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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oligopeptide
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Accession:CHEBI:25676 term browser browse the term
Definition:A peptide containing a relatively small number of amino acids.
Synonyms:related_synonym: Oligopeptid;   oligopeptides;   oligopeptido
 alt_id: CHEBI:7755;   MESH:D009842
 xref_mesh: MESH:D009842
 xref: Wikipedia:Oligopeptide


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oligopeptide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein] CTD PMID:24875536 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atg12 autophagy related 12 decreases expression ISO Oligopeptides analog results in decreased expression of ATG12 protein CTD PMID:24875536 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Oligopeptides analog results in increased expression of ATG3 protein CTD PMID:24875536 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Oligopeptides analog results in increased expression of ATG5 protein CTD PMID:24875536 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Oligopeptides analog results in increased expression of ATG7 protein CTD PMID:24875536 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Oligopeptides analog results in increased expression of BAX protein CTD PMID:24875536 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Oligopeptides analog results in decreased expression of BCL2 protein CTD PMID:24875536 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO BECN1 mutant form inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]
Oligopeptides analog results in increased expression of BECN1 protein
CTD PMID:24875536 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Oligopeptides analog results in increased cleavage of CASP3 protein]
Oligopeptides inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
CTD PMID:24875536, PMID:25868679 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Oligopeptides inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP9 protein] CTD PMID:25868679 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions ISO Oligopeptides inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased activity of CAT protein] CTD PMID:22154906 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ctss cathepsin S decreases expression ISO Oligopeptides analog results in decreased expression of CTSS protein CTD PMID:24875536 NCBI chr 2:197,655,780...197,679,768
Ensembl chr 2:197,655,786...197,679,458
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL2 protein] CTD PMID:22154906 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Gss glutathione synthetase increases activity ISO Oligopeptides results in increased activity of GSS protein CTD PMID:23796539 NCBI chr 3:151,076,254...151,106,557
Ensembl chr 3:151,076,254...151,106,557
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Oligopeptides analog results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [Oligopeptides analog results in increased phosphorylation of MAPK1 protein]
CTD PMID:24875536 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Oligopeptides analog results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [Oligopeptides analog results in increased phosphorylation of MAPK3 protein]
CTD PMID:24875536 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Oligopeptides analog results in decreased phosphorylation of MTOR protein CTD PMID:24875536 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Oligopeptides inhibits the reaction [Galactose results in increased activity of NOS2 protein]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22154906, PMID:23796539 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein] CTD PMID:24875536 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] CTD PMID:22154906 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Oligopeptides analog results in decreased phosphorylation of RPS6KB1 protein CTD PMID:24875536 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Oligopeptides inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:22154906 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta3 glutathione S-transferase alpha 3 affects binding ISO 8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 binds to GSTA3 protein CTD PMID:8910329 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
[des-Arg(9)]-bradykinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb1 bradykinin receptor B1 increases expression
multiple interactions
ISO bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein
lipopolysaccharide A promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; TNF protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]; TNFRSF1A protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein]
CTD PMID:16039549 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] CTD PMID:16039549 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO TNFRSF1A protein promotes the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] CTD PMID:16039549 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
Ac-Asp-Glu term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folh1 folate hydrolase 1 affects binding
multiple interactions
ISO isospaglumic acid binds to FOLH1 protein
[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [isospaglumic acid binds to FOLH1 protein]
CTD PMID:24508213 NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
JBrowse link
acetylleucyl-leucyl-norleucinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:15364539 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Apob apolipoprotein B multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Glucosamine results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; acetylleucyl-leucyl-norleucinal results in increased expression of and results in increased secretion of APOB protein CTD PMID:19342510, PMID:19383982 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of BIRC5 protein] CTD PMID:29974605 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO acetylleucyl-leucyl-norleucinal results in increased activity of CASP3 protein
acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in increased cleavage of CASP3 protein]
CTD PMID:15618349, PMID:27481217, PMID:29111403 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Immunologic Factors results in increased expression of CASP7 protein modified form] CTD PMID:29974605 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenite results in increased degradation of CCNB1 protein] CTD PMID:17373649 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [resveratrol results in increased degradation of CCND1 protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND1 protein] CTD PMID:11895924, PMID:16024653 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Tretinoin results in increased degradation of and results in decreased expression of CCND3 protein] CTD PMID:16024653 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in increased degradation of CDC20 protein]; acetylleucyl-leucyl-norleucinal promotes the reaction [Cadmium Chloride results in increased ubiquitination of CDC20 protein] CTD PMID:20054826 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of CTNNB1 protein] CTD PMID:29974605 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein] CTD PMID:27481217 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [arsenic trioxide results in decreased expression of GJA1 mRNA] CTD PMID:17559834 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein] CTD PMID:17291458 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO acetylleucyl-leucyl-norleucinal promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of JUN protein CTD PMID:15618349 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation ISO acetylleucyl-leucyl-norleucinal results in increased phosphorylation of MAPK8 protein CTD PMID:15618349 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO
EXP
acetylleucyl-leucyl-norleucinal results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr 3:81,295,023...81,304,181
Ensembl chr 3:81,295,024...81,304,181
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Immunologic Factors results in decreased expression of MYC protein] CTD PMID:29974605 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases degradation
ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [4-(3-(1-adamantyl)-4-hydroxyphenyl)-3-chlorocinnamic acid results in increased degradation of and results in decreased expression of NFKBIA protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [IL1B protein results in increased ubiquitination of NFKBIA protein]
acetylleucyl-leucyl-norleucinal results in decreased degradation of NFKBIA protein
CTD PMID:15930313, PMID:17291458, PMID:18606398 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] CTD PMID:29111403 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rad51 RAD51 recombinase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Mitomycin co-treated with Curcumin] results in decreased expression of RAD51 mRNA]; acetylleucyl-leucyl-norleucinal inhibits the reaction [Curcumin inhibits the reaction [Mitomycin results in increased expression of RAD51 protein]] CTD PMID:21810436 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO acetylleucyl-leucyl-norleucinal results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma increases methylation
decreases expression
ISO acetylleucyl-leucyl-norleucinal results in increased methylation of SCNN1G promoter
acetylleucyl-leucyl-norleucinal results in decreased expression of SCNN1G mRNA
CTD PMID:15564131 NCBI chr 1:191,704,397...191,738,271
Ensembl chr 1:191,704,311...191,738,268
JBrowse link
G Slc38a3 solute carrier family 38, member 3 multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 8:116,406,258...116,423,752
Ensembl chr 8:116,406,241...116,422,366
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [SGA 360 results in increased degradation of and results in decreased expression of SREBF1 protein] CTD PMID:31225620 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Ttn titin multiple interactions EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [Doxorubicin results in increased degradation of TTN protein] CTD PMID:22532871 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Tymp thymidine phosphorylase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMP protein]; acetylleucyl-leucyl-norleucinal inhibits the reaction [tanespimycin inhibits the reaction [salinomycin results in increased expression of TYMP protein]] CTD PMID:21444628, PMID:30796972 NCBI chr 7:130,342,481...130,347,845
Ensembl chr 7:130,342,483...130,347,587
JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO acetylleucyl-leucyl-norleucinal inhibits the reaction [[Fluorouracil co-treated with Cisplatin] results in decreased stability of TYMS protein] CTD PMID:21444628 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564
JBrowse link
Ala-Gln term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 multiple interactions ISO alanylglutamine inhibits the reaction [tcdA protein, Clostridium difficile results in increased activity of CASP8 protein] CTD PMID:16368960 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCA1 mRNA CTD PMID:23783067 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCB4 mRNA CTD PMID:23783067 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcd1 ATP binding cassette subfamily D member 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ABCD1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD1 mRNA CTD PMID:23783067 NCBI chr  X:157,073,860...157,095,652
Ensembl chr  X:157,072,736...157,095,274
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ABCD2 mRNA CTD PMID:23783067 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACAA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1A mRNA CTD PMID:23783067 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACAA1B mRNA CTD PMID:23783067 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acacb acetyl-CoA carboxylase beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACACB mRNA CTD PMID:23783067 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADS mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADS mRNA CTD PMID:23783067 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACADVL mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACADVL mRNA CTD PMID:23783067 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Ache acetylcholinesterase decreases activity ISO
EXP
Aspartame metabolite results in decreased activity of ACHE protein CTD PMID:16129618, PMID:17580119, PMID:17673349 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aco1 aconitase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of ACO1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACO1 mRNA CTD PMID:23783067 NCBI chr 5:56,425,076...56,481,218
Ensembl chr 5:56,425,024...56,481,218
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ACOT1 mRNA CTD PMID:23783067 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ADGRE1 mRNA CTD PMID:23783067 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Agt angiotensinogen decreases expression ISO Aspartame results in decreased expression of AGT mRNA CTD PMID:31655124 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO Aspartame results in decreased expression of AGTR1 mRNA CTD PMID:31655124 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ALOX15 mRNA CTD PMID:23783067 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Apoe apolipoprotein E decreases expression ISO Aspartame results in decreased expression of APOE mRNA CTD PMID:31655124 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
[Aspartame co-treated with Methotrexate] results in increased expression of BAX mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of BAX protein
[Fats, Unsaturated co-treated with Aspartame] affects the expression of BAX mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of BAX mRNA
CTD PMID:23783067, PMID:25009784 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 mRNA; [Aspartame co-treated with Methotrexate] results in decreased expression of BCL2 protein CTD PMID:25009784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Cabp2 calcium binding protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CABP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CABP2 mRNA CTD PMID:23783067 NCBI chr 1:219,329,186...219,335,046
Ensembl chr 1:219,329,574...219,335,043
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1A mRNA CTD PMID:23783067 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA1I mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA1I mRNA CTD PMID:23783067 NCBI chr 7:121,521,787...121,619,300
Ensembl chr 7:121,511,097...121,619,283
JBrowse link
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNA2D4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNA2D4 mRNA CTD PMID:23783067 NCBI chr 4:151,298,548...151,409,263
Ensembl chr 4:151,298,548...151,409,263
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNB2 mRNA CTD PMID:23783067 NCBI chr17:81,673,862...82,019,219
Ensembl chr17:81,798,756...82,017,682
JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG4 mRNA CTD PMID:23783067 NCBI chr10:95,954,160...96,015,484
Ensembl chr10:95,951,234...96,015,499
JBrowse link
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CACNG8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CACNG8 mRNA CTD PMID:23783067 NCBI chr 1:64,330,106...64,350,338
Ensembl chr 1:64,330,106...64,350,338
JBrowse link
G Calhm2 calcium homeostasis modulator family member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALHM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALHM2 mRNA CTD PMID:23783067 NCBI chr 1:266,908,367...266,914,093
Ensembl chr 1:266,908,369...266,914,093
JBrowse link
G Calr3 calreticulin 3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CALR3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CALR3 mRNA CTD PMID:23783067 NCBI chr16:19,097,391...19,124,062
Ensembl chr16:19,097,391...19,124,062
JBrowse link
G Cant1 calcium activated nucleotidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CANT1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CANT1 mRNA CTD PMID:23783067 NCBI chr10:107,432,500...107,445,634
Ensembl chr10:107,432,506...107,445,522
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 mRNA; [Aspartame co-treated with Methotrexate] results in increased expression of CASP3 protein modified form CTD PMID:25009784 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CASP9 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CASP9 mRNA CTD PMID:23783067 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions EXP [Aspartame co-treated with Methotrexate] results in increased activity of CAT protein CTD PMID:25009784 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of CCL2 protein; [Sodium Glutamate co-treated with Aspartame] inhibits the reaction [Fats, Unsaturated results in increased expression of CCL2 protein] CTD PMID:23783067 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CDKN1B mRNA CTD PMID:23783067 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CHERP mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CHERP mRNA CTD PMID:23783067 NCBI chr16:19,068,783...19,081,837
Ensembl chr16:19,068,783...19,081,837
JBrowse link
G Cmc1 C-x(9)-C motif containing 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CMC1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CMC1 mRNA CTD PMID:23783067 NCBI chr 8:126,437,345...126,495,347
Ensembl chr 8:126,437,345...126,495,347
JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX11 mRNA CTD PMID:23783067 NCBI chr10:78,168,691...78,173,845
NCBI chr10:78,102,620...78,174,584
Ensembl chr10:78,111,050...78,174,584
JBrowse link
G Cox7a1 cytochrome c oxidase subunit 7A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of COX7A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of COX7A1 mRNA CTD PMID:23783067 NCBI chr 1:88,619,619...88,650,672
Ensembl chr 1:91,071,493...91,074,294
Ensembl chr 1:91,071,493...91,074,294
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of CPT1B mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1B mRNA CTD PMID:23783067 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt1c carnitine palmitoyltransferase 1c multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CPT1C mRNA CTD PMID:23783067 NCBI chr 1:100,955,094...100,970,579
Ensembl chr 1:100,955,095...100,969,560
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CREB1 mRNA CTD PMID:23783067 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of CSF1 mRNA CTD PMID:23783067 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity EXP Aspartame results in increased activity of CYP1A1 protein CTD PMID:16937917 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity EXP Aspartame results in increased activity of CYP1A2 protein CTD PMID:16937917 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Aspartame results in increased expression of and results in increased activity of CYP2B1 protein CTD PMID:16937917 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases activity EXP Aspartame results in increased activity of CYP2B2 protein CTD PMID:16937917 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Aspartame results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:16937917 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity EXP Aspartame results in increased activity of CYP3A62 protein CTD PMID:16937917 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DIABLO mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DIABLO mRNA CTD PMID:23783067 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of DNAJC27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of DNAJC27 mRNA CTD PMID:23783067 NCBI chr 6:28,515,054...28,544,756
Ensembl chr 6:28,515,025...28,544,790
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of E2F1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of E2F1 mRNA CTD PMID:23783067 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Edn2 endothelin 2 decreases expression ISO Aspartame results in decreased expression of EDN2 mRNA CTD PMID:31655124 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Ednra endothelin receptor type A decreases expression ISO Aspartame results in decreased expression of EDNRA mRNA CTD PMID:31655124 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EHHADH mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EHHADH mRNA CTD PMID:23783067 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of EPHX2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of EPHX2 mRNA CTD PMID:23783067 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G F2 coagulation factor II decreases activity ISO Aspartame analog results in decreased activity of F2 protein; Aspartame results in decreased activity of F2 protein CTD PMID:15572260 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO Aspartame results in increased expression of FGF1 mRNA CTD PMID:31655124 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of FOXO3 mRNA CTD PMID:23783067 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GADD45B mRNA CTD PMID:23783067 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322
JBrowse link
G Gfm2 GTP dependent ribosome recycling factor mitochondrial 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of GFM2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of GFM2 mRNA CTD PMID:23783067 NCBI chr 2:27,949,195...27,984,045
Ensembl chr 2:27,949,208...27,984,256
JBrowse link
G Gip gastric inhibitory polypeptide multiple interactions ISO Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]; Sodium Glutamate inhibits the reaction [Aspartame promotes the reaction [Fats, Unsaturated results in increased expression of GIP protein]] CTD PMID:23783067 NCBI chr10:83,835,080...83,848,399
Ensembl chr10:83,840,303...83,848,396
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Aspartame co-treated with Methotrexate] results in decreased activity of GSR protein CTD PMID:25009784 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHA mRNA CTD PMID:23783067 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of HADHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HADHB mRNA CTD PMID:23783067 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hdac1 histone deacetylase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC1 mRNA CTD PMID:23783067 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hdac5 histone deacetylase 5 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HDAC5 mRNA CTD PMID:23783067 NCBI chr10:90,140,183...90,169,853
Ensembl chr10:90,140,183...90,151,042
JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HGF mRNA CTD PMID:23783067 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hras HRas proto-oncogene, GTPase increases expression ISO Aspartame results in increased expression of HRAS CTD PMID:17354619 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of HSPG2 mRNA CTD PMID:23783067 NCBI chr 5:155,812,096...155,913,751 JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IDH2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IDH2 mRNA CTD PMID:23783067 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Il11 interleukin 11 decreases expression ISO Aspartame results in decreased expression of IL11 mRNA CTD PMID:31655124 NCBI chr 1:72,636,959...72,643,255
Ensembl chr 1:72,635,267...72,643,255
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Aspartame results in increased expression of IL1B mRNA CTD PMID:31655124 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il3 interleukin 3 decreases expression ISO Aspartame results in decreased expression of IL3 mRNA CTD PMID:31655124 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il6 interleukin 6 increases secretion ISO Aspartame results in increased secretion of IL6 protein CTD PMID:20837131 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Immt inner membrane mitochondrial protein multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of IMMT mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of IMMT mRNA CTD PMID:23783067 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484
JBrowse link
G Ins2 insulin 2 increases expression
multiple interactions
ISO Aspartame results in increased expression of INS protein
[Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] results in increased expression of INS2 protein; Aspartame inhibits the reaction [Fats, Unsaturated results in increased expression of INS2 protein]
CTD PMID:1805284, PMID:23783067 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Kdr kinase insert domain receptor increases secretion ISO Aspartame results in increased secretion of KDR protein CTD PMID:20837131 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lep leptin decreases expression
multiple interactions
EXP
ISO
Aspartame results in decreased expression of LEP protein
[Fats, Unsaturated co-treated with Aspartame] results in increased expression of LEP protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of LEP protein]
CTD PMID:11890951, PMID:23783067 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LIPG mRNA CTD PMID:23783067 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708
JBrowse link
G LOC100912008 uncharacterized LOC100912008 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 3:4,869,790...4,872,633
Ensembl chr 3:4,869,795...4,872,632
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP1 mRNA CTD PMID:23783067 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Lrp2 LDL receptor related protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP2 mRNA CTD PMID:23783067 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Lrp4 LDL receptor related protein 4 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of LRP4 mRNA CTD PMID:23783067 NCBI chr 3:80,362,643...80,416,684
Ensembl chr 3:80,362,858...80,416,679
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK1 protein CTD PMID:20837131 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Aspartame results in increased phosphorylation of MAPK3 protein CTD PMID:20837131 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcu mitochondrial calcium uniporter multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MCU mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MCU mRNA CTD PMID:23783067 NCBI chr20:29,037,452...29,199,224
Ensembl chr20:29,038,480...29,199,224
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MDM2 mRNA CTD PMID:23783067 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Med23 mediator complex subunit 23 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MED23 mRNA CTD PMID:23783067 NCBI chr 1:21,539,765...21,587,675
Ensembl chr 1:21,539,765...21,586,910
JBrowse link
G Mef2d myocyte enhancer factor 2D multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MEF2D mRNA CTD PMID:23783067 NCBI chr 2:187,511,775...187,541,285
Ensembl chr 2:187,512,164...187,538,026
JBrowse link
G Micos10 mitochondrial contact site and cristae organizing system subunit 10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MINOS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MINOS1 mRNA CTD PMID:23783067 NCBI chr 5:157,546,855...157,573,183
Ensembl chr 5:157,546,856...157,573,183
JBrowse link
G Micu1 mitochondrial calcium uptake 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MICU1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MICU1 mRNA CTD PMID:23783067 NCBI chr20:29,284,833...29,433,617
Ensembl chr20:29,284,853...29,432,258
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL20 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL20 mRNA CTD PMID:23783067 NCBI chr 5:173,248,245...173,252,775
Ensembl chr 5:173,248,245...173,252,775
JBrowse link
G Mrpl3 mitochondrial ribosomal protein L3 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPL3 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPL3 mRNA CTD PMID:23783067 NCBI chr 8:113,603,533...113,626,893
Ensembl chr 8:113,603,533...113,626,893
JBrowse link
G Mrps12 mitochondrial ribosomal protein S12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS12 mRNA CTD PMID:23783067 NCBI chr 1:86,920,679...86,923,626
Ensembl chr 1:86,920,680...86,923,575
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS24 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS24 mRNA CTD PMID:23783067 NCBI chr14:85,947,763...85,951,891
Ensembl chr14:85,947,765...85,951,899
JBrowse link
G Mrps27 mitochondrial ribosomal protein S27 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS27 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS27 mRNA CTD PMID:23783067 NCBI chr 2:29,598,344...29,666,711
Ensembl chr 2:29,598,344...29,666,724
JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MRPS7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MRPS7 mRNA CTD PMID:23783067 NCBI chr10:104,155,805...104,158,840
Ensembl chr10:104,155,805...104,158,839
JBrowse link
G Mtfp1 mitochondrial fission process 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of MTFP1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of MTFP1 mRNA CTD PMID:23783067 NCBI chr14:84,330,223...84,334,063
Ensembl chr14:84,330,218...84,334,066
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Aspartame results in increased expression of MYC CTD PMID:17354619 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NCOR1 mRNA CTD PMID:23783067 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA12 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA12 mRNA CTD PMID:23783067 NCBI chr 7:35,125,516...35,163,182
Ensembl chr 7:35,125,424...35,167,406
JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFA5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFA5 mRNA CTD PMID:23783067 NCBI chr 4:51,590,413...51,598,771
Ensembl chr 4:51,590,413...51,598,771
JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB10 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB10 mRNA CTD PMID:23783067 NCBI chr10:14,090,128...14,092,289
Ensembl chr10:14,090,128...14,092,289
JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB2 mRNA CTD PMID:23783067 NCBI chr 4:67,378,188...67,385,267
Ensembl chr 4:67,378,188...67,385,266
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFB6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFB6 mRNA CTD PMID:23783067 NCBI chr 5:56,567,109...56,576,676
Ensembl chr 5:56,567,109...56,576,676
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS1 mRNA CTD PMID:23783067 NCBI chr 9:69,919,863...69,953,182
Ensembl chr 9:69,919,867...69,953,182
JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFS6 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFS6 mRNA CTD PMID:23783067 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584
JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of NDUFV1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NDUFV1 mRNA CTD PMID:23783067 NCBI chr 1:219,254,293...219,259,328
Ensembl chr 1:219,254,279...219,259,448
JBrowse link
G Nf1 neurofibromin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NF1 mRNA CTD PMID:23783067 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOTCH1 mRNA CTD PMID:23783067 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NOX1 mRNA CTD PMID:23783067 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nppb natriuretic peptide B decreases expression ISO Aspartame results in decreased expression of NPPB mRNA CTD PMID:31655124 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npy neuropeptide Y decreases expression EXP Aspartame results in decreased expression of NPY protein CTD PMID:11890951 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of NR1I3 mRNA CTD PMID:23783067 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Onecut1 one cut homeobox 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ONECUT1 mRNA CTD PMID:23783067 NCBI chr 8:81,765,779...81,799,894
Ensembl chr 8:81,766,041...81,793,577
JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHA2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHA2 mRNA CTD PMID:23783067 NCBI chr 2:246,736,449...246,737,997
Ensembl chr 2:246,736,459...246,737,997
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PDHB mRNA CTD PMID:23783067 NCBI chr15:18,540,826...18,546,855
Ensembl chr15:18,539,210...18,546,854
JBrowse link
G Pex1 peroxisomal biogenesis factor 1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX1 mRNA CTD PMID:23783067 NCBI chr 4:27,659,376...27,698,037
Ensembl chr 4:27,659,381...27,698,037
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX11A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX11A mRNA CTD PMID:23783067 NCBI chr 1:141,474,189...141,481,270
Ensembl chr 1:141,474,180...141,481,315
JBrowse link
G Pex13 peroxisomal biogenesis factor 13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX13 mRNA CTD PMID:23783067 NCBI chr14:108,394,299...108,411,994
Ensembl chr14:108,394,303...108,412,823
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX5 mRNA CTD PMID:23783067 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
JBrowse link
G Pex7 peroxisomal biogenesis factor 7 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PEX7 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PEX7 mRNA CTD PMID:23783067 NCBI chr 1:15,311,768...15,374,702
Ensembl chr 1:15,311,770...15,374,850
JBrowse link
G Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB2 mRNA CTD PMID:23783067 NCBI chr13:47,413,453...47,440,682
Ensembl chr13:47,413,458...47,440,682
JBrowse link
G Pfkfb4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PFKFB4 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PFKFB4 mRNA CTD PMID:23783067 NCBI chr 8:117,733,347...117,776,525
Ensembl chr 8:117,737,117...117,775,386
JBrowse link
G Pld2 phospholipase D2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLD2 mRNA CTD PMID:23783067 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Plg plasminogen decreases expression ISO Aspartame results in decreased expression of PLG mRNA CTD PMID:31655124 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Plxnd1 plexin D1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PLXND1 mRNA CTD PMID:23783067 NCBI chr 4:147,854,309...147,894,170
Ensembl chr 4:147,854,309...147,893,992
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of POLG mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of POLG mRNA CTD PMID:23783067 NCBI chr 1:141,172,117...141,188,893
Ensembl chr 1:141,172,531...141,188,031
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Aspartame results in increased expression of POMC protein alternative form CTD PMID:1805284 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARA mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARA mRNA CTD PMID:23783067 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARD mRNA CTD PMID:23783067 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARG mRNA CTD PMID:23783067 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PPARGC1A mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PPARGC1A mRNA CTD PMID:23783067 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prdx5 peroxiredoxin 5 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of PRDX5 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of PRDX5 mRNA CTD PMID:23783067 NCBI chr 1:222,164,462...222,167,447
Ensembl chr 1:222,164,462...222,167,447
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of ROCK1 mRNA CTD PMID:23783067 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G S100a13 S100 calcium binding protein A13 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A13 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A13 mRNA CTD PMID:23783067 NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516
JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of S100A8 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of S100A8 mRNA CTD PMID:23783067 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SDHB mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SDHB mRNA CTD PMID:23783067 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT1 mRNA CTD PMID:23783067 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt2 sirtuin 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SIRT2 mRNA CTD PMID:23783067 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Slc15a1 solute carrier family 15 member 1 decreases activity ISO Aspartame results in decreased activity of SLC15A1 protein CTD PMID:15846457 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC4A2 mRNA CTD PMID:23783067 NCBI chr 4:7,264,677...7,282,355
Ensembl chr 4:7,264,683...7,281,223
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SLC8A1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SLC8A1 mRNA CTD PMID:23783067 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SREBF2 mRNA CTD PMID:23783067 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of STAT3 mRNA CTD PMID:23783067 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of SURF1 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of SURF1 mRNA CTD PMID:23783067 NCBI chr 3:5,461,717...5,464,560
Ensembl chr 3:4,869,795...4,872,632
JBrowse link
G Tas1r2 taste 1 receptor member 2 multiple interactions
affects binding
ISO Aspartame binds to and results in increased activity of TAS1R2 protein; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]; Aspartame binds to TAS1R2 protein
CTD PMID:15353592, PMID:17168764, PMID:17935609, PMID:20173092 NCBI chr 5:158,119,894...158,135,733
Ensembl chr 5:158,042,587...158,135,733
JBrowse link
G Tas1r3 taste 1 receptor member 3 affects binding
multiple interactions
ISO Aspartame binds to [TAS1R2 protein binds to TAS1R3 protein]
lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]
CTD PMID:17168764, PMID:17935609 NCBI chr 5:173,307,325...173,312,950
Ensembl chr 5:173,308,870...173,312,023
JBrowse link
G Tfam transcription factor A, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TFAM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TFAM mRNA CTD PMID:23783067 NCBI chr20:18,594,057...18,606,106
Ensembl chr20:18,594,037...18,606,151
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of THBS1 mRNA CTD PMID:23783067 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] results in increased expression of TNF protein; [Sodium Glutamate co-treated with Aspartame] promotes the reaction [Fats, Unsaturated results in increased expression of TNF protein] CTD PMID:23783067 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Aspartame results in increased expression of TRP53
[Fats, Unsaturated co-treated with Aspartame] affects the expression of TRP53 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TRP53 mRNA
CTD PMID:17354619, PMID:23783067 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity ISO Aspartame results in increased activity of TRPV1 protein CTD PMID:17567713, PMID:18804451 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of TUFM mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of TUFM mRNA CTD PMID:23783067 NCBI chr 1:197,903,582...197,907,189
Ensembl chr 1:197,903,582...197,907,189
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UCP2 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UCP2 mRNA CTD PMID:23783067 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI multiple interactions ISO [Fats, Unsaturated co-treated with Aspartame] affects the expression of UQCR11 mRNA; [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of UQCR11 mRNA CTD PMID:23783067 NCBI chr 7:12,171,146...12,175,838
Ensembl chr 7:12,171,185...12,175,835
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion ISO Aspartame results in increased secretion of VEGFA protein CTD PMID:20837131 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [Fats, Unsaturated co-treated with Sodium Glutamate co-treated with Aspartame] affects the expression of XDH mRNA CTD PMID:23783067 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link
atosiban term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO atosiban inhibits the reaction [Sildenafil Citrate results in increased phosphorylation of CREB1 protein] CTD PMID:27220266 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
B 581 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO B 581 results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO B 581 results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO B 581 results in decreased activity of RELA protein CTD PMID:12085227 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
buserelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in increased expression of ABCC3 mRNA CTD PMID:19955106 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ahnak2 AHNAK nucleoprotein 2 multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in increased expression of AHNAK2 mRNA CTD PMID:19955106 NCBI chr 6:137,335,273...137,380,219 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Buserelin results in increased expression of BAX protein CTD PMID:15965100 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Casp3 caspase 3 increases expression ISO Buserelin results in increased expression of CASP3 protein CTD PMID:15965100 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases expression ISO Buserelin results in increased expression of CASP9 protein CTD PMID:15965100 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Buserelin affects the localization of CYCS protein CTD PMID:15965100 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 mRNA; [Buserelin co-treated with CGB3 protein] results in increased expression of DKK1 protein CTD PMID:19955106 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in decreased expression of DKK2 mRNA CTD PMID:19955106 NCBI chr 2:237,148,918...237,240,883
Ensembl chr 2:237,148,941...237,241,350
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Buserelin inhibits the reaction [Doxorubicin inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol]] CTD PMID:17028438 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor multiple interactions ISO Buserelin binds to and results in increased activity of GNRHR protein; Buserelin inhibits the reaction [GNRHR protein results in increased transport of deslorelin] CTD PMID:15212170 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Muc16 mucin 16, cell surface associated multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in increased expression of MUC16 mRNA CTD PMID:19955106 NCBI chr 8:18,438,838...18,639,777 JBrowse link
G Sfrp4 secreted frizzled-related protein 4 multiple interactions ISO [Buserelin co-treated with CGB3 protein] results in decreased expression of SFRP4 mRNA CTD PMID:19955106 NCBI chr17:47,383,983...47,394,065
Ensembl chr17:47,297,489...47,394,328
JBrowse link
carfilzomib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:24632418 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor multiple interactions ISO carfilzomib inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:30818834 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Brca1 BRCA1, DNA repair associated increases response to substance ISO BRCA1 mutant form results in increased susceptibility to carfilzomib CTD PMID:25522274 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO carfilzomib inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Cox8a cytochrome c oxidase subunit 8A decreases expression ISO carfilzomib results in decreased expression of COX8A mRNA CTD PMID:30818834 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO carfilzomib inhibits the reaction [Estradiol results in increased activity of ESR2 protein] CTD PMID:30818834 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein]; carfilzomib inhibits the reaction [XCT790 results in decreased activity of ESRRA protein] CTD PMID:30818834 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:27900802 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein] CTD PMID:24632418 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO carfilzomib results in increased activity of NFE2L2 protein CTD PMID:30818834 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA] CTD PMID:27900802 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Pgr progesterone receptor multiple interactions ISO carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein] CTD PMID:30818834 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO carfilzomib inhibits the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkcsh protein kinase C substrate 80K-H increases response to substance ISO PRKCSH gene mutant form results in increased susceptibility to carfilzomib CTD PMID:21685914 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of PTGS2 mRNA] CTD PMID:27900802 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases activity ISO carfilzomib results in decreased activity of TGFB1 protein CTD PMID:31652400 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP carfilzomib inhibits the reaction [Diethylnitrosamine results in increased expression of TIMP1 protein] CTD PMID:24632418 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO carfilzomib inhibits the reaction [Acetaminophen results in increased expression of TNF protein] CTD PMID:27900802 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 increases activity ISO carfilzomib results in increased activity of TP53 protein CTD PMID:30818834 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
carnosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein] CTD PMID:28266762 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Carnosine results in decreased expression of APP protein modified form CTD PMID:21423579 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases abundance ISO ARNTL gene mutant form results in increased abundance of Carnosine CTD PMID:27056296 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Glucose results in increased expression of BAX mRNA]
