Ckb (creatine kinase B) - Rat Genome Database

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Gene: Ckb (creatine kinase B) Rattus norvegicus
Analyze
Symbol: Ckb
Name: creatine kinase B
RGD ID: 2357
Description: Predicted to have creatine kinase activity and ubiquitin protein ligase binding activity. Involved in cellular chloride ion homeostasis and cerebellum development. Localizes to dendrite; neuronal cell body; and nucleus. Orthologous to human CKB (creatine kinase B); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH 1-bromopropane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-CK; brain creatine kinase; Ckbb; Ckbr; CPK-B; creatine kinase B chain; creatine kinase B-type; creatine kinase, brain; creatine kinase-B; creatine phosphokinase M-type; RATCKBR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   LEM  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26130,729,420 - 130,732,301 (-)NCBI
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06136,142,956 - 136,145,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06144,270,901 - 144,273,776 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,452,215 - 136,455,122 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16136,458,401 - 136,461,309 (-)NCBI
Celera6128,284,759 - 128,287,594 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R)-tramadol  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxyestrone  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
afimoxifene  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
ampicillin  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcidiol  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
Citreoviridin  (EXP,ISO)
clobetasol  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
daidzein  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dichromium trioxide  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
estriol  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
furan  (EXP)
gallic acid  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glycine betaine  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isoflavones  (EXP)
isoprenaline  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
loperamide  (EXP)
lycopene  (EXP)
melatonin  (EXP)
menadione  (ISO)
methamphetamine  (EXP)
methoxychlor  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naphthalene  (ISO)
nickel sulfate  (ISO)
nitroglycerin  (EXP)
ouabain  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Pristimerin  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
rotenone  (EXP)
ruthenium atom  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tapentadol  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thiamine(1+) chloride  (EXP,ISO)
topotecan  (EXP)
tramadol  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin D  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:1939264   PMID:6477506   PMID:10481911   PMID:11487543   PMID:14651853   PMID:15489334   PMID:15548869   PMID:17634366   PMID:18304734   PMID:18418703   PMID:19056867   PMID:19370404  
PMID:19409453   PMID:19410564   PMID:19725078   PMID:22307408   PMID:22871113   PMID:22926577   PMID:23376485   PMID:23533145   PMID:23620342   PMID:29339092   PMID:31505169  


Genomics

Comparative Map Data
Ckb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.26130,729,420 - 130,732,301 (-)NCBI
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.06136,142,956 - 136,145,838 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06144,270,901 - 144,273,776 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,452,215 - 136,455,122 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16136,458,401 - 136,461,309 (-)NCBI
Celera6128,284,759 - 128,287,594 (-)NCBICelera
Cytogenetic Map6q32NCBI
CKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl14103,519,667 - 103,522,833 (-)EnsemblGRCh38hg38GRCh38
GRCh3814103,519,667 - 103,522,833 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714103,986,004 - 103,989,167 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,055,749 - 103,058,923 (-)NCBINCBI36hg18NCBI36
Build 3414103,055,748 - 103,058,923NCBI
Celera1484,040,224 - 84,043,398 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1484,164,414 - 84,167,557 (-)NCBIHuRef
CHM1_114103,924,170 - 103,927,371 (-)NCBICHM1_1
Ckb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912111,635,789 - 111,638,772 (-)NCBIGRCm39mm39
GRCm39 Ensembl12111,635,795 - 111,638,772 (-)Ensembl
GRCm3812111,669,355 - 111,672,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12111,669,361 - 111,672,338 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712112,907,566 - 112,910,549 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612112,117,169 - 112,120,076 (-)NCBImm8
Celera12112,866,533 - 112,869,516 (-)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.09NCBI
Ckb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555382,379,868 - 2,380,771 (-)NCBIChiLan1.0ChiLan1.0
CKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.114103,957,347 - 103,960,736 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01484,145,931 - 84,149,093 (-)NCBIMhudiblu_PPA_v0panPan3
LOC100855552
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,284,104 - 71,287,379 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha870,795,385 - 70,798,712 (-)NCBI
ROS_Cfam_1.0871,559,900 - 71,563,227 (-)NCBI
UMICH_Zoey_3.1871,249,019 - 71,252,346 (-)NCBI
UNSW_CanFamBas_1.0871,288,738 - 71,292,065 (-)NCBI
UU_Cfam_GSD_1.0871,687,984 - 71,691,311 (-)NCBI
Ckb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,783,394 - 2,786,864 (+)NCBI
SpeTri2.0NW_0049366211,612,398 - 1,615,821 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CKB
(Sus scrofa - pig)
No map positions available.
CKB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12481,462,164 - 81,463,873 (-)NCBI
Ckb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247341,346,056 - 1,349,383 (+)NCBI

Position Markers
D6Mit6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,145,450 - 136,145,596NCBIRnor6.0
Rnor_5.06144,271,142 - 144,271,289NCBIRnor5.0
Rnor_5.06144,271,143 - 144,271,290NCBIRnor5.0
RGSC_v3.46136,454,719 - 136,454,865RGDRGSC3.4
RGSC_v3.46136,454,720 - 136,454,866UniSTSRGSC3.4
RGSC_v3.16136,460,906 - 136,461,052RGD
Celera6128,287,206 - 128,287,352UniSTS
RH 3.4 Map6780.7RGD
RH 3.4 Map6780.7UniSTS
Cytogenetic Map6q32UniSTS
D6Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,142,742 - 136,143,011NCBIRnor6.0
Rnor_5.06144,273,721 - 144,273,990UniSTSRnor5.0
RGSC_v3.46136,451,997 - 136,452,267RGDRGSC3.4
RGSC_v3.46136,451,998 - 136,452,267UniSTSRGSC3.4
RGSC_v3.16136,458,184 - 136,458,454RGD
Celera6128,284,545 - 128,284,814UniSTS
RH 2.0 Map20692.9RGD
Cytogenetic Map6q32UniSTS
D6Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.46136,452,099 - 136,452,354RGDRGSC3.4
RGSC_v3.46136,452,100 - 136,452,354UniSTSRGSC3.4
Celera6128,284,647 - 128,284,901UniSTS
RH 3.4 Map6780.1RGD
Cytogenetic Map6 RGD
D6Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,142,832 - 136,143,093NCBIRnor6.0
Rnor_5.06144,273,639 - 144,273,900UniSTSRnor5.0
RGSC_v3.46136,452,087 - 136,452,349RGDRGSC3.4
RGSC_v3.46136,452,088 - 136,452,349UniSTSRGSC3.4
RGSC_v3.16136,458,274 - 136,458,536RGD
Celera6128,284,635 - 128,284,896UniSTS
Cytogenetic Map6q32UniSTS
RH127492  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,143,026 - 136,143,243NCBIRnor6.0
Rnor_5.06144,273,489 - 144,273,706UniSTSRnor5.0
RGSC_v3.46136,452,282 - 136,452,499UniSTSRGSC3.4
Celera6128,284,829 - 128,285,046UniSTS
RH 3.4 Map6779.5UniSTS
Cytogenetic Map6q32UniSTS
Egfr-rs  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,143,561 - 136,143,839NCBIRnor6.0
Rnor_5.06144,272,893 - 144,273,171UniSTSRnor5.0
RGSC_v3.46136,452,817 - 136,453,095UniSTSRGSC3.4
Celera6128,285,364 - 128,285,642UniSTS
Cytogenetic Map6q32UniSTS
D6Wox15  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,142,844 - 136,143,098NCBIRnor6.0
Rnor_5.06144,273,634 - 144,273,888UniSTSRnor5.0
RGSC_v3.46136,452,100 - 136,452,354UniSTSRGSC3.4
Celera6128,284,647 - 128,284,901UniSTS
RH 3.4 Map6780.1UniSTS
Cytogenetic Map6q32UniSTS
UniSTS:546700  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.06136,142,959 - 136,143,564NCBIRnor6.0
Rnor_5.06144,273,168 - 144,273,773UniSTSRnor5.0
Celera6128,284,762 - 128,285,367UniSTS
Cytogenetic Map6q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)692879510137879510Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)699273921144273921Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)699273921144792678Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)6101207574147991367Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6104363890147991367Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6104381930138066274Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6111134524138065254Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6117355600147991367Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6127286494144745573Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6127286494147249902Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6127286494147991367Rat
2312560Pur20Proteinuria QTL 202.10.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6130561943144745573Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6132652096138068606Rat


Related Rat Strains
The following Strains have been annotated to Ckb
LEM

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:39
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000015122
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19
Medium 3 43 42 26 19 26 5 8 55 35 36 11 5
Low 15 15 15 3 3 5 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015122   ⟹   ENSRNOP00000015122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl6136,142,956 - 136,145,837 (-)Ensembl
RefSeq Acc Id: NM_012529   ⟹   NP_036661
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.26130,729,420 - 130,732,301 (-)NCBI
Rnor_6.06136,142,956 - 136,145,838 (-)NCBI
Rnor_5.06144,270,901 - 144,273,776 (+)NCBI
RGSC_v3.46136,452,215 - 136,455,122 (-)RGD
Celera6128,284,759 - 128,287,594 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036661   ⟸   NM_012529
- UniProtKB: P07335 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015122   ⟸   ENSRNOT00000015122
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694842
Promoter ID:EPDNEW_R5366
Type:single initiation site
Name:Ckb_1
Description:creatine kinase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06136,145,847 - 136,145,907EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2357 AgrOrtholog
Ensembl Genes ENSRNOG00000010872 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000015122 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015122 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.135.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598839 IMAGE-MGC_LOAD
  IMAGE:7104205 IMAGE-MGC_LOAD
  IMAGE:7312830 IMAGE-MGC_LOAD
  IMAGE:7929525 IMAGE-MGC_LOAD
  IMAGE:8367180 IMAGE-MGC_LOAD
InterPro ATP-guanido_PTrfase UniProtKB/Swiss-Prot
  ATP-guanido_PTrfase_AS UniProtKB/Swiss-Prot
  ATP-guanido_PTrfase_cat UniProtKB/Swiss-Prot
  ATP-guanido_PTrfase_N UniProtKB/Swiss-Prot
  ATP-guanido_PTrfase_N_sf UniProtKB/Swiss-Prot
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:24264 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105277 IMAGE-MGC_LOAD
  MGC:124546 IMAGE-MGC_LOAD
  MGC:156567 IMAGE-MGC_LOAD
  MGC:72258 IMAGE-MGC_LOAD
  MGC:91404 IMAGE-MGC_LOAD
NCBI Gene 24264 ENTREZGENE
PANTHER PTHR11547 UniProtKB/Swiss-Prot
Pfam ATP-gua_Ptrans UniProtKB/Swiss-Prot
  ATP-gua_PtransN UniProtKB/Swiss-Prot
PhenoGen Ckb PhenoGen
PROSITE PHOSPHAGEN_KINASE UniProtKB/Swiss-Prot
  PHOSPHAGEN_KINASE_C UniProtKB/Swiss-Prot
  PHOSPHAGEN_KINASE_N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48034 UniProtKB/Swiss-Prot
  SSF55931 UniProtKB/Swiss-Prot
TIGR TC228968
UniProt KCRB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0JPK7 UniProtKB/Swiss-Prot
  Q499P7 UniProtKB/Swiss-Prot
  Q5PPJ5 UniProtKB/Swiss-Prot
  Q6IRE0 UniProtKB/Swiss-Prot
  Q6P139 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Ckb  creatine kinase B  Ckb  creatine kinase, brain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ckb  creatine kinase, brain      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to cytosolic membrane 625711
gene_expression mRNA and protein expression levels were low during the early postnatal period, which increased thereafter and attained a stable plateau by postnatal week 4 625711
gene_expression expressed in a number of tissues and is most abundant in cerebellar granular neurons of adult brain, neonatal cerebral astrocytes and oligodendrocytes, detected at lower levels in the stomach, heart and barely in liver 625711
gene_expression proximal promoter contains two CCAAT boxes (at -80bp and -50bp), a TA-rich element (TATAAATA, at -60bp), a non-consensus TATA box (TTAA, at -28bp), both CCAAT boxes and the (-60bp) TA-rich element bind trans-acting protein factors that activate Ckb transc 625711
gene_function reversibly catalyzes the transfer of phosphate between ATP and various phosphogens 625711
gene_function catalyses the synthesis of phosphocreatine (PCr) 625711
gene_process plays a role in energy transduction in tissues with large, changing energy demands 625711
gene_process involved in ATP regeneration to support synaptic transmission events like protein phosphorylation, transport of ions and glutamate 625711
gene_regulation increased cerebellar protein expression is regulated by transcription and is coincident with expression of myelin basic protein 625711