 18,817,238 (-)NCBI
Celera1416,678,302 - 16,679,106 (-)NCBICelera
Cytogenetic Map14p22NCBI
PPBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,986,439 - 73,988,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,986,439 - 73,988,190 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,852,156 - 74,853,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,071,619 - 75,072,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,217,792 - 75,218,935NCBI
Celera472,212,305 - 72,214,056 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,663,087 - 70,664,838 (-)NCBIHuRef
CHM1_1474,888,045 - 74,889,796 (-)NCBICHM1_1
T2T-CHM13v2.0477,330,080 - 77,331,831 (-)NCBIT2T-CHM13v2.0
Ppbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,916,377 - 90,917,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,916,377 - 90,917,922 (+)EnsemblGRCm39 Ensembl
GRCm38590,768,518 - 90,770,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,768,518 - 90,770,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,197,544 - 91,199,086 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,843,718 - 91,845,260 (+)NCBIMGSCv36mm8
Celera588,920,145 - 88,921,687 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
PPBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,071,080 - 56,073,080 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,260,189 - 56,262,313 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,203,168 - 50,204,303 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,035,433 - 56,036,580 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,035,060 - 56,037,702 (+)Ensemblpanpan1.1panPan2
PPBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,526,571 - 62,528,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,526,571 - 62,528,527 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,195,002 - 62,196,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,324,944 - 63,340,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,337,296 - 63,339,253 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,947,100 - 62,949,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,436,835 - 62,438,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,577,683 - 63,579,641 (+)NCBIUU_Cfam_GSD_1.0
Ppbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,267,431 - 13,268,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,719,480 - 1,720,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,719,501 - 1,720,890 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,021,439 - 70,023,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,021,468 - 70,022,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,173,312 - 74,174,334 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,470,670 - 22,471,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,470,573 - 22,471,809 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084305,796 - 308,564 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ppbp
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000003794
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 18 18 10 18
Low 6 6 6 1 6 1 3 11
Below cutoff 3 32 26 11 7 11 3 5 31 17 21 3

Sequence


RefSeq Acc Id: ENSRNOT00000003794   ⟹   ENSRNOP00000003794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1417,302,326 - 17,303,130 (-)Ensembl
Rnor_6.0 Ensembl1418,851,954 - 18,853,315 (-)Ensembl
RefSeq Acc Id: NM_153721   ⟹   NP_714943
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81417,586,495 - 17,587,299 (-)NCBI
mRatBN7.21417,302,326 - 17,303,130 (-)NCBI
Rnor_6.01418,852,433 - 18,853,237 (-)NCBI
Rnor_5.01418,762,075 - 18,762,879 (-)NCBI
RGSC_v3.41418,816,434 - 18,817,238 (-)RGD
Celera1416,678,302 - 16,679,106 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_714943 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK30166 (Get FASTA)   NCBI Sequence Viewer  
  EDL88564 (Get FASTA)   NCBI Sequence Viewer  
  EDL88565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003794.1
RefSeq Acc Id: NP_714943   ⟸   NM_153721
- Peptide Label: precursor
- UniProtKB: Q99ME0 (UniProtKB/TrEMBL),   A6KKE5 (UniProtKB/TrEMBL),   F7EY20 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003794   ⟸   ENSRNOT00000003794
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99ME0-F1-model_v2 AlphaFold Q99ME0 1-111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699228
Promoter ID:EPDNEW_R9753
Type:single initiation site
Name:Ppbp_1
Description:pro-platelet basic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01418,853,311 - 18,853,371EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70548 AgrOrtholog
BioCyc Gene G2FUF-16204 BioCyc
Ensembl Genes ENSRNOG00000002829 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003794.4 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8 UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/TrEMBL
  CXC_chmkine_smll UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report rno:246358 UniProtKB/TrEMBL
NCBI Gene 246358 ENTREZGENE
PANTHER PLATELET BASIC PROTEIN UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PhenoGen Ppbp PhenoGen
PRINTS INTERLEUKIN8 UniProtKB/TrEMBL
  SMALLCYTKCXC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002829 RatGTEx
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL
UniProt A6KKE5 ENTREZGENE, UniProtKB/TrEMBL
  F7EY20 ENTREZGENE, UniProtKB/TrEMBL
  Q99ME0 ENTREZGENE
UniProt Secondary Q99ME0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-20 Ppbp  pro-platelet basic protein  Ppbp  pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Ppbp  pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)  Ppbp  pro-platelet basic protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Ppbp  pro-platelet basic protein  Cxcl7  chemokine (C-X-C motif) ligand 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cxcl7  chemokine (C-X-C motif) ligand 7  Ppbp  pro-platelet basic protein  Symbol and Name updated 1299863 APPROVED
2002-06-10 Ppbp  pro-platelet basic protein      Symbol and Name status set to approved 70586 APPROVED