C6 (complement C6) - Rat Genome Database

Name: C6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: C6 (complement C6) Rattus norvegicus

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Symbol:

Name:

complement C6

RGD ID:

2238

Description:

Involved in positive regulation of apoptotic process. Located in extracellular space. Used to study end stage renal disease; glomerulonephritis; and proteinuria. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6); PARTICIPATES IN coagulation cascade pathway; complement system pathway; prion disease pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

complement component 6; complement component C6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C6 (complement C6)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	C6 (complement component 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C6 (complement C6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KLF2 (KLF transcription factor 2)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	C6 (complement C6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	C6 (complement component 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	c6 (complement component 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	c6.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,573,596 - 55,648,857 (+)	NCBI		GRCr8
mRatBN7.2	2	53,846,028 - 53,921,279 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,851,985 - 53,921,275 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	60,958,141 - 61,035,012 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	59,016,847 - 59,093,705 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	54,022,072 - 54,097,285 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	54,460,333 - 54,533,801 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,466,280 - 54,533,797 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	73,494,910 - 73,562,334 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	53,691,290 - 53,764,539 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	53,619,522 - 53,692,772 (+)	NCBI
Celera	2	49,510,682 - 49,574,053 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alcoholic Liver Diseases (IAGP)

C6 Deficiency, Subtotal (ISO)

calcinosis (ISO)

complement component 6 deficiency (ISO)

complement deficiency (ISO)

end stage renal disease (IAGP)

Experimental Autoimmune Encephalomyelitis (IAGP)

Experimental Autoimmune Myasthenia Gravis (IAGP)

genetic disease (ISO)

glomerulonephritis (IAGP)

heart valve disease (ISO)

Neurodevelopmental Disorders (ISO)

proteinuria (IDA)

Sepsis (IAGP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,6-dinitrotoluene (EXP)

2-acetamidofluorene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aconitine (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphibole asbestos (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buspirone (EXP)

C60 fullerene (EXP)

carbon nanotube (ISO)

cefaloridine (EXP)

chlorendic acid (EXP)

chlorohydrocarbon (EXP)

chlorpromazine (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dichloroacetic acid (ISO)

diethyl maleate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

fulvestrant (ISO)

genistein (ISO)

indometacin (ISO)

leflunomide (EXP)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (EXP)

methimazole (EXP)

methylmercury chloride (EXP)

monuron (EXP)

N-nitrosodiethylamine (EXP,ISO)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

olanzapine (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propanal (ISO)

propiconazole (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (ISO)

sulfasalazine (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

complement activation (IBA,ISO)

complement activation, classical pathway (IEA)

in utero embryonic development (IEA,ISO)

innate immune response (IEA)

killing of cells of another organism (IEA)

positive regulation of activation of membrane attack complex (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of apoptotic process (IMP)

positive regulation of complement activation (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IDA)

membrane attack complex (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

prion disease pathway (IEA)

systemic lupus erythematosus pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased susceptibility to experimental autoimmune myasthenia gravis (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats.	Baker PJ, etal., Am J Pathol. 1989 Jul;135(1):185-94.
2.	Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat.	Brauer RB, etal., J Immunol. 1994 Oct 1;153(7):3168-76.
3.	Inhibition of C5 or absence of C6 protects from sepsis mortality.	Buras JA, etal., Immunobiology. 2004;209(8):629-35.
4.	Protective function of complement against alcohol-induced rat liver damage.	Bykov IL, etal., Int Immunopharmacol. 2004 Nov;4(12):1445-54.
5.	Complement membrane attack is required for endplate damage and clinical disease in passive experimental myasthenia gravis in Lewis rats.	Chamberlain-Banoub J, etal., Clin Exp Immunol. 2006 Nov;146(2):278-86.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis.	Hughes J, etal., Am J Physiol Renal Physiol. 2000 May;278(5):F747-57.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection.	Nakashima S, etal., J Immunol 2002 Oct 15;169(8):4620-7.
10.	C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys.	Nangaku M, etal., J Am Soc Nephrol. 2002 Apr;13(4):928-36.
11.	The membrane attack complex of complement induces caspase activation and apoptosis.	Nauta AJ, etal., Eur J Immunol 2002 Mar;32(3):783-92.
12.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords.	Tran GT, etal., J Immunol 2002 May 1;168(9):4293-300.

