Ckb (creatine kinase B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ckb (creatine kinase B) Rattus norvegicus
Analyze
Symbol: Ckb
Name: creatine kinase B
RGD ID: 2357
Description: Predicted to enable creatine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and intracellular chloride ion homeostasis. Located in dendrite and neuronal cell body. Orthologous to human CKB (creatine kinase B); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; INTERACTS WITH (R,R)-tramadol; 1-bromopropane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-CK; brain creatine kinase; Ckbb; Ckbr; CPK-B; creatine kinase B chain; creatine kinase B-type; creatine kinase, brain; creatine kinase-B; creatine phosphokinase M-type; RATCKBR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   LEM  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,550,583 - 136,553,464 (-)NCBIGRCr8
mRatBN7.26130,729,420 - 130,732,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,729,423 - 130,732,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,896,519 - 130,899,400 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,192,501 - 131,195,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,559,479 - 130,562,360 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,142,956 - 136,145,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,270,901 - 144,273,776 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,452,215 - 136,455,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,458,401 - 136,461,309 (-)NCBI
Celera6128,284,759 - 128,287,594 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxyestrone  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benidipine  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celastrol  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP,ISO)
clobetasol  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (EXP)
Cuprizon  (ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
estriol  (EXP)
estrogen  (EXP)
ethanol  (EXP,ISO)
fenamidone  (ISO)
fenthion  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gallic acid  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glycine betaine  (EXP)
hydrogen peroxide  (ISO)
imetit  (EXP)
indometacin  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loperamide  (EXP)
lutein  (EXP)
lycopene  (EXP)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naphthalene  (ISO)
nickel sulfate  (ISO)
nitroglycerin  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
proanthocyanidin  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
rotenone  (EXP)
ruthenium atom  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tapentadol  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
tetrahydropalmatine  (ISO)
thapsigargin  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
tramadol  (EXP,ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin D  (EXP)
vitamin E  (ISO)
wortmannin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression of a rat brain creatine kinase-beta-galactosidase fusion protein in Escherichia coli and derivation of the complete amino acid sequence of rat brain creatine kinase. Benfield PA, etal., Gene 1985;39(2-3):263-7.
2. Isolation of four rat creatine kinase genes and identification of multiple potential promoter sequences within the rat brain creatine kinase promoter region. Benfield PA, etal., Gene 1988 Mar 31;63(2):227-43.
3. Expression of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in the fetal rat brain: evidence for a nuclear energy shuttle. Chen L, etal., J Comp Neurol. 1995 Dec 18;363(3):389-401.
4. Compartmentation of brain-type creatine kinase and ubiquitous mitochondrial creatine kinase in neurons: evidence for a creatine phosphate energy shuttle in adult rat brain. Friedman DL and Roberts R, J Comp Neurol. 1994 May 15;343(3):500-11.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. Inoue K, etal., FEBS Lett. 2004 Apr 23;564(1-2):131-5.
8. Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2. Inoue K, etal., J Neurochem. 2006 Jan;96(2):598-608. Epub 2005 Nov 29.
9. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Hippocalcin mediates calcium-dependent translocation of brain-type creatine kinase (BB-CK) in hippocampal neurons. Kobayashi M, etal., Biochem Biophys Res Commun. 2012 Dec 14;429(3-4):142-7. doi: 10.1016/j.bbrc.2012.10.125. Epub 2012 Nov 6.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Myocardial creatine kinase expression after left ventricular assist device support. Park SJ, etal., J Am Coll Cardiol. 2002 Jun 5;39(11):1773-9.
15. Estrogen regulation of creatine kinase-B in the rat uterus. Pentecost BT, etal., Mol Endocrinol 1990 Jul;4(7):1000-10.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation. Shen W, etal., Biochem J 2002 Oct 15;367(Pt 2):369-80.
