Gene: Apln (apelin) Rattus norvegicus
Analyze
Symbol:
Apln
Name:
apelin
Description:
Exhibits apelin receptor binding activity and identical protein binding activity. Involved in several processes, including positive regulation of cellular metabolic process; positive regulation of peptide hormone secretion; and regulation of blood circulation. Localizes to the extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin); PARTICIPATES IN apelin signaling pathway; INTERACTS WITH (S)-colchicine; 17alpha-ethynylestradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Apel; apelin, AGTRL1 ligand; APJ endogenous ligand
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
APLN (apelin) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):
Apln (apelin) HGNC
NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Apln (apelin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
APLN (apelin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
APLN (apelin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Apln (apelin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
APLN (apelin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Mus musculus (house mouse):
Apln (apelin)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
APLN (apelin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
apln (apelin)
Alliance
DIOPT (PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 X 134,856,719 - 134,866,210 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl X 134,856,726 - 134,866,210 (-) Ensembl Rnor_5.0 X 134,929,116 - 134,938,607 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 X 134,387,285 - 134,396,762 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 X 134,460,719 - 134,470,195 (-) NCBI Celera X 126,154,452 - 126,163,943 (-) NCBI Celera Cytogenetic Map X q36 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
autistic disorder ISO RGD:1351986 8554872 ClinVar Annotator: match by term: Autistic disorder of childhood onset ClinVar PMID:21681106 , PMID:30208311 syndromic X-linked intellectual disability Lubs type ISO RGD:1351986 8554872 ClinVar Annotator: match by term: MECP2 duplication syndrome ClinVar PMID:25741868
Imported Annotations - CTD
diastolic heart failure ISO RGD:1351986 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29556499 hepatocellular carcinoma ISO RGD:1351986 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:28284560 hyperuricemia ISO RGD:1351986 11554173 CTD Direct Evidence: therapeutic CTD PMID:30710622
(+)-catechin multiple interactions ISO RGD:1351986 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of APLN mRNA CTD PMID:24763279 (R)-lipoic acid multiple interactions ISO RGD:1332289 6480464 AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA], AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 (R)-lipoic acid increases secretion ISO RGD:1332289 6480464 Thioctic Acid results in increased secretion of APLN protein CTD PMID:21461750 (R)-lipoic acid increases expression ISO RGD:1332289 6480464 Thioctic Acid results in increased expression of APLN mRNA CTD PMID:21461750 (S)-colchicine decreases expression EXP 6480464 Colchicine results in decreased expression of APLN mRNA CTD PMID:20624997 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of APLN mRNA CTD PMID:17557909 17beta-estradiol multiple interactions ISO RGD:1351986 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of APLN mRNA CTD PMID:30165855 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1332289 6480464 Tetrachlorodibenzodioxin affects the expression of APLN mRNA CTD PMID:26377647 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23196670 3,3',5,5'-tetrabromobisphenol A decreases expression ISO RGD:1332289 6480464 tetrabromobisphenol A results in decreased expression of APLN mRNA CTD PMID:25172293 3,3',5,5'-tetrabromobisphenol A multiple interactions ISO RGD:1351986 6480464 tetrabromobisphenol A results in increased expression of and results in increased secretion of APLN protein CTD PMID:28111160 3,3',5,5'-tetrabromobisphenol A increases expression ISO RGD:1351986 6480464 tetrabromobisphenol A results in increased expression of APLN mRNA CTD PMID:28111160 4-hydroxyphenyl retinamide increases expression ISO RGD:1332289 6480464 Fenretinide results in increased expression of APLN mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of APLN mRNA CTD PMID:24780913 , PMID:25825206 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1332289 6480464 APLN protein modified form inhibits the reaction [Uric Acid results in decreased activity of CAT protein] more ... CTD PMID:30710622 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of APLN mRNA CTD PMID:28959563 AICA ribonucleotide multiple interactions ISO RGD:1332289 6480464 AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA], AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of APLN mRNA CTD PMID:16483693 benzo[a]pyrene increases expression ISO RGD:1332289 6480464 Benzo(a)pyrene results in increased expression of APLN mRNA CTD PMID:22610609 benzo[b]fluoranthene decreases expression ISO RGD:1332289 6480464 benzo(b)fluoranthene results in decreased expression of APLN mRNA CTD PMID:26377693 Benzo[ghi]perylene increases expression ISO RGD:1332289 