Apln (apelin) - Rat Genome Database

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Gene: Apln (apelin) Rattus norvegicus
Analyze
Symbol: Apln
Name: apelin
RGD ID: 620672
Description: Exhibits apelin receptor binding activity and identical protein binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of peptide hormone secretion; and regulation of blood circulation. Localizes to extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin); PARTICIPATES IN apelin signaling pathway; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Apel; apelin, AGTRL1 ligand; APJ endogenous ligand
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X127,180,801 - 127,213,567 (-)NCBI
Rnor_6.0 EnsemblX134,856,726 - 134,866,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X134,856,719 - 134,866,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X134,929,116 - 134,938,607 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,387,285 - 134,396,762 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,460,719 - 134,470,195 (-)NCBI
CeleraX126,154,452 - 126,163,943 (-)NCBICelera
Cytogenetic MapXq36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(R)-lipoic acid  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acadesine  (ISO)
acrylamide  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
BQ 123  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP,ISO)
cypermethrin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (EXP)
isoprenaline  (EXP)
lipoic acid  (ISO)
LY294002  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
pentane-2,3-dione  (EXP)
pirinixic acid  (ISO)
quercetin  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
Tetrachlorobisphenol A  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP)
zearalenone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Atluri P, etal., Cell Mol Biol Lett. 2007;12(1):127-38. Epub 2006 Nov 19.
2. Cheng X, etal., Eur J Pharmacol. 2003 Jun 6;470(3):171-5.
3. Dai T, etal., Eur J Pharmacol. 2006 Dec 28;553(1-3):222-8. Epub 2006 Sep 23.
4. De Mota N, etal., Proc Natl Acad Sci U S A 2004 Jul 13;101(28):10464-9. Epub 2004 Jul 01.
5. Ellinor PT, etal., Eur Heart J. 2006 Jan;27(2):222-6. Epub 2005 Nov 8.
6. Erdem G, etal., Exp Clin Endocrinol Diabetes. 2008 May;116(5):289-92.
7. Garcia-Diaz D, etal., Mol Cell Biochem. 2007 Jun 27;.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Goetze JP, etal., Regul Pept. 2006 Jan 15;133(1-3):134-8. Epub 2005 Nov 2.
11. Gurzu B, etal., J Renin Angiotensin Aldosterone Syst. 2006 Dec;7(4):212-6.
12. Habata Y, etal., Biochim Biophys Acta 1999 Oct 13;1452(1):25-35.
13. Han S, etal., Regul Pept. 2007 Aug 16;142(3):131-7. Epub 2007 Feb 22.
14. Hashimoto T, etal., Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1267-72. Epub 2006 Mar 23.
15. Heinonen MV, etal., Regul Pept. 2005 Aug 15;130(1-2):7-13.
16. Jaszberenyi M, etal., Neuroscience. 2004;129(3):811-6.
17. Kawamata Y, etal., Biochim Biophys Acta. 2001 Apr 23;1538(2-3):162-71.
18. Lee DK, etal., Endocrinology. 2005 Jan;146(1):231-6. Epub 2004 Oct 14.
19. Lee DK, etal., J Biol Chem 2004 Feb 27;279(9):7901-8. Epub 2003 Nov 26.
20. Lee DK, etal., J Neurochem 2000 Jan;74(1):34-41.
21. Li Z, etal., Intern Med. 2008;47(22):1951-5. Epub 2008 Nov 17.
22. MGD data from the GO Consortium
23. Mitra A, etal., Physiol Behav. 2006 Sep 30;89(2):221-5. Epub 2006 Jul 12.
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. O'Carroll AM and Lolait SJ, J Neuroendocrinol 2003 Jul;15(7):661-6.
26. Perjes A, etal., Basic Res Cardiol. 2016 Jan;111(1):2. doi: 10.1007/s00395-015-0521-6. Epub 2015 Nov 26.
27. Reaux A, etal., J Neurochem. 2001 May;77(4):1085-96.
28. Reaux-Le Goazigo A, etal., Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E7-15. Epub 2006 Aug 8.
29. Reaux-Le Goazigo A, etal., Endocrinology. 2004 Sep;145(9):4392-400. Epub 2004 May 27.
30. RGD automated data pipeline
31. RGD automated import pipeline for gene-chemical interactions
32. Soriguer F, etal., Obes Surg. 2009 Sep 15.
33. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Sunter D, etal., Neurosci Lett. 2003 Dec 15;353(1):1-4.
35. Tatemoto K, etal., Biochem Biophys Res Commun 1998 Oct 20;251(2):471-6.
36. Wang G, etal., Endocrinology 2004 Mar;145(3):1342-8. Epub 2003 Dec 11.
37. Zhang J, etal., Life Sci. 2006 Aug 15;79(12):1153-9. Epub 2006 Apr 15.
38. Zhong JC, etal., Cardiovasc Res. 2005 Feb 15;65(3):743-50.
Additional References at PubMed
PMID:15489334   PMID:15582714   PMID:16278022   PMID:16919293   PMID:17060400   PMID:17341685   PMID:17466269   PMID:17767704   PMID:18367654   PMID:18509323   PMID:18816630   PMID:18818315  
PMID:19070926   PMID:19346461   PMID:19443838   PMID:19660504   PMID:20055692   PMID:20079140   PMID:20580085   PMID:21733827   PMID:21864607   PMID:22081427   PMID:22209991   PMID:22240274  
PMID:22446510   PMID:22493882   PMID:23263626   PMID:23387534   PMID:23629509   PMID:23668014   PMID:23771946   PMID:23874984   PMID:23973488   PMID:24304571   PMID:24363088   PMID:24386141  
PMID:24770651   PMID:24995933   PMID:25012663   PMID:25311903   PMID:25708823   PMID:25931124   PMID:25995451   PMID:26494002   PMID:26546817   PMID:26607438   PMID:26631739   PMID:26680735  
PMID:27109054   PMID:27378063   PMID:27512001   PMID:27632349   PMID:27663841   PMID:27773659   PMID:27994053   PMID:28137936   PMID:28164323   PMID:28627589   PMID:28890073   PMID:28935153  
PMID:28987634   PMID:29091306   PMID:29329678   PMID:30142367   PMID:30170158   PMID:30334404   PMID:30345769   PMID:30582943   PMID:31385138   PMID:31829402   PMID:31932110   PMID:32223946  


