Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6)

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Gene: Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6) Rattus norvegicus

Analyze

Symbol:

Hsd17b6

Name:

hydroxysteroid (17-beta) dehydrogenase 6

RGD ID:

708343

Description:

Enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in brexanolone catabolic process and retinol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6); PARTICIPATES IN steroid hormone biosynthetic pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

17-beta-HSD 6; 17-beta-HSD6; 17-beta-hydroxysteroid dehydrogenase type 6; 3-alpha->beta-HSE; 3-alpha->beta-hydroxysteroid epimerase; Hsd17b9; hydroxysteroid (17-beta) dehydrogenase 9; hydroxysteroid 17-beta dehydrogenase 6; hydroxysteroid 17-beta dehydrogenase 6-like; LOC100362350; LOC286964; MGC108559; oxidative 17 beta hydroxysteroid dehydrogenase type 6; oxidative 3-alpha hydroxysteroid dehydrogenase

RGD Orthologs

Human

Mouse

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hsd17b6 (hydroxysteroid 17-beta dehydrogenase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RDH16 (retinol dehydrogenase 16)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Hsd17b6 (hydroxysteroid (17-beta) dehydrogenase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rdh1 (retinol dehydrogenase 1)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8888	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dhs-16	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dhs-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	dhs-20	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	drd-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	422,466 - 442,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	422,480 - 442,425 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,181,210 - 3,200,875 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,057,225 - 5,076,887 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	5,355,342 - 5,375,051 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	2,412,370 - 2,431,249 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,412,363 - 2,431,197 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,633,786 - 110,642,754 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,390,308 - 2,409,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,118,183 - 1,137,670 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,270,995 - 1,274,641 (-)	NCBI
Celera	7	310,880 - 321,035 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1-nitropropane (EXP)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-diaminotoluene (EXP)

2,6-diaminotoluene (EXP)

2-acetamidofluorene (EXP)

2-nitro-p-phenylenediamine (EXP)

2-nitropropane (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4-acetylaminofluorene (EXP)

4-hydroxyphenyl retinamide (ISO)

4-nitro-1,2-phenylenediamine (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

captan (ISO)

carbon nanotube (ISO)

cetrorelix (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cocaine (EXP)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

endosulfan (EXP,ISO)

Enterolactone (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (EXP)

fipronil (ISO)

flutamide (EXP)

formaldehyde (ISO)

furan (EXP)

indometacin (ISO)

leflunomide (EXP)

lipopolysaccharide (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

mifepristone (ISO)

N,N-diethyl-m-toluamide (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

NAD zwitterion (ISO)

NAD(+) (ISO)

naphthalene (EXP)

nefazodone (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

paracetamol (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

Propiverine (EXP)

quercetin (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

tauroursodeoxycholic acid (EXP)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichostatin A (ISO)

troglitazone (ISO)

tunicamycin (ISO)

ursodeoxycholic acid (EXP)

valproic acid (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen metabolic process (TAS)

brexanolone catabolic process (ISO,ISS)

retinol metabolic process (IBA)

steroid metabolic process (IBA)

Cellular Component

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IBA)

membrane (IEA)

Molecular Function

17-beta-hydroxysteroid dehydrogenase (NAD+) activity (IEA)

5alpha-androstane-3beta,17beta-diol dehydrogenase activity (ISO,ISS)

androstan-3-alpha,17-beta-diol dehydrogenase activity (IDA,ISO)

androsterone dehydrogenase activity (IDA,ISO)

estradiol 17-beta-dehydrogenase [NAD(P)] activity (IDA,ISO)

NAD-retinol dehydrogenase activity (IBA,ISO)

oxidoreductase activity (IEA)

testosterone 17-beta-dehydrogenase (NADP+) activity (ISO)

testosterone dehydrogenase (NAD+) activity (IDA,ISO,TAS)

