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Gene: Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) Rattus norvegicus

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Symbol:

Papss2

Name:

3'-phosphoadenosine 5'-phosphosulfate synthase 2

RGD ID:

1307012

Description:

Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process; hormone metabolic process; and sulfate assimilation. Predicted to act upstream of or within blood coagulation and bone development. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2); PARTICIPATES IN sulfite oxidase deficiency pathway; purine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; LOC294103; MGC189455

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	239,867,597 - 239,952,614 (+)	NCBI		GRCr8
mRatBN7.2	1	230,454,314 - 230,539,332 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	230,454,426 - 230,539,331 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	238,827,264 - 238,914,193 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	245,756,967 - 245,843,895 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	238,595,075 - 238,682,007 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	251,145,264 - 251,230,716 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	251,145,253 - 251,230,715 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	258,376,054 - 258,461,337 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	236,592,414 - 236,677,379 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	236,796,239 - 236,839,791 (+)	NCBI
Celera	1	227,570,258 - 227,654,408 (+)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	brachyolmia		ISO	RGD:1315952	8554872	ClinVar Annotator: match by term: Brachyolmia	ClinVar	PMID:22791835\|PMID:23633440\|PMID:24033266\|PMID:25741868\|PMID:28492532
Papss2	Rat	genetic disease		ISO	RGD:1315952	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:28492532
Papss2	Rat	juvenile polyposis syndrome		ISO	RGD:1315952	8554872	ClinVar Annotator: match by term: Generalized juvenile polyposis/juvenile polyposis coli \| ClinVar Annotator: match by more ...	ClinVar	PMID:14526373\|PMID:16287957\|PMID:16685657\|PMID:18456716\|PMID:18510548\|PMID:21194675\|PMID:22993021\|PMID:23331837\|PMID:23335809\|PMID:23399955\|PMID:28492532\|PMID:9286463\|PMID:9467011
Papss2	Rat	PTEN hamartoma tumor syndrome		ISO	RGD:1315952	8554872	ClinVar Annotator: match by term: PTEN hamartoma tumor syndrome	ClinVar	PMID:16287957\|PMID:16685657\|PMID:18456716\|PMID:18510548\|PMID:21194675\|PMID:22993021\|PMID:23331837\|PMID:23335809\|PMID:23399955\|PMID:28492532\|PMID:9286463\|PMID:9467011
Papss2	Rat	spondyloepimetaphyseal dysplasia, Pakistani type		ISO	RGD:1315952	8554872	ClinVar Annotator: match by term: BRACHYOLMIA TYPE 4 WITH MILD EPIPHYSEAL AND METAPHYSEAL CHANGES \| more ...	ClinVar	PMID:16199547\|PMID:17576681\|PMID:19474428\|PMID:22791835\|PMID:23633440\|PMID:23824674\|PMID:24033266\|PMID:25326635\|PMID:25594860\|PMID:25741868\|PMID:27544198\|PMID:28492532\|PMID:31313512\|PMID:35261200\|PMID:9536098\|PMID:9714015\|PMID:9771708

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	spondyloepimetaphyseal dysplasia, Pakistani type		ISO	RGD:1315952	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	spondyloepimetaphyseal dysplasia, Pakistani type		ISS	RGD:1315953	13592920	OMIM:612847	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	spondyloepimetaphyseal dysplasia, Pakistani type		ISO	RGD:1315952	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	(1->4)-beta-D-glucan	multiple interactions	ISO	RGD:1315953	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PAPSS2 mRNA	CTD	PMID:36331819
Papss2	Rat	1,1-dichloroethene	decreases expression	ISO	RGD:1315953	6480464	vinylidene chloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:26682919
Papss2	Rat	1,2-dichloroethane	decreases expression	ISO	RGD:1315953	6480464	ethylene dichloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:28960355
Papss2	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1315953	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAPSS2 mRNA	CTD	PMID:22206623
Papss2	Rat	17beta-estradiol	affects expression	ISO	RGD:1315952	6480464	Estradiol affects the expression of PAPSS2 mRNA	CTD	PMID:14699072
