Pbk (PDZ binding kinase) - Rat Genome Database

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Gene: Pbk (PDZ binding kinase) Rattus norvegicus
Analyze
Symbol: Pbk
Name: PDZ binding kinase
RGD ID: 1309565
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in phosphorylation. Predicted to act upstream of or within several processes, including cellular response to UV; negative regulation of protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Orthologous to human PBK (PDZ binding kinase); INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290326; lymphokine-activated killer T-cell-originated protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,022,873 - 40,034,014 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,023,002 - 40,034,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1541,887,040 - 41,897,909 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,037,240 - 43,048,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,483,331 - 41,494,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,489,253 - 42,500,377 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,489,377 - 42,500,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,092,278 - 49,103,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,227,251 - 45,238,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,243,243 - 45,253,246 (+)NCBI
Celera1539,695,399 - 39,706,400 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-diaminotoluene  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
diallyl trisulfide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
kojic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
mitomycin C  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
zaragozic acid A  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21715333   PMID:25065601   PMID:25575812  


Genomics

Comparative Map Data
Pbk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21540,022,873 - 40,034,014 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,023,002 - 40,034,014 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1541,887,040 - 41,897,909 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01543,037,240 - 43,048,109 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01541,483,331 - 41,494,332 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01542,489,253 - 42,500,377 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,489,377 - 42,500,395 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,092,278 - 49,103,401 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,227,251 - 45,238,096 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11545,243,243 - 45,253,246 (+)NCBI
Celera1539,695,399 - 39,706,400 (+)NCBICelera
Cytogenetic Map15p12NCBI
PBK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,809,624 - 27,837,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,809,624 - 27,838,082 (-)EnsemblGRCh38hg38GRCh38
GRCh37827,667,141 - 27,695,334 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,723,057 - 27,751,268 (-)NCBINCBI36Build 36hg18NCBI36
Build 34827,723,058 - 27,751,268NCBI
Celera826,627,008 - 26,655,180 (-)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,212,013 - 26,240,449 (-)NCBIHuRef
CHM1_1827,869,078 - 27,897,509 (-)NCBICHM1_1
T2T-CHM13v2.0828,086,996 - 28,115,148 (-)NCBIT2T-CHM13v2.0
Pbk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,043,337 - 66,055,271 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,043,286 - 66,055,271 (+)EnsemblGRCm39 Ensembl
GRCm381465,805,911 - 65,817,822 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,805,837 - 65,817,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv371466,424,748 - 66,436,659 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,760,021 - 64,771,932 (+)NCBIMGSCv36mm8
Celera1463,558,969 - 63,570,871 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Pbk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,330,981 - 50,352,570 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,332,167 - 50,353,147 (-)NCBIChiLan1.0ChiLan1.0
PBK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1822,059,428 - 22,087,514 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0827,084,789 - 27,112,986 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,285,395 - 24,313,658 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,285,395 - 24,313,658 (-)Ensemblpanpan1.1panPan2
PBK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,751,805 - 29,781,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,751,848 - 29,781,300 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,404,998 - 30,434,687 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02529,943,454 - 29,973,465 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2529,943,487 - 29,972,927 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12529,873,334 - 29,903,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,754,800 - 29,784,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02529,921,110 - 29,951,165 (+)NCBIUU_Cfam_GSD_1.0
Pbk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,861,465 - 7,882,241 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675704,516 - 722,755 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675704,001 - 722,769 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PBK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1411,543,603 - 11,566,702 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11411,543,657 - 11,577,286 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,722,902 - 12,728,961 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21412,786,445 - 12,795,922 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PBK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,921,124 - 25,943,349 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,921,133 - 25,943,062 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,195,068 - 16,217,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pbk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,603,039 - 22,625,763 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,603,076 - 22,625,817 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pbk
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:162
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000064306
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
AW538537  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,033,316 - 40,033,401 (+)MAPPERmRatBN7.2
Rnor_6.01542,499,680 - 42,499,764NCBIRnor6.0
Rnor_5.01549,092,891 - 49,092,975UniSTSRnor5.0
RGSC_v3.41545,237,401 - 45,237,485UniSTSRGSC3.4
Celera1539,705,705 - 39,705,789UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 26 20 12 20 43 20 36
Low 1 12 24 15 7 15 4 5 22 14 5 11 4
Below cutoff 5 6 5 5 4 6 8 1 4

Sequence


RefSeq Acc Id: ENSRNOT00000064306   ⟹   ENSRNOP00000061382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,023,002 - 40,034,014 (+)Ensembl
Rnor_6.0 Ensembl1542,489,377 - 42,500,395 (+)Ensembl
RefSeq Acc Id: NM_001079937   ⟹   NP_001073406
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,023,010 - 40,034,012 (+)NCBI
Rnor_6.01542,489,374 - 42,500,375 (+)NCBI
Rnor_5.01549,092,278 - 49,103,401 (-)NCBI
RGSC_v3.41545,227,251 - 45,238,096 (+)RGD
Celera1539,695,399 - 39,706,400 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252103   ⟹   XP_006252165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,022,873 - 40,034,014 (+)NCBI
Rnor_6.01542,489,253 - 42,500,377 (+)NCBI
Rnor_5.01549,092,278 - 49,103,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252104   ⟹   XP_006252166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,025,028 - 40,034,014 (+)NCBI
Rnor_6.01542,491,989 - 42,500,377 (+)NCBI
Rnor_5.01549,092,278 - 49,103,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252105   ⟹   XP_006252167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,023,418 - 40,034,014 (+)NCBI
Rnor_6.01542,489,782 - 42,500,377 (+)NCBI
Rnor_5.01549,092,278 - 49,103,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006252106   ⟹   XP_006252168
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,023,001 - 40,034,014 (+)NCBI
Rnor_6.01542,489,351 - 42,500,377 (+)NCBI
Rnor_5.01549,092,278 - 49,103,401 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093142   ⟹   XP_038949070
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21540,023,323 - 40,034,014 (+)NCBI
RefSeq Acc Id: NP_001073406   ⟸   NM_001079937
- UniProtKB: A1L1J7 (UniProtKB/TrEMBL),   D4A9B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252165   ⟸   XM_006252103
- Peptide Label: isoform X1
- UniProtKB: A1L1J7 (UniProtKB/TrEMBL),   D4A9B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252168   ⟸   XM_006252106
- Peptide Label: isoform X1
- UniProtKB: A1L1J7 (UniProtKB/TrEMBL),   D4A9B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252167   ⟸   XM_006252105
- Peptide Label: isoform X1
- UniProtKB: A1L1J7 (UniProtKB/TrEMBL),   D4A9B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252166   ⟸   XM_006252104
- Peptide Label: isoform X1
- UniProtKB: A1L1J7 (UniProtKB/TrEMBL),   D4A9B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061382   ⟸   ENSRNOT00000064306
RefSeq Acc Id: XP_038949070   ⟸   XM_039093142
- Peptide Label: isoform X1
- UniProtKB: D4A9B1 (UniProtKB/TrEMBL),   A1L1J7 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L1J7-F1-model_v2 AlphaFold A1L1J7 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699747
Promoter ID:EPDNEW_R10271
Type:initiation region
Name:Pbk_1
Description:PDZ binding kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,489,366 - 42,489,426EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309565 AgrOrtholog
BioCyc Gene G2FUF-13345 BioCyc
Ensembl Genes ENSRNOG00000015308 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064306 ENTREZGENE
  ENSRNOT00000064306.4 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8375047 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  PKc_TOPK UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:290326 UniProtKB/TrEMBL
MGC_CLONE MGC:156686 IMAGE-MGC_LOAD
NCBI Gene 290326 ENTREZGENE
PANTHER LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Pbk PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015308 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A1L1J7 ENTREZGENE, UniProtKB/TrEMBL
  D4A9B1 ENTREZGENE
UniProt Secondary D4A9B1 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Pbk  PDZ binding kinase   Pbk_predicted  PDZ binding kinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pbk_predicted  PDZ binding kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED