C4bpa (complement component 4 binding protein, alpha) - Rat Genome Database

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Gene: C4bpa (complement component 4 binding protein, alpha) Rattus norvegicus
Analyze
Symbol: C4bpa
Name: complement component 4 binding protein, alpha
RGD ID: 2235
Description: Predicted to enable complement binding activity. Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in acrosomal matrix; cell body; and outer acrosomal membrane. Predicted to be part of zona pellucida receptor complex. Predicted to be active in extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha); PARTICIPATES IN coagulation cascade pathway; complement system pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C4b-binding protein alpha chain; C4BP; MGC108761
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,627,959 - 44,663,552 (-)NCBIGRCr8
mRatBN7.21342,075,715 - 42,111,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,075,717 - 42,111,205 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,682,730 - 44,717,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01345,970,875 - 46,005,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,215,123 - 43,250,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,342,090 - 47,377,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,342,079 - 47,377,703 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,430,754 - 52,466,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,552,947 - 43,588,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,567,082 - 43,598,278 (-)NCBI
Celera1342,426,949 - 42,461,963 (-)NCBICelera
RH 3.4 Map13109.8RGD
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
Actein  (EXP)
aflatoxin B1  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
carbon nanotube  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corosolic acid  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
flutamide  (EXP)
furan  (EXP)
genistein  (ISO)
graphite  (EXP)
hexachlorobenzene  (EXP)
L-ethionine  (EXP)
lansoprazole  (EXP)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
ozone  (EXP)
pantoprazole  (EXP)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
propanal  (ISO)
quartz  (EXP)
quercetin  (ISO)
rabeprazole  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP)
trichloroethene  (EXP)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5. Decline in the expression of C4 binding protein alpha-chain gene during ageing of the rat liver. Lavery LW and Goyns MH, Biogerontology 2002;3(4):207-11.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Immune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7604284   PMID:9013975   PMID:9890753   PMID:11133656   PMID:11417900   PMID:11784086   PMID:12477932   PMID:14607961   PMID:16502470   PMID:16540102   PMID:21640725   PMID:21880732  
PMID:22333221   PMID:22516433   PMID:22658674   PMID:23976951  


Genomics

Comparative Map Data
C4bpa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81344,627,959 - 44,663,552 (-)NCBIGRCr8
mRatBN7.21342,075,715 - 42,111,205 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,075,717 - 42,111,205 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1344,682,730 - 44,717,817 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01345,970,875 - 46,005,959 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,215,123 - 43,250,642 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,342,090 - 47,377,580 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,342,079 - 47,377,703 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,430,754 - 52,466,244 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,552,947 - 43,588,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,567,082 - 43,598,278 (-)NCBI
Celera1342,426,949 - 42,461,963 (-)NCBICelera
RH 3.4 Map13109.8RGD
Cytogenetic Map13q13NCBI
C4BPA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381207,104,233 - 207,144,972 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1207,104,233 - 207,144,972 (+)EnsemblGRCh38hg38GRCh38
GRCh371207,277,578 - 207,318,317 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,344,230 - 205,384,940 (+)NCBINCBI36Build 36hg18NCBI36
Build 341203,666,001 - 203,706,701NCBI
Celera1180,529,170 - 180,570,903 (+)NCBICelera
Cytogenetic Map1q32.2NCBI
HuRef1177,975,014 - 178,014,972 (+)NCBIHuRef
CHM1_11208,550,269 - 208,591,017 (+)NCBICHM1_1
T2T-CHM13v2.01206,369,472 - 206,410,221 (+)NCBIT2T-CHM13v2.0
Zp3r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,474,847 - 130,557,371 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,504,450 - 130,557,358 (-)EnsemblGRCm39 Ensembl
GRCm381130,547,110 - 130,629,634 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1130,576,713 - 130,629,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,473,283 - 132,526,183 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,404,259 - 132,457,141 (-)NCBIMGSCv36mm8
Celera1133,204,292 - 133,253,007 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
C4bpa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,613,607 - 42,641,670 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,613,659 - 42,641,918 (+)NCBIChiLan1.0ChiLan1.0
LOC100984709
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,225,348 - 42,261,919 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,191,856 - 42,232,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,707,221 - 182,747,878 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,985,220 - 187,025,898 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,985,264 - 187,025,898 (+)Ensemblpanpan1.1panPan2
C4BPA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.176,239,036 - 6,268,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl76,241,102 - 6,268,910 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,802,297 - 5,832,192 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,927,762 - 5,957,518 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,929,843 - 5,957,511 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,861,425 - 5,891,162 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,962,886 - 5,992,819 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.076,003,175 - 6,033,127 (+)NCBIUU_Cfam_GSD_1.0
C4BPA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,731,179 - 67,776,115 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,726,159 - 67,774,369 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2974,106,142 - 74,154,500 (+)NCBISscrofa10.2Sscrofa10.2susScr3
C4BPA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,169,355 - 22,254,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605522,832,939 - 22,844,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in C4bpa
450 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:26
Count of miRNA genes:19
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000005461
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
RH94833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,075,847 - 42,075,959 (+)MAPPERmRatBN7.2
Rnor_6.01347,342,223 - 47,342,334NCBIRnor6.0
Rnor_5.01352,430,887 - 52,430,998UniSTSRnor5.0
RGSC_v3.41343,553,080 - 43,553,191UniSTSRGSC3.4
Celera1342,427,082 - 42,427,193UniSTS
RH 3.4 Map13109.8UniSTS
Cytogenetic Map13q13UniSTS
RH94834  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,075,852 - 42,075,947 (+)MAPPERmRatBN7.2
Rnor_6.01347,342,228 - 47,342,322NCBIRnor6.0
Rnor_5.01352,430,892 - 52,430,986UniSTSRnor5.0
RGSC_v3.41343,553,085 - 43,553,179UniSTSRGSC3.4
Celera1342,427,087 - 42,427,181UniSTS
Cytogenetic Map13q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 9 19 72 88 90 59 21 59 6 170 60 53 39 51 31

Sequence


Ensembl Acc Id: ENSRNOT00000005461   ⟹   ENSRNOP00000005461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,075,717 - 42,111,205 (-)Ensembl
Rnor_6.0 Ensembl1347,342,079 - 47,377,703 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113710   ⟹   ENSRNOP00000081096
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,075,717 - 42,111,205 (-)Ensembl
RefSeq Acc Id: NM_012516   ⟹   NP_036648
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,627,980 - 44,663,471 (-)NCBI
mRatBN7.21342,075,715 - 42,111,205 (-)NCBI
Rnor_6.01347,342,090 - 47,377,580 (-)NCBI
Rnor_5.01352,430,754 - 52,466,244 (-)NCBI
RGSC_v3.41343,552,947 - 43,588,565 (-)RGD
Celera1342,426,949 - 42,461,963 (-)RGD
Sequence:
RefSeq Acc Id: XM_039090318   ⟹   XP_038946246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,627,959 - 44,651,634 (-)NCBI
mRatBN7.21342,075,796 - 42,099,373 (-)NCBI
RefSeq Acc Id: XM_063272018   ⟹   XP_063128088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81344,647,722 - 44,663,552 (-)NCBI
RefSeq Acc Id: NP_036648   ⟸   NM_012516
- UniProtKB: Q5M891 (UniProtKB/TrEMBL),   A6IBY8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005461   ⟸   ENSRNOT00000005461
RefSeq Acc Id: XP_038946246   ⟸   XM_039090318
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000081096   ⟸   ENSRNOT00000113710
RefSeq Acc Id: XP_063128088   ⟸   XM_063272018
- Peptide Label: isoform X2
Protein Domains
Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63514-F1-model_v2 AlphaFold Q63514 1-558 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698784
Promoter ID:EPDNEW_R9309
Type:initiation region
Name:C4bpa_1
Description:complement component 4 binding protein, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01347,377,591 - 47,377,651EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2235 AgrOrtholog
BioCyc Gene G2FUF-18372 BioCyc
Ensembl Genes ENSRNOG00000004062 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005461.6 UniProtKB/TrEMBL
  ENSRNOT00000113710.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.3730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.20.28.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7324823 IMAGE-MGC_LOAD
InterPro C4bp_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Compl-Cell_Adhes-Reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24235 UniProtKB/TrEMBL
MGC_CLONE MGC:108761 IMAGE-MGC_LOAD
NCBI Gene 24235 ENTREZGENE
PANTHER C4B-BINDING PROTEIN ALPHA CHAIN UniProtKB/TrEMBL
  COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LOCOMOTION-RELATED PROTEIN HIKARU GENKI UniProtKB/Swiss-Prot
Pfam C4bp_oligo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C4bpa PhenoGen
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004062 RatGTEx
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC223559
UniProt A0A8I5ZSA2_RAT UniProtKB/TrEMBL
  A6IBY7_RAT UniProtKB/TrEMBL
  A6IBY8 ENTREZGENE, UniProtKB/TrEMBL
  A9CME3_RAT UniProtKB/TrEMBL
  C4BPA_RAT UniProtKB/Swiss-Prot
  Q5M891 ENTREZGENE, UniProtKB/TrEMBL
  Q63514 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 C4bpa  Complement component 4 binding protein, alpha      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process key regulatory protein of the complement system and involved in immune function 634674
gene_regulation expression in liver is reduced with ageing 1299828