Pdha2 (pyruvate dehydrogenase E1 subunit alpha 2) - Rat Genome Database

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Gene: Pdha2 (pyruvate dehydrogenase E1 subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Pdha2
Name: pyruvate dehydrogenase E1 subunit alpha 2 (Ensembl:pyruvate dehydrogenase E1 alpha 2 subunit)
RGD ID: 620095
Description: Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Part of pyruvate dehydrogenase complex. Human ortholog(s) of this gene implicated in spermatogenic failure 70. Orthologous to human PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2); PARTICIPATES IN pyruvate metabolic pathway; butanoate metabolic pathway; citric acid cycle pathway; INTERACTS WITH 3-chloropropane-1,2-diol; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pdhal; PDHE1-A type II; pyruvate dehydrogenase (lipoamide) alpha 2; pyruvate dehydrogenase alpha 2; pyruvate dehydrogenase E1 alpha 2; pyruvate dehydrogenase E1 alpha 2 subunit; pyruvate dehydrogenase E1 alpha-like; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82232,545,550 - 232,547,098 (-)NCBIGRCr8
mRatBN7.22229,872,300 - 229,873,848 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2237,628,495 - 237,630,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02235,521,610 - 235,523,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02230,386,197 - 230,387,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02246,736,449 - 246,737,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02265,263,422 - 265,264,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42238,983,103 - 238,984,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12238,970,107 - 238,971,414 (-)NCBI
Celera2221,953,528 - 221,955,076 (-)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation and characterisation of the mouse pyruvate dehydrogenase E1 alpha genes. Fitzgerald J, etal., Biochim Biophys Acta 1992 May 7;1131(1):83-90.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Maury J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):531-5.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS and Korotchkina LG, Exp Mol Med. 2001 Dec 31;33(4):191-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7916643   PMID:12477932   PMID:15489334   PMID:16436377   PMID:18614015   PMID:21630459  


Genomics

Comparative Map Data
Pdha2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82232,545,550 - 232,547,098 (-)NCBIGRCr8
mRatBN7.22229,872,300 - 229,873,848 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2237,628,495 - 237,630,043 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02235,521,610 - 235,523,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02230,386,197 - 230,387,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02246,736,449 - 246,737,997 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02265,263,422 - 265,264,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42238,983,103 - 238,984,651 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12238,970,107 - 238,971,414 (-)NCBI
Celera2221,953,528 - 221,955,076 (-)NCBICelera
Cytogenetic Map2q44NCBI
PDHA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38495,840,093 - 95,841,464 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl495,840,093 - 95,841,464 (+)EnsemblGRCh38hg38GRCh38
GRCh37496,761,244 - 96,762,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36496,980,262 - 96,981,648 (+)NCBINCBI36Build 36hg18NCBI36
Build 34497,118,420 - 97,119,802NCBI
Celera494,057,862 - 94,059,248 (+)NCBICelera
Cytogenetic Map4q22.3NCBI
HuRef492,497,707 - 92,499,093 (+)NCBIHuRef
CHM1_1496,737,910 - 96,739,296 (+)NCBICHM1_1
T2T-CHM13v2.0499,155,293 - 99,156,664 (+)NCBIT2T-CHM13v2.0
Pdha2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393140,915,765 - 140,918,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3140,915,765 - 140,918,116 (-)EnsemblGRCm39 Ensembl
GRCm383141,210,004 - 141,212,355 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3141,210,004 - 141,212,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv373140,872,968 - 140,875,319 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363141,147,391 - 141,149,742 (-)NCBIMGSCv36mm8
Celera3147,635,677 - 147,638,028 (-)NCBICelera
Cytogenetic Map3H1NCBI
cM Map365.3NCBI
Pdha2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554056,383,088 - 6,383,946 (+)NCBIChiLan1.0ChiLan1.0
PDHA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2393,878,837 - 93,883,621 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1494,157,900 - 94,160,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0488,213,492 - 88,216,451 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1498,883,210 - 98,884,591 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl498,883,109 - 98,884,853 (+)Ensemblpanpan1.1panPan2
PDHA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha3223,393,738 - 23,401,128 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03218,716,064 - 18,722,917 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.03218,509,502 - 18,516,891 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03221,376,199 - 21,383,047 (-)NCBIUU_Cfam_GSD_1.0
Pdha2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530123,160,363 - 23,161,554 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367172,377,982 - 2,379,137 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDHA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.18123,926,253 - 123,927,419 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28133,145,223 - 133,146,389 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDHA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1744,056,991 - 44,058,705 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl744,057,352 - 44,058,518 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603722,435,111 - 22,436,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdha2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475723,806,964 - 23,808,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000021719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat

Markers in Region
RW2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22229,872,928 - 229,873,136 (+)MAPPERmRatBN7.2
Rnor_6.02246,737,078 - 246,737,285NCBIRnor6.0
Rnor_5.02265,264,051 - 265,264,258UniSTSRnor5.0
RGSC_v3.42238,983,732 - 238,983,939UniSTSRGSC3.4
Celera2221,954,157 - 221,954,364UniSTS
Cytogenetic Map2q44UniSTS


Expression

RNA-SEQ Expression

appendage
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 8 6 7 3 5 3 16 8 6 2 41 4

Sequence


Ensembl Acc Id: ENSRNOT00000021719   ⟹   ENSRNOP00000071767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2246,736,459 - 246,737,997 (-)Ensembl
RefSeq Acc Id: NM_053994   ⟹   NP_446446
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82232,545,550 - 232,547,098 (-)NCBI
mRatBN7.22229,872,300 - 229,873,848 (-)NCBI
Rnor_6.02246,736,449 - 246,737,997 (-)NCBI
Rnor_5.02265,263,422 - 265,264,970 (-)NCBI
RGSC_v3.42238,983,103 - 238,984,651 (-)RGD
Celera2221,953,528 - 221,955,076 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446446 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78757 (Get FASTA)   NCBI Sequence Viewer  
  EDL82338 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00055015815
  ENSRNOP00060037638
  ENSRNOP00065037352
GenBank Protein Q06437 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446446   ⟸   NM_053994
- Peptide Label: precursor
- UniProtKB: Q06437 (UniProtKB/Swiss-Prot),   A6HW52 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071767   ⟸   ENSRNOT00000021719
Protein Domains
Dehydrogenase E1 component

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06437-F1-model_v2 AlphaFold Q06437 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691792
Promoter ID:EPDNEW_R2316
Type:multiple initiation site
Name:Pdha2_1
Description:pyruvate dehydrogenase E1 alpha 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02246,738,011 - 246,738,071EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620095 AgrOrtholog
BioCyc Gene G2FUF-51004 BioCyc
Ensembl Genes ENSRNOG00000016223 Ensembl
  ENSRNOG00055011529 UniProtKB/Swiss-Prot
  ENSRNOG00060026187 UniProtKB/Swiss-Prot
  ENSRNOG00065026402 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055019595 UniProtKB/Swiss-Prot
  ENSRNOT00060045333 UniProtKB/Swiss-Prot
  ENSRNOT00065045553 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.970 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7113421 IMAGE-MGC_LOAD
InterPro DH_E1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDH_E1_Alpha_Subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_DH_E1_asu_subgrp-y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THDP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93262 IMAGE-MGC_LOAD
NCBI Gene 117098 ENTREZGENE
PANTHER PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA, TESTIS-SPECIFIC FORM, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam E1_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pdha2 PhenoGen
RatGTEx ENSRNOG00000016223 RatGTEx
  ENSRNOG00055011529 RatGTEx
  ENSRNOG00060026187 RatGTEx
  ENSRNOG00065026402 RatGTEx
Superfamily-SCOP SSF52518 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HW52 ENTREZGENE, UniProtKB/TrEMBL
  ODPAT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Pdha2  pyruvate dehydrogenase E1 subunit alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-08-23 Pdha2  pyruvate dehydrogenase E1 alpha 2 subunit  Pdha2  pyruvate dehydrogenase alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-06-20 Pdha2  pyruvate dehydrogenase alpha 2  Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-29 Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-08 Pdha2  pyruvate dehydrogenase E1 alpha 2  Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Pdha2  pyruvate dehydrogenase (lipoamide) alpha 2  Pdha2  pyruvate dehydrogenase E1 alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-03 Pdha2  pyruvate dehydrogenase E1 alpha 2  Pdhal  pyruvate dehydrogenase E1 alpha-like  Symbol and Name updated 1299863 APPROVED
2002-08-07 Pdhal  pyruvate dehydrogenase E1 alpha-like      Symbol and Name status set to provisional 70820 PROVISIONAL