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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:treprostinil
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Accession:CHEBI:50861 term browser browse the term
Definition:A carbotricyclic compound that has formula C23H34O5.
Synonyms:exact_synonym: ({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
 related_synonym: Formula=C23H34O5;   InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1;   InChIKey=PAJMKGZZBBTTOY-ZFORQUDYSA-N;   SMILES=[H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])Cc1cccc(OCC(O)=O)c1C2;   treprostinilo;   treprostinilum
 xref: CAS:81846-19-7;   DrugBank:DB00374;   Drug_Central:2720;   KEGG:D06213
 xref_mesh: MESH:C427248


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treprostinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Id1 inhibitor of DNA binding 1 increases expression
multiple interactions		 ISO
EXP		 treprostinil results in increased expression of ID1 protein
treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]		 CTD PMID:20522807 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19825
      application 19667
        pharmaceutical 19507
          drug 19507
            cardiovascular drug 8641
              treprostinil 1
                treprostinil sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19797
                    p-block element atom 19797
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            heteroorganic entity 19492
                              organochalcogen compound 19254
                                organooxygen compound 19170
                                  carbon oxoacid 18637
                                    carboxylic acid 18634
                                      treprostinil 1
                                        treprostinil sodium 0
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