Papss2	Rat	17beta-estradiol	decreases expression	ISO	RGD:1315953	6480464	Estradiol results in decreased expression of PAPSS2 mRNA	CTD	PMID:39298647
Papss2	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in decreased expression of PAPSS2 mRNA	CTD	PMID:26496021
Papss2	Rat	17beta-estradiol	decreases expression	ISO	RGD:1315952	6480464	Estradiol results in decreased expression of PAPSS2 mRNA	CTD	PMID:24758408
Papss2	Rat	17beta-estradiol	increases expression	ISO	RGD:1315952	6480464	Estradiol results in increased expression of PAPSS2 mRNA	CTD	PMID:19619570\|PMID:31614463
Papss2	Rat	17beta-estradiol	multiple interactions	ISO	RGD:1315952	6480464	[Estradiol binds to ESR2 protein] which results in increased expression of PAPSS2 mRNA; [Estradiol co-treated more ...	CTD	PMID:19619570\|PMID:20404318\|PMID:20660070\|PMID:24758408\|PMID:30165855
Papss2	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	RGD:1315953	6480464	2,4,5,2',4',5'-hexachlorobiphenyl affects the reaction [NR1I2 protein affects the expression of PAPSS2 mRNA]	CTD	PMID:32352317
Papss2	Rat	2,2',4,4'-Tetrabromodiphenyl ether	decreases expression	ISO	RGD:1315952	6480464	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PAPSS2 protein	CTD	PMID:31675489
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1315952	6480464	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PAPSS2 mRNA	CTD	PMID:19619570
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of PAPSS2 mRNA	CTD	PMID:34747641
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNA	CTD	PMID:32109520
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1315953	6480464	Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNA	CTD	PMID:19933214\|PMID:22496397
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1315953	6480464	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNA]	CTD	PMID:22496397
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1315953	6480464	Tetrachlorodibenzodioxin affects the expression of PAPSS2 mRNA	CTD	PMID:21570461
Papss2	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1315952	6480464	Tetrachlorodibenzodioxin results in decreased expression of PAPSS2 mRNA	CTD	PMID:19619570
Papss2	Rat	2,4-dinitrotoluene	affects expression	EXP		6480464	2,4-dinitrotoluene affects the expression of PAPSS2 mRNA	CTD	PMID:21346803
Papss2	Rat	3,3',5,5'-tetrabromobisphenol A	decreases expression	ISO	RGD:1315952	6480464	tetrabromobisphenol A results in decreased expression of PAPSS2 protein	CTD	PMID:31675489
Papss2	Rat	3-chloropropane-1,2-diol	increases expression	EXP		6480464	alpha-Chlorohydrin results in increased expression of PAPSS2 mRNA	CTD	PMID:28522335
Papss2	Rat	4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1315953	6480464	4,4'-diaminodiphenylmethane results in increased expression of PAPSS2 mRNA	CTD	PMID:18648102
Papss2	Rat	4,4'-diaminodiphenylmethane	decreases expression	EXP		6480464	4,4'-diaminodiphenylmethane results in decreased expression of PAPSS2 mRNA	CTD	PMID:30723492
Papss2	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1315953	6480464	bisphenol S results in increased expression of PAPSS2 mRNA	CTD	PMID:30951980
Papss2	Rat	4,4'-sulfonyldiphenol	affects expression	ISO	RGD:1315953	6480464	bisphenol S affects the expression of PAPSS2 mRNA	CTD	PMID:39298647
Papss2	Rat	4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid	increases expression	ISO	RGD:1315952	6480464	Am 580 results in increased expression of PAPSS2 mRNA	CTD	PMID:16982809
Papss2	Rat	4-octylphenol	decreases expression	ISO	RGD:1315952	6480464	4-octylphenol results in decreased expression of PAPSS2 mRNA	CTD	PMID:16223563
Papss2	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of PAPSS2 mRNA	CTD	PMID:30047161
Papss2	Rat	7,12-dimethyltetraphene	decreases expression	EXP		6480464	9,10-Dimethyl-1,2-benzanthracene results in decreased expression of PAPSS2 mRNA	CTD	PMID:19480007
Papss2	Rat	8-Br-cAMP	increases expression	ISO	RGD:1315952	6480464	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PAPSS2 mRNA	CTD	PMID:22079614
Papss2	Rat	acetamide	decreases expression	EXP		6480464	acetamide results in decreased expression of PAPSS2 mRNA	CTD	PMID:31881176
