Pdha2 (pyruvate dehydrogenase E1 subunit alpha 2) - Rat Genome Database

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Gene: Pdha2 (pyruvate dehydrogenase E1 subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Pdha2
Name: pyruvate dehydrogenase E1 subunit alpha 2
RGD ID: 620095
Description: Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2); PARTICIPATES IN pyruvate metabolic pathway; butanoate metabolic pathway; citric acid cycle pathway; INTERACTS WITH 3-chloropropane-1,2-diol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pdhal; PDHE1-A type II; pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase alpha 2; pyruvate dehydrogenase E1 alpha 2; pyruvate dehydrogenase E1 alpha 2 subunit; pyruvate dehydrogenase E1 alpha-like; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22229,872,300 - 229,873,848 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2237,628,495 - 237,630,043 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02235,521,610 - 235,523,158 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02230,386,197 - 230,387,745 (-)NCBIRnor_WKY
Rnor_6.02246,736,449 - 246,737,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02265,263,422 - 265,264,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42238,983,103 - 238,984,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12238,970,107 - 238,971,414 (-)NCBI
Celera2221,953,528 - 221,955,076 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes. Fitzgerald J, etal., Biochim Biophys Acta 1992 May 7;1131(1):83-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7916643   PMID:12477932   PMID:15489334   PMID:16436377   PMID:18614015   PMID:21630459  


Genomics

Comparative Map Data
Pdha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22229,872,300 - 229,873,848 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2237,628,495 - 237,630,043 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02235,521,610 - 235,523,158 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02230,386,197 - 230,387,745 (-)NCBIRnor_WKY
Rnor_6.02246,736,449 - 246,737,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02265,263,422 - 265,264,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42238,983,103 - 238,984,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12238,970,107 - 238,971,414 (-)NCBI
Celera2221,953,528 - 221,955,076 (-)NCBICelera
Cytogenetic Map2q44NCBI
PDHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38495,840,093 - 95,841,464 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl495,840,093 - 95,841,464 (+)EnsemblGRCh38hg38GRCh38
GRCh37496,761,244 - 96,762,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36496,980,262 - 96,981,648 (+)NCBINCBI36Build 36hg18NCBI36
Build 34497,118,420 - 97,119,802NCBI
Celera494,057,862 - 94,059,248 (+)NCBICelera
Cytogenetic Map4q22.3NCBI
HuRef492,497,707 - 92,499,093 (+)NCBIHuRef
CHM1_1496,737,910 - 96,739,296 (+)NCBICHM1_1
T2T-CHM13v2.0499,155,293 - 99,156,664 (+)NCBIT2T-CHM13v2.0
Pdha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393140,915,765 - 140,918,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3140,915,765 - 140,918,116 (-)EnsemblGRCm39 Ensembl
GRCm383141,210,004 - 141,212,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3141,210,004 - 141,212,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv373140,872,968 - 140,875,319 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363141,147,391 - 141,149,742 (-)NCBIMGSCv36mm8
Celera3147,635,677 - 147,638,028 (-)NCBICelera
Cytogenetic Map3H1NCBI
Pdha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554056,383,088 - 6,383,946 (+)NCBIChiLan1.0ChiLan1.0
PDHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1498,883,210 - 98,884,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl498,883,109 - 98,884,853 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0488,213,492 - 88,216,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PDHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3223,393,738 - 23,401,128 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03218,716,064 - 18,722,917 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.03218,509,502 - 18,516,891 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03221,376,199 - 21,383,047 (-)NCBIUU_Cfam_GSD_1.0
Pdha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530123,160,363 - 23,161,554 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367172,377,982 - 2,379,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.18123,926,253 - 123,927,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28133,145,223 - 133,146,389 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1744,056,991 - 44,058,705 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl744,057,352 - 44,058,518 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603722,435,111 - 22,436,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475723,806,964 - 23,808,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RW2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22229,872,928 - 229,873,136 (+)MAPPERmRatBN7.2
Rnor_6.02246,737,078 - 246,737,285NCBIRnor6.0
Rnor_5.02265,264,051 - 265,264,258UniSTSRnor5.0
RGSC_v3.42238,983,732 - 238,983,939UniSTSRGSC3.4
Celera2221,954,157 - 221,954,364UniSTS
Cytogenetic Map2q44UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87hepatic copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000021719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 8
Low 1 12
Below cutoff 2 1 2 1 3 4 2 6 2 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021719   ⟹   ENSRNOP00000071767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)Ensembl
RefSeq Acc Id: NM_053994   ⟹   NP_446446
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22229,872,300 - 229,873,848 (-)NCBI
Rnor_6.02246,736,449 - 246,737,997 (-)NCBI
Rnor_5.02265,263,422 - 265,264,970 (-)NCBI
RGSC_v3.42238,983,103 - 238,984,651 (-)RGD
Celera2221,953,528 - 221,955,076 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446446 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78757 (Get FASTA)   NCBI Sequence Viewer  
  EDL82338 (Get FASTA)   NCBI Sequence Viewer  
  Q06437 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446446   ⟸   NM_053994
- Peptide Label: precursor
- UniProtKB: Q06437 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071767   ⟸   ENSRNOT00000021719

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06437-F1-model_v2 AlphaFold Q06437 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691792
Promoter ID:EPDNEW_R2316
Type:multiple initiation site
Name:Pdha2_1
Description:pyruvate dehydrogenase E1 alpha 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02246,738,011 - 246,738,071EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620095 AgrOrtholog
BioCyc Gene G2FUF-51004 BioCyc
Ensembl Genes ENSRNOG00000016223 Ensembl
IMAGE_CLONE IMAGE:7113421 IMAGE-MGC_LOAD
InterPro DH_E1 UniProtKB/Swiss-Prot
  Pyrv_DH_E1_asu_subgrp-y UniProtKB/Swiss-Prot
  THDP-binding UniProtKB/Swiss-Prot
KEGG Report rno:117098 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93262 IMAGE-MGC_LOAD
NCBI Gene 117098 ENTREZGENE
Pfam E1_dh UniProtKB/Swiss-Prot
PhenoGen Pdha2 PhenoGen
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot
TIGRFAMs PDH_E1_alph_y UniProtKB/Swiss-Prot
UniProt ODPAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Pdha2  pyruvate dehydrogenase E1 subunit alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-23 Pdha2  pyruvate dehydrogenase E1 alpha 2 subunit  Pdha2  pyruvate dehydrogenase alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-20 Pdha2  pyruvate dehydrogenase alpha 2  Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-29 Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-08 Pdha2  pyruvate dehydrogenase E1 alpha 2  Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-03 Pdha2  pyruvate dehydrogenase E1 alpha 2  Pdhal  pyruvate dehydrogenase E1 alpha-like  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pdhal  pyruvate dehydrogenase E1 alpha-like      Symbol and Name status set to provisional 70820 PROVISIONAL