CTD PMID:28266762, PMID:28833918, PMID:30802477 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]; Carnosine inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]]
CTD PMID:28266762, PMID:30802477 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of and results in increased cleavage of CASP3 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Carnosine inhibits the reaction [Glucose results in increased activity of CASP3 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]
CTD PMID:19748544, PMID:28833918, PMID:29191451, PMID:30802477 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased cleavage of CASP8 protein] CTD PMID:29191451 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cat catalase multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Carnosine inhibits the reaction [Cisplatin results in decreased expression of CAT mRNA] CTD PMID:19748544, PMID:19799668, PMID:29191451 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of CCL2 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of CCL2 mRNA] CTD PMID:19799668, PMID:29191451 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Crp C-reactive protein multiple interactions ISO
EXP
Carnosine inhibits the reaction [Acetaminophen results in increased expression of CRP protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein]
CTD PMID:19799668, PMID:28266762, PMID:28833918 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased activity of CYP2E1 protein] CTD PMID:19799668 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Carnosine results in increased expression of FOS protein CTD PMID:17628717 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein] CTD PMID:28833918 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in decreased expression of GPX1 mRNA] CTD PMID:19799668 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein] CTD PMID:28266762 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Carnosine results in increased expression of HSPA1B protein CTD PMID:16984587 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of ICAM1 mRNA] CTD PMID:29191451 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL10 protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of IL10 mRNA] CTD PMID:19799668, PMID:29191451 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL1B protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD PMID:30802477 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Glucose results in increased secretion of IL6 protein]; Carnosine inhibits the reaction [Glucose results in increased secretion of IL6 protein]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]
CTD PMID:19799668, PMID:28266762, PMID:30802477 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Carnosine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] CTD PMID:30802477 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Carnosine inhibits the reaction [Cadmium Chloride results in increased activity of MPO protein] CTD PMID:19748544 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA] CTD PMID:28833918 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Carnosine inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:29191451 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Carnosine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PARP1 protein] CTD PMID:23011206 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]]; Carnosine inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased activity of PTGS2 protein]] CTD PMID:30802477 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carnosine inhibits the reaction [Cisplatin affects the localization of RELA protein]; Carnosine inhibits the reaction [Streptozocin results in increased expression of RELA protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of RELA protein]] CTD PMID:29191451, PMID:30802477 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein] CTD PMID:28266762 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein] CTD PMID:28266762 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Carnosine inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; Carnosine inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of TNF protein]]
asiatic acid promotes the reaction [Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]]; Carnosine inhibits the reaction [Glucose results in increased secretion of TNF protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Glucose results in increased secretion of TNF protein]]
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
CTD PMID:19799668, PMID:28266762, PMID:29191451, PMID:30802477 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein] CTD PMID:28266762 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression
ISO PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein] CTD PMID:25035110 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression EXP Ceruletide results in decreased expression of AHCY protein CTD PMID:18024178 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases expression EXP Ceruletide results in increased expression of AKR1B1 protein CTD PMID:18024178 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein CTD PMID:26390243 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alb albumin decreases expression EXP Ceruletide results in decreased expression of ALB protein modified form CTD PMID:17169977 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression ISO Ceruletide results in increased expression of BDKRB1 mRNA CTD PMID:21484880 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression ISO Ceruletide results in increased expression of BDKRB2 mRNA CTD PMID:21484880 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Brd4 bromodomain containing 4 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein CTD PMID:26390243 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Glycodeoxycholic Acid co-treated with Ceruletide] results in decreased activity of CASP3 protein; Ceruletide results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:16339139, PMID:18832452 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16339139 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Ceruletide results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16339139 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
ISO PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; rosiglitazone inhibits the reaction [Ceruletide results in increased expression of CCL2 mRNA] CTD PMID:17463185, PMID:21484880 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 increases expression EXP Ceruletide results in increased expression of CCT2 protein CTD PMID:18024178 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression
multiple interactions
EXP Ceruletide results in increased expression of CEBPA mRNA
[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPA mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPA protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPA mRNA]
CTD PMID:26873426 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
EXP [Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein; Dietary Fats promotes the reaction [Ceruletide results in increased expression of CEBPB mRNA]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Ceruletide] results in increased expression of CEBPB protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of CEBPB mRNA] CTD PMID:26873426 NCBI chr 3:164,424,502...164,425,933
Ensembl chr 3:164,424,515...164,425,910
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]
CTD PMID:22280800, PMID:25035110 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Ctsb cathepsin B affects localization
multiple interactions
EXP Ceruletide affects the localization of CTSB protein
sodium arsenite inhibits the reaction [Ceruletide affects the localization of CTSB protein]
CTD PMID:17941083 NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Ceruletide results in increased expression of CXCL1 mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; HU 211 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA]
CTD PMID:17463185, PMID:17484889 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of ERN1 mRNA; Ceruletide results in increased expression of ERN1 protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of ERN1 protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of ERN1 protein]
CTD PMID:26873426 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP Ceruletide results in increased expression of GLUD1 protein CTD PMID:18024178 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 increases expression EXP Ceruletide results in increased expression of HNRNPH1 protein CTD PMID:18024178 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Ceruletide results in decreased expression of HSPA5 protein CTD PMID:18024178 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression EXP Ceruletide results in decreased expression of HSPA8 protein CTD PMID:18024178 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Ceruletide results in increased expression of HYOU1 protein CTD PMID:18024178 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
ISO PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]
CTD PMID:17463185, PMID:25035110 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [resveratrol co-treated with Ceruletide] results in increased expression of IL10 protein CTD PMID:24234420 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
EXP
ISO
Ceruletide results in increased expression of IL1B mRNA; Ceruletide results in increased expression of IL1B protein
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL1B protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL1B mRNA]]; resveratrol inhibits the reaction [Ceruletide results in increased expression of IL1B protein]
CTD PMID:14751415, PMID:21484880, PMID:24234420, PMID:26873426 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion
ISO
EXP
Ceruletide results in increased expression of IL6 mRNA
Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of IL6 protein]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]]
(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; HU 211 inhibits the reaction [Ceruletide results in increased expression of IL6 protein]; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ceruletide results in increased expression of IL6 mRNA; Ceruletide results in increased expression of IL6 protein
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
CTD PMID:17484889, PMID:22280800, PMID:25035110, PMID:26390243, PMID:26873426 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
ISO Ceruletide results in increased expression of JUN mRNA
rosiglitazone inhibits the reaction [Ceruletide results in increased expression of JUN mRNA]
CTD PMID:17463185 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein]; (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of BRD4 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased expression of IL6 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of AKT1 protein; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Mir216a microRNA 216a increases expression EXP Ceruletide results in increased expression of MIR216A mRNA CTD PMID:27521901 NCBI chr14:113,112,129...113,112,234
Ensembl chr14:113,112,129...113,112,234
JBrowse link
G Mir216b microRNA 216b increases expression EXP Ceruletide results in increased expression of MIR216B mRNA CTD PMID:27521901 NCBI chr14:113,101,078...113,101,179
Ensembl chr14:113,101,078...113,101,179
JBrowse link
G Mir217 microRNA 217 increases expression EXP Ceruletide results in increased expression of MIR217 mRNA CTD PMID:27521901 NCBI chr14:113,119,529...113,119,633
Ensembl chr14:113,119,529...113,119,633
JBrowse link
G Mpo myeloperoxidase increases expression
multiple interactions
ISO Ceruletide results in increased expression of MPO protein
HU 211 inhibits the reaction [Ceruletide results in increased expression of MPO protein]
CTD PMID:17484889 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nfkbia NFKB inhibitor alpha increases degradation
multiple interactions
EXP Ceruletide results in increased degradation of NFKBIA protein
sodium arsenite inhibits the reaction [Ceruletide results in increased degradation of NFKBIA protein]
CTD PMID:17941083 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression EXP Ceruletide results in increased expression of PDIA4 protein CTD PMID:18024178 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO PPARG affects the reaction [Ceruletide results in increased expression of CCL2 mRNA]; PPARG affects the reaction [Ceruletide results in increased expression of CXCL1 mRNA] CTD PMID:17463185 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Ceruletide results in increased expression of PRDX2 protein CTD PMID:18024178 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ceruletide results in increased expression of PTGS2 mRNA; Ceruletide results in increased expression of PTGS2 protein CTD PMID:14751415 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions
affects response to substance
increases expression
ISO
EXP
PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of ICAM1 mRNA]; PTHLH protein modified form inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
Ethanol results in increased susceptibility to [Ceruletide results in increased expression of PTHLH mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein inhibits the reaction [Ceruletide results in increased expression of IL6 mRNA]
PTHLH protein affects the susceptibility to Ceruletide
Ceruletide results in increased expression of PTHLH mRNA; Ceruletide results in increased expression of PTHLH protein
PTHLH protein promotes the reaction [Ceruletide results in increased expression of ACTA2 protein]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of COL1A1 mRNA]; PTHLH protein promotes the reaction [Ceruletide results in increased expression of IL6 mRNA]
CTD PMID:22280800, PMID:25035110 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression
ISO ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate inhibits the reaction [Ceruletide results in increased expression of RELA protein] CTD PMID:22982818 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases cleavage EXP Ceruletide results in increased cleavage of RIPK1 protein CTD PMID:16339139 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ruvbl1 RuvB-like AAA ATPase 1 increases expression EXP Ceruletide results in increased expression of RUVBL1 protein CTD PMID:18024178 NCBI chr 4:120,411,917...120,447,458
Ensembl chr 4:120,411,991...120,447,455
JBrowse link
G Serpinf1 serpin family F member 1 increases activity EXP cerulein increases activity of Serpinf1 protein in blood RGD PMID:10423332 RGD:1625538 NCBI chr10:62,241,750...62,254,145
Ensembl chr10:62,241,756...62,254,287
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO (+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]; [KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein; IL6 protein inhibits the reaction [(+)-JQ1 compound inhibits the reaction [[KRAS protein mutant form co-treated with Ceruletide] results in increased phosphorylation of STAT3 protein]] CTD PMID:26390243 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion
EXP Ceruletide results in increased expression of TNF mRNA; Ceruletide results in increased expression of TNF protein
2-acetoxy-5-(2-4-(trifluoromethyl)phenethylamino)benzoic acid inhibits the reaction [[Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; [Ceruletide co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; arsenic trioxide inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]; Dietary Fats promotes the reaction [Ceruletide results in increased secretion of TNF protein]; Pentoxifylline inhibits the reaction [Ceruletide results in increased expression of TNF protein]; Quercetin inhibits the reaction [Ceruletide results in increased expression of TNF mRNA]; Quercetin inhibits the reaction [Dietary Fats promotes the reaction [Ceruletide results in increased expression of TNF mRNA]]
CTD PMID:10773043, PMID:17517186, PMID:22575522, PMID:26873426 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Ceruletide results in increased expression of TPI1 protein CTD PMID:18024178 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
JBrowse link
G Vcp valosin-containing protein decreases expression EXP Ceruletide results in decreased expression of VCP protein CTD PMID:18024178 NCBI chr 5:58,426,548...58,445,953
Ensembl chr 5:58,426,549...58,445,953
JBrowse link
G Xbp1 X-box binding protein 1 increases expression
multiple interactions
EXP Ceruletide results in increased expression of XBP1 mRNA alternative form; Ceruletide results in increased expression of XBP1 protein alternative form
Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Dietary Fats promotes the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 mRNA alternative form]; Quercetin inhibits the reaction [Ceruletide results in increased expression of XBP1 protein alternative form]
CTD PMID:26873426 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xiap X-linked inhibitor of apoptosis increases degradation EXP Ceruletide results in increased degradation of XIAP protein CTD PMID:16339139 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
cetrorelix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO cetrorelix results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of APOE mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of APOE mRNA CTD PMID:18160741 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
cetrorelix results in increased expression of BAX mRNA; cetrorelix results in increased expression of BAX protein CTD PMID:17268770, PMID:18829022 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO
EXP
cetrorelix results in decreased expression of BCL2 protein
cetrorelix results in decreased expression of BCL2 mRNA
CTD PMID:18829022, PMID:21062912 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO cetrorelix results in decreased expression of BCL2L1 protein CTD PMID:21062912 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP
cetrorelix results in increased activity of CASP3 protein CTD PMID:17268770, PMID:21062912 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases activity ISO
EXP
cetrorelix results in increased activity of CASP9 protein CTD PMID:17268770 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccn5 cellular communication network factor 5 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CCN5 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CCN5 mRNA CTD PMID:18160741 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO cetrorelix results in increased expression of CDKN1A protein CTD PMID:21062912 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chga chromogranin A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CHGA mRNA CTD PMID:18160741 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 decreases expression ISO cetrorelix results in decreased expression of CLCF1 mRNA CTD PMID:21062912 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
JBrowse link
G Cst9l cystatin 9-like multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of CST9L mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of CST9L mRNA CTD PMID:18160741 NCBI chr 3:143,172,691...143,175,504
Ensembl chr 3:143,172,686...143,175,500
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO cetrorelix results in decreased expression of CXCL12 mRNA CTD PMID:21062912 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYB5A mRNA CTD PMID:18160741 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP11A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP11A1 mRNA CTD PMID:18160741 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of CYP17A1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of CYP17A1 mRNA CTD PMID:18160741 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in increased expression of DDR1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in increased expression of DDR1 mRNA CTD PMID:18160741 NCBI chr20:3,553,430...3,574,959
Ensembl chr20:3,552,929...3,575,780
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DHCR24 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DHCR24 mRNA CTD PMID:18160741 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dpep3 dipeptidase 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of DPEP3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of DPEP3 mRNA CTD PMID:18160741 NCBI chr19:37,946,516...37,955,199
Ensembl chr19:37,946,722...37,952,501
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO
EXP
cetrorelix results in increased expression of FAS mRNA; cetrorelix results in increased expression of FAS protein CTD PMID:17268770 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression ISO
EXP
cetrorelix results in decreased expression of FSHB protein CTD PMID:10077358, PMID:17638707 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of GSTA2 mRNA CTD PMID:18160741 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP cetrorelix results in decreased expression of HCRTR1 mRNA CTD PMID:17638707 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hcrtr2 hypocretin receptor 2 decreases expression EXP cetrorelix results in decreased expression of HCRTR2 mRNA CTD PMID:17638707 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of HMGCS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HMGCS2 mRNA CTD PMID:18160741 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of HSD17B6 mRNA CTD PMID:18160741 NCBI chr 7:2,412,370...2,431,249
Ensembl chr 7:2,412,363...2,431,197
Ensembl chr13:2,412,363...2,431,197
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO cetrorelix results in decreased expression of IGF1 mRNA CTD PMID:21062912 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 decreases expression ISO cetrorelix results in decreased expression of IL6 mRNA CTD PMID:21062912 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Insl3 insulin-like 3 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of INSL3 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of INSL3 mRNA CTD PMID:18160741 NCBI chr16:20,120,753...20,122,702
Ensembl chr16:20,121,352...20,122,696
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
multiple interactions
decreases secretion
EXP
ISO
cetrorelix results in decreased expression of LHB protein
cypermethrin inhibits the reaction [cetrorelix results in decreased secretion of LHB protein]
CTD PMID:10077358, PMID:16914592, PMID:17638707, PMID:28731686 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK1 protein CTD PMID:21062912 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of MAPK3 protein CTD PMID:21062912 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Msmo1 methylsterol monooxygenase 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of MSMO1 mRNA CTD PMID:18160741 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PAPSS2 mRNA CTD PMID:18160741 NCBI chr 1:251,145,264...251,230,716
Ensembl chr 1:251,145,253...251,230,715
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PGRMC1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PGRMC1 mRNA CTD PMID:18160741 NCBI chr  X:123,205,869...123,213,880
Ensembl chr  X:123,205,869...123,213,882
JBrowse link
G Prl prolactin decreases expression EXP cetrorelix results in decreased expression of PRL protein CTD PMID:17638707 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prok1 prokineticin 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PROK1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PROK1 mRNA CTD PMID:18160741 NCBI chr 2:209,986,503...209,994,438
Ensembl chr 2:209,987,992...209,993,250
JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of PRPS2 mRNA CTD PMID:18160741 NCBI chr  X:28,435,275...28,472,882
Ensembl chr  X:28,435,507...28,472,880
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO cetrorelix results in decreased phosphorylation of and results in decreased activity of RELA protein CTD PMID:21062912 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhob ras homolog family member B multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of RHOB mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of RHOB mRNA CTD PMID:18160741 NCBI chr 6:33,689,127...33,691,301
Ensembl chr 6:33,689,127...33,691,301
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [cetrorelix co-treated with testosterone enanthate] results in decreased expression of STAR mRNA CTD PMID:18160741 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO cetrorelix results in decreased phosphorylation of STAT3 protein CTD PMID:21062912 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sycp1 synaptonemal complex protein 1 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of SYCP1 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of SYCP1 mRNA CTD PMID:18160741 NCBI chr 2:205,274,766...205,426,869
Ensembl chr 2:205,274,769...205,426,869
JBrowse link
G Taf4b TATA-box binding protein associated factor 4b multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TAF4B mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TAF4B mRNA CTD PMID:18160741 NCBI chr18:6,206,939...6,338,794
Ensembl chr18:6,207,280...6,318,219
JBrowse link
G Tex19.2 testis expressed gene 19.2 multiple interactions ISO [cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of TEX19 mRNA; [cetrorelix co-treated with testosterone enanthate] results in decreased expression of TEX19 mRNA CTD PMID:18160741 NCBI chr10:110,305,926...110,308,514
Ensembl chr10:110,305,928...110,308,514
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO cetrorelix results in decreased expression of TGFB1 mRNA CTD PMID:21062912 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnfsf13 TNF superfamily member 13 decreases expression ISO cetrorelix results in decreased expression of TNFSF13 mRNA CTD PMID:21062912 NCBI chr10:56,286,964...56,290,680
Ensembl chr10:56,286,887...56,289,952
JBrowse link
G Tp53 tumor protein p53 increases expression ISO cetrorelix results in increased expression of TP53 protein CTD PMID:21062912 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO cetrorelix results in decreased expression of VEGFA mRNA CTD PMID:21062912 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
CGP-42112A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions ISO CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 protein]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]; CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]; CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]] CTD PMID:25446015 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions ISO
EXP
CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]; CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
[CGP 42112A binds to and results in increased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of and results in increased secretion of Triglycerides; [CGP 42112A binds to and results in increased activity of AGTR2 protein] which results in increased abundance of Fatty Acids, Nonesterified; CGP 42112A binds to and results in increased activity of AGTR2 protein
CTD PMID:16003179, PMID:19151255, PMID:25446015 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Agtrap angiotensin II receptor-associated protein multiple interactions ISO CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]; CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] CTD PMID:25446015 NCBI chr 5:164,888,069...164,898,387
Ensembl chr 5:164,886,813...164,898,420
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]] CTD PMID:25446015 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]; CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] CTD PMID:25446015 NCBI chr 1:150,796,359...150,976,186
Ensembl chr 1:150,797,084...150,976,194
JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 increases expression EXP CGP 42112A results in increased expression of UBE2V2 mRNA; CGP 42112A results in increased expression of UBE2V2 protein CTD PMID:17068200 NCBI chr11:89,557,273...89,591,175
Ensembl chr11:89,557,273...89,591,175
JBrowse link
DAPT term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased expression of ACTA2 protein]] CTD PMID:31348943 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one promotes the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of AKT1 protein] CTD PMID:31348943 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased secretion of APP protein modified form] CTD PMID:22115781 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of BAX protein CTD PMID:21209419 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of BCL2 protein CTD PMID:21209419 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA] CTD PMID:23566955 NCBI chr17:26,955,142...27,112,820
Ensembl chr17:26,955,142...27,112,820
JBrowse link
G Casp3 caspase 3 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of and results in increased activity of CASP3 protein CTD PMID:21209419 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA] CTD PMID:19160421 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester co-treated with 1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one] inhibits the reaction [polyhexamethyleneguanidine results in decreased expression of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased secretion of CDH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased cleavage of CDH1 protein] CTD PMID:18791180, PMID:31348943 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of CDH2 protein] CTD PMID:23876460 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of CSF1 mRNA] CTD PMID:24223152 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Eno2 enolase 2 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of ENO2 mRNA] CTD PMID:24929042 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FLT1 protein] CTD PMID:21843347 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Foxo3 forkhead box O3 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of FOXO3 protein] CTD PMID:25108166 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Hes1 hes family bHLH transcription factor 1 multiple interactions
decreases expression
ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of HES1 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HES1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of HES1 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of HES1 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of HES1 protein
