Ndufb10 (NADH:ubiquinone oxidoreductase subunit B10) - Rat Genome Database

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Gene: Ndufb10 (NADH:ubiquinone oxidoreductase subunit B10) Rattus norvegicus
Analyze
Symbol: Ndufb10
Name: NADH:ubiquinone oxidoreductase subunit B10
RGD ID: 1310782
Description: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 35. Orthologous to human NDUFB10 (NADH:ubiquinone oxidoreductase subunit B10); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC287121; LOC681418; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; similar to NADH-ubiquinone oxidoreductase PDSW subunit (Complex I-PDSW) (CI-PDSW)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,253,805 - 14,255,966 (-)NCBIGRCr8
mRatBN7.21013,749,273 - 13,751,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,749,275 - 13,751,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,496,065 - 18,498,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,984,925 - 17,987,201 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,484,121 - 13,486,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,090,128 - 14,092,289 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,090,128 - 14,092,289 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,905,856 - 13,908,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,977,307 - 13,979,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,428,991 - 13,431,152 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12611891   PMID:12865426   PMID:14651853   PMID:18614015   PMID:21700703   PMID:23376485   PMID:27626371   PMID:34800366  


Genomics

Comparative Map Data
Ndufb10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,253,805 - 14,255,966 (-)NCBIGRCr8
mRatBN7.21013,749,273 - 13,751,434 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1013,749,275 - 13,751,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1018,496,065 - 18,498,341 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01017,984,925 - 17,987,201 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01013,484,121 - 13,486,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,090,128 - 14,092,289 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,090,128 - 14,092,289 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01013,905,856 - 13,908,017 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41013,977,307 - 13,979,468 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1013,428,991 - 13,431,152 (-)NCBICelera
Cytogenetic Map10q12NCBI
NDUFB10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38161,959,538 - 1,961,975 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl161,959,538 - 1,961,975 (+)EnsemblGRCh38hg38GRCh38
GRCh37162,009,539 - 2,011,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,949,520 - 1,951,977 (+)NCBINCBI36Build 36hg18NCBI36
Build 34161,949,519 - 1,951,977NCBI
Celera162,221,698 - 2,224,158 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef161,933,643 - 1,936,103 (+)NCBIHuRef
CHM1_1162,009,462 - 2,011,922 (+)NCBICHM1_1
T2T-CHM13v2.0161,979,496 - 1,981,934 (+)NCBIT2T-CHM13v2.0
Ndufb10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391724,941,034 - 24,943,397 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1724,941,034 - 24,943,452 (-)EnsemblGRCm39 Ensembl
GRCm381724,722,060 - 24,724,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1724,722,060 - 24,724,478 (-)EnsemblGRCm38mm10GRCm38
MGSCv371724,859,012 - 24,861,333 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361724,449,667 - 24,451,988 (-)NCBIMGSCv36mm8
Celera1725,245,195 - 25,247,516 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.51NCBI
Ndufb10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,306,741 - 15,309,167 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,306,688 - 15,309,281 (-)NCBIChiLan1.0ChiLan1.0
NDUFB10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2182,385,452 - 2,389,332 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,167,362 - 6,171,242 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v016742,402 - 744,850 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1162,048,550 - 2,051,005 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl162,048,550 - 2,051,005 (+)Ensemblpanpan1.1panPan2
NDUFB10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,968,737 - 38,971,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,968,742 - 38,971,196 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,208,429 - 40,210,907 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,285,757 - 39,288,235 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,282,767 - 39,288,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,962,532 - 38,965,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,934,840 - 38,937,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0639,413,727 - 39,416,205 (-)NCBIUU_Cfam_GSD_1.0
Ndufb10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,633,467 - 104,635,982 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366942,073,354 - 2,076,043 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366942,073,481 - 2,075,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NDUFB10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,003,115 - 40,005,588 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,003,109 - 40,005,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NDUFB10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,856,476 - 1,859,336 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl51,856,157 - 1,862,529 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606829,217,128 - 29,219,978 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ndufb10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913297,732 - 300,213 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913297,657 - 300,348 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:46
Interacting mature miRNAs:46
Transcripts:ENSRNOT00000019624
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
RH128247  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81014,253,891 - 14,254,198 (+)Marker Load Pipeline
mRatBN7.21013,749,359 - 13,749,666 (+)MAPPERmRatBN7.2
Rnor_6.01014,090,215 - 14,090,521NCBIRnor6.0
Rnor_5.01013,905,943 - 13,906,249UniSTSRnor5.0
RGSC_v3.41013,977,394 - 13,977,700UniSTSRGSC3.4
Celera1013,429,078 - 13,429,384UniSTS
RH 3.4 Map10191.3UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000019624   ⟹   ENSRNOP00000019624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1013,749,275 - 13,751,442 (-)Ensembl
Rnor_6.0 Ensembl1014,090,128 - 14,092,289 (-)Ensembl
RefSeq Acc Id: NM_001109443   ⟹   NP_001102913
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,253,805 - 14,255,966 (-)NCBI
mRatBN7.21013,749,273 - 13,751,434 (-)NCBI
Rnor_6.01014,090,128 - 14,092,289 (-)NCBI
Rnor_5.01013,905,856 - 13,908,017 (-)NCBI
RGSC_v3.41013,977,307 - 13,979,468 (-)RGD
Celera1013,428,991 - 13,431,152 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102913 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03875 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019624.5
RefSeq Acc Id: NP_001102913   ⟸   NM_001109443
- UniProtKB: A6HCX0 (UniProtKB/TrEMBL),   D4A0T0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019624   ⟸   ENSRNOT00000019624

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A0T0-F1-model_v2 AlphaFold D4A0T0 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697025
Promoter ID:EPDNEW_R7550
Type:initiation region
Name:Ndufb10_1
Description:NADH:ubiquinone oxidoreductase subunit B10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,092,268 - 14,092,328EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310782 AgrOrtholog
BioCyc Gene G2FUF-25826 BioCyc
BioCyc Pathway PWY-3781 [aerobic respiration I (cytochrome c)] BioCyc
BioCyc Pathway Image PWY-3781 BioCyc
Ensembl Genes ENSRNOG00000014568 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019624.6 UniProtKB/TrEMBL
InterPro NADH_UbQ_OxRdtase_su10 UniProtKB/TrEMBL
  NDUFB10 UniProtKB/TrEMBL
KEGG Report rno:681418 UniProtKB/TrEMBL
NCBI Gene Ndufb10 ENTREZGENE
PANTHER NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 10 UniProtKB/TrEMBL
  PTHR13094 UniProtKB/TrEMBL
Pfam NDUFB10 UniProtKB/TrEMBL
PhenoGen Ndufb10 PhenoGen
RatGTEx ENSRNOG00000014568 RatGTEx
UniProt A6HCX0 ENTREZGENE, UniProtKB/TrEMBL
  D4A0T0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Ndufb10  NADH:ubiquinone oxidoreductase subunit B10  Ndufb10  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Ndufb10  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10   LOC681867  similar to NADH-ubiquinone oxidoreductase PDSW subunit (Complex I-PDSW) (CI-PDSW)  Data merged from RGD:1590497 1643240 APPROVED
2008-12-12 Ndufb10  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10   LOC681418  similar to NADH-ubiquinone oxidoreductase PDSW subunit (Complex I-PDSW) (CI-PDSW)  Data merged from RGD:1595406 737654 APPROVED
2008-04-30 Ndufb10  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10   Ndufb10_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC681418  similar to NADH-ubiquinone oxidoreductase PDSW subunit (Complex I-PDSW) (CI-PDSW)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681867  similar to NADH-ubiquinone oxidoreductase PDSW subunit (Complex I-PDSW) (CI-PDSW)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ndufb10_predicted  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 (predicted)      Symbol and Name status set to approved 70820 APPROVED