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1939264   PMID:6477506   PMID:10481911   PMID:11487543   PMID:14651853   PMID:15489334   PMID:15548869   PMID:17634366   PMID:18304734   PMID:18418703   PMID:19056867   PMID:19370404  
PMID:19409453   PMID:19410564   PMID:19725078   PMID:22307408   PMID:22871113   PMID:22926577   PMID:23376485   PMID:23533145   PMID:23620342   PMID:29339092   PMID:31505169   PMID:32357304  


Genomics

Comparative Map Data
Ckb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86136,550,583 - 136,553,464 (-)NCBIGRCr8
mRatBN7.26130,729,420 - 130,732,301 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6130,729,423 - 130,732,315 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6130,896,519 - 130,899,400 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,192,501 - 131,195,382 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06130,559,479 - 130,562,360 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,142,956 - 136,145,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06144,270,901 - 144,273,776 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,452,215 - 136,455,122 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,458,401 - 136,461,309 (-)NCBI
Celera6128,284,759 - 128,287,594 (-)NCBICelera
Cytogenetic Map6q32NCBI
CKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814103,519,667 - 103,522,830 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14103,519,667 - 103,522,833 (-)EnsemblGRCh38hg38GRCh38
GRCh3714103,986,004 - 103,989,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,055,749 - 103,058,923 (-)NCBINCBI36Build 36hg18NCBI36
Build 3414103,055,748 - 103,058,923NCBI
Celera1484,040,224 - 84,043,398 (-)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1484,164,414 - 84,167,557 (-)NCBIHuRef
CHM1_114103,924,170 - 103,927,371 (-)NCBICHM1_1
T2T-CHM13v2.01497,755,711 - 97,758,874 (-)NCBIT2T-CHM13v2.0
Ckb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,635,789 - 111,638,772 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12111,635,795 - 111,638,772 (-)EnsemblGRCm39 Ensembl
GRCm3812111,669,355 - 111,672,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,669,361 - 111,672,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712112,907,566 - 112,910,549 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,117,169 - 112,120,076 (-)NCBIMGSCv36mm8
Celera12112,866,533 - 112,869,516 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.09NCBI
Ckb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555382,379,868 - 2,380,771 (-)NCBIChiLan1.0ChiLan1.0
CKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215104,678,952 - 104,682,157 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114103,895,452 - 103,898,675 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,145,931 - 84,149,093 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114103,957,347 - 103,960,736 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC100855552
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,284,104 - 71,287,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,795,385 - 70,798,712 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0871,559,900 - 71,563,227 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl871,559,903 - 71,563,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,249,019 - 71,252,346 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,288,738 - 71,292,065 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0871,687,984 - 71,691,311 (-)NCBIUU_Cfam_GSD_1.0
Ckb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,783,394 - 2,786,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,612,393 - 1,615,822 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,612,398 - 1,615,821 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CKB
(Sus scrofa - pig)		 No map positions available.
CKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,462,164 - 81,463,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605368,763,838 - 68,767,259 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ckb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247341,346,510 - 1,349,383 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247341,346,056 - 1,349,383 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ckb
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000015122
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat

Markers in Region
D6Mit6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,731,912 - 130,732,059 (+)MAPPERmRatBN7.2
Rnor_6.06136,145,450 - 136,145,596NCBIRnor6.0
Rnor_5.06144,271,143 - 144,271,290NCBIRnor5.0
Rnor_5.06144,271,142 - 144,271,289NCBIRnor5.0
RGSC_v3.46136,454,720 - 136,454,866UniSTSRGSC3.4
RGSC_v3.46136,454,719 - 136,454,865RGDRGSC3.4
RGSC_v3.16136,460,906 - 136,461,052RGD
Celera6128,287,206 - 128,287,352UniSTS
RH 3.4 Map6780.7UniSTS
RH 3.4 Map6780.7RGD
Cytogenetic Map6q32UniSTS
D6Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,729,205 - 130,729,475 (+)MAPPERmRatBN7.2
Rnor_6.06136,142,742 - 136,143,011NCBIRnor6.0
Rnor_5.06144,273,721 - 144,273,990UniSTSRnor5.0
RGSC_v3.46136,451,997 - 136,452,267RGDRGSC3.4
RGSC_v3.46136,451,998 - 136,452,267UniSTSRGSC3.4
RGSC_v3.16136,458,184 - 136,458,454RGD
Celera6128,284,545 - 128,284,814UniSTS
RH 2.0 Map20692.9RGD
Cytogenetic Map6q32UniSTS
D6Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46136,452,099 - 136,452,354RGDRGSC3.4
RGSC_v3.46136,452,100 - 136,452,354UniSTSRGSC3.4
Celera6128,284,647 - 128,284,901UniSTS
RH 3.4 Map6780.1RGD
Cytogenetic Map6 RGD
D6Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,729,295 - 130,729,557 (+)MAPPERmRatBN7.2
Rnor_6.06136,142,832 - 136,143,093NCBIRnor6.0
Rnor_5.06144,273,639 - 144,273,900UniSTSRnor5.0
RGSC_v3.46136,452,087 - 136,452,349RGDRGSC3.4
RGSC_v3.46136,452,088 - 136,452,349UniSTSRGSC3.4
RGSC_v3.16136,458,274 - 136,458,536RGD
Celera6128,284,635 - 128,284,896UniSTS
Cytogenetic Map6q32UniSTS
RH127492  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,729,489 - 130,729,707 (+)MAPPERmRatBN7.2
Rnor_6.06136,143,026 - 136,143,243NCBIRnor6.0
Rnor_5.06144,273,489 - 144,273,706UniSTSRnor5.0
RGSC_v3.46136,452,282 - 136,452,499UniSTSRGSC3.4
Celera6128,284,829 - 128,285,046UniSTS
RH 3.4 Map6779.5UniSTS
Cytogenetic Map6q32UniSTS
Egfr-rs  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,730,024 - 130,730,303 (+)MAPPERmRatBN7.2
Rnor_6.06136,143,561 - 136,143,839NCBIRnor6.0
Rnor_5.06144,272,893 - 144,273,171UniSTSRnor5.0
RGSC_v3.46136,452,817 - 136,453,095UniSTSRGSC3.4
Celera6128,285,364 - 128,285,642UniSTS
Cytogenetic Map6q32UniSTS
D6Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,729,307 - 130,729,562 (+)MAPPERmRatBN7.2
Rnor_6.06136,142,844 - 136,143,098NCBIRnor6.0
Rnor_5.06144,273,634 - 144,273,888UniSTSRnor5.0
RGSC_v3.46136,452,100 - 136,452,354UniSTSRGSC3.4
Celera6128,284,647 - 128,284,901UniSTS
RH 3.4 Map6780.1UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:546700  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26130,729,422 - 130,730,028 (+)MAPPERmRatBN7.2
Rnor_6.06136,142,959 - 136,143,564NCBIRnor6.0
Rnor_5.06144,273,168 - 144,273,773UniSTSRnor5.0
Celera6128,284,762 - 128,285,367UniSTS
Cytogenetic Map6q32UniSTS


Related Rat Strains
The following Strains have been annotated to Ckb
LEM    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19
Medium 3 43 42 26 19 26 5 8 55 35 36 11 5
Low 15 15 15 3 3 5 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015122   ⟹   ENSRNOP00000015122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6130,729,423 - 130,732,315 (-)Ensembl
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)Ensembl
RefSeq Acc Id: NM_012529   ⟹   NP_036661
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86136,550,583 - 136,553,464 (-)NCBI
mRatBN7.26130,729,420 - 130,732,301 (-)NCBI
Rnor_6.06136,142,956 - 136,145,838 (-)NCBI
Rnor_5.06144,270,901 - 144,273,776 (+)NCBI
RGSC_v3.46136,452,215 - 136,455,122 (-)RGD
Celera6128,284,759 - 128,287,594 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036661   ⟸   NM_012529
- UniProtKB: Q6IRE0 (UniProtKB/Swiss-Prot),   Q5PPJ5 (UniProtKB/Swiss-Prot),   Q499P7 (UniProtKB/Swiss-Prot),   A0JPK7 (UniProtKB/Swiss-Prot),   Q6P139 (UniProtKB/Swiss-Prot),   P07335 (UniProtKB/Swiss-Prot),   A6KBS5 (UniProtKB/TrEMBL),   A0A8L2Q875 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015122   ⟸   ENSRNOT00000015122
Protein Domains
Phosphagen kinase C-terminal   Phosphagen kinase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07335-F1-model_v2 AlphaFold P07335 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694842
Promoter ID:EPDNEW_R5366
Type:single initiation site
Name:Ckb_1
Description:creatine kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06136,145,847 - 136,145,907EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2357 AgrOrtholog
BioCyc Gene G2FUF-35836 BioCyc
BioCyc Pathway PWY-6158 [creatine phosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6158 BioCyc
Ensembl Genes ENSRNOG00000010872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015122 ENTREZGENE
  ENSRNOT00000015122.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.135.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutamine synthetase/guanido kinase, catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598839 IMAGE-MGC_LOAD
  IMAGE:7104205 IMAGE-MGC_LOAD
  IMAGE:7312830 IMAGE-MGC_LOAD
  IMAGE:7929525 IMAGE-MGC_LOAD
  IMAGE:8367180 IMAGE-MGC_LOAD
InterPro ATP-guanido_PTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-guanido_PTrfase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105277 IMAGE-MGC_LOAD
  MGC:124546 IMAGE-MGC_LOAD
  MGC:156567 IMAGE-MGC_LOAD
  MGC:72258 IMAGE-MGC_LOAD
  MGC:91404 IMAGE-MGC_LOAD
NCBI Gene 24264 ENTREZGENE
PANTHER CREATINE KINASE B-TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11547 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ATP-gua_Ptrans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-gua_PtransN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ckb PhenoGen
PROSITE PHOSPHAGEN_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHAGEN_KINASE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHOSPHAGEN_KINASE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010872 RatGTEx
Superfamily-SCOP SSF48034 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55931 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228968
UniProt A0A8L2Q875 ENTREZGENE, UniProtKB/TrEMBL
  A0JPK7 ENTREZGENE
  A6KBS4_RAT UniProtKB/TrEMBL
  A6KBS5 ENTREZGENE, UniProtKB/TrEMBL
  KCRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499P7 ENTREZGENE
  Q5PPJ5 ENTREZGENE
  Q6IRE0 ENTREZGENE
  Q6P139 ENTREZGENE
UniProt Secondary A0JPK7 UniProtKB/Swiss-Prot
  Q499P7 UniProtKB/Swiss-Prot
  Q5PPJ5 UniProtKB/Swiss-Prot
  Q6IRE0 UniProtKB/Swiss-Prot
  Q6P139 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Ckb  creatine kinase B  Ckb  creatine kinase, brain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ckb  creatine kinase, brain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytosolic membrane 625711
gene_expression mRNA and protein expression levels were low during the early postnatal period, which increased thereafter and attained a stable plateau by postnatal week 4 625711
gene_expression expressed in a number of tissues and is most abundant in cerebellar granular neurons of adult brain, neonatal cerebral astrocytes and oligodendrocytes, detected at lower levels in the stomach, heart and barely in liver 625711
gene_expression proximal promoter contains two CCAAT boxes (at -80bp and -50bp), a TA-rich element (TATAAATA, at -60bp), a non-consensus TATA box (TTAA, at -28bp), both CCAAT boxes and the (-60bp) TA-rich element bind trans-acting protein factors that activate Ckb transc 625711
gene_function reversibly catalyzes the transfer of phosphate between ATP and various phosphogens 625711
gene_function catalyses the synthesis of phosphocreatine (PCr) 625711
gene_process plays a role in energy transduction in tissues with large, changing energy demands 625711
gene_process involved in ATP regeneration to support synaptic transmission events like protein phosphorylation, transport of ions and glutamate 625711
gene_regulation increased cerebellar protein expression is regulated by transcription and is coincident with expression of myelin basic protein 625711