Molecular Pathway Annotations Click to see Annotation Detail View

steroid hormone biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate.	Biswas MG and Russell DW, J Biol Chem 1997 Jun 20;272(25):15959-66.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Hsd17b6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	422,466 - 442,008 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	422,480 - 442,425 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,181,210 - 3,200,875 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,057,225 - 5,076,887 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	7	5,355,342 - 5,375,051 (-)	NCBI	Rnor_WKY
Rnor_6.0	7	2,412,370 - 2,431,249 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,412,363 - 2,431,197 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	110,633,786 - 110,642,754 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,390,308 - 2,409,187 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,118,183 - 1,137,670 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,270,995 - 1,274,641 (-)	NCBI
Celera	7	310,880 - 321,035 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

HSD17B6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,763,324 - 56,787,790 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	56,752,161 - 56,787,790 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	57,157,108 - 57,181,574 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,443,375 - 55,467,841 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	56,811,056 - 56,835,545 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,196,177 - 54,220,440 (+)	NCBI		HuRef
CHM1_1	12	57,124,709 - 57,149,178 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,731,256 - 56,755,674 (+)	NCBI		T2T-CHM13v2.0

Hsd17b6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,826,800 - 127,843,517 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	127,826,805 - 127,843,480 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	127,990,931 - 128,007,648 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,990,936 - 128,007,611 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	127,427,992 - 127,444,564 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,393,885 - 127,410,457 (-)	NCBI		MGSCv36	mm8
Celera	10	130,386,654 - 130,402,718 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI

HSD17B6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	32,371,489 - 32,409,079 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	32,371,489 - 32,408,860 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	32,117,696 - 32,155,740 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

HSD17B6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	948,982 - 1,016,651 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,000,199 - 1,016,420 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,013,547 - 1,081,648 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	959,903 - 1,028,028 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	1,008,915 - 1,027,809 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	936,956 - 1,005,109 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	1,178,872 - 1,246,960 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	1,303,521 - 1,371,687 (+)	NCBI		UU_Cfam_GSD_1.0

HSD17B6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,092,578 - 22,273,382 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,089,496 - 22,114,319 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	23,775,876 - 23,800,805 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,710,903 - 52,736,645 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	52,710,758 - 52,736,629 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	193,238,228 - 193,265,612 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,115,928 - 11,162,174 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	11,125,544 - 11,162,914 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hsd17b6
153 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	352
Count of miRNA genes:	175
Interacting mature miRNAs:	191
Transcripts:	ENSRNOT00000003498, ENSRNOT00000029039
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat

Markers in Region

RH134999

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	422,564 - 422,752 (+)	MAPPER	mRatBN7.2
Rnor_6.0	13	110,633,879 - 110,634,064	NCBI	Rnor6.0
Rnor_6.0	7	2,412,469 - 2,412,655	NCBI	Rnor6.0
Rnor_5.0	7	2,390,407 - 2,390,593	UniSTS	Rnor5.0
Rnor_5.0	13	115,193,898 - 115,194,083	UniSTS	Rnor5.0
RGSC_v3.4	7	1,267,872 - 1,268,059	UniSTS	RGSC3.4
RGSC_v3.4	7	1,118,278 - 1,118,464	UniSTS	RGSC3.4
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2		13	13		13
Low	1		6	6		6
Below cutoff		2	7	4	1	4	1	1	1	1	4	3	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017594688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039078532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U89280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000003498 ⟹ ENSRNOP00000003498

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	422,480 - 441,958 (-)	Ensembl
Rnor_6.0 Ensembl	7	2,412,363 - 2,431,197 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000029039 ⟹ ENSRNOP00000031599

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	110,633,786 - 110,642,754 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103179 ⟹ ENSRNOP00000094822

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	422,480 - 442,425 (-)	Ensembl

RefSeq Acc Id:

NM_173305 ⟹ NP_775427

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	422,470 - 442,008 (-)	NCBI
Rnor_6.0	7	2,412,374 - 2,431,249 (-)	NCBI
Rnor_5.0	7	2,390,308 - 2,409,187 (-)	NCBI
RGSC_v3.4	7	1,118,183 - 1,137,670 (-)	RGD
Celera	7	310,880 - 321,035 (-)	NCBI