Additional References at PubMed

PMID:9688553	PMID:15568620	PMID:15611275	PMID:17579035	PMID:18178252	PMID:18668646	PMID:18947875	PMID:19833392	PMID:21575686	PMID:22832194	PMID:23533145	PMID:25011063

Genomics

Comparative Map Data

C6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	55,573,596 - 55,648,857 (+)	NCBI		GRCr8
mRatBN7.2	2	53,846,028 - 53,921,279 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	53,851,985 - 53,921,275 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	60,958,141 - 61,035,012 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	59,016,847 - 59,093,705 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	54,022,072 - 54,097,285 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	54,460,333 - 54,533,801 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	54,466,280 - 54,533,797 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	73,494,910 - 73,562,334 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	53,691,290 - 53,764,539 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	53,619,522 - 53,692,772 (+)	NCBI
Celera	2	49,510,682 - 49,574,053 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

C6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	41,142,116 - 41,261,469 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	41,142,116 - 41,261,438 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	41,142,218 - 41,261,571 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	41,178,093 - 41,249,369 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	41,178,092 - 41,249,369	NCBI
Celera	5	41,030,916 - 41,150,111 (-)	NCBI		Celera
Cytogenetic Map	5	p13.1	NCBI
HuRef	5	41,094,469 - 41,213,870 (-)	NCBI		HuRef
CHM1_1	5	41,144,249 - 41,263,574 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	41,398,594 - 41,517,945 (-)	NCBI		T2T-CHM13v2.0

C6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	4,756,550 - 4,833,527 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	4,756,657 - 4,844,449 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	4,727,067 - 4,804,045 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	4,727,175 - 4,814,967 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	4,677,210 - 4,754,045 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	4,677,212 - 4,754,044 (+)	NCBI		MGSCv36	mm8
Celera	15	4,580,241 - 4,656,631 (+)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	1.97	NCBI

C6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	69,076,007 - 69,197,128 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	67,229,638 - 67,350,759 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	69,174,411 - 69,245,801 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	74,171,926 - 74,288,590 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	74,216,244 - 74,288,588 (+)	Ensembl	panpan1.1		panPan2

C6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	68,223,626 - 68,318,773 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	68,253,255 - 68,318,252 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	67,906,727 - 68,001,886 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	68,735,676 - 68,831,218 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	68,735,478 - 68,831,020 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	68,496,658 - 68,591,527 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	68,608,273 - 68,703,504 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	69,147,692 - 69,242,660 (+)	NCBI		UU_Cfam_GSD_1.0

C6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	229,837,753 - 229,916,130 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	1,471,355 - 1,532,439 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	1,471,116 - 1,532,733 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	26,020,628 - 26,084,652 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	26,023,646 - 26,089,518 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	27,211,345 - 27,261,841 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	39,912,385 - 40,033,338 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	39,912,155 - 39,983,634 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	30,341,029 - 30,411,917 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	13,775,358 - 13,842,648 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	13,775,339 - 13,842,415 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in C6
590 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	74
Count of miRNA genes:	68
Interacting mature miRNAs:	71
Transcripts:	ENSRNOT00000033112
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755430	Coatc6	Coat color QTL 6		0.02576	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	11591100	56591100	Rat
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	43162366	148478373	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	35023117	80023117	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
10755434	Coatc7	Coat color QTL 7		0.04794	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	30648065	75648065	Rat
2293676	Bmd19	Bone mineral density QTL 19	10.7	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	2	43162366	111362592	Rat
2293682	Bmd24	Bone mineral density QTL 24	8.9	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	43162366	111362592	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	20304672	65304672	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	203928301	Rat
738012	Anxrr3	Anxiety related response QTL 3	3.8		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	2	9023519	54023519	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	25413423	143657569	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43154682	202446871	Rat
10402051	Gdil2	Gastrointestinal dilation QTL 2			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	24903853	74786777	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	27157160	72157160	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	40067944	102785628	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	43171017	83575226	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	42804607	60653831	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	157142209	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	5873687	102844969	Rat
2300168	Bmd47	Bone mineral density QTL 47	6.6	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	2	20662448	65662448	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46123260	202447032	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	25413423	157142209	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	81754745	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	42804607	182042367	Rat
1357990	Ael1	Aortic elastin QTL 1	3.1	0.00091	aorta elastin amount (VT:0003905)	aortic elastin	2	19076825	64076825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	25413652	157142078	Rat
12879863	Bp402	Blood pressure QTL 402		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	41125789	56532139	Rat
1354592	Rf50	Renal function QTL 50	3.5		urine output (VT:0003620)	timed urine volume (CMO:0000260)	2	53822747	74786777	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42804607	202447032	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	26917817	136917119	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	25413423	157142209	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	16491740	61491740	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	35134841	88029593	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	43171017	184114403	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	26917817	127469484	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	39	91	91	90	59	25	59	6	208	87	71	45	58	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_176074	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760747	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY230250	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000033112 ⟹ ENSRNOP00000029891