CTD PMID:19160421, PMID:24223152, PMID:25005833, PMID:25108166, PMID:32041402 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA] CTD PMID:19160421 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of HEY2 mRNA]
CTD PMID:19160421, PMID:32041402 NCBI chr 1:29,191,170...29,201,257
Ensembl chr 1:29,191,192...29,201,531
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Hydrogen Peroxide results in increased expression of HIF1A protein] CTD PMID:25108166 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of HMGB1 protein] CTD PMID:21843347 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Il10 interleukin 10 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] CTD PMID:24223152 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]
CTD PMID:21843347, PMID:24223152 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of IL6 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]
CTD PMID:21843347, PMID:24223152 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein] CTD PMID:28130038 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Ivl involucrin decreases expression ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL protein CTD PMID:18633435 NCBI chr 2:192,761,171...192,773,346
Ensembl chr 2:192,761,538...192,763,577
JBrowse link
G Jag1 jagged canonical Notch ligand 1 decreases expression ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of JAG1 protein CTD PMID:18633435 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Krt1 keratin 1 multiple interactions
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT1 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT1 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT1 mRNA
CTD PMID:18633435, PMID:23566955 NCBI chr 7:143,448,318...143,453,544
Ensembl chr 7:143,448,318...143,453,544
JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [BMP6 protein results in increased expression of KRT10 mRNA]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [U 0126 results in increased expression of KRT10 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 mRNA; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT10 protein
CTD PMID:18633435, PMID:23566955 NCBI chr10:87,296,445...87,301,307
Ensembl chr10:87,296,451...87,300,736
JBrowse link
G Lgr5 leucine rich repeat containing G protein coupled receptor 5 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of LGR5 mRNA] CTD PMID:32041402 NCBI chr 7:58,447,097...58,587,787
Ensembl chr 7:58,448,277...58,587,787
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of MAP2 mRNA] CTD PMID:24929042 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
ISO Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of MDM2 protein] CTD PMID:25005833 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of MYD88 mRNA]
CTD PMID:24223152 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of NOS2 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of NOS2 mRNA]
CTD PMID:24223152 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Notch1 notch receptor 1 multiple interactions
decreases expression
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Hydrogen Peroxide results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [phenethyl isothiocyanate results in increased cleavage of and results in increased activity of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one inhibits the reaction [polyhexamethyleneguanidine results in increased cleavage of NOTCH1 protein]]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH1 protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of NOTCH1 protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Tunicamycin results in increased cleavage of NOTCH1 protein]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [Oxygen deficiency results in increased expression of NOTCH1 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of NOTCH1 protein modified form
CTD PMID:18633435, PMID:22039516, PMID:22115781, PMID:24223152, PMID:25108166, PMID:25118938, PMID:28130038, PMID:31348943 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch2 notch receptor 2 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased cleavage of and results in decreased activity of NOTCH2 protein CTD PMID:22039516 NCBI chr 2:200,187,184...200,320,403
Ensembl chr 2:200,187,179...200,320,215
JBrowse link
G Numb NUMB, endocytic adaptor protein increases expression ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of NUMB protein CTD PMID:25005833 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA] CTD PMID:18791180 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]] CTD PMID:28130038 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region multiple interactions
increases expression
EXP
ISO
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RBPJ mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in increased expression of RBPJ protein
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Cycloheximide results in decreased expression of RBPJ protein]
CTD PMID:22302987, PMID:24223152 NCBI chr14:59,657,738...59,865,427
Ensembl chr14:59,658,935...59,735,450
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency affects the localization of RELA protein modified form]; N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of RELA protein] CTD PMID:24223152 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 mRNA] CTD PMID:24223152 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TLR4 mRNA] CTD PMID:24223152 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TNF protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD PMID:24223152 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression
multiple interactions
ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of TP53 protein
Hydrogen Peroxide inhibits the reaction [N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of TP53 protein]
CTD PMID:25005833 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO
EXP
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 protein]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Oxygen deficiency results in increased expression of TRAF6 mRNA]
CTD PMID:24223152 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester promotes the reaction [rhodioloside results in increased expression of TUBB3 mRNA] CTD PMID:24929042 NCBI chr19:56,220,759...56,229,813
Ensembl chr19:56,220,755...56,229,813
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein] CTD PMID:21843347 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vil1 villin 1 multiple interactions EXP N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [tetrabromobisphenol A results in increased expression of VIL1 mRNA] CTD PMID:32041402 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Enalapril CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Ace angiotensin I converting enzyme decreases activity
multiple interactions
increases expression
ISO
EXP
Enalapril results in decreased activity of ACE protein
Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]
ACE gene polymorphism affects the susceptibility to [Enalapril co-treated with Sodium Chloride]; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]
Enalapril results in increased expression of ACE mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril promotes the reaction [Folic Acid results in increased expression of ACE mRNA]
CTD PMID:15728788, PMID:15816410, PMID:20679179, PMID:20829712, PMID:23733546, PMID:28973481, PMID:30940551 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression EXP Enalapril results in decreased expression of ACTA2 protein CTD PMID:19349682 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Acvrl1 activin A receptor like type 1 decreases expression EXP Enalapril results in decreased expression of ACVRL1 protein CTD PMID:12883979 NCBI chr 7:142,769,942...142,787,336
Ensembl chr 7:142,776,252...142,787,335
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Enalapril results in increased expression of ADIPOQ protein CTD PMID:25037058 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adrb1 adrenoceptor beta 1 increases expression EXP Enalapril results in increased expression of ADRB1 protein CTD PMID:7586371 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Agt angiotensinogen decreases activity
affects response to substance
increases expression
decreases response to substance
multiple interactions
decreases expression
EXP
ISO
Enalapril results in decreased activity of AGT protein modified form
AGT gene alternative form affects the susceptibility to Enalapril; AGT protein polymorphism affects the susceptibility to Enalapril
Enalapril results in increased expression of AGT mRNA
Enalapril results in decreased susceptibility to AGT protein modified form
Enalapril affects the reaction [chymostatin results in decreased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [Cyclosporine results in increased expression of AGT protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of AGT protein]
Enalapril results in decreased expression of AGT protein modified form
[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form; ACE gene polymorphism inhibits the reaction [[Enalapril co-treated with Sodium Chloride] results in increased susceptibility to AGT protein modified form]; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in decreased expression of AGT mRNA
CTD PMID:1330361, PMID:2474097, PMID:6319675, PMID:12003776, PMID:12911327, PMID:14659064, PMID:16685205, PMID:18300870, PMID:18679781, PMID:18796534, PMID:19114890, PMID:20829712, PMID:21602471 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a increases expression
multiple interactions
decreases expression
affects expression
EXP
ISO
Enalapril results in increased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Dexamethasone results in increased expression of AGTR1 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of AGTR1 protein]]
Enalapril results in decreased expression of AGTR1A mRNA
Enalapril inhibits the reaction [Cyclosporine results in decreased expression of AGTR1A mRNA]
Enalapril affects the expression of AGTR1A mRNA
CTD PMID:14659064, PMID:18403896, PMID:18765277, PMID:18796534, PMID:30940551 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
decreases expression
EXP Enalapril results in increased expression of AGTR2 mRNA
Enalapril results in decreased expression of AGTR2 mRNA
CTD PMID:9740612, PMID:18403896, PMID:18765277 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Enalapril promotes the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:18806606 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of ALPL mRNA] CTD PMID:30423288 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Ang angiogenin decreases expression ISO Enalapril results in decreased expression of ANG protein CTD PMID:3038326 NCBI chr15:28,022,926...28,028,636 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA] CTD PMID:19958114 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195
JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein
Enalapril inhibits the reaction [APOE gene mutant form results in decreased abundance of Antioxidants]; Enalapril inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]
CTD PMID:19603250, PMID:25037058 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Atf2 activating transcription factor 2 increases expression EXP Enalapril results in increased expression of ATF2 protein CTD PMID:15531746 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Enalapril results in increased expression of ATP1A2 mRNA; Enalapril results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Enalapril results in decreased expression of ATP1A3 mRNA; Enalapril results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Avp arginine vasopressin multiple interactions EXP Enalapril promotes the reaction [Dexamethasone results in increased activity of AVP protein] CTD PMID:3346065 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression EXP Enalapril results in decreased expression of BAX protein CTD PMID:21153712 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
multiple interactions
EXP Enalapril results in increased expression of BCL2 protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
CTD PMID:21153712, PMID:30623541 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb1 bradykinin receptor B1 increases expression
multiple interactions
EXP Enalapril results in increased expression of BDKRB1 mRNA
[kallidin, des-Arg(10)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Enalapril
CTD PMID:18796534, PMID:21430409 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 increases expression EXP Enalapril results in increased expression of BDKRB2 mRNA; Enalapril results in increased expression of BDKRB2 protein CTD PMID:18190998 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of BGLAP mRNA] CTD PMID:30423288 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO Enalapril results in decreased activity of CA2 protein CTD PMID:28126276 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of CASP3 protein
Enalapril inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]
CTD PMID:21153712, PMID:30623541 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 decreases activity EXP Enalapril results in decreased activity of CASP9 protein CTD PMID:21153712 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP Enalapril results in increased activity of CAT protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]
CTD PMID:12124199, PMID:30623541 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
[paricalcitol co-treated with Enalapril] results in decreased expression of CCL2 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Enalapril results in decreased expression of CCL2 protein
Enalapril results in decreased expression of CCL2 mRNA
CTD PMID:10925121, PMID:17513326, PMID:19627010, PMID:20720404, PMID:25037058, PMID:28973481 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of CCN2 mRNA; Enalapril results in decreased expression of CCN2 protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
CTD PMID:18812665, PMID:19349682, PMID:21416479, PMID:25037058 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cela2a chymotrypsin like elastase 2A decreases expression EXP Enalapril results in decreased expression of CELA2A mRNA CTD PMID:21602471 NCBI chr 5:160,374,031...160,383,782
Ensembl chr 5:160,374,031...160,383,782
JBrowse link
G Cltrn collectrin, amino acid transport regulator decreases expression EXP Enalapril results in decreased expression of CLTRN mRNA; Enalapril results in decreased expression of CLTRN protein CTD PMID:12887829 NCBI chr  X:32,118,082...32,153,687
Ensembl chr  X:32,118,054...32,153,794
JBrowse link
G Clu clusterin decreases expression EXP Enalapril results in decreased expression of CLU protein CTD PMID:12193663 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cma1 chymase 1 decreases expression EXP Enalapril results in decreased expression of CMA1 mRNA CTD PMID:18796534 NCBI chr15:34,601,037...34,603,819
Ensembl chr15:34,601,037...34,603,819
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Enalapril inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA] CTD PMID:12003776 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
increases expression
EXP
ISO
Enalapril results in decreased expression of COL3A1 mRNA