Sequence:

show sequence

CCGGAAAGAACAAACAGGGCAGAAGAAAGGTGATTTCCTCTTTCCTAAACCTGGAACACTTTAA
TTCTGTCCACAAGGGCAGAGTGGTGAACTCCCAGCAATCTAGGACTCAACCTTTAGCCTTTAGC
CTCACTCTGAGGGTTATGGTGATCAATTTTCCTGGATCTGAAGACTTGGACATGGACTGAGACC
TCAGTTACAGACAGCCTGTTGTGAGACTTCTCAGCCTCTATGATTACTGCTCCTGGACATTCCC
TCATAATGTGGTTTTACCTGGTGACTCTTGTGGGCCTTTACTACCTTCTGCGTTGGTATCGTGA
AAGGCAGGTGGTGAGCCATCTACATGACAAGTATGTCTTCATCACGGGTTGTGACTCTGGCTTT
GGGAACCTGCTGGCCAGACAGCTGGACAGGAGAGGCATGAGGGTGCTGGCTGCATGTCTGACTG
AGAAGGGAGCAGAGGAGCTGAAGAGCAAGACATCTGACAGGCTGGAGACAGTGATCCTTGACGT
TACCAACACAGACAGTATTTCAGCAGCCACTCAGTGGGTGAAGGAGCATGTTGGAGACAAAGGA
CTCTGGGGTTTGGTTAATAATGCAGGTGTGTTTCAAGCATTTGCCTACATTGAGTGGTGCCGAC
CGGAGGACTGCATGTCTATCTTTCAAGTGAACCTCATTGGTTTGGCACAGGTGACTCTGAGCAT
GCTTTTCCTGGTAAAGAAGGCTCGGGGCAGGATCGTCAACGTCTCCAGTGTTTTGGGAAGAGTT
GCATTGTTTGGAGGATTCTACAGTTGCTCCAAGTATGGAGTCGAGGCATTTTCGGACGTGCTAA
GACGTGAGATTCGAGATTTTGGGGTGAAAGTCAGCATAATTGAACCTGGAAGCTTCAAAACGAG
AATGACTGACGCAGAGCTAAGCATTGAGAAAACCAAGAAAACCTGGGAGGCGACCCCTGAGCAC
ATCAGGGAGTCCTACGGACAGCAGTTTTTTGATGACTTTTGCAACACCACCAGACGAGAACTGA
AGAAGTGCAGCACGAACCTGAGCCTGGTCACAGACTGCATGGAGCACGCTCTGACCTCTAAGTA
TCCTCGCACCCGGTACTCAGCTGGCTGGGATGCCAGACTTTTCTTCATCCCTCTGTCTTATTTG
CCTACATCACTGGTAGACTGCCTACTGGCCATATCTAGGCGCAAGCCAGCTCAGGCAGTCTGAA
GGATCCTGGGTCGGCGGCTCTGGGAATGAANAAACAACTCAGTTATTCCCAGCTCAAGCTGTGT
GCGCTGACATACTTTCTTGCCTAAACCACGTATGGGCTGTCTTTTCCTCTTCTACACCCACAGG
CACCTGGCCTCGCTCTATAACCCTGGCTGGCAGCAAACTCATAGAAAACGTCTGTCTCTCTCTT
AATCAAGGCGTTTGCATTCCAGGCGTACAAAACTTAGTACTAACTTAGCCACTTTTTCCTGGGG
ATATTTCCATATTGTGTTATTCTTTCTTGTCCTATTAAAAAGTATCCCATATAAGAACAAAAAA
AAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017594688 ⟹ XP_017450177

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	422,466 - 441,841 (-)	NCBI
Rnor_6.0	7	2,412,370 - 2,431,219 (-)	NCBI

