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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:treprostinil
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Accession:CHEBI:50861 term browser browse the term
Definition:A carbotricyclic compound that has formula C23H34O5.
Synonyms:exact_synonym: ({(1R,2R,3aS,9aS)-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl}oxy)acetic acid
 related_synonym: Formula=C23H34O5;   InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1;   InChIKey=PAJMKGZZBBTTOY-ZFORQUDYSA-N;   SMILES=[H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])Cc1cccc(OCC(O)=O)c1C2;   treprostinilo;   treprostinilum
 xref: CAS:81846-19-7;   DrugBank:DB00374;   Drug_Central:2720;   KEGG:D06213
 xref_mesh: MESH:C427248


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treprostinil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Id1 inhibitor of DNA binding 1 increases expression
multiple interactions		 ISO
EXP		 treprostinil results in increased expression of ID1 protein
treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]		 CTD PMID:20522807 NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19751
    role 19724
      application 19557
        pharmaceutical 19440
          drug 19440
            cardiovascular drug 8488
              treprostinil 1
                treprostinil sodium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19751
    subatomic particle 19749
      composite particle 19749
        hadron 19749
          baryon 19749
            nucleon 19749
              atomic nucleus 19749
                atom 19749
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19644
                        carbon atom 19640
                          organic molecular entity 19640
                            organic group 18846
                              organic divalent group 18832
                                organodiyl group 18832
                                  carbonyl group 18799
                                    carbonyl compound 18799
                                      carboxylic acid 18515
                                        treprostinil 1
                                          treprostinil sodium 0
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