Papss2	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of PAPSS2 mRNA	CTD	PMID:28959563
Papss2	Rat	aflatoxin B1	decreases expression	ISO	RGD:1315953	6480464	Aflatoxin B1 results in decreased expression of PAPSS2 mRNA	CTD	PMID:19770486
Papss2	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1315952	6480464	Aflatoxin B1 results in decreased methylation of PAPSS2 gene	CTD	PMID:27153756
Papss2	Rat	aflatoxin B1	decreases expression	ISO	RGD:1315952	6480464	Aflatoxin B1 results in decreased expression of PAPSS2 mRNA	CTD	PMID:22100608
Papss2	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1315952	6480464	Tretinoin results in increased expression of PAPSS2 mRNA	CTD	PMID:23830798
Papss2	Rat	all-trans-retinoic acid	multiple interactions	ISO	RGD:1315953	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of PAPSS2 mRNA	CTD	PMID:36189433
Papss2	Rat	amitrole	increases expression	EXP		6480464	Amitrole results in increased expression of PAPSS2 mRNA	CTD	PMID:30047161
Papss2	Rat	Aroclor 1254	decreases expression	EXP		6480464	Chlorodiphenyl (54% Chlorine) results in decreased expression of PAPSS2 mRNA	CTD	PMID:18178546
Papss2	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1315952	6480464	arsenite inhibits the reaction [G3BP1 protein binds to PAPSS2 mRNA]	CTD	PMID:32406909
Papss2	Rat	arsenous acid	increases expression	ISO	RGD:1315952	6480464	Arsenic Trioxide results in increased expression of PAPSS2 mRNA	CTD	PMID:22521957
Papss2	Rat	avobenzone	increases expression	ISO	RGD:1315952	6480464	avobenzone results in increased expression of PAPSS2 mRNA	CTD	PMID:31016361
Papss2	Rat	Azoxymethane	multiple interactions	ISO	RGD:1315953	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PAPSS2 more ...	CTD	PMID:29950665
Papss2	Rat	benzene	increases expression	ISO	RGD:1315952	6480464	Benzene results in increased expression of PAPSS2 mRNA	CTD	PMID:19162166
Papss2	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1315953	6480464	Benzo(a)pyrene results in decreased expression of PAPSS2 mRNA	CTD	PMID:19770486
Papss2	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1315952	6480464	Benzo(a)pyrene results in decreased expression of PAPSS2 mRNA	CTD	PMID:32234424
Papss2	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1315952	6480464	Benzo(a)pyrene results in increased methylation of PAPSS2 promoter	CTD	PMID:27901495
Papss2	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1315952	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PAPSS2 mRNA	CTD	PMID:20018196
Papss2	Rat	Benzo[ghi]perylene	increases expression	ISO	RGD:1315953	6480464	1,12-benzoperylene results in increased expression of PAPSS2 mRNA	CTD	PMID:26377693
Papss2	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1315952	6480464	Diethylhexyl Phthalate results in decreased expression of PAPSS2 mRNA	CTD	PMID:16223563
Papss2	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1315953	6480464	Diethylhexyl Phthalate results in decreased expression of PAPSS2 mRNA	CTD	PMID:34319233
Papss2	Rat	bis(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in decreased expression of PAPSS2 mRNA	CTD	PMID:26496021
Papss2	Rat	bisphenol A	decreases expression	ISO	RGD:1315953	6480464	bisphenol A results in decreased expression of PAPSS2 mRNA	CTD	PMID:32156529
Papss2	Rat	bisphenol A	multiple interactions	ISO	RGD:1315952	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of PAPSS2 gene	CTD	PMID:31601247
Papss2	Rat	bisphenol A	increases expression	ISO	RGD:1315952	6480464	bisphenol A results in increased expression of PAPSS2 mRNA	CTD	PMID:31715268
Papss2	Rat	bisphenol A	increases expression	ISO	RGD:1315953	6480464	bisphenol A results in increased expression of PAPSS2 mRNA	CTD	PMID:30951980
Papss2	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of PAPSS2 gene	CTD	PMID:28505145
Papss2	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of PAPSS2 mRNA	CTD	PMID:30816183\|PMID:32528016
Papss2	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of PAPSS2 mRNA	CTD	PMID:25181051
Papss2	Rat	bisphenol AF	increases expression	ISO	RGD:1315952	6480464	bisphenol AF results in increased expression of PAPSS2 protein	CTD	PMID:34186270
