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Gene: Ckb (creatine kinase B) Ictidomys tridecemlineatus

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Symbol:

Ckb

Name:

creatine kinase B

RGD ID:

12511397

Description:

ENCODES a protein that exhibits creatine kinase activity (ortholog); INVOLVED IN cellular response to estrogen stimulus (ortholog); cellular response to wortmannin (ortholog); cerebellum development (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); adenocarcinoma (ortholog); Charcot-Marie-Tooth disease axonal type 2O (ortholog); FOUND IN dendrite (ortholog); extracellular space (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

creatine kinase B-type

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CKB (creatine kinase B)	NCBI	Ortholog
Mus musculus (house mouse):	Ckb (creatine kinase, brain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ckb (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ckb (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CKB (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC100855552 (creatine kinase B-type)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CKB (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CKB (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ckb (creatine kinase B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	2,783,394 - 2,786,864 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936621	1,612,393 - 1,615,822 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936621	1,612,398 - 1,615,821 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

adenocarcinoma (ISO)

Charcot-Marie-Tooth disease axonal type 2O (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Herpes Simplex Encephalitis 3 (ISO)

Left Ventricular Hypertrophy (ISO)

lung small cell carcinoma (ISO)

mitochondrial complex IV deficiency nuclear type 17 (ISO)

myocardial infarction (ISO)

primary ovarian insufficiency (ISO)

Stomach Neoplasms (ISO)

Ventricular Dysfunction, Left (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to estrogen stimulus (ISO)

cellular response to wortmannin (ISO)

cerebellum development (ISO)

futile creatine cycle (IEA)

intracellular chloride ion homeostasis (ISO)

phosphocreatine biosynthetic process (IEA)

substantia nigra development (ISO)

Cellular Component

cytosol (IEA)

dendrite (ISO)

extracellular space (IEA,ISS)

mitochondrion (IEA,ISO)

neuronal cell body (ISO)

Molecular Function

ATP binding (IEA)

creatine kinase activity (IEA,ISS)

kinase activity (IEA)

protein binding (ISO)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

ornithine translocase deficiency pathway (ISO)

phosphatidylinositol 3-kinase-Akt signaling pathway (ISO)

prolidase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Ckb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	2,783,394 - 2,786,864 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936621	1,612,393 - 1,615,822 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936621	1,612,398 - 1,615,821 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CKB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	103,519,667 - 103,522,830 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	103,519,667 - 103,522,833 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	103,986,004 - 103,989,167 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	103,055,749 - 103,058,923 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	103,055,748 - 103,058,923	NCBI
Celera	14	84,040,224 - 84,043,398 (-)	NCBI		Celera
Cytogenetic Map	14	q32.33	NCBI
HuRef	14	84,164,414 - 84,167,557 (-)	NCBI		HuRef
CHM1_1	14	103,924,170 - 103,927,371 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	97,755,711 - 97,758,874 (-)	NCBI		T2T-CHM13v2.0

Ckb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	111,635,789 - 111,638,772 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	111,635,795 - 111,638,772 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	111,669,355 - 111,672,338 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	111,669,361 - 111,672,338 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	112,907,566 - 112,910,549 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	112,117,169 - 112,120,076 (-)	NCBI		MGSCv36	mm8
Celera	12	112,866,533 - 112,869,516 (-)	NCBI		Celera
Cytogenetic Map	12	F1	NCBI
cM Map	12	61.09	NCBI

Ckb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	136,550,583 - 136,553,464 (-)	NCBI		GRCr8
mRatBN7.2	6	130,729,420 - 130,732,301 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	130,729,423 - 130,732,315 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	130,896,519 - 130,899,400 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	131,192,501 - 131,195,382 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	130,559,479 - 130,562,360 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	136,142,956 - 136,145,838 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	136,142,956 - 136,145,837 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	144,270,901 - 144,273,776 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	136,452,215 - 136,455,122 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	136,458,401 - 136,461,309 (-)	NCBI
Celera	6	128,284,759 - 128,287,594 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Ckb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955538	2,379,868 - 2,380,771 (-)	NCBI	ChiLan1.0	ChiLan1.0

CKB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	104,678,952 - 104,682,157 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	103,895,452 - 103,898,675 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	84,145,931 - 84,149,093 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	103,957,347 - 103,960,736 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

LOC100855552
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	71,284,104 - 71,287,379 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	70,795,385 - 70,798,712 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	71,559,900 - 71,563,227 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	71,559,903 - 71,563,745 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	71,249,019 - 71,252,346 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	71,288,738 - 71,292,065 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	71,687,984 - 71,691,311 (-)	NCBI		UU_Cfam_GSD_1.0

CKB
(Sus scrofa - pig)

No map positions available.

