Aldh3a1 (aldehyde dehydrogenase 3 family, member A1) - Rat Genome Database

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Gene: Aldh3a1 (aldehyde dehydrogenase 3 family, member A1) Rattus norvegicus
Analyze
Symbol: Aldh3a1
Name: aldehyde dehydrogenase 3 family, member A1
RGD ID: 2088
Description: Enables 3-chloroallyl aldehyde dehydrogenase activity. Involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1); PARTICIPATES IN alkaptonuria pathway; cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; INTERACTS WITH 1,2,3,7,8-Pentachlorodibenzodioxin; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ahd-c; AHDC; Aldehyde dehydrogenase (Ahd-c); aldehyde dehydrogenase 3A1; aldehyde dehydrogenase class 3; aldehyde dehydrogenase family 3 member A1; aldehyde dehydrogenase family 3 subfamily A1; aldehyde dehydrogenase family 3, member A1; Aldehyde dehydrogenase family 3, subfamily A1; aldehyde dehydrogenase, dimeric NADP-preferring; Aldh; Aldh3; HTC-ALDH; tumor-associated aldehyde dehydrogenase tumor ALDH; tumor-associated aldehyde dehydrogenase, tumor ALDH
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,892,993 - 45,902,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,892,924 - 45,902,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,595,478 - 50,605,184 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01050,085,870 - 50,095,575 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01045,589,438 - 45,599,135 (+)NCBIRnor_WKY
Rnor_6.01047,490,168 - 47,499,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,265,007 - 47,274,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,365,195 - 47,374,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,378,817 - 47,388,503 (+)NCBI
Celera1045,146,398 - 45,156,083 (+)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-naphthoquinone  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,3',4,4',5-Hexachlorobiphenyl  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-hexenal  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenyl acetate  (ISO)
5-azacytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aldophosphamide  (ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzaldehyde  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
butylated hydroxyanisole  (ISO)
calciol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
cefaloridine  (EXP)
chlordecone  (ISO)
chloroethene  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
chromium atom  (ISO)
cimetidine  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
cycloheximide  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofuran  (EXP)
diethyldithiocarbamic acid  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
diuron  (EXP)
endosulfan  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexanal  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
MeIQx  (ISO)
methyl methacrylate  (ISO)
mitomycin C  (ISO)
monosodium L-glutamate  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
non-2-enal  (ISO)
O-methyleugenol  (ISO)
oct-2-enal  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorononanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
PhIP  (EXP,ISO)
picene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
puromycin  (EXP)
pyrene  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
temozolomide  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
Thiotepa  (ISO)
trichloroethene  (EXP)
urethane  (ISO)
valproic acid  (ISO)
zinc oxide  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IDA,ISO)
endoplasmic reticulum  (ISO)
membrane  (ISO)
plasma membrane  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Preliminary characterization of the rat class 3 aldehyde dehydrogenase gene. Asman DC, etal., Adv Exp Med Biol 1993;328:81-6.
2. Constitutive expression of class 3 aldehyde dehydrogenase in cultured rat corneal epithelium. Boesch JS, etal., J Biol Chem. 1996 Mar 1;271(9):5150-7.
3. The negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: involvement of a single imperfect palindromic glucocorticoid responsive element. Falkner KC, etal., Mol Pharmacol. 1999 Apr;55(4):649-57.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Aldehyde dehydrogenase activity and large vessel disease in diabetes mellitus. A preliminary study. Jerntorp P, etal., Diabetes. 1986 Mar;35(3):291-4.
7. Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase. Jones DE Jr, etal., Proc Natl Acad Sci U S A 1988 Mar;85(6):1782-6.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Persistent induction of hepatic and pulmonary phase II enzymes by 3-methylcholanthrene in rats. Kondraganti SR, etal., Toxicol Sci. 2008 Apr;102(2):337-44. Epub 2008 Jan 17.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Inhibition of cytosolic class 3 aldehyde dehydrogenase by antisense oligonucleotides in rat hepatoma cells. Muzio G, etal., Chem Biol Interact. 2001 Jan 30;130-132(1-3):219-25.
12. Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases. Muzio G, etal., Chem Biol Interact. 2003 Feb 1;143-144:37-43.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Acute-phase response to benzopyrene and induction of rat ALDH3A1. Pappas P, etal., Chem Biol Interact. 2003 Feb 1;143-144:55-62.
15. Anti-inflammatory agents and inducibility of hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):457-60.
16. Zoxazolamine-induced paralysis in two rat substrains: differences in hepatic drug metabolism. Pappas P, etal., Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):461-7.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Aldehyde dehydrogenase 3 gene regulation: studies on constitutive and hypoxia-modulated expression. Reisdorph R and Lindahl R, Chem Biol Interact. 2001 Jan 30;130-132(1-3):227-33.
20. GOA pipeline RGD automated data pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. cAMP-dependent negative regulation of rat aldehyde dehydrogenase class 3 gene expression. Xiao G, etal., J Biol Chem. 1997 Feb 7;272(6):3238-45.
25. Comparative study of alcohol metabolism in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats fed normal or low levels of dietary protein. Yang SC, etal., J Nutr Sci Vitaminol (Tokyo). 1994 Dec;40(6):547-55.
26. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
Additional References at PubMed
PMID:742739   PMID:1737758   PMID:2091023   PMID:2713359   PMID:3284529   PMID:4015840   PMID:8509394   PMID:9095201   PMID:10376761   PMID:11784860   PMID:12610736   PMID:15489334  
PMID:17530188   PMID:22664934   PMID:25286108   PMID:26674287  


Genomics

Comparative Map Data
Aldh3a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21045,892,993 - 45,902,680 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,892,924 - 45,902,681 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1050,595,478 - 50,605,184 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01050,085,870 - 50,095,575 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01045,589,438 - 45,599,135 (+)NCBIRnor_WKY
Rnor_6.01047,490,168 - 47,499,855 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01047,265,007 - 47,274,692 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41047,365,195 - 47,374,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11047,378,817 - 47,388,503 (+)NCBI
Celera1045,146,398 - 45,156,083 (+)NCBICelera
Cytogenetic Map10q22NCBI
ALDH3A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381719,737,984 - 19,748,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1719,737,984 - 19,748,943 (-)EnsemblGRCh38hg38GRCh38
GRCh371719,641,297 - 19,651,611 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361719,581,889 - 19,592,200 (-)NCBINCBI36Build 36hg18NCBI36
Build 341719,581,891 - 19,592,200NCBI
Celera1717,054,645 - 17,065,094 (-)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1719,020,080 - 19,030,532 (-)NCBIHuRef
CHM1_11719,650,159 - 19,660,608 (-)NCBICHM1_1
T2T-CHM13v2.01719,686,602 - 19,696,916 (-)NCBIT2T-CHM13v2.0
Aldh3a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391161,099,336 - 61,109,244 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1161,098,363 - 61,109,247 (+)EnsemblGRCm39 Ensembl
GRCm381161,208,510 - 61,218,418 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1161,207,537 - 61,218,421 (+)EnsemblGRCm38mm10GRCm38
MGSCv371161,022,244 - 61,031,920 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,024,940 - 61,034,609 (+)NCBIMGSCv36mm8
MGSCv361161,638,438 - 61,648,107 (+)NCBIMGSCv36mm8
Cytogenetic Map11B2NCBI
cM Map1137.96NCBI
Aldh3a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546796,140 - 105,738 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546796,140 - 105,738 (+)NCBIChiLan1.0ChiLan1.0
ALDH3A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11759,539,704 - 59,550,581 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01731,384,740 - 31,395,719 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11736,531,830 - 36,539,428 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1736,531,720 - 36,542,504 (+)Ensemblpanpan1.1panPan2
ALDH3A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1540,466,237 - 40,474,272 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl540,466,237 - 40,474,457 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,608,116 - 40,616,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0540,572,237 - 40,580,273 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl540,572,237 - 40,580,458 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1540,543,623 - 40,551,653 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0540,489,252 - 40,497,281 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,681,916 - 40,689,952 (+)NCBIUU_Cfam_GSD_1.0
