Pgrmc1 (progesterone receptor membrane component 1) - Rat Genome Database

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Gene: Pgrmc1 (progesterone receptor membrane component 1) Rattus norvegicus
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Symbol: Pgrmc1
Name: progesterone receptor membrane component 1
RGD ID: 70890
Description: Predicted to enable heme binding activity and protein homodimerization activity. Involved in several processes, including learning or memory; modification of synaptic structure; and negative regulation of synapse organization. Located in neuron projection; neuronal cell body; and synapse. Orthologous to human PGRMC1 (progesterone receptor membrane component 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25-Dx; 25Dx; acidic 25 kDa protein; membrane-associated progesterone receptor component 1; membrane-bound progesterone receptor; MPR; VEMA; ventral midline antigen
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,698,610 - 120,706,805 (+)NCBIGRCr8
mRatBN7.2X115,832,865 - 115,841,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX115,832,884 - 115,888,682 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX117,934,866 - 117,943,066 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,504,010 - 121,512,210 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,050,166 - 119,058,365 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,205,869 - 123,213,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,205,869 - 123,213,882 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,352,144 - 123,360,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X8,265,543 - 8,273,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X8,271,098 - 8,279,223 (-)NCBI
CeleraX115,065,055 - 115,073,267 (+)NCBICelera
Cytogenetic MapXq34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Pgrmc1Ratautistic disorder  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Pgrmc1Ratautosomal hemophilia A  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Pgrmc1Ratcataract  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital cataractClinVarPMID:25741868 and PMID:33867527
Pgrmc1Ratfactor VIII deficiency  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Pgrmc1Rathereditary breast ovarian cancer syndrome  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Genetic non-acquired premature ovarian failureClinVar 
Pgrmc1Ratprimary ovarian insufficiency 16  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Genetic non-acquired premature ovarian failureClinVar 
Pgrmc1Ratsyndromic X-linked intellectual disability 14  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: INTELLECTUAL DEVELOPMENTAL DISORDER more ...ClinVarPMID:17236139 more ...
Pgrmc1Ratsyndromic X-linked intellectual disability Cabezas type  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual developmental disorder more ...ClinVarPMID:17236139 more ...
Pgrmc1Ratsyndromic X-linked intellectual disability Lubs type  ISOPGRMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
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Pgrmc1RatAlzheimer's disease  ISOPGRMC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25390692
Pgrmc1RatProstatic Neoplasms  ISOPGRMC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17199135
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Pgrmc1Ratmetabolic dysfunction-associated steatotic liver disease  ISSPgrmc1 (Mus musculus)13592920OMIM:613282 more ...MouseDO 

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Original Reference(s)
Pgrmc1Rat(1->4)-beta-D-glucan multiple interactionsISOPgrmc1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PGRMC1 mRNACTDPMID:36331819
Pgrmc1Rat1,2-dichloroethane decreases expressionISOPgrmc1 (Mus musculus)6480464ethylene dichloride results in decreased expression of PGRMC1 mRNACTDPMID:28960355
Pgrmc1Rat1,2-dimethylhydrazine decreases expressionISOPgrmc1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PGRMC1 mRNACTDPMID:22206623
Pgrmc1Rat1,2-dimethylhydrazine multiple interactionsISOPgrmc1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PGRMC1 mRNACTDPMID:22206623
Pgrmc1Rat17alpha-ethynylestradiol affects expressionISOPgrmc1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of PGRMC1 mRNACTDPMID:17555576
Pgrmc1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PGRMC1 proteinCTDPMID:32145629
Pgrmc1Rat17beta-estradiol decreases expressionISOPgrmc1 (Mus musculus)6480464Estradiol results in decreased expression of PGRMC1 mRNACTDPMID:39298647
Pgrmc1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PGRMC1 mRNACTDPMID:32145629
Pgrmc1Rat2,3',4,4',5-Pentachlorobiphenyl affects expressionISOPgrmc1 (Mus musculus)64804642 more ...CTDPMID:31388691
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PGRMC1 proteinCTDPMID:12361703
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPgrmc1 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PGRMC1 gene]CTDPMID:28213091
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPgrmc1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PGRMC1 mRNACTDPMID:21496263
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPGRMC1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of PGRMC1 mRNACTDPMID:21496263
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPgrmc1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PGRMC1 mRNACTDPMID:21570461 and PMID:28213091
Pgrmc1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PGRMC1 mRNACTDPMID:9006096
Pgrmc1Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of PGRMC1 mRNACTDPMID:21346803
Pgrmc1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOPgrmc1 (Mus musculus)64804642 more ...CTDPMID:38648751
Pgrmc1Rat2-hydroxypropanoic acid decreases expressionISOPGRMC1 (Homo sapiens)6480464Lactic Acid results in decreased expression of PGRMC1 mRNACTDPMID:30851411
Pgrmc1Rat3-chloropropane-1,2-diol increases expressionEXP 6480464alpha-Chlorohydrin results in increased expression of PGRMC1 mRNACTDPMID:28522335
Pgrmc1Rat4,4'-sulfonyldiphenol increases expressionISOPgrmc1 (Mus musculus)6480464bisphenol S results in increased expression of PGRMC1 mRNACTDPMID:39298647

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Biological Process
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Original Reference(s)
Pgrmc1Ratassociative learning involved_inIGIComplexPortal:CPX-113412910997PMID:25390368ARUK-UCL 
Pgrmc1Rataxon guidance  IEP 727289 RGD 
Pgrmc1Ratheme biosynthetic process involved_inISSUniProtKB:O002641600115GO_REF:0000024UniProtGO_REF:0000024
Pgrmc1Ratheme biosynthetic process involved_inIEAUniProtKB:O00264 and ensembl:ENSP000002179711600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratheme biosynthetic process involved_inISOPGRMC1 (Homo sapiens)1624291 PMID:27599036RGDPMID:27599036
Pgrmc1Ratmemory involved_inIGIComplexPortal:CPX-113412910997PMID:25390368ARUK-UCL 
Pgrmc1Ratmodification of synaptic structure involved_inIGIComplexPortal:CPX-113412910997PMID:25390368ARUK-UCL 
Pgrmc1Ratnegative regulation of synapse organization involved_inIGIComplexPortal:CPX-113412910997PMID:25390368ARUK-UCL 
Pgrmc1Ratpositive regulation of lipoprotein transport involved_inISSUniProtKB:O002641600115GO_REF:0000024UniProtGO_REF:0000024
Pgrmc1Ratpositive regulation of lipoprotein transport involved_inIEAUniProtKB:O00264 and ensembl:ENSP000002179711600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratpositive regulation of lipoprotein transport involved_inISOPGRMC1 (Homo sapiens)1624291 PMID:30443021RGDPMID:30443021
Pgrmc1Ratpositive regulation of protein localization to plasma membrane involved_inISOPGRMC1 (Homo sapiens)1624291 PMID:25390692RGDPMID:25390692
Pgrmc1Ratpositive regulation of protein localization to plasma membrane involved_inIEAUniProtKB:O00264 and ensembl:ENSP000002179711600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Pgrmc1Ratcell body located_inIDA 12859076PMID:25390692ARUK-UCL 
Pgrmc1Ratendomembrane system is_active_inIBAFB:FBgn0052675 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pgrmc1Ratendoplasmic reticulum is_active_inIBAMGI:1913458 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pgrmc1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Pgrmc1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Pgrmc1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratintracellular membrane-bounded organelle located_inIEAUniProtKB-KW:KW-04921600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratmembrane is_active_inIBAFB:FBgn0030703 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pgrmc1Ratmitochondrial outer membrane located_inISSUniProtKB:O550221600115GO_REF:0000024UniProtGO_REF:0000024
Pgrmc1Ratmitochondrial outer membrane located_inIEAUniProtKB:O55022 and ensembl:ENSMUSP000000730611600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratmitochondrial outer membrane located_inISOPgrmc1 (Mus musculus)1624291 PMID:27599036RGDPMID:27599036
Pgrmc1Ratmitochondrial outer membrane located_inIEAUniProtKB-KW:KW-10001600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratmitochondrial outer membrane located_inIEAUniProtKB-SubCell:SL-01721600115GO_REF:0000044UniProtGO_REF:0000044
Pgrmc1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratneuron projection located_inIDA 12859076PMID:25390692ARUK-UCL 
Pgrmc1Ratneuronal cell body located_inIDA 12859076PMID:25390692ARUK-UCL 
Pgrmc1Ratpostsynaptic density located_inTAS 12859076PMID:25390692ARUK-UCL 
Pgrmc1Ratsmooth endoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-02501600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
Pgrmc1Ratheme binding enablesISSUniProtKB:O002641600115GO_REF:0000024UniProtGO_REF:0000024
Pgrmc1Ratheme binding enablesISOPgrmc1 (Mus musculus)1624291 PMID:31748741RGDPMID:31748741
Pgrmc1Ratheme binding enablesIEAUniProtKB:O00264 and ensembl:ENSP000002179711600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratheme binding enablesIEAUniProtKB:O55022 and ensembl:ENSMUSP000000730611600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratheme binding enablesISOPGRMC1 (Homo sapiens)1624291 PMID:26988023 and PMID:27599036RGDPMID:26988023 and PMID:27599036
Pgrmc1Ratlipid binding enablesIEAUniProtKB-KW:KW-04461600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Pgrmc1Ratprotein binding enablesISOPGRMC1 (Homo sapiens)1624291UniProtKB:O15173 more ...RGDPMID:21081644 more ...
Pgrmc1Ratprotein binding enablesISOPgrmc1 (Mus musculus)1624291UniProtKB:Q80UU9 and PMID:31748741RGDPMID:31748741
Pgrmc1Ratprotein homodimerization activity enablesISOPGRMC1 (Homo sapiens)1624291 PMID:26988023RGDPMID:26988023
Pgrmc1Ratprotein homodimerization activity enablesIEAUniProtKB:O00264 and ensembl:ENSP000002179711600115GO_REF:0000107EnsemblGO_REF:0000107
Pgrmc1Ratprotein homodimerization activity enablesISSUniProtKB:O002641600115GO_REF:0000024UniProtGO_REF:0000024
Pgrmc1Ratsteroid binding enablesIEAUniProtKB-KW:KW-07541600115GO_REF:0000043UniProtGO_REF:0000043
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Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. Izzo NJ, etal., PLoS One. 2014 Nov 12;9(11):e111898. doi: 10.1371/journal.pone.0111898. eCollection 2014.
4. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Izzo NJ, etal., PLoS One. 2014 Nov 12;9(11):e111899. doi: 10.1371/journal.pone.0111899. eCollection 2014.
5. Gene Data Set MGD Curation, June 12, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS. Runko E, etal., Mol Cell Neurosci 1999 Dec;14(6):428-43.
9. Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Selmin O, etal., Carcinogenesis 1996 Dec;17(12):2609-15.
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:11087948   PMID:15033482   PMID:15207350   PMID:15489334   PMID:15570619   PMID:15934950   PMID:16279947   PMID:16641100   PMID:17991724   PMID:19946888   PMID:20144686   PMID:20977928  
PMID:21148105   PMID:21730960   PMID:22147012   PMID:22719051   PMID:22778217   PMID:23211561   PMID:23242527   PMID:23376485   PMID:23653459   PMID:25002582   PMID:25253729   PMID:26335282  
PMID:26988023   PMID:27599036   PMID:31748741   PMID:34645803   PMID:34970218  



Pgrmc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X120,698,610 - 120,706,805 (+)NCBIGRCr8
mRatBN7.2X115,832,865 - 115,841,060 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX115,832,884 - 115,888,682 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX117,934,866 - 117,943,066 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X121,504,010 - 121,512,210 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X119,050,166 - 119,058,365 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X123,205,869 - 123,213,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX123,205,869 - 123,213,882 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X123,352,144 - 123,360,155 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X8,265,543 - 8,273,667 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X8,271,098 - 8,279,223 (-)NCBI
CeleraX115,065,055 - 115,073,267 (+)NCBICelera
Cytogenetic MapXq34NCBI
PGRMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X119,236,285 - 119,244,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX119,236,245 - 119,244,466 (+)EnsemblGRCh38hg38GRCh38
GRCh37X118,370,248 - 118,378,429 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X118,254,291 - 118,262,457 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X118,152,144 - 118,160,310NCBI
CeleraX118,824,941 - 118,833,159 (+)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX107,864,078 - 107,872,271 (+)NCBIHuRef
CHM1_1X118,281,446 - 118,289,662 (+)NCBICHM1_1
T2T-CHM13v2.0X117,614,039 - 117,622,220 (+)NCBIT2T-CHM13v2.0
Pgrmc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X35,861,846 - 35,869,732 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX35,861,859 - 35,869,732 (+)EnsemblGRCm39 Ensembl
GRCm38X36,598,193 - 36,606,079 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX36,598,206 - 36,606,079 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X34,138,220 - 34,146,074 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X33,029,670 - 33,037,524 (+)NCBIMGSCv36mm8
CeleraX23,322,277 - 23,330,131 (+)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX21.0NCBI
Pgrmc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955534698,734 - 706,946 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955534698,895 - 706,586 (-)NCBIChiLan1.0ChiLan1.0
PGRMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X118,631,349 - 118,639,583 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X118,634,953 - 118,643,187 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X108,282,958 - 108,291,187 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X118,711,495 - 118,719,714 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX118,711,495 - 118,719,714 (+)Ensemblpanpan1.1panPan2
PGRMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X91,329,243 - 91,337,951 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX91,329,243 - 91,337,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX77,405,200 - 77,413,908 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X93,069,899 - 93,078,605 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX93,069,840 - 93,078,601 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X90,522,743 - 90,531,448 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X92,281,492 - 92,290,197 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X92,010,000 - 92,018,705 (+)NCBIUU_Cfam_GSD_1.0
Pgrmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X90,353,427 - 90,361,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647910,625,889 - 10,634,136 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647910,625,989 - 10,634,058 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGRMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX97,735,244 - 97,743,423 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X97,735,402 - 97,743,424 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X113,925,761 - 113,933,800 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGRMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606531,998,876 - 32,007,022 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgrmc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248953,264,798 - 3,273,529 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248953,265,326 - 3,273,531 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pgrmc1
29 total Variants

Predicted Target Of
Summary Value
Count of predictions:311
Count of miRNA genes:188
Interacting mature miRNAs:235
Transcripts:ENSRNOT00000017101
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 11 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX112934952138400867Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
5685004Bss104Bone structure and strength QTL 1043.9tibia area (VT:1000281)tibia area measurement (CMO:0001382)X113805422126975220Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X113937816152453651Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat

1 to 10 of 11 rows
RH139267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,511,961 - 30,512,089 (+)MAPPERmRatBN7.2
Rnor_6.01934,204,203 - 34,204,330NCBIRnor6.0
Rnor_5.01945,084,621 - 45,084,748UniSTSRnor5.0
RGSC_v3.41932,324,466 - 32,324,593UniSTSRGSC3.4
Celera1929,992,287 - 29,992,414UniSTS
RH 3.4 Map19234.8UniSTS
Cytogenetic Map19q11UniSTS
Cytogenetic MapXq12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000017101   ⟹   ENSRNOP00000017101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX115,832,884 - 115,888,682 (+)Ensembl
Rnor_6.0 EnsemblX123,205,869 - 123,213,882 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079231   ⟹   ENSRNOP00000071066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX123,205,891 - 123,212,727 (+)Ensembl
RefSeq Acc Id: NM_021766   ⟹   NP_068534
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X120,698,610 - 120,706,805 (+)NCBI
mRatBN7.2X115,832,865 - 115,841,060 (+)NCBI
Rnor_6.0X123,205,869 - 123,213,880 (+)NCBI
Rnor_5.0X123,352,144 - 123,360,155 (+)NCBI
RGSC_v3.4X8,265,543 - 8,273,667 (-)RGD
CeleraX115,065,055 - 115,073,267 (+)RGD
Sequence:
Protein RefSeqs NP_068534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB07125 (Get FASTA)   NCBI Sequence Viewer  
  AAF17359 (Get FASTA)   NCBI Sequence Viewer  
  AAH62073 (Get FASTA)   NCBI Sequence Viewer  
  CAA06732 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017101
  ENSRNOP00000017101.6
GenBank Protein P70580 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068534   ⟸   NM_021766
- UniProtKB: P70580 (UniProtKB/Swiss-Prot),   O70606 (UniProtKB/Swiss-Prot),   Q549C4 (UniProtKB/Swiss-Prot),   A6JMF3 (UniProtKB/TrEMBL),   A0A0H2UHK2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071066   ⟸   ENSRNOT00000079231
Ensembl Acc Id: ENSRNOP00000017101   ⟸   ENSRNOT00000017101
Cytochrome b5 heme-binding

Name Modeler Protein Id AA Range Protein Structure
AF-P70580-F1-model_v2 AlphaFold P70580 1-195 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701981
Promoter ID:EPDNEW_R12504
Type:multiple initiation site
Name:Pgrmc1_1
Description:progesterone receptor membrane component 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X123,205,872 - 123,205,932EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1318 BioCyc
Ensembl Genes ENSRNOG00000012786 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017101 ENTREZGENE
  ENSRNOT00000017101.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.120.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599449 IMAGE-MGC_LOAD
InterPro Cyt_B5-like_heme/steroid-bd UniProtKB/Swiss-Prot
  Cyt_B5-like_heme/steroid_sf UniProtKB/Swiss-Prot
  Cytochrome_b5-MAPR/VMP1_fams UniProtKB/Swiss-Prot
KEGG Report rno:291948 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72462 IMAGE-MGC_LOAD
NCBI Gene 291948 ENTREZGENE
PANTHER MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT 1 UniProtKB/Swiss-Prot
  MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED UniProtKB/Swiss-Prot
Pfam Cyt-b5 UniProtKB/Swiss-Prot
PhenoGen Pgrmc1 PhenoGen
RatGTEx ENSRNOG00000012786 RatGTEx
SMART Cyt-b5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55856 UniProtKB/Swiss-Prot
UniProt A0A0H2UHK2 ENTREZGENE, UniProtKB/TrEMBL
  A6JMF3 ENTREZGENE, UniProtKB/TrEMBL
  O70606 ENTREZGENE
  P70580 ENTREZGENE, UniProtKB/Swiss-Prot
  Q549C4 ENTREZGENE
UniProt Secondary O70606 UniProtKB/Swiss-Prot
  Q549C4 UniProtKB/Swiss-Prot
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Pgrmc1  progesterone receptor membrane component 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_drugs mRNA expression is induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) 70623