Enalapril results in increased expression of COL3A1 mRNA
CTD PMID:17164399, PMID:25037058 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of COL4A1 protein; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of COL4A1 mRNA]]; Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA]
Enalapril results in decreased expression of COL4A1 mRNA; Enalapril results in decreased expression of COL4A1 protein
CTD PMID:9175058, PMID:18682491 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression
ISO [paricalcitol co-treated with Enalapril] results in decreased expression of CYBA protein
Enalapril results in decreased expression of CYBA protein
CTD PMID:20720404, PMID:25037058 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cycs cytochrome c, somatic affects localization EXP Enalapril affects the localization of CYCS protein CTD PMID:21153712 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:9175058 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Eng endoglin multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485
JBrowse link
G Epo erythropoietin decreases expression
multiple interactions
ISO
EXP
Enalapril results in decreased expression of EPO protein
Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]
CTD PMID:2474097, PMID:9434678, PMID:19958114 NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
JBrowse link
G Epor erythropoietin receptor multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein] CTD PMID:19958114 NCBI chr 8:22,969,737...22,974,468
Ensembl chr 8:22,969,745...22,974,321
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
ISO Enalapril results in decreased expression of F3 protein
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]
CTD PMID:18060435, PMID:22188725 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Faslg Fas ligand decreases expression EXP Enalapril results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gh1 growth hormone 1 increases response to substance ISO GH1 protein results in increased susceptibility to Enalapril CTD PMID:12883983 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Gja5 gap junction protein, alpha 5 multiple interactions ISO GJA5 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr 2:199,162,745...199,184,942
Ensembl chr 2:199,162,745...199,184,939
JBrowse link
G Gjc1 gap junction protein, gamma 1 multiple interactions ISO GJC1 affects the reaction [Enalapril results in increased secretion of REN protein] CTD PMID:19109587 NCBI chr10:90,781,408...90,912,440
Ensembl chr10:90,781,402...90,912,287
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein] CTD PMID:18806606 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Has2 hyaluronan synthase 2 increases expression EXP Enalapril results in increased expression of HAS2 mRNA CTD PMID:20933085 NCBI chr 7:96,438,046...96,464,049
Ensembl chr 7:96,438,046...96,464,049
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP
ISO
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]
CTD PMID:19114890 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Enalapril results in increased expression of HMOX1 protein CTD PMID:21263376 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hyal1 hyaluronidase 1 decreases expression EXP Enalapril results in decreased expression of HYAL1 mRNA; Enalapril results in decreased expression of HYAL1 protein CTD PMID:20933085 NCBI chr 8:116,332,834...116,337,522
Ensembl chr 8:116,332,796...116,335,435
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of ICAM1 protein
Enalapril inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
[Enalapril co-treated with paricalcitol] results in decreased expression of ICAM1 mRNA
Enalapril results in decreased expression of ICAM1 protein modified form
CTD PMID:14716214, PMID:17347482, PMID:25037058, PMID:28973481 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression
decreases expression
EXP Enalapril affects the expression of IGF1 protein
Enalapril results in decreased expression of IGF1 mRNA
CTD PMID:12883983 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Enalapril results in increased expression of IGFBP1 mRNA CTD PMID:12883983 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein] CTD PMID:17299153 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Enalapril results in decreased expression of IL1B mRNA
CTD PMID:17167242, PMID:21265103, PMID:25037058 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
affects response to substance
EXP
ISO
Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of IL6 protein]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of IL6 protein]
IL6 gene polymorphism affects the susceptibility to Enalapril
CTD PMID:15342284, PMID:17167242, PMID:19114890, PMID:21265103, PMID:30623541 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Itga2 integrin subunit alpha 2 decreases expression ISO Enalapril results in decreased expression of ITGA2 mRNA CTD PMID:25037058 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Enalapril inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Kng2 kininogen 2 increases response to substance EXP Enalapril results in increased susceptibility to KNG1 protein modified form CTD PMID:18190998 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:9175058 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Enalapril inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:9175058 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lep leptin increases response to substance ISO LEP protein results in increased susceptibility to Enalapril CTD PMID:20614101 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression
increases phosphorylation
EXP Enalapril results in increased expression of MAPK9 mRNA; Enalapril results in increased expression of MAPK9 protein
Enalapril results in increased phosphorylation of MAPK9 protein
CTD PMID:15531746 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases expression ISO Enalapril results in decreased expression of MMP3 mRNA CTD PMID:25037058 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased activity of MPO protein] CTD PMID:19114890 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Enalapril inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression
multiple interactions
EXP Enalapril results in decreased expression of MYH7 mRNA
Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of MYH7 protein]
CTD PMID:15362513, PMID:21423293 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:55,951,497...56,014,107
Ensembl chr18:55,955,389...55,992,885
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression EXP Enalapril results in decreased expression of NFE2L2 mRNA CTD PMID:18765277 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity
multiple interactions
EXP Enalapril results in decreased activity of NFKB1 protein
Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 mRNA]; Enalapril inhibits the reaction [Acrolein results in increased expression of NFKB1 protein]
CTD PMID:19225048, PMID:21265102 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:19114890 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Noa1 nitric oxide associated 1 increases expression
increases activity
EXP Enalapril results in increased expression of NOA1 mRNA
Enalapril results in increased activity of NOA1 protein
CTD PMID:14588141 NCBI chr14:33,107,868...33,124,172
Ensembl chr14:33,108,024...33,124,171
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of NOS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of NOS2 protein
CTD PMID:20720404, PMID:21377515, PMID:25037058 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects expression
EXP
ISO
[Enalapril co-treated with eplerenone] results in decreased expression of NOS3 mRNA; Enalapril inhibits the reaction [Nitric Oxide deficiency results in decreased expression of NOS3 protein]
Enalapril results in increased expression of NOS3 protein
[paricalcitol co-treated with Enalapril] results in increased expression of NOS3 protein; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]
Enalapril affects the expression of NOS3 mRNA
CTD PMID:12176110, PMID:16197366, PMID:20571278, PMID:20720404, PMID:25037058, PMID:30940551 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO
EXP
Enalapril results in decreased expression of NPPA protein
Enalapril results in decreased expression of NPPA mRNA
CTD PMID:2136812, PMID:8112904, PMID:21423293 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of NPPB protein] CTD PMID:18806606 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Enalapril results in increased expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Enalapril results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Pdpn podoplanin increases expression EXP Enalapril results in increased expression of PDPN protein CTD PMID:20933085 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Enalapril co-treated with Glucose] binds to PPARA protein; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]] CTD PMID:18812576 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
EXP Enalapril results in decreased expression of PPARG protein
Enalapril inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
CTD PMID:19225048, PMID:30623541 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Enalapril results in increased expression of PPARGC1A mRNA CTD PMID:18765277 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases expression ISO Enalapril results in increased expression of PRKAA1 protein CTD PMID:25037058 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha decreases expression EXP Enalapril results in decreased expression of PRKCA protein modified form CTD PMID:21565836 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression ISO Enalapril results in decreased expression of PTGS1 mRNA CTD PMID:25037058 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of PTGS2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of PTGS2 protein
CTD PMID:20720404, PMID:21377515, PMID:25037058 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Enalapril inhibits the reaction [Folic Acid results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:181,663,425...181,674,181 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Enalapril inhibits the reaction [Isoproterenol results in increased expression of RELA protein] CTD PMID:30623541 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin multiple interactions
increases expression
increases secretion
decreases activity
increases activity
ISO
EXP
[Indomethacin co-treated with Enalapril] results in decreased expression of REN protein; Enalapril inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
Enalapril results in increased expression of REN mRNA; Enalapril results in increased expression of REN protein
Enalapril results in increased secretion of REN protein
[Sodium Chloride deficiency co-treated with Enalapril] results in increased expression of REN mRNA; GJA5 affects the reaction [Enalapril results in increased secretion of REN protein]; GJC1 affects the reaction [Enalapril results in increased secretion of REN protein]; REN enhancer mutant form results in decreased susceptibility to [Sodium Chloride deficiency co-treated with Enalapril]; Sodium inhibits the reaction [Enalapril results in increased expression of REN mRNA]; Sodium inhibits the reaction [Enalapril results in increased expression of REN protein]; Sodium inhibits the reaction [Enalapril results in increased secretion of REN protein]
Enalapril results in decreased activity of REN protein
Enalapril results in increased activity of REN protein
CTD PMID:1330361, PMID:2994932, PMID:6094050, PMID:11078175, PMID:12434137, PMID:17846348, PMID:18679781, PMID:18796534, PMID:19109587, PMID:19536436, PMID:19767874, PMID:21423293, PMID:21424707 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Enalapril inhibits the reaction [Corticosterone results in decreased expression of RUNX2 mRNA] CTD PMID:30423288 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Sele selectin E multiple interactions ISO Enalapril inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Sell selectin L multiple interactions ISO [Enalapril co-treated with paricalcitol] results in decreased expression of SELL mRNA CTD PMID:25037058 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Selp selectin P multiple interactions
decreases expression
EXP
ISO
Enalapril inhibits the reaction [Diclofenac results in decreased expression of SELP protein]
Enalapril results in decreased expression of SELP mRNA
CTD PMID:14716214, PMID:25037058 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpinb2 serpin family B member 2 decreases expression ISO Enalapril results in decreased expression of SERPINB2 mRNA CTD PMID:25037058 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of SERPINE1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 mRNA]; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased expression of SERPINE1 protein]
Enalapril results in decreased expression of SERPINE1 mRNA; Enalapril results in decreased expression of SERPINE1 protein
CTD PMID:18682491 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Slc15a2 solute carrier family 15 member 2 multiple interactions ISO Enalapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine] CTD PMID:18713951 NCBI chr11:66,932,664...66,961,708
Ensembl chr11:66,932,614...66,961,713
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 NCBI chr 1:221,910,787...221,919,277
Ensembl chr 1:221,910,767...221,919,301
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Enalapril inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Enalapril inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15100168 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP Enalapril promotes the reaction [paricalcitol results in decreased phosphorylation of SMAD2 protein] CTD PMID:17513326 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad7 SMAD family member 7 increases expression EXP Enalapril results in increased expression of SMAD7 mRNA; Enalapril results in increased expression of SMAD7 protein CTD PMID:19197123, PMID:19349682 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
ISO [paricalcitol co-treated with Enalapril] results in increased expression of SOD1 protein
Enalapril results in increased expression of SOD1 protein
CTD PMID:20720404, PMID:25037058 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity
decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased activity of SOD2 protein
Enalapril results in decreased expression of SOD2 protein
[paricalcitol co-treated with Enalapril] results in decreased expression of SOD2 protein
CTD PMID:18765277, PMID:20720404, PMID:25037058 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO
EXP
[Enalapril co-treated with paricalcitol] results in decreased expression of SPP1 mRNA
Enalapril inhibits the reaction [Corticosterone results in decreased expression of SPP1 mRNA]
CTD PMID:25037058, PMID:30423288 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Ssbp1 single stranded DNA binding protein 1 increases expression EXP Enalapril results in increased expression of SSBP1 mRNA CTD PMID:18765277 NCBI chr 4:68,634,844...68,645,112
Ensembl chr 4:68,634,929...68,645,172
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of STAT3 protein] CTD PMID:19958114 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Enalapril inhibits the reaction [Streptozocin results in increased expression of TEK mRNA] CTD PMID:19958114 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
EXP [eplerenone co-treated with Enalapril] inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; [eplerenone co-treated with Enalapril] inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 mRNA; [eplerenone co-treated with Enalapril] results in decreased expression of TGFB1 protein; Enalapril inhibits the reaction [[Aldosterone co-treated with Glucose] results in increased secretion of TGFB1 protein]; Enalapril inhibits the reaction [Aldosterone promotes the reaction [Glucose results in increased expression of TGFB1 mRNA]]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 mRNA]; Enalapril promotes the reaction [paricalcitol results in decreased expression of TGFB1 protein]
Enalapril results in decreased expression of TGFB1 mRNA; Enalapril results in decreased expression of TGFB1 protein
CTD PMID:12883979, PMID:15309289, PMID:17164399, PMID:17513326, PMID:18682491, PMID:19197123, PMID:19349682, PMID:23733546 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP Enalapril results in decreased expression of TGFB2 mRNA CTD PMID:17164399 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfbi transforming growth factor, beta induced decreases secretion
multiple interactions
EXP Enalapril results in decreased secretion of TGFBI protein
[eplerenone co-treated with Enalapril] results in decreased secretion of TGFBI protein
CTD PMID:18682491 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression EXP Enalapril results in decreased expression of TGFBR1 mRNA; Enalapril results in decreased expression of TGFBR1 protein CTD PMID:12883979 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Thbs4 thrombospondin 4 increases expression ISO Enalapril results in increased expression of THBS4 mRNA CTD PMID:25037058 NCBI chr 2:22,343,727...22,385,855
Ensembl chr 2:22,343,727...22,385,855
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Enalapril] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
EXP
ISO
Enalapril results in decreased expression of TNF protein
Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]; Enalapril inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]
[paricalcitol co-treated with Enalapril] results in decreased expression of TNF protein; Enalapril inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]
Enalapril inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]
CTD PMID:12003776, PMID:16336586, PMID:17167242, PMID:17299153, PMID:18060435, PMID:19114890, PMID:19225048, PMID:20720404, PMID:25037058, PMID:30623541 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Enalapril results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Enalapril] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 affects expression
decreases expression
ISO Enalapril affects the expression of VCAM1
Enalapril results in decreased expression of VCAM1 mRNA; Enalapril results in decreased expression of VCAM1 protein modified form
CTD PMID:17347482, PMID:19939336 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
EXP
ISO
Enalapril inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Enalapril inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Enalapril inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
Enalapril results in increased expression of VEGFA protein
CTD PMID:12110003, PMID:16202860, PMID:17299153, PMID:21263376 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vwf von Willebrand factor decreases expression ISO Enalapril results in decreased expression of VWF mRNA CTD PMID:25037058 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of ACE protein] CTD PMID:16452552 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Adrb1 adrenoceptor beta 1 affects expression EXP Enalaprilat affects the expression of ADRB1 protein CTD PMID:9260993 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Enalaprilat affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP
ISO
Enalaprilat results in decreased expression of AGT protein modified form
Enalaprilat inhibits the reaction [Glucose results in increased expression of AGT protein]
CTD PMID:16452552, PMID:21795644 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in increased expression of AGTR1 protein] CTD PMID:16452552 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO Enalaprilat results in increased expression of BCL2 mRNA CTD PMID:17342403 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions
increases activity
ISO bradykinin, Lys-Leu(8)-desArg(9)- inhibits the reaction [Enalaprilat results in increased activity of BDKRB1 protein]; Zinc affects the reaction [Enalaprilat results in increased activity of BDKRB1 protein] CTD PMID:11880373 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Edn1 endothelin 1 decreases secretion ISO Enalaprilat results in decreased secretion of EDN1 protein CTD PMID:19079593 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fn1 fibronectin 1 decreases expression
multiple interactions
EXP
ISO
Enalaprilat results in decreased expression of FN1 mRNA; Enalaprilat results in decreased expression of FN1 protein
Enalaprilat inhibits the reaction [Glucose results in increased expression of FN1 mRNA]
CTD PMID:14520012, PMID:21795644 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Glud1 glutamate dehydrogenase 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in decreased expression of GLUD2 mRNA] CTD PMID:32494933 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Grm1 glutamate metabotropic receptor 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of GRM1 mRNA] CTD PMID:32494933 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Enalaprilat inhibits the reaction [Glucose results in decreased secretion of INS protein] CTD PMID:16452552 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions EXP [Enalaprilat co-treated with Daunorubicin] results in increased expression of PPARD mRNA CTD PMID:23834779 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
JBrowse link
G Ren renin increases expression EXP Enalaprilat results in increased expression of REN mRNA CTD PMID:21795644 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Enalaprilat results in decreased expression of SERPINE1 mRNA CTD PMID:21795644 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP Enalaprilat results in decreased expression of TGFB1 mRNA; Enalaprilat results in decreased expression of TGFB1 protein CTD PMID:21795644 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of TLR4 mRNA] CTD PMID:32494933 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Enalaprilat results in decreased expression of TNF mRNA CTD PMID:17342403 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
epoxomicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO epoxomicin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
epoxomicin affects the localization of AHR protein
CTD PMID:17445780 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ATF4 protein]] CTD PMID:25639565 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of BAX protein]] CTD PMID:25639565 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of BCL2 protein]] CTD PMID:25639565 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 increases expression
multiple interactions
ISO epoxomicin results in increased expression of BIRC5 protein
epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein]
CTD PMID:17510429, PMID:18483385 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased cleavage of and results in increased activity of CASP3 protein]] CTD PMID:25639565 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO epoxomicin inhibits the reaction [NSC606985 results in decreased expression of CEBPA protein] CTD PMID:19662097 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator affects expression ISO epoxomicin affects the expression of CFLAR protein alternative form CTD PMID:17510429 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Dao D-amino-acid oxidase affects localization ISO epoxomicin affects the localization of DAO protein CTD PMID:28451739 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:25639565 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of EIF2S1 protein]] CTD PMID:25639565 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO epoxomicin inhibits the reaction [troxerutin inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of ERN1 protein]] CTD PMID:25639565 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]
epoxomicin results in increased expression of HIF1A protein
CTD PMID:25192544 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 multiple interactions ISO epoxomicin results in increased expression of and affects the localization of NFE2L1 protein; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMA2 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA] CTD PMID:27345029 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO epoxomicin results in increased expression of NFE2L2 protein CTD PMID:22558124 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Optn optineurin increases expression ISO
EXP
epoxomicin results in increased expression of OPTN protein CTD PMID:21059646 NCBI chr17:77,167,700...77,218,374
Ensembl chr17:77,167,740...77,218,389
JBrowse link
G Pacrg parkin coregulated decreases expression EXP
ISO
epoxomicin results in decreased expression of PACRG mRNA CTD PMID:18586549 NCBI chr 1:50,070,273...50,491,323 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [epoxomicin results in increased cleavage of PARP1 protein] CTD PMID:20153345 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdyn prodynorphin multiple interactions
decreases expression
ISO
EXP
epoxomicin inhibits the reaction [Potassium results in increased secretion of PDYN protein alternative form]; epoxomicin results in decreased expression of and results in decreased secretion of PDYN protein alternative form
epoxomicin results in decreased expression of PDYN protein alternative form
CTD PMID:17670969 NCBI chr 3:122,194,327...122,206,671
Ensembl chr 3:122,194,329...122,206,671
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO epoxomicin inhibits the reaction [resveratrol results in decreased expression of PPARG protein]; epoxomicin inhibits the reaction [rosiglitazone results in decreased expression of PPARG protein] CTD PMID:18555852 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases expression
multiple interactions
ISO
EXP
epoxomicin results in decreased expression of PRKN mRNA
epoxomicin inhibits the reaction [PRKN protein results in decreased susceptibility to Ceramides]
CTD PMID:12588799, PMID:18586549 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Psma2 proteasome 20S subunit alpha 2 multiple interactions
increases expression
ISO NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMA2 mRNA] CTD PMID:27345029 NCBI chr17:53,091,937...53,102,324
Ensembl chr17:53,091,933...53,102,342
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 increases expression
multiple interactions
ISO epoxomicin results in increased expression of PSMB6 mRNA
Ascorbic Acid inhibits the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMB6 mRNA]; sulforafan inhibits the reaction [epoxomicin results in increased expression of PSMB6 mRNA]
CTD PMID:27345029 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637
JBrowse link
G Psmc4 proteasome 26S subunit, ATPase 4 multiple interactions
increases expression
ISO NFE2L1 protein affects the reaction [epoxomicin results in increased expression of PSMC4 mRNA] CTD PMID:27345029 NCBI chr 1:84,978,220...84,986,536
Ensembl chr 1:84,978,206...84,986,581
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions
increases ubiquitination
ISO epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of SP1 protein]; epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in increased degradation of SP1 protein]
epoxomicin results in increased ubiquitination of SP1 protein
CTD PMID:17409431 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
JBrowse link
G Taf1 TATA-box binding protein associated factor 1 multiple interactions ISO epoxomicin inhibits the reaction [5-(4-((6-(allyloxy)-2,5,7,8-tetramethylchroman-2-yl)methoxy)-3-methoxybenzylidene)thiazolidine-2,4-dione results in decreased expression of TAF1 protein] CTD PMID:17409431 NCBI chr  X:71,412,291...71,486,456
Ensembl chr  X:71,412,289...71,485,085
JBrowse link
G Tardbp TAR DNA binding protein multiple interactions ISO epoxomicin inhibits the reaction [Cycloheximide results in decreased expression of and results in decreased stability of TARDBP protein mutant form]; epoxomicin inhibits the reaction [Cycloheximide results in decreased expression of TARDBP protein] CTD PMID:24477737 NCBI chr 5:165,432,089...165,442,232
Ensembl chr 5:165,432,095...165,442,048
JBrowse link
gamma-glutamyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta4 glutathione S-transferase alpha 4 multiple interactions EXP GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions EXP GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
gliotoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Gliotoxin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BIRC3 mRNA] CTD PMID:14527959 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP Gliotoxin results in increased cleavage of and results in increased activity of CASP3 protein; Mercuric Chloride inhibits the reaction [Gliotoxin results in increased activity of CASP3 protein] CTD PMID:17466404, PMID:20958918 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 decreases expression EXP Gliotoxin results in decreased expression of CYP2B2 mRNA CTD PMID:18346771 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Decr2 2,4-dienoyl-CoA reductase 2 decreases expression EXP Gliotoxin results in decreased expression of DECR2 mRNA CTD PMID:18346771 NCBI chr10:15,451,850...15,460,227
Ensembl chr10:15,431,638...15,465,413
JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Gliotoxin results in increased expression of DNAJB1 mRNA CTD PMID:18346771 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919
JBrowse link
G Dpys dihydropyrimidinase decreases expression EXP Gliotoxin results in decreased expression of DPYS mRNA CTD PMID:18346771 NCBI chr 7:78,769,918...78,847,941
Ensembl chr 7:78,769,807...78,847,974
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Gliotoxin results in decreased expression of ECH1 mRNA CTD PMID:18346771 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Gliotoxin results in increased expression of GADD45A mRNA CTD PMID:18346771 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression EXP Gliotoxin results in decreased expression of GJB1 mRNA CTD PMID:18346771 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Gliotoxin results in decreased expression of GNMT mRNA CTD PMID:18346771 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Gliotoxin results in decreased expression of GSTM2 mRNA CTD PMID:18346771 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Gliotoxin results in decreased expression of HAL mRNA CTD PMID:18346771 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G