Gene: Ndufs4 (NADH:ubiquinone oxidoreductase subunit S4) Rattus norvegicus
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Symbol: Ndufs4
Name: NADH:ubiquinone oxidoreductase subunit S4
Description: Predicted to have NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in several processes, including mitochondrial respiratory chain complex I assembly; positive regulation of fibroblast proliferation; and response to cAMP. Predicted to localize to the mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leigh disease and mitochondrial complex I deficiency. Orthologous to human NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH (RS)-amphetamine; 2,2,2-tetramine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aqdq; CI-18 kDa; complex I-18 kDa; NADH dehydrogenase (ubiquinone) Fe-S protein 4; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit
Orthologs:
Homo sapiens (human) : NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4)  HGNC  Alliance
Mus musculus (house mouse) : Ndufs4 (NADH:ubiquinone oxidoreductase core subunit S4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ndufs4 (NADH:ubiquinone oxidoreductase subunit S4)
Pan paniscus (bonobo/pygmy chimpanzee) : NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4)
Canis lupus familiaris (dog) : NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ndufs4 (NADH:ubiquinone oxidoreductase subunit S4)
Sus scrofa (pig) : NDUFS4 (NADH:ubiquinone oxidoreductase subunit S4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0246,372,488 - 46,476,162 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0265,403,197 - 65,515,243 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4245,839,236 - 46,479,619 (-)NCBIRGSC3.4rn4RGSC3.4
Celera241,712,356 - 41,822,320 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ndufs4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1594380
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.