Genomics

Comparative Map Data
Apln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X127,180,801 - 127,213,567 (-)NCBI
Rnor_6.0 EnsemblX134,856,726 - 134,866,210 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X134,856,719 - 134,866,210 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X134,929,116 - 134,938,607 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X134,387,285 - 134,396,762 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X134,460,719 - 134,470,195 (-)NCBI
CeleraX126,154,452 - 126,163,943 (-)NCBICelera
Cytogenetic MapXq36NCBI
APLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX129,645,259 - 129,654,956 (-)EnsemblGRCh38hg38GRCh38
GRCh38X129,645,259 - 129,654,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X128,779,236 - 128,788,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,607,006 - 128,616,595 (-)NCBINCBI36hg18NCBI36
Build 34X128,504,860 - 128,514,449NCBI
CeleraX129,165,798 - 129,175,495 (-)NCBI
Cytogenetic MapXq26.1NCBI
HuRefX118,183,705 - 118,187,243 (-)NCBIHuRef
CHM1_1X128,690,603 - 128,700,300 (-)NCBICHM1_1
Apln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X47,114,023 - 47,123,730 (-)NCBIGRCm39mm39
GRCm39 EnsemblX47,114,023 - 47,123,730 (-)Ensembl
GRCm38X48,025,146 - 48,034,853 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX48,025,146 - 48,034,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X45,378,323 - 45,388,029 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X44,269,773 - 44,279,461 (-)NCBImm8
CeleraX35,527,952 - 35,537,661 (-)NCBICelera
Cytogenetic MapXA4NCBI
Apln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554735,346,747 - 5,356,359 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554735,346,822 - 5,356,359 (+)NCBIChiLan1.0ChiLan1.0
APLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X129,073,135 - 129,082,484 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0X118,775,509 - 118,785,224 (-)NCBIMhudiblu_PPA_v0panPan3
APLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X100,863,360 - 100,873,105 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX87,037,314 - 87,047,056 (-)NCBI
ROS_Cfam_1.0X102,715,584 - 102,725,338 (-)NCBI
UMICH_Zoey_3.1X100,133,401 - 100,143,158 (-)NCBI
UNSW_CanFamBas_1.0X101,979,328 - 101,989,085 (-)NCBI
UU_Cfam_GSD_1.0X101,757,148 - 101,766,893 (-)NCBI
Apln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X99,087,672 - 99,097,573 (-)NCBI
SpeTri2.0NW_0049364791,889,930 - 1,899,811 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX106,236,748 - 106,246,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X106,236,746 - 106,246,563 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X122,005,684 - 122,015,536 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APLN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X104,885,639 - 104,896,371 (-)NCBI
ChlSab1.1 EnsemblX104,888,996 - 104,895,014 (-)Ensembl
Apln
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247978,857,490 - 8,866,157 (-)NCBI

Position Markers
RH139900  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X134,856,901 - 134,857,086NCBIRnor6.0
Rnor_5.0X134,929,298 - 134,929,483UniSTSRnor5.0
RGSC_v3.4X134,387,467 - 134,387,652UniSTSRGSC3.4
CeleraX126,154,634 - 126,154,819UniSTS
RH 3.4 MapX910.9UniSTS
Cytogenetic MapXq35UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X101333032146333032Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX107886746152409805Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X110957467155957467Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X110957467155957467Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118715462159970021Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX120045041143145818Rat
634346Insul4Insulin level QTL 40blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)X134627816159970021Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:153
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000005331
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 2 2 24 11 10 11 2
Low 2 26 38 22 11 22 6 9 50 24 31 6
Below cutoff 1 6 19 19 8 19

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005331   ⟹   ENSRNOP00000005331
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX134,856,726 - 134,866,210 (-)Ensembl
RefSeq Acc Id: NM_031612   ⟹   NP_113800
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,203,821 - 127,213,312 (-)NCBI
Rnor_6.0X134,856,719 - 134,866,210 (-)NCBI
Rnor_5.0X134,929,116 - 134,938,607 (-)NCBI
RGSC_v3.4X134,387,285 - 134,396,762 (-)RGD
CeleraX126,154,452 - 126,163,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039100000   ⟹   XP_038955928
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X127,180,801 - 127,213,567 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_113800   ⟸   NM_031612
- Peptide Label: preproprotein
- UniProtKB: Q9R0R3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005331   ⟸   ENSRNOT00000005331
RefSeq Acc Id: XP_038955928   ⟸   XM_039100000
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13702008
Promoter ID:EPDNEW_R12532
Type:single initiation site
Name:Apln_1
Description:apelin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X134,866,220 - 134,866,280EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620672 AgrOrtholog
Ensembl Genes ENSRNOG00000003984 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005331 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005331 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7099981 IMAGE-MGC_LOAD
InterPro Apelin UniProtKB/Swiss-Prot
KEGG Report rno:58812 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91630 IMAGE-MGC_LOAD
NCBI Gene 58812 ENTREZGENE
PANTHER PTHR15953 UniProtKB/Swiss-Prot
Pfam Apelin UniProtKB/Swiss-Prot
PhenoGen Apln PhenoGen
UniProt APEL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-27 Apln  apelin  Apln  apelin, AGTRL1 ligand  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Apln  apelin, AGTRL1 ligand  Apel  apelin  Symbol and Name updated 1299863 APPROVED
2002-08-07 Apel        Symbol and Name status set to provisional 70820 PROVISIONAL