Papss2	Rat	Bisphenol B	increases expression	ISO	RGD:1315952	6480464	bisphenol B results in increased expression of PAPSS2 protein	CTD	PMID:34186270
Papss2	Rat	butane-2,3-dione	decreases expression	ISO	RGD:1315952	6480464	Diacetyl results in decreased expression of PAPSS2 mRNA	CTD	PMID:30710127
Papss2	Rat	Butylbenzyl phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	cadmium atom	multiple interactions	ISO	RGD:1315953	6480464	[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression more ...	CTD	PMID:31904401
Papss2	Rat	cadmium dichloride	decreases expression	EXP		6480464	Cadmium Chloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:25993096
Papss2	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1315953	6480464	[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression more ...	CTD	PMID:31904401
Papss2	Rat	cadmium dichloride	increases expression	ISO	RGD:1315952	6480464	Cadmium Chloride results in increased expression of PAPSS2 mRNA	CTD	PMID:38382870
Papss2	Rat	cadmium dichloride	decreases expression	ISO	RGD:1315952	6480464	Cadmium Chloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:26472689
Papss2	Rat	carbon nanotube	decreases expression	ISO	RGD:1315953	6480464	Nanotubes, Carbon analog results in decreased expression of PAPSS2 mRNA; Nanotubes, Carbon results in decreased more ...	CTD	PMID:25620056
Papss2	Rat	carbon nanotube	increases expression	ISO	RGD:1315953	6480464	Nanotubes, Carbon results in increased expression of PAPSS2 mRNA	CTD	PMID:25554681
Papss2	Rat	cetrorelix	multiple interactions	ISO	RGD:1315952	6480464	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; more ...	CTD	PMID:18160741
Papss2	Rat	chlordecone	increases expression	ISO	RGD:1315953	6480464	Chlordecone results in increased expression of PAPSS2 mRNA	CTD	PMID:33711761
Papss2	Rat	chloroprene	increases expression	ISO	RGD:1315953	6480464	Chloroprene results in increased expression of PAPSS2 mRNA	CTD	PMID:23125180
Papss2	Rat	chlorpyrifos	decreases expression	ISO	RGD:1315953	6480464	Chlorpyrifos results in decreased expression of PAPSS2 mRNA	CTD	PMID:37019170
Papss2	Rat	cholic acid	increases expression	ISO	RGD:1315953	6480464	Cholic Acid results in increased expression of PAPSS2 mRNA	CTD	PMID:17521389
Papss2	Rat	choline	multiple interactions	ISO	RGD:1315953	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ...	CTD	PMID:20938992
Papss2	Rat	clofibrate	decreases expression	EXP		6480464	Clofibrate results in decreased expression of PAPSS2 mRNA	CTD	PMID:12851107
Papss2	Rat	clofibrate	increases expression	ISO	RGD:1315953	6480464	Clofibrate results in increased expression of PAPSS2 mRNA	CTD	PMID:22496397
Papss2	Rat	clofibric acid	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAPSS2 mRNA	CTD	PMID:17602206
Papss2	Rat	cobalt dichloride	decreases expression	EXP		6480464	cobaltous chloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:24386269
Papss2	Rat	copper atom	multiple interactions	ISO	RGD:1315952	6480464	[NSC 689534 binds to Copper] which results in decreased expression of PAPSS2 mRNA	CTD	PMID:20971185
Papss2	Rat	copper(0)	multiple interactions	ISO	RGD:1315952	6480464	[NSC 689534 binds to Copper] which results in decreased expression of PAPSS2 mRNA	CTD	PMID:20971185
Papss2	Rat	coumestrol	multiple interactions	ISO	RGD:1315952	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PAPSS2 mRNA	CTD	PMID:19167446
Papss2	Rat	Cuprizon	decreases expression	EXP		6480464	Cuprizone results in decreased expression of PAPSS2 mRNA	CTD	PMID:26577399\|PMID:27523638
Papss2	Rat	cyclosporin A	decreases expression	ISO	RGD:1315953	6480464	Cyclosporine results in decreased expression of PAPSS2 mRNA	CTD	PMID:19770486
Papss2	Rat	cyclosporin A	increases expression	ISO	RGD:1315952	6480464	Cyclosporine results in increased expression of PAPSS2 mRNA	CTD	PMID:27989131
Papss2	Rat	cyproconazole	increases expression	ISO	RGD:1315953	6480464	cyproconazole results in increased expression of PAPSS2 mRNA	CTD	PMID:22334560
Papss2	Rat	decabromodiphenyl ether	decreases expression	ISO	RGD:1315952	6480464	decabromobiphenyl ether results in decreased expression of PAPSS2 protein	CTD	PMID:31675489
Papss2	Rat	desogestrel	multiple interactions	ISO	RGD:1315952	6480464	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA	CTD	PMID:18160741
