RGD Reference Report - Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. - Rat Genome Database

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Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase.

Authors: Inoue, K  Ueno, S  Fukuda, A 
Citation: Inoue K, etal., FEBS Lett. 2004 Apr 23;564(1-2):131-5.
RGD ID: 1598444
Pubmed: PMID:15094054   (View Abstract at PubMed)
DOI: DOI:10.1016/S0014-5793(04)00328-X   (Journal Full-text)

gamma-Aminobutyric acid, a major inhibitory neurotransmitter within the adult central nervous system, is also known to be excitatory at early developmental stages due to the elevated intracellular Cl(-) concentration. This functional change is primarily attributable to a K(+)-Cl(-) cotransporter, KCC2, the expression of which is developmentally regulated in neurons. However, little detail information is available concerning the intracellular regulation of KCC2 function. Here, we identify an interaction between KCC2 and brain-type creatine kinase by means of yeast two-hybrid screening. This interaction, which was also detected in cultured cells and brain extracts, might contribute to KCC2-mediated modulation of Cl(-) homeostasis.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CkbRatprotein binding  IPISlc12a5 (Rattus norvegicus) RGD 
Slc12a5Ratprotein binding  IPICkb (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ckb  (creatine kinase B)
Slc12a5  (solute carrier family 12 member 5)


Additional Information