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	53,851,985 - 53,921,275 (+)	Ensembl
Rnor_6.0 Ensembl	2	54,466,280 - 54,533,797 (+)	Ensembl

RefSeq Acc Id:

NM_176074 ⟹ NP_788263

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	55,573,633 - 55,648,857 (+)	NCBI
mRatBN7.2	2	53,846,051 - 53,921,279 (+)	NCBI
Rnor_6.0	2	54,466,282 - 54,533,795 (+)	NCBI
Rnor_5.0	2	73,494,910 - 73,562,334 (+)	NCBI
RGSC_v3.4	2	53,691,290 - 53,764,539 (+)	RGD
Celera	2	49,510,682 - 49,574,053 (+)	RGD

Sequence:

show sequence

GCATGACCAGACATCTCACCTTGTGTTTCATTTTGCTGATCATACTGATTGACAAGAGTGAAGC
CTGTTTCTGTGACCACTACCCATGGACTCACTGGTCCAGCTGTTCTAAGTCCTGCAATTCTGGA
ACCCAGAGCAGACAGAGACAAATCGTAGTGAACGATTACTATCGGGATAACTCATGCGATCAGC
TCTGTACCAAGCAGGAGACCAGACAGTGCAACGTGGAGACATGTCCCATCAACTGTGTCCTAGG
AGACTATGGAACATGGTCAGACTGTGACCCTTGTATTAGAAAACAGGTTAAAGTTAGATCTGTT
CTGCGCCCAAGTCAGTTTGGGGGACAACCATGCACAGAGCCCCTGGTGACCTTTCAACCATGTG
TCCCATCTGAGCTCTGCAAAATTGAAGAGACTGATTGCAAGAATAAATTCCTCTGTGACAGTGG
GCGCTGTATTCCCAGCAAGTTAAAATGCAATGGAGAAAATGACTGTGGAGACAATTCAGACGAA
AGGAACTGTGGGAGGACAAAGCCAGTATGCTCACGGACATACACTCCTATCCCCAGTGTGCAGC
TGATGGGCGCTGGGTTTCATTTTCTGGCAGGAGAGCCCAGAGGAGATGTCCCTGATAACTCCTT
CACTGGAGGAATATGTAAATCCGTCAGGAGCAGCCGAACGAGTAATCCACACCGAGTTCCAGCC
AATCTGGAAAATGTCAACTTTGAGGTACAAACTATAGAAGATGACTTGAAAACAGATTTCTACA
AGGATTTAGCCACTATTGGAAAAAATAAAAATGAAGACCGTTCATTGTCTGGTGAGAAGAAAGA
CTCTTTCTACGTACCAATTTTTTATTCCTCAAAGAAAAGTGAAAATTTCCAACGTAACTCAGGC
TTCAAAAACGCCATTGAAGCCTCCCACAAGAAGGATTCGAGCTTTGTTAGGATCCATAAAGTGA
TAAAAGTCTTAAACTTCACAATGAAAACGACAGACCTGCAGCTCTCAGACGTCTTCCTAAAAGC
CCTCATCCACCTGCCTTTAGAATACAACTTTGCTTTGTACAGCCGGATATTTGATGACTTTGGG
ACCCACTATTTCACCTCAGGCTCCCTTGGGGGCAAGTATGACCTTCTCTACCAATTCAGCCGCC
AGGAGCTACAGAACTCAGGTTTAACAGAAGAAGAAACTCGAAACTGTGTCCGGTATGAAACAAA
GAAACGTTTCTTATTTTTTACGAAAACATACAAGGAAGACCGGTGTACCACAAATAGGCTGTCT
GAAAAGTACAAAGGTTCCTTTTTACAGGGATCGGAGAAATCTATATCCCTGGTCCAGGGCGGGA
GGAGTCAGCAGGCAGCAGCCTTGGCTTGGGAGAAGGGCAGCTCTGGTCCAGAGGCGAATGTCTT
CTCTGAGTGGTTAGAGTCGGTGAAGGAAAACCCTGCTGTGGTTGATTATGAGCTTGCTCCGATC
ATCGACTTGGTCAGAAACATCCCATGTGCAGTGACAAAACGGAACAACCTCAGGAAAGCCCTTC
AAGAATATGCAGCCAAGTTTGACCCTTGCCAATGTGCTCCATGTCCTAATAATGGCCGCCCCAG
GCTCTCAGGCACAGAATGTTTGTGTGTGTGCCAGAGTGGTACCTACGGTGAGAACTGTGAAAAA
CGGTCCCCAGATTATAAATCGAATGCAGTGGATGGGAACTGGGGCTGCTGGTCTTCCTGGAGCG
CATGCAATGCTGCTTATAGGAGGTCAAGGAGCCGGGAGTGTAATAACCCTGAGCCACAGCGAGG
AGGGCAGCGCTGTGAGGGCAAGCATTGGCAAGAAGAAGACTGTACATTCTCAATAATGGAAAAA
GTTGGACAACCGTGCATCAGTGATGATGAAGAAATAAAAGAAGTAGACCTTGCTGAGCCAGAAG
CAGATTCAGGGTGTCCTCAGCCACCTCTCCCAGAAAATGCATTTGTCTGGAATGAAAAGAAACT
GTACTCAGTCGGGGAGGAAGTTGAAATTTCATGTCTCACTGGATTCAAAGCTGTGGGATACCAG
TACTTCAGATGCTTACCAGACAGAACCTGGAGGCAAGGGGATGTCGAATGCCAACGGACCGAGT
GCCTCAAACCAGTCGTTCAGGATGTCCTGACCATCTCCCCATTTCAGAGTGTGTACAAGATTGG
GGAATCCATTGAGCTGACCTGTCCCAGAGGCTTTGTTGTTGCTGGCCCATCGAGGTATACATGC
AAGGGAGACTCCTGGACACCTCCCATTCCAAATTCACTGAGCTGTGAAAAAGATATTCTGACAA
AGTCAAAGGGCCTTTGTCAACCAGGACAAAAGCAATCAGGATCCGAGTGTGTTTGTATGTCCCC
AGAAGAAGACTGTAGCAGTTATTCGGAAGATCTCTGTATATTTGATGAGGGATCCAGTCAGTAC
TTCACTTCATCTGCTTGCAAATTTTTGGCTGAAAAATGTTTAAACAGCAACCAGTTCCACTTTG
TCCATGCTGGTTCCTGCCAAGAAGGCCCACAGTTAGAATGGGGTCTTGAGAGGCTAAAACTCGC
AATGAAGAGCACAAAGAGAGTGCCCTGTGGATATGATACTTGCTATGACTGGGAAAAATGTTCA
GCCCACACCTCCAACTGTGTCTGCCTATTGCCCCCACAATGCCCCAAGGATGAAAACCAACTCC
ACTGTGTCAAAATGGGATCATCAATGCGTGGGAAAACAGTAAACATCTGTACACTGGGAGCCGT
GAGGTGTGCAAACAGGAAGGTGGAAATACTGAATCCTGGGAGGTGCTTGGATTAGCACTGCTAG
TGATGAATGAATTTATTATTCAAAAACAACGGACAGGAAGTGAGGAAAGTGAATGGATGGGAGC
AAAGTATGATAACACATATCTTCAGGAATGTAATGATAAAAACCCATTACTTTGTATAATAACC
TAAACAAACTCTTTTTTAAAAAAAACTCATTATATGTAAACTAACATAGCCATAAATTGCTGGC
AAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008760747 ⟹ XP_008758969

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	55,573,596 - 55,648,857 (+)	NCBI
mRatBN7.2	2	53,846,028 - 53,921,279 (+)	NCBI
Rnor_6.0	2	54,460,333 - 54,533,801 (+)	NCBI

Sequence:

show sequence

CTTTCGGACTACACCATCTTGTGTTGCCCAGTAGTATAAAGAAGGGCTCTCTGGGAGTACCACA
CAAATTGCTTCTTAACGTGTGTGCCTTTTGTTTCTATGGCCATTCAGCTTAGGTTCCTGGACAT
AGCTAGATCGCTTTAAAGGCCACTCTATTTCAGGGCCTGGGAAAAGGTCCTGTGGAAGCATGAC
CAGACATCTCCCCTTGTGTTTCATTTTGCTGATCATACTGATTGACAAGAGTGAAGCCTGTTTC
TGTGACCACTACCCATGGACTCACTGGTCCAGCTGTTCTAAGTCCTGCAATTCTGGAACCCAGA
GCAGACAGAGACAAATCGTAGTGAACGATTACTATCGGGATAACTCATGCGATCAGCTCTGTAC
CAAGCAGGAGACCAGACAGTGCAACGTGGAGACATGTCCCATCAACTGTGTCCTAGGAGACTAT
GGAACATGGTCAGACTGTGACCCTTGTATTAGAAAACAGGTTAAAGTTAGATCTGTTCTGCGCC
CAAGTCAGTTTGGGGGACAACCATGCACAGAGCCCCTGGTGACCTTTCAACCATGTGTCCCATC
TGAGCTCTGCAAAATTGAAGAGACTGATTGCAAGAATAAATTCCTCTGTGACAGTGGGCGCTGT
ATTCCCAGCAAGTTAGAATGCAATGGAGAAAATGACTGTGGAGACAATTCAGACGAAAGGAACT
GTGGGAGGACAAAGCCAGTATGCTCACGGACATACACTCCTATCCCCAGTGTGCAGCTGATGGG
CGCTGGGTTTCATTTCTGGCAGGAGAGCCCAGAGGAGATGCCTTGAAATCCTTCACTGGAGGAA
TATGTAAATCCGTCAGGAGCAGCCGAACGAGTAATCCACACCGAGTTCCAGCCAATCTGGAAAA
TGTCAACTTTGAGGTACAAACTATAGAAGATGACTTGAAAACAGATTTCTACAAGGATTTAGCC
ACTATTGGAAAAAATAAAAATGAAGACCGTTCATTGTCTGGTGAGAAGAAAGACTCTTTCTACG
TACCAATTTTTTATTCCTCAAAGAAAAGTGAAAATTTCCAACGTAACTCAGGCTTCAAAAACGC
CATTGAAGCCTCCCACAAGAAGGATTCGAGCTTTGTTAGGATCCATAAAGTGATAAAAGTCTTA
AACTTCACAATGAAAACGACAGACCTGCAGCTTTCAGACGTCTTCCTAAAAGCCCTCATCCACC
TGCCTTTAGAATACAACTTTGCTTTGTACAGCCGGATATTTGATGACTTTGGGACCCACTATTT
CACCTCAGGCTCCCTTGGGGGCAAGTATGACCTTCTCTACCAATTCAGCCGCCAGGAGCTACAG
AACTCAGGTTTAACAGAAGAAGAAACTCGAAACTGTGTCCGGTATGAAACAAAGAAACGTTTCT
TATTTTTTACGAAAACATACAAGGAAGACCGGTGTACCACAAATAGGCTGTCTGAAAAGTACAA
AGGTTCCTTTTTACAGGGATCAGAGAAATCTATATCCCTGGTCCAGGGCGGGAGGAGTCAGCAG
GCAGCAGCCTTGGCTTGGGAGAAGGGCAGCTCTGGTCCAGAGGCGAATGTCTTCTCTGAGTGGT
TAGAGTCGGTGAAGGAAAACCCTGCTGTGGTTGATTATGAGCTTGCTCCAATCATCGACTTGGT
CAGAAACATCCCATGTGCAGTGACAAAACGGAACAACCTCAGGAAAGCCCTTCAAGAATATGCA
GCCAAGTTTGACCCTTGCCAATGTGCTCCATGTCCTAATAATGGCCGCCCCAGGCTCTCAGGCA
CAGAATGTTTGTGTGTGTGCCAGAGTGGTACCTACGGTGAGAACTGTGAAAAACGGTCCCCAGA
TTATAAATCGAATGCAGTGGATGGGAACTGGGGCTGCTGGTCTTCCTGGAGCGCATGCAATGCT
GCTTATAGGAGGTCAAGGAGCCGGGAGTGTAATAACCCTGAGCCACAGCGAGGAGGGCAGCGCT
GTGAGGGCAAGCATTGGCAAGAAGAAGACTGTACATTCTCAATAATGGAAAAAGTTGGACAACC
GTGCATCAGTGATGATGAAGAAATAAAAGAAGTAGACCTTGCTGAGCCAGAAGCAGATTCAGGG
TGTCCTCAGCCACCTCTCCCAGAAAATGCATTTGTCTGGAATGAAAAGAAACTGTACTCAGTCG
GGGAGGAAGTTGAAATTTCATGTCTCACTGGATTCAAGAGCCTGTGGATACCAGTACTCAGATG
CTTACCAGCAGAACCTGGAGGGCAAGGGGATGTCGAATGCCAACGGACCGAGTGCCTCAAACCA