Sequence:

show sequence

TGATTTCCTCTTTCCTAAACCTGGAACACTTTAATTCTGTCCACAAGGGCAGAGTGGTGAACTC
CCAGCAATCTAGGACTCAACCTTTAGCCTTTAGCCTCACTCTGAGGGTTATGGTGATCAATTTT
CCTGGATCTGAAGACTTGGACATGGACTGAGACCTCAGTTACAGACAGCCTGTTGTGAGACTTC
TCAGCCTCTATGATTACTGCTCCTGCTCCATCGAAGTGAAGTGAAAACGCCAACTACGCCAATA
TTTGGACATTCCCTCATAATGTGGTTTTACCTGGTGACTCTTGTGGGCCTTTACTACCTTCTGC
GTTGGTATCGTGAAAGGCAGGTGGTGAGCCATCTACATGACAAGTATGTCTTCATCACGGGTTG
TGACTCTGGCTTTGGGAACCTGCTGGCCAGACAGCTGGACAGGAGAGGCATGAGGGTGCTGGCT
GCATGTCTGACTGAGAAGGGAGCAGAGGAGCTGAAGAGCAAGACATCTGACAGGCTGGAGACAG
TGATCCTTGACGTTACCAACACAGACAGTATTTCAGCAGCCACTCAGTGGGTGAAGGAGCATGT
TGGAGACAAAGGACTCTGGGGTTTGGTTAATAATGCAGGTGTGTTTCAAGCATTTGCCTACATT
GAGTGGTGCCGACCGGAGGACTGCATGTCTATCTTTCAAGTGAACCTCATTGGTTTGGCACAGG
TGACTCTGAGCATGCTTTTCCTGGTAAAGAAGGCTCGGGGCAGGATCGTCAACGTCTCCAGTGT
TTTGGGAAGAGTTGCATTGTTTGGAGGATTCTACAGTTGCTCCAAGTATGGAGTCGAGGCATTT
TCGGACGTGCTAAGACGTGAGATTCGAGATTTCGGGGTGAAAGTCAGCATAATTGAACCTGGAA
GCTTCAAAACGAGAATGACTGACGCAGAGCTAAGCATTGAGAAAACCAAGAAAACCTGGGAGGC
GACCCCTGAGCACATCAGGGAGTCCTACGGACAGCAGTTTTTTGATGACTTTTGCAACACCACC
AGACGAGAACTGAAGAAGTGCAGCACGAACCTGAGCCTGGTCACAGACTGCATGGAGCACGCTC
TGACCTCTAAGTATCCTCGCACCCGATACTCAGCTGGCTGGGATGCCAGACTTTTCTTCATCCC
TCTGTCTTATTTGCCTACATCACTGGTAGACTGCCTACTGGCCATATCTAGGCGCAAGCCAGCT
CAGGCAGTCTGAAGGATCCTGGGTCGGCGGCTCTGGGAATGAAGAAACAACTCAGTTATTCCCA
GCTCAAGCTGTGTGCGCTGACATACTTTCTTGCCTAAACCACGTATGGGCTGTCTTTTCCTCTT
CTACACCCACAGGCACCTGGCCTCGCTCTATAACCCTGGCTGGCAGCAAACTCATAGAAAACGT
CTGTCTCTCTCTTAATCAAGGCGTTTGCATTCCAGGCGTACAAAACTTAGTACTAACTTAGCCA
CTTTTTCCTGGGGATATTTCCATATTGTGTTATTCTTTCTTGTCCTATTAAAAAGTATCCCATA
TAAGAACAATTTA

hide sequence

RefSeq Acc Id:

XM_039078532 ⟹ XP_038934460

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	422,466 - 438,384 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_775427	(Get FASTA)	NCBI Sequence Viewer
	XP_017450177	(Get FASTA)	NCBI Sequence Viewer
	XP_038934460	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB88253	(Get FASTA)	NCBI Sequence Viewer
	AAH88104	(Get FASTA)	NCBI Sequence Viewer
	AAH91114	(Get FASTA)	NCBI Sequence Viewer
	O54753	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_775427 ⟸ NM_173305

- Sequence:

show sequence

MITAPGHSLIMWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDRRGM
RVLAACLTEKGAEELKSKTSDRLETVILDVTNTDSISAATQWVKEHVGDKGLWGLVNNAGVFQA
FAYIEWCRPEDCMSIFQVNLIGLAQVTLSMLFLVKKARGRIVNVSSVLGRVALFGGFYSCSKYG
VEAFSDVLRREIRDFGVKVSIIEPGSFKTRMTDAELSIEKTKKTWEATPEHIRESYGQQFFDDF
CNTTRRELKKCSTNLSLVTDCMEHALTSKYPRTRYSAGWDARLFFIPLSYLPTSLVDCLLAISR
RKPAQAV

hide sequence

RefSeq Acc Id:	XP_017450177 ⟸ XM_017594688
- Peptide Label:	isoform X1
- UniProtKB:	Q5M8C8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEK GAEELKSKTSDRLETVILDVTNTDSISAATQWVKEHVGDKGLWGLVNNAGVFQAFAYIEWCRPE DCMSIFQVNLIGLAQVTLSMLFLVKKARGRIVNVSSVLGRVALFGGFYSCSKYGVEAFSDVLRR EIRDFGVKVSIIEPGSFKTRMTDAELSIEKTKKTWEATPEHIRESYGQQFFDDFCNTTRRELKK CSTNLSLVTDCMEHALTSKYPRTRYSAGWDARLFFIPLSYLPTSLVDCLLAISRRKPAQAV hide sequence

RefSeq Acc Id:

ENSRNOP00000003498 ⟸ ENSRNOT00000003498

RefSeq Acc Id:	XP_038934460 ⟸ XM_039078532
- Peptide Label:	isoform X1
- UniProtKB:	Q5M8C8 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:

ENSRNOP00000031599 ⟸ ENSRNOT00000029039

RefSeq Acc Id:

ENSRNOP00000094822 ⟸ ENSRNOT00000103179

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O54753-F1-model_v2	AlphaFold	O54753	1-317	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694917

Promoter ID:

EPDNEW_R5442

Type:

initiation region

Name:

Hsd17b6_2

Description:

hydroxysteroid (17-beta) dehydrogenase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5443

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	2,431,055 - 2,431,115	EPDNEW

RGD ID:

13694918

Promoter ID:

EPDNEW_R5443

Type:

initiation region

Name:

Hsd17b6_1

Description:

hydroxysteroid (17-beta) dehydrogenase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R5442

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	2,431,186 - 2,431,246	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708343	AgrOrtholog
BioCyc Gene	G2FUF-35403	BioCyc
Ensembl Genes	ENSRNOG00000002597	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000007758	Ensembl
Ensembl Protein	ENSRNOP00000003498.7	UniProtKB/TrEMBL
	ENSRNOP00000094822	ENTREZGENE
	ENSRNOP00000094822.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003498.7	UniProtKB/TrEMBL
	ENSRNOT00000103179	ENTREZGENE
	ENSRNOT00000103179.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7321553	IMAGE-MGC_LOAD
	IMAGE:7326228	IMAGE-MGC_LOAD
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sc_DH/Rdtase_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDR_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286964	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108558	IMAGE-MGC_LOAD
	MGC:108559	IMAGE-MGC_LOAD
NCBI Gene	286964	ENTREZGENE
PANTHER	17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Hsd17b6	PhenoGen
PRINTS	GDHRDH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SDRFAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	ADH_SHORT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6AMC0_RAT	UniProtKB/TrEMBL
	F1LYR5_RAT	UniProtKB/TrEMBL
	H17B6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5M8C8	ENTREZGENE
UniProt Secondary	Q5M8C8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Hsd17b6	hydroxysteroid (17-beta) dehydrogenase 6	LOC100362350	hydroxysteroid 17-beta dehydrogenase 6-like	Data Merged	737654	PROVISIONAL
2010-05-05	LOC100362350	hydroxysteroid 17-beta dehydrogenase 6-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2006-12-05	Hsd17b6	hydroxysteroid (17-beta) dehydrogenase 6	Hsd17b9	hydroxysteroid (17-beta) dehydrogenase 9	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2004-09-10	Hsd17b9	hydroxysteroid (17-beta) dehydrogenase 9	LOC286964	oxidative 17 beta hydroxysteroid dehydrogenase type 6	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)