Aldh3a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560260,509,720 - 60,516,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688170,951 - 77,839 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493688171,047 - 77,543 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH3A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,897,496 - 59,905,897 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11259,895,476 - 59,905,900 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21262,639,844 - 62,660,135 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH3A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11618,302,145 - 18,312,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1618,302,142 - 18,312,756 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660592,534,705 - 2,545,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Aldh3a1
45 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:118
Interacting mature miRNAs:127
Transcripts:ENSRNOT00000003182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
RH132563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21045,902,338 - 45,902,644 (+)MAPPERmRatBN7.2
Rnor_6.01047,499,514 - 47,499,819NCBIRnor6.0
Rnor_5.01047,274,351 - 47,274,656UniSTSRnor5.0
RGSC_v3.41047,374,539 - 47,374,844UniSTSRGSC3.4
Celera1045,155,742 - 45,156,047UniSTS
Cytogenetic Map10q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 5
Low 1 17 8 17 7 10 22 1 10 6 7
Below cutoff 1 8 12 8 2 8 1 1 40 20 20 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003182   ⟹   ENSRNOP00000003182
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,892,924 - 45,902,680 (+)Ensembl
Rnor_6.0 Ensembl1047,490,153 - 47,499,876 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107161   ⟹   ENSRNOP00000078369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1045,892,953 - 45,902,681 (+)Ensembl
RefSeq Acc Id: NM_031972   ⟹   NP_114178
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21045,892,993 - 45,902,680 (+)NCBI
Rnor_6.01047,490,168 - 47,499,855 (+)NCBI
Rnor_5.01047,265,007 - 47,274,692 (+)NCBI
RGSC_v3.41047,365,195 - 47,374,880 (+)RGD
Celera1045,146,398 - 45,156,083 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114178 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40713 (Get FASTA)   NCBI Sequence Viewer  
  AAA40722 (Get FASTA)   NCBI Sequence Viewer  
  AAH70924 (Get FASTA)   NCBI Sequence Viewer  
  EDM04678 (Get FASTA)   NCBI Sequence Viewer  
  P11883 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_114178   ⟸   NM_031972
- UniProtKB: P11883 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003182   ⟸   ENSRNOT00000003182
RefSeq Acc Id: ENSRNOP00000078369   ⟸   ENSRNOT00000107161
Protein Domains
Aldehyde dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11883-F1-model_v2 AlphaFold P11883 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697259
Promoter ID:EPDNEW_R7784
Type:single initiation site
Name:Aldh3a1_1
Description:aldehyde dehydrogenase 3 family, member A1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01047,490,289 - 47,490,349EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2088 AgrOrtholog
BioCyc Gene G2FUF-24823 BioCyc
Ensembl Genes ENSRNOG00000002331 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003182 ENTREZGENE
  ENSRNOP00000003182.5 UniProtKB/TrEMBL
  ENSRNOP00000078369.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003182 ENTREZGENE
  ENSRNOT00000003182.6 UniProtKB/TrEMBL
  ENSRNOT00000107161.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7096634 IMAGE-MGC_LOAD
InterPro Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_NAD(P) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25375 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91608 IMAGE-MGC_LOAD
NCBI Gene 25375 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43570 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ALDH3A1 RGD
PhenoGen Aldh3a1 PhenoGen
PIRSF ALDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC231508
UniProt A0A8I5ZKQ2_RAT UniProtKB/TrEMBL
  A0A8L2Q0S9_RAT UniProtKB/TrEMBL
  AL3A1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-12 Aldh3a1  aldehyde dehydrogenase 3 family, member A1  Aldh3a1  aldehyde dehydrogenase family 3, member A1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Aldh3a1  aldehyde dehydrogenase family 3, member A1     Aldehyde dehydrogenase family 3, subfamily A1  Name updated 629478 APPROVED
2001-06-12 Aldh3  Aldehyde dehydrogenase class 3      Symbol and Name withdrawn 62408 WITHDRAWN
2001-06-12 Aldh3a1  Aldehyde dehydrogenase family 3, subfamily A1      Symbol and Name updated to reflect Human and Mouse nomenclature 62408 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease expressed during hepatocarcinogenesis 632185
gene_function has aldehyde dehydrogenase activity in vitro 632185
gene_product member of the aldehyde dehydrogenase family 632185