GTCGTTCAGGATGTCCTGACCATCTCCCCATTTCAGAGTGTGTACAAGATTGGGGAATCCATTG
AGCTGACCTGTCCCAGAGGCTTTGTTGTTGCTGGCCCATCGAGGTATACATGCAAGGGAGACTC
CTGGACACCTCCCATTCCAAATTCACTGAGCTGTGAAAAAGATATTCTGACAAAGTCAAAGGGC
CTTTGTCAACCAGGACAAAAGCAATCAGGATCCGAGTGTGTTTGTATGTCCCCAGAAGAAGACT
GTAGCAGTTATTCGGAAGATCTCTGTATATTTGATGAGGGATCCAGTCAGTACTTCACTTCATC
TGCTTGCAAATTTTTGGCTGAAAAATGTTTAAACAGCAACCAGTTCCACTTTGTCCATGCTGGT
TCCTGCCAAGAAGGCCCACAGTTAGAATGGGGTCTTGAGAGGCTAAAACTCGCAATGAAGAGCA
CAAAGAGAGTGCCCTGTGGATATGATACCTGCTATGACTGGGAAAAATGTTCAGCCCACACCTC
CAACTGTGTCTGCCTATTGCCCCCACAATGCCCCAAGGATGAAAACCAACTCCACTGTGTCAAA
ATGGGATCATCAATGCGTGGGAAAACAGTAAACATCTGTACACTGGGAGCCGTGAGGTGTGCAA
ACAGGAAGGTGGAAATACTGAATCCTGGGAGGTGCTTGGATTAGCACTGCTAGTGATGAATGAA
TTTATTATTCAAAAACAACGGACAGGAAGTGAGGAAAGTGAATGGATGGGAGCAAAGTATGATA
ACACATATCTTCAGGAATGTAATGATAAAAACCCATTACTTTGTATAATAACCTAAACAAACTC
TTTTTTAAAAAAAACTCATTATATGTAAACTAACATAGCCATAAATTGCTGACAGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_788263	(Get FASTA)	NCBI Sequence Viewer
	XP_008758969	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO40768	(Get FASTA)	NCBI Sequence Viewer
	EDL75735	(Get FASTA)	NCBI Sequence Viewer
	EDL75736	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000029891.5
GenBank Protein	Q811M5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_788263 ⟸ NM_176074
- Peptide Label:	precursor
- UniProtKB:	Q811M5 (UniProtKB/Swiss-Prot), F1M7F7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTRHLTLCFILLIILIDKSEACFCDHYPWTHWSSCSKSCNSGTQSRQRQIVVNDYYRDNSCDQL CTKQETRQCNVETCPINCVLGDYGTWSDCDPCIRKQVKVRSVLRPSQFGGQPCTEPLVTFQPCV PSELCKIEETDCKNKFLCDSGRCIPSKLKCNGENDCGDNSDERNCGRTKPVCSRTYTPIPSVQL MGAGFHFLAGEPRGDVPDNSFTGGICKSVRSSRTSNPHRVPANLENVNFEVQTIEDDLKTDFYK DLATIGKNKNEDRSLSGEKKDSFYVPIFYSSKKSENFQRNSGFKNAIEASHKKDSSFVRIHKVI KVLNFTMKTTDLQLSDVFLKALIHLPLEYNFALYSRIFDDFGTHYFTSGSLGGKYDLLYQFSRQ ELQNSGLTEEETRNCVRYETKKRFLFFTKTYKEDRCTTNRLSEKYKGSFLQGSEKSISLVQGGR SQQAAALAWEKGSSGPEANVFSEWLESVKENPAVVDYELAPIIDLVRNIPCAVTKRNNLRKALQ EYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCEKRSPDYKSNAVDGNWGCWSSWSA CNAAYRRSRSRECNNPEPQRGGQRCEGKHWQEEDCTFSIMEKVGQPCISDDEEIKEVDLAEPEA DSGCPQPPLPENAFVWNEKKLYSVGEEVEISCLTGFKAVGYQYFRCLPDRTWRQGDVECQRTEC LKPVVQDVLTISPFQSVYKIGESIELTCPRGFVVAGPSRYTCKGDSWTPPIPNSLSCEKDILTK SKGLCQPGQKQSGSECVCMSPEEDCSSYSEDLCIFDEGSSQYFTSSACKFLAEKCLNSNQFHFV HAGSCQEGPQLEWGLERLKLAMKSTKRVPCGYDTCYDWEKCSAHTSNCVCLLPPQCPKDENQLH CVKMGSSMRGKTVNICTLGAVRCANRKVEILNPGRCLD hide sequence

RefSeq Acc Id:	XP_008758969 ⟸ XM_008760747
- Peptide Label:	isoform X1
- UniProtKB:	Q811M5 (UniProtKB/Swiss-Prot), F1M7F7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLTDIHSYPQCAADGRWVSFLAGEPRGDALKSFTGGICKSVRSSRTSNPHRVPANLENVNFEVQ TIEDDLKTDFYKDLATIGKNKNEDRSLSGEKKDSFYVPIFYSSKKSENFQRNSGFKNAIEASHK KDSSFVRIHKVIKVLNFTMKTTDLQLSDVFLKALIHLPLEYNFALYSRIFDDFGTHYFTSGSLG GKYDLLYQFSRQELQNSGLTEEETRNCVRYETKKRFLFFTKTYKEDRCTTNRLSEKYKGSFLQG SEKSISLVQGGRSQQAAALAWEKGSSGPEANVFSEWLESVKENPAVVDYELAPIIDLVRNIPCA VTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPRLSGTECLCVCQSGTYGENCEKRSPDYKSNAV DGNWGCWSSWSACNAAYRRSRSRECNNPEPQRGGQRCEGKHWQEEDCTFSIMEKVGQPCISDDE EIKEVDLAEPEADSGCPQPPLPENAFVWNEKKLYSVGEEVEISCLTGFKSLWIPVLRCLPAEPG GQGDVECQRTECLKPVVQDVLTISPFQSVYKIGESIELTCPRGFVVAGPSRYTCKGDSWTPPIP NSLSCEKDILTKSKGLCQPGQKQSGSECVCMSPEEDCSSYSEDLCIFDEGSSQYFTSSACKFLA EKCLNSNQFHFVHAGSCQEGPQLEWGLERLKLAMKSTKRVPCGYDTCYDWEKCSAHTSNCVCLL PPQCPKDENQLHCVKMGSSMRGKTVNICTLGAVRCANRKVEILNPGRCLD hide sequence

Ensembl Acc Id:

ENSRNOP00000029891 ⟸ ENSRNOT00000033112

Protein Domains

EGF-like Kazal-like LDL-receptor class A MACPF Sushi TSP type-1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q811M5-F1-model_v2	AlphaFold	Q811M5	1-934	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2238	AgrOrtholog
BioCyc Gene	G2FUF-54187	BioCyc
Ensembl Genes	ENSRNOG00000024115	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000033112.5	UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.60.30	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C6_KAZAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C8A_B_C6_EGF-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FacI_MAC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kazal_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDrepeatLR_classA_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MAC_perforin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sushi_SCR_CCP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:24237	UniProtKB/Swiss-Prot
NCBI Gene	24237	ENTREZGENE
PANTHER	COMPLEMENT COMPONENT C6	UniProtKB/Swiss-Prot
	COMPLEMENT COMPONENT C6	UniProtKB/Swiss-Prot
	COMPLEMENT COMPONENT C6	UniProtKB/TrEMBL
	COMPLEMENT COMPONENT C6	UniProtKB/TrEMBL
Pfam	C6_KAZAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C8A_B_C6_EGF-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sushi	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	C6	PhenoGen
PRINTS	COMPLEMENTC9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/Swiss-Prot
	KAZAL_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SUSHI	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000024115	RatGTEx
SMART	CCP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FIMAC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDLa	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MACPF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF57424	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57535	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF82895	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KGC9_RAT	UniProtKB/TrEMBL
	A6KGD0_RAT	UniProtKB/TrEMBL
	CO6_RAT	UniProtKB/Swiss-Prot
	F1M7F7	ENTREZGENE, UniProtKB/TrEMBL
	Q811M5	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-18	C6	complement C6	C6	complement component 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2003-04-09	C6	complement component 6		Complement component 6	Name updated	629478	APPROVED
2002-06-10	C6	Complement component 6			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype