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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620539
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tas1r3
Name: taste 1 receptor member 3
Acc ID: CHEBI:2877
Term: aspartame
Definition: A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener.
Chemical ID: MESH:D001218
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tas1r3affects bindingISOTAS1R3 (Homo sapiens)6480464CTDAspartame binds to [TAS1R2 protein binds to TAS1R3 protein]PMID:17168764
Tas1r3decreases expressionISOTAS1R3 (Homo sapiens)6480464CTDAspartame results in decreased expression of TAS1R3 proteinPMID:33992720
Tas1r3multiple interactionsISOTAS1R3 (Homo sapiens)6480464CTDAspartame promotes the reaction [TAS1R3 protein binds to TAS1R1 protein]; Aspartame promotes the reaction [TAS1R3 protein binds to TAS1R2 protein]; lactisole inhibits the reaction [Aspartame results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]PMID:17935609 PMID:33992720
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