6480464 1, 12-benzoperylene results in increased expression of APLN mRNA CTD PMID:26377693 beta-naphthoflavone multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of APLN mRNA CTD PMID:18164116 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of APLN mRNA CTD PMID:18180321 bisphenol A multiple interactions ISO RGD:1351986 6480464 2-chloro-5-nitrobenzanilide inhibits the reaction [bisphenol A results in increased expression of APLN mRNA] more ... CTD PMID:28111160 bisphenol A increases expression ISO RGD:1351986 6480464 bisphenol A results in increased expression of APLN mRNA CTD PMID:27685785 , PMID:28111160 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of APLN mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1332289 6480464 bisphenol A results in decreased expression of APLN mRNA CTD PMID:26063408 BQ 123 multiple interactions ISO RGD:1332289 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of APLN mRNA] CTD PMID:25203536 cadmium dichloride decreases expression ISO RGD:1332289 6480464 Cadmium Chloride results in decreased expression of APLN mRNA CTD PMID:24982889 carbon nanotube decreases expression ISO RGD:1332289 6480464 Nanotubes, Carbon analog results in decreased expression of APLN mRNA, Nanotubes, Carbon results in decreased expression of APLN mRNA CTD PMID:25554681 chloroprene decreases expression ISO RGD:1332289 6480464 Chloroprene results in decreased expression of APLN mRNA CTD PMID:23125180 clobetasol decreases expression ISO RGD:1332289 6480464 Clobetasol results in decreased expression of APLN mRNA CTD PMID:27462272 cobalt dichloride affects secretion ISO RGD:1332289 6480464 cobaltous chloride affects the secretion of APLN protein CTD PMID:17878221 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of APLN mRNA CTD PMID:24386269 cobalt dichloride decreases expression ISO RGD:1351986 6480464 cobaltous chloride results in decreased expression of APLN mRNA CTD PMID:19320972 cobalt dichloride multiple interactions ISO RGD:1332289 6480464 HIF1A gene mutant form inhibits the reaction [cobaltous chloride affects the secretion of APLN protein] CTD PMID:17878221 cobalt dichloride increases expression ISO RGD:1332289 6480464 cobaltous chloride results in increased expression of APLN mRNA, cobaltous chloride results in increased expression of APLN protein CTD PMID:17878221 cypermethrin increases expression ISO RGD:1332289 6480464 cypermethrin results in increased expression of APLN mRNA CTD PMID:29020013 decabromodiphenyl ether increases expression EXP 6480464 decabromobiphenyl ether results in increased expression of APLN mRNA CTD PMID:23640034 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of APLN mRNA CTD PMID:20032058 dexamethasone decreases expression ISO RGD:1351986 6480464 Dexamethasone results in decreased expression of APLN mRNA CTD PMID:19853017 dexamethasone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of APLN mRNA] CTD PMID:20032058 dextran sulfate multiple interactions ISO RGD:1332289 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APLN mRNA CTD PMID:29950665 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of APLN mRNA CTD PMID:24893172 dibutyl phthalate decreases expression ISO RGD:1332289 6480464 Dibutyl Phthalate results in decreased expression of APLN mRNA CTD PMID:17361019 , PMID:21266533 dioxygen increases expression ISO RGD:1332289 6480464 Oxygen deficiency results in increased expression of APLN mRNA more ... CTD PMID:17878221 , PMID:25203536 dioxygen increases expression ISO RGD:1351986 6480464 Oxygen deficiency results in increased expression of APLN mRNA CTD PMID:24236059 dioxygen increases secretion ISO RGD:1332289 6480464 Oxygen deficiency results in increased secretion of APLN protein CTD PMID:17878221 dioxygen multiple interactions ISO RGD:1332289 6480464 cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [Oxygen results in increased expression of APLN mRNA] more ... CTD PMID:17878221 , PMID:25203536 ethanol increases expression ISO RGD:1332289 6480464 Ethanol results in increased expression of APLN mRNA CTD PMID:30319688 fluoranthene multiple interactions ISO RGD:1332289 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of APLN mRNA CTD PMID:28329830 fructose multiple interactions EXP 6480464 APLN protein modified form inhibits the reaction [Fructose results in decreased activity of CAT protein] more ... CTD PMID:30710622 isoprenaline multiple interactions EXP 6480464 Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN mRNA], Plant Extracts inhibits the reaction [Isoproterenol results in decreased expression of APLN protein] CTD PMID:19960946 isoprenaline decreases expression EXP 6480464 Isoproterenol results in decreased expression of APLN mRNA, Isoproterenol results in decreased expression of APLN protein CTD PMID:19960946 lipoic acid multiple interactions ISO RGD:1332289 6480464 AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased expression of APLN mRNA], AICA ribonucleotide inhibits the reaction [Thioctic Acid results in increased secretion of APLN protein] CTD PMID:21461750 lipoic acid increases secretion ISO RGD:1332289 6480464 Thioctic Acid results in increased secretion of APLN protein CTD PMID:21461750 lipoic acid increases expression ISO RGD:1332289 6480464 Thioctic Acid results in increased expression of APLN mRNA CTD PMID:21461750 LY294002 increases expression ISO RGD:1332289 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of APLN mRNA CTD PMID:21461750 LY294002 multiple interactions ISO RGD:1332289 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Eicosapentaenoic Acid results in increased expression of APLN mRNA] CTD PMID:20352620 LY294002 increases secretion ISO RGD:1332289 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased secretion of APLN protein CTD PMID:21461750 methotrexate decreases expression ISO RGD:1351986 6480464 Methotrexate results in decreased expression of APLN mRNA CTD PMID:17400583 methylmercury chloride increases expression ISO RGD:1351986 6480464 methylmercuric chloride results in increased expression of APLN mRNA CTD PMID:28001369 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of APLN mRNA CTD PMID:18164116 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of APLN mRNA CTD PMID:19041683 nickel atom decreases expression ISO RGD:1332289 6480464 Nickel results in decreased expression of APLN mRNA CTD PMID:12540486 nickel dichloride affects expression EXP 6480464 nickel chloride affects the expression of APLN mRNA CTD PMID:22110744 nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of APLN mRNA, nitrofen results in decreased expression of APLN protein CTD PMID:24363088 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of APLN mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of APLN mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:1332289 6480464 Acetaminophen affects the expression of APLN mRNA CTD PMID:17562736 pentane-2,3-dione increases expression EXP 6480464 2, 3-pentanedione results in increased expression of APLN mRNA CTD PMID:25710175 pirinixic acid decreases expression ISO RGD:1332289 6480464 pirinixic acid results in decreased expression of APLN mRNA CTD PMID:17950772 pirinixic acid increases expression ISO RGD:1332289 6480464 pirinixic acid results in increased expression of APLN mRNA CTD PMID:20813756 quercetin affects expression EXP 6480464 Quercetin affects the expression of APLN mRNA CTD PMID:18178720 resveratrol increases expression ISO RGD:1332289 6480464 resveratrol metabolite results in increased expression of APLN mRNA, resveratrol results in increased expression of APLN mRNA CTD PMID:23717508 rotenone multiple interactions ISO RGD:1332289 6480464 Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of APLN mRNA], Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of APLN protein] CTD PMID:17878221 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of APLN mRNA CTD PMID:28374803 silicon dioxide increases expression ISO RGD:1351986 6480464 Silicon Dioxide analog results in increased expression of APLN mRNA CTD PMID:25895662 silver atom decreases expression ISO RGD:1332289 6480464 Silver results in decreased expression of APLN mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1332289 6480464 Silver results in decreased expression of APLN mRNA CTD PMID:27131904 Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of APLN mRNA CTD PMID:21515302 testosterone multiple interactions EXP 6480464 Testosterone inhibits the reaction [Dexamethasone results in decreased expression of APLN mRNA] CTD PMID:20032058 Tetrachlorobisphenol A multiple interactions ISO RGD:1351986 6480464 tetrachlorodian results in increased expression of and results in increased secretion of APLN protein CTD PMID:28111160 Tetrachlorobisphenol A increases expression ISO RGD:1351986 6480464 tetrachlorodian results in increased expression of APLN mRNA CTD PMID:28111160 thalidomide decreases expression ISO RGD:1332289 6480464 Thalidomide results in decreased expression of APLN mRNA CTD PMID:26217789 titanium dioxide decreases expression ISO RGD:1332289 6480464 titanium dioxide results in decreased expression of APLN mRNA CTD PMID:23557971 , PMID:27760801 titanium dioxide multiple interactions ISO RGD:1332289 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of APLN mRNA CTD PMID:29950665 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of APLN mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of APLN mRNA CTD PMID:25729387 triclosan increases expression ISO RGD:1351986 6480464 Triclosan results in increased expression of APLN mRNA CTD PMID:30510588 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1351986 6480464 tris(2-butoxyethyl) phosphate affects the expression of APLN mRNA CTD PMID:29024780 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of APLN mRNA CTD PMID:21515302 valproic acid increases expression ISO RGD:1351986 6480464 Valproic Acid results in increased expression of APLN mRNA CTD PMID:28001369 vincaleukoblastine decreases expression EXP 6480464 Vinblastine results in decreased expression of APLN mRNA CTD PMID:20624997 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of APLN mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of APLN mRNA CTD PMID:22570695 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of APLN mRNA CTD PMID:20624997 zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of APLN mRNA CTD PMID:17557909
Gene-Chemical Interaction Annotations