CKB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	81,462,164 - 81,463,873 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	68,763,838 - 68,767,259 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ckb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	1,346,510 - 1,349,383 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	1,346,056 - 1,349,383 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000026728 ⟹ ENSSTOP00000014962

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936621	1,612,393 - 1,615,822 (+)	Ensembl

RefSeq Acc Id:

XM_005334667 ⟹ XP_005334724

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	2,783,394 - 2,786,864 (+)	NCBI
SpeTri2.0	NW_004936621	1,612,398 - 1,615,821 (+)	NCBI

Sequence:

show sequence

CCCGGGGAGCGCCTAGCGGCCGCTGTTCGCCTGCACCGCACTCGGAGCTGCTGGCAGACTGAGC
GCTCCCGCCCCTCCAGGCCGCCCGCTCGCCGCCGCCGTCATGCCCTTCTCCAATGGCCACAACG
CGTTGAAGCTGCGCTTCCCTGCCGAGGATGAGTTCCCCGACCTGAGCGTCCACAACAACCACAT
GGCCAAAGTGCTGACCCCCGAGCTGTACGCAGAGCTGCGCGCCAAGAGCACGCCAAGCGGCTTC
ACGCTGGACGACGTCATTCAGACTGGCGTGGACAACCCGGGCCACCCGTACATCATGACCGTGG
GCTGCGTGGCGGGCGACGAGGAGTCGTACGAGGTGTTCAAGGCACTTTTCGACCCCATCATCGA
GGACCGGCACGGCGGCTACCAGCCCAGCGATGAACACAAGACCGACCTAAACCCGGACAACCTG
CAGGGCGGCGATGACCTGGACCCCAACTACGTGCTGAGCTCGCGGGTGCGCACGGGCCGCAGCA
TCCGCGGCTTCTGCCTTCCCCCGCACTGCAGCCGCGGGGAGCGCCGGGCCATCGAGAAGCTCGC
GGTGGAAGCCCTGTCGAGCCTAGACGGCGACCTGGCGGGCAGGTACTACGCGCTCAAGAGCATG
ACCGAGGCGGAGCAGCAGCAACTCATCGACGACCACTTCCTCTTCGACAAGCCGGTGTCGCCCC
TGCTGCTGGCCTCGGGCATGGCCCGCGACTGGCCGGACGCCCGCGGCATCTGGCACAATGACAA
TAAGACTTTCCTGGTGTGGATCAATGAGGAGGACCACCTGAGGGTCATCTCCATGCAGAAGGGG
GGCAACATGAAGGAGGTGTTCACTCGCTTCTGCACTGGCCTCACCCAGATTGAAACTCTCTTCA
AGTCCAAGAACTACGAGTTCATGTGGAACCCTCACCTGGGCTACATCCTTACCTGCCCTTCCAA
CCTGGGCACAGGGCTGAGGGCGGGTGTGCACATCAAGCTGCCCCACCTGGGCAAGCATGAGAAG
TTCTCTGAGGTGCTCAAGCGGCTGCGGCTTCAGAAGCGGGGCACAGGTGGTGTGGACACAGCTG
CTGTGGGCGGGGTTTTTGACGTCTCCAATGCAGACCGCCTGGGCTTCTCAGAGGTAGAGCTGGT
GCAGATGGTGGTGGACGGAGTGAAGCTGCTGATCGAGATGGAGCAGCGGCTGGAGCAGGGCCAG
GCCATTGACGACCTCATGCCTGCCCAGAAGTGAAGCCTGGCCCACGCCACCACCAGCCTGCTGC
TTCCTAACTTATTGCCCCTGGCAGTGCCCGCCCGCCATGCACCCCTGATGTTCACCGCCTGGCG
GCTGAGCCCTTAGCCTCTCTGTAGAGACTTTTCTGTCGCCCTGGGTAGAGTTTATTTTTTTGAT
GGCTGAGCTGTTGCTGATGCTGAAATAAACTAGGGTTTTGGCCTGCCC

hide sequence

Protein Sequences


Protein RefSeqs	XP_005334724	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000014962.1

RefSeq Acc Id:

XP_005334724 ⟸ XM_005334667

- UniProtKB:

I3MS67 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPFSNGHNALKLRFPAEDEFPDLSVHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTGVDNP
GHPYIMTVGCVAGDEESYEVFKALFDPIIEDRHGGYQPSDEHKTDLNPDNLQGGDDLDPNYVLS
SRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHF
LFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTG
LTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKR
GTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK

hide sequence

Ensembl Acc Id:

ENSSTOP00000014962 ⟸ ENSSTOT00000026728

Protein Domains

Phosphagen kinase C-terminal Phosphagen kinase N-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000023632	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000026728.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.135.10	UniProtKB/TrEMBL
	Glutamine synthetase/guanido kinase, catalytic domain	UniProtKB/TrEMBL
InterPro	ATP-guanido_PTrfase	UniProtKB/TrEMBL
	ATP-guanido_PTrfase_AS	UniProtKB/TrEMBL
	ATP-guanido_PTrfase_cat	UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N	UniProtKB/TrEMBL
	ATP-guanido_PTrfase_N_sf	UniProtKB/TrEMBL
	Gln_synth/guanido_kin_cat_dom	UniProtKB/TrEMBL
NCBI Gene	Ckb	ENTREZGENE
PANTHER	CREATINE KINASE B-TYPE	UniProtKB/TrEMBL
	PTHR11547	UniProtKB/TrEMBL
Pfam	ATP-gua_Ptrans	UniProtKB/TrEMBL
	ATP-gua_PtransN	UniProtKB/TrEMBL
PROSITE	PHOSPHAGEN_KINASE	UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_C	UniProtKB/TrEMBL
	PHOSPHAGEN_KINASE_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48034	UniProtKB/TrEMBL
	SSF55931	UniProtKB/TrEMBL
UniProt	I3MS67	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB