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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:treprostinil
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Accession:CHEBI:50861 term browser browse the term
Definition:A carbotricyclic compound that has formula C23H34O5.
Synonyms:exact_synonym: ({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
 related_synonym: Formula=C23H34O5;   InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1;   InChIKey=PAJMKGZZBBTTOY-ZFORQUDYSA-N;   SMILES=[H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])Cc1cccc(OCC(O)=O)c1C2;   treprostinilo;   treprostinilum
 xref: CAS:81846-19-7;   DrugBank:DB00374;   Drug_Central:2720;   KEGG:D06213
 xref_mesh: MESH:C427248


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treprostinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Id1 inhibitor of DNA binding 1, HLH protein increases expression
multiple interactions
ISO
EXP
treprostinil results in increased expression of ID1 protein
treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]
CTD PMID:20522807 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pharmaceutical 19289
          drug 19289
            cardiovascular drug 7664
              treprostinil 1
                treprostinil sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            organic group 18593
                              organic divalent group 18584
                                organodiyl group 18584
                                  carbonyl group 18499
                                    carbonyl compound 18499
                                      carboxylic acid 18151
                                        treprostinil 1
                                          treprostinil sodium 0
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