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Gene: Slc12a5 (solute carrier family 12 member 5) Rattus norvegicus
Symbol: Slc12a5
Name: solute carrier family 12 member 5
RGD ID: 620811
Description: Exhibits ammonium transmembrane transporter activity and potassium:chloride symporter activity. Involved in several processes, including dendritic spine development; intracellular pH reduction; and monovalent inorganic cation transport. Localizes to dendrite membrane and perikaryon. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Orthologous to human SLC12A5 (solute carrier family 12 member 5); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
Also known as: electroneutral potassium-chloride cotransporter 2; furosemide-sensitive K-Cl cotransporter; K-Cl cotransporter 2; Kcc2; neuronal K-Cl cotransporter; neuronal-specific K-Cl cotransporter; rKCC2; solute carrier family 12 (potassium-chloride transporter), member 5; solute carrier family 12, (potassium-chloride transporter) member 5; solute carrier family 12, member 5
Homo sapiens (human) : SLC12A5 (solute carrier family 12 member 5)  HGNC  Alliance
Mus musculus (house mouse) : Slc12a5 (solute carrier family 12, member 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a5 (solute carrier family 12 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A5 (solute carrier family 12 member 5)
Canis lupus familiaris (dog) : SLC12A5 (solute carrier family 12 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a5 (solute carrier family 12 member 5)
Sus scrofa (pig) : SLC12A5 (solute carrier family 12 member 5)
Chlorocebus sabaeus (African green monkey) : SLC12A5 (solute carrier family 12 member 5)
Heterocephalus glaber (naked mole-rat) : Slc12a5 (solute carrier family 12 member 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03161,433,303 - 161,465,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,425,988 - 161,462,879 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,617,776 - 167,649,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43156,006,017 - 156,037,915 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13155,912,052 - 155,943,951 (+)NCBI
Celera3152,309,197 - 152,341,061 (+)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc12a5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620811
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.