Papss2	Rat	dextran sulfate	multiple interactions	ISO	RGD:1315953	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PAPSS2 more ...	CTD	PMID:29950665
Papss2	Rat	diarsenic trioxide	increases expression	ISO	RGD:1315952	6480464	Arsenic Trioxide results in increased expression of PAPSS2 mRNA	CTD	PMID:22521957
Papss2	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1315952	6480464	di-n-butylphosphoric acid affects the expression of PAPSS2 mRNA	CTD	PMID:37042841
Papss2	Rat	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of PAPSS2 mRNA	CTD	PMID:21266533
Papss2	Rat	dibutyl phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	diethyl phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	diethylstilbestrol	increases expression	EXP		6480464	Diethylstilbestrol results in increased expression of PAPSS2 mRNA	CTD	PMID:17005392
Papss2	Rat	diisobutyl phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	Diisodecyl phthalate	decreases expression	ISO	RGD:1315952	6480464	diisodecyl phthalate results in decreased expression of PAPSS2 mRNA	CTD	PMID:16223563
Papss2	Rat	diisononyl phthalate	multiple interactions	ISO	RGD:1315953	6480464	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with diisononyl phthalate co-treated with Dibutyl Phthalate co-treated more ...	CTD	PMID:39150890
Papss2	Rat	diuron	decreases expression	EXP		6480464	Diuron results in decreased expression of PAPSS2 mRNA	CTD	PMID:25152437
Papss2	Rat	dorsomorphin	multiple interactions	ISO	RGD:1315952	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Papss2	Rat	doxorubicin	increases expression	ISO	RGD:1315953	6480464	Doxorubicin results in increased expression of PAPSS2 mRNA	CTD	PMID:15033991
Papss2	Rat	endosulfan	decreases expression	EXP		6480464	Endosulfan results in decreased expression of PAPSS2 mRNA	CTD	PMID:29391264
Papss2	Rat	Enterolactone	multiple interactions	ISO	RGD:1315952	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of PAPSS2 mRNA	CTD	PMID:19167446
Papss2	Rat	epoxiconazole	increases expression	ISO	RGD:1315953	6480464	epoxiconazole results in increased expression of PAPSS2 mRNA	CTD	PMID:22334560\|PMID:23970803
Papss2	Rat	epoxiconazole	decreases expression	ISO	RGD:1315953	6480464	epoxiconazole results in decreased expression of PAPSS2 mRNA	CTD	PMID:35436446
Papss2	Rat	ethanol	increases expression	ISO	RGD:1315953	6480464	Ethanol results in increased expression of PAPSS2 mRNA	CTD	PMID:30319688
Papss2	Rat	ethanol	affects expression	ISO	RGD:1315953	6480464	Ethanol affects the expression of PAPSS2 mRNA	CTD	PMID:30319688
Papss2	Rat	etoposide	increases expression	ISO	RGD:1315953	6480464	Etoposide results in increased expression of PAPSS2 mRNA	CTD	PMID:25270620
Papss2	Rat	flurbiprofen	increases expression	ISO	RGD:1315953	6480464	Flurbiprofen results in increased expression of PAPSS2 mRNA	CTD	PMID:16949054
Papss2	Rat	folic acid	multiple interactions	ISO	RGD:1315953	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAPSS2 mRNA; [Methionine deficiency co-treated more ...	CTD	PMID:20938992\|PMID:22206623
Papss2	Rat	fulvestrant	multiple interactions	ISO	RGD:1315952	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of PAPSS2 gene	CTD	PMID:31601247
Papss2	Rat	genistein	decreases expression	ISO	RGD:1315952	6480464	Genistein results in decreased expression of PAPSS2 mRNA	CTD	PMID:22228119
Papss2	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of PAPSS2 mRNA	CTD	PMID:33387578
Papss2	Rat	glafenine	decreases expression	EXP		6480464	Glafenine results in decreased expression of PAPSS2 mRNA	CTD	PMID:24136188
Papss2	Rat	glycidyl methacrylate	decreases expression	ISO	RGD:1315952	6480464	glycidyl methacrylate results in decreased expression of PAPSS2 protein	CTD	PMID:36641056
Papss2	Rat	glyphosate	decreases expression	ISO	RGD:1315953	6480464	Glyphosate results in decreased expression of PAPSS2 protein	CTD	PMID:37208198
Papss2	Rat	griseofulvin	affects expression	ISO	RGD:1315953	6480464	Griseofulvin affects the expression of PAPSS2 mRNA	CTD	PMID:12735108
Papss2	Rat	indole-3-methanol	affects expression	EXP		6480464	indole-3-carbinol affects the expression of PAPSS2 mRNA	CTD	PMID:21396975
Papss2	Rat	inulin	multiple interactions	ISO	RGD:1315953	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of PAPSS2 mRNA	CTD	PMID:36331819
Papss2	Rat	isoprenaline	increases expression	ISO	RGD:1315953	6480464	Isoproterenol results in increased expression of PAPSS2 mRNA	CTD	PMID:20003209
Papss2	Rat	ivermectin	decreases expression	ISO	RGD:1315952	6480464	Ivermectin results in decreased expression of PAPSS2 protein	CTD	PMID:32959892
Papss2	Rat	L-methionine	multiple interactions	ISO	RGD:1315953	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ...	CTD	PMID:20938992
Papss2	Rat	lead diacetate	decreases expression	EXP		6480464	lead acetate results in decreased expression of PAPSS2 mRNA	CTD	PMID:22641619
Papss2	Rat	methimazole	increases expression	EXP		6480464	Methimazole results in increased expression of PAPSS2 mRNA	CTD	PMID:30047161
Papss2	Rat	methyltestosterone	multiple interactions	ISO	RGD:1315952	6480464	[Methyltestosterone co-treated with Cholic Acids] affects the expression of PAPSS2 mRNA	CTD	PMID:27344345
Papss2	Rat	mono(2-ethylhexyl) phthalate	multiple interactions	ISO	RGD:1315953	6480464	[mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of PAPSS2 mRNA	CTD	PMID:36189433
Papss2	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PAPSS2 mRNA	CTD	PMID:17602206
Papss2	Rat	nickel atom	increases expression	ISO	RGD:1315952	6480464	Nickel results in increased expression of PAPSS2 mRNA	CTD	PMID:24768652\|PMID:25583101
Papss2	Rat	nimesulide	decreases expression	EXP		6480464	nimesulide results in decreased expression of PAPSS2 mRNA	CTD	PMID:24136188
Papss2	Rat	okadaic acid	decreases expression	ISO	RGD:1315952	6480464	Okadaic Acid results in decreased expression of PAPSS2 mRNA	CTD	PMID:38832940
Papss2	Rat	paracetamol	affects expression	ISO	RGD:1315953	6480464	Acetaminophen affects the expression of PAPSS2 mRNA	CTD	PMID:17562736
Papss2	Rat	paracetamol	multiple interactions	ISO	RGD:1315953	6480464	PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of PAPSS2 mRNA]	CTD	PMID:29246445
Papss2	Rat	paracetamol	decreases expression	ISO	RGD:1315953	6480464	Acetaminophen results in decreased expression of PAPSS2 mRNA	CTD	PMID:29246445
Papss2	Rat	paracetamol	decreases expression	ISO	RGD:1315952	6480464	Acetaminophen results in decreased expression of PAPSS2 mRNA	CTD	PMID:21420995
Papss2	Rat	paraquat	decreases expression	EXP		6480464	Paraquat results in decreased expression of PAPSS2 mRNA	CTD	PMID:32680482
Papss2	Rat	pentane-2,3-dione	decreases expression	ISO	RGD:1315952	6480464	2,3-pentanedione results in decreased expression of PAPSS2 mRNA	CTD	PMID:30710127
Papss2	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1315953	6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PAPSS2 mRNA; [perfluorooctane sulfonic more ...	CTD	PMID:36331819
Papss2	Rat	perfluorooctanoic acid	decreases expression	EXP		6480464	perfluorooctanoic acid results in decreased expression of PAPSS2 mRNA; perfluorooctanoic acid results in decreased expression more ...	CTD	PMID:19162173\|PMID:34958885
Papss2	Rat	phenobarbital	increases expression	ISO	RGD:1315953	6480464	Phenobarbital results in increased expression of PAPSS2 mRNA	CTD	PMID:19270015\|PMID:19482888\|PMID:23091169
Papss2	Rat	phenobarbital	multiple interactions	ISO	RGD:1315953	6480464	[Phenobarbital results in increased activity of NR1I3 protein] which results in increased expression of PAPSS2 more ...	CTD	PMID:14742670
Papss2	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1315952	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Papss2	Rat	phorbol 13-acetate 12-myristate	multiple interactions	ISO	RGD:1315953	6480464	[Tetradecanoylphorbol Acetate co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] affects the expression more ...	CTD	PMID:31904401
Papss2	Rat	pirinixic acid	decreases expression	EXP		6480464	pirinixic acid results in decreased expression of PAPSS2 mRNA	CTD	PMID:19162173\|PMID:22484513
Papss2	Rat	pregnenolone 16alpha-carbonitrile	multiple interactions	ISO	RGD:1315953	6480464	[Pregnenolone Carbonitrile co-treated with NR1I2 protein mutant form] results in increased expression of PAPSS2 mRNA; more ...	CTD	PMID:20693526\|PMID:22496397
Papss2	Rat	pregnenolone 16alpha-carbonitrile	increases expression	ISO	RGD:1315953	6480464	Pregnenolone Carbonitrile results in increased expression of PAPSS2 mRNA	CTD	PMID:22496397\|PMID:27413110\|PMID:28903501\|PMID:31388680
Papss2	Rat	progesterone	multiple interactions	ISO	RGD:1315952	6480464	[Estradiol co-treated with Progesterone] results in decreased expression of PAPSS2 mRNA	CTD	PMID:20660070
Papss2	Rat	propiconazole	increases expression	ISO	RGD:1315953	6480464	propiconazole results in increased expression of PAPSS2 mRNA	CTD	PMID:21278054\|PMID:22334560\|PMID:23970803
Papss2	Rat	SB 431542	multiple interactions	ISO	RGD:1315952	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Papss2	Rat	silicon dioxide	decreases expression	ISO	RGD:1315952	6480464	Silicon Dioxide analog results in decreased expression of PAPSS2 mRNA	CTD	PMID:25895662
Papss2	Rat	sodium arsenite	increases expression	EXP		6480464	sodium arsenite results in increased expression of PAPSS2 protein	CTD	PMID:29459688
Papss2	Rat	sodium arsenite	increases expression	ISO	RGD:1315952	6480464	sodium arsenite results in increased expression of PAPSS2 mRNA	CTD	PMID:38568856
Papss2	Rat	sodium dichromate	decreases expression	EXP		6480464	sodium bichromate results in decreased expression of PAPSS2 mRNA	CTD	PMID:25993096
Papss2	Rat	Soman	increases expression	EXP		6480464	Soman results in increased expression of PAPSS2 mRNA	CTD	PMID:19281266
Papss2	Rat	sulfadimethoxine	increases expression	EXP		6480464	Sulfadimethoxine results in increased expression of PAPSS2 mRNA	CTD	PMID:30047161
Papss2	Rat	sunitinib	increases expression	ISO	RGD:1315952	6480464	Sunitinib results in increased expression of PAPSS2 mRNA	CTD	PMID:31533062
Papss2	Rat	tert-butyl hydroperoxide	increases expression	ISO	RGD:1315952	6480464	tert-Butylhydroperoxide results in increased expression of PAPSS2 mRNA	CTD	PMID:15336504
Papss2	Rat	testosterone enanthate	multiple interactions	ISO	RGD:1315952	6480464	[cetrorelix co-treated with testosterone enanthate co-treated with Desogestrel] results in decreased expression of PAPSS2 mRNA; more ...	CTD	PMID:18160741
Papss2	Rat	tetrachloromethane	decreases expression	ISO	RGD:1315953	6480464	Carbon Tetrachloride results in decreased expression of PAPSS2 mRNA	CTD	PMID:27339419\|PMID:31919559
Papss2	Rat	thapsigargin	decreases expression	ISO	RGD:1315952	6480464	Thapsigargin results in decreased expression of PAPSS2 mRNA	CTD	PMID:29453283
Papss2	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of PAPSS2 mRNA	CTD	PMID:23411599\|PMID:34492290
Papss2	Rat	titanium dioxide	multiple interactions	ISO	RGD:1315953	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PAPSS2 more ...	CTD	PMID:29950665
Papss2	Rat	titanium dioxide	increases methylation	ISO	RGD:1315953	6480464	titanium dioxide results in increased methylation of PAPSS2 gene	CTD	PMID:35295148
Papss2	Rat	triadimefon	increases expression	ISO	RGD:1315953	6480464	triadimefon results in increased expression of PAPSS2 mRNA	CTD	PMID:23970803
Papss2	Rat	trichloroethene	increases expression	ISO	RGD:1315953	6480464	Trichloroethylene results in increased expression of PAPSS2 mRNA	CTD	PMID:19254012
Papss2	Rat	trichostatin A	decreases expression	ISO	RGD:1315952	6480464	trichostatin A results in decreased expression of PAPSS2 mRNA	CTD	PMID:24935251\|PMID:26272509
Papss2	Rat	trichostatin A	multiple interactions	ISO	RGD:1315952	6480464	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Papss2	Rat	triphenyl phosphate	decreases expression	EXP		6480464	triphenyl phosphate results in decreased expression of PAPSS2 mRNA	CTD	PMID:30589522
Papss2	Rat	triphenyl phosphate	affects expression	ISO	RGD:1315952	6480464	triphenyl phosphate affects the expression of PAPSS2 mRNA	CTD	PMID:37042841
Papss2	Rat	tris(2-butoxyethyl) phosphate	affects expression	ISO	RGD:1315952	6480464	tris(2-butoxyethyl) phosphate affects the expression of PAPSS2 mRNA	CTD	PMID:29024780
Papss2	Rat	troglitazone	decreases expression	ISO	RGD:1315952	6480464	troglitazone results in decreased expression of PAPSS2 mRNA	CTD	PMID:19140230
Papss2	Rat	troglitazone	decreases expression	ISO	RGD:1315953	6480464	troglitazone results in decreased expression of PAPSS2 mRNA	CTD	PMID:28973697
Papss2	Rat	tunicamycin	decreases expression	ISO	RGD:1315952	6480464	Tunicamycin results in decreased expression of PAPSS2 mRNA	CTD	PMID:29453283
Papss2	Rat	valproic acid	increases expression	ISO	RGD:1315952	6480464	Valproic Acid results in increased expression of PAPSS2 mRNA	CTD	PMID:19101580\|PMID:23179753
Papss2	Rat	valproic acid	multiple interactions	ISO	RGD:1315952	6480464	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ...	CTD	PMID:27188386
Papss2	Rat	valproic acid	decreases expression	ISO	RGD:1315952	6480464	Valproic Acid results in decreased expression of PAPSS2 mRNA	CTD	PMID:23179753\|PMID:26272509
Papss2	Rat	valproic acid	affects expression	ISO	RGD:1315952	6480464	Valproic Acid affects the expression of PAPSS2 mRNA	CTD	PMID:25979313
Papss2	Rat	vancomycin	increases expression	ISO	RGD:1315953	6480464	Vancomycin results in increased expression of PAPSS2 mRNA	CTD	PMID:18930951

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	involved_in	ISO	RGD:1315953	1624291	MGI:1856688 PMID:10559207, PMID:9671738	RGD	PMID:10559207\|PMID:9671738
Papss2	Rat	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	involved_in	IBA	MGI:1330223\|MGI:1330587\|PANTHER:PTN000868599\|UniProtKB:O43252\|UniProtKB:O95340	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Papss2	Rat	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	involved_in	ISO	RGD:1315952	1624291	PMID:23824674	RGD	PMID:23824674
Papss2	Rat	biological_process		ND		1598407	20061212: no relevant rat data	RGD
Papss2	Rat	blood coagulation	acts_upstream_of_or_within	ISO	RGD:1315953	1624291	MGI:1856688 PMID:8835524	RGD	PMID:8835524
Papss2	Rat	bone development	acts_upstream_of_or_within	ISO	RGD:1315953	1624291	MGI:1856688 PMID:624676	RGD	PMID:624676
Papss2	Rat	hormone metabolic process	involved_in	ISO	RGD:1315952	1624291	PMID:19474428	RGD	PMID:19474428
Papss2	Rat	purine-containing compound biosynthetic process	involved_in	IEA	ARBA:ARBA00026861	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Papss2	Rat	sulfate assimilation	involved_in	IEA	UniPathway:UPA00097	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Papss2	Rat	sulfate assimilation	involved_in	IEA	InterPro:IPR002650\|InterPro:IPR002891	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Papss2	Rat	sulfate assimilation	acts_upstream_of_or_within	ISO	RGD:1315953	1624291	PMID:10559207	RGD	PMID:10559207
Papss2	Rat	sulfate assimilation	involved_in	IBA	MGI:1330223\|PANTHER:PTN000114642\|PomBase:SPAC1782.11\|SGD:S000001484\|TAIR:locus:2046901\|TAIR:locus:2140005\|UniProtKB:O43252\|UniProtKB:O95340\|UniProtKB:Q92203	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Papss2	Rat	sulfate assimilation	involved_in	ISO	RGD:1315952	1624291	PMID:19474428	RGD	PMID:19474428
Papss2	Rat	sulfur compound metabolic process	involved_in	IEA	ARBA:ARBA00028021	1600115	GO_REF:0000117	UniProt	GO_REF:0000117

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	cytosol	located_in	TAS		1600115	Reactome:R-RNO-2408504	Reactome	Reactome:R-RNO-2408504
Papss2	Rat	cytosol	is_active_in	ISO	RGD:1315952	1624291	PMID:22242175	RGD	PMID:22242175
Papss2	Rat	nucleus	is_active_in	ISO	RGD:1315952	1624291	PMID:22242175	RGD	PMID:22242175

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	adenylylsulfate kinase activity	enables	ISO	RGD:1315953	1624291	MGI:1856688 PMID:10559207, PMID:230515	RGD	PMID:10559207\|PMID:230515
Papss2	Rat	adenylylsulfate kinase activity	enables	IBA	MGI:1330223\|MGI:1330587\|PANTHER:PTN000114732\|SGD:S000001484\|TAIR:locus:2046901\|TAIR:locus:2079379\|TAIR:locus:2140005\|TAIR:locus:2158626\|UniProtKB:O43252\|UniProtKB:P0A6J1\|UniProtKB:P9WNM5	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Papss2	Rat	adenylylsulfate kinase activity	enables	IEA	InterPro:IPR002891	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Papss2	Rat	adenylylsulfate kinase activity	enables	IEA	EC:2.7.1.25	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Papss2	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Papss2	Rat	ATP binding	enables	IEA	InterPro:IPR002891	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Papss2	Rat	catalytic activity	enables	IEA	UniProtKB-KW:KW-0511	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Papss2	Rat	kinase activity	enables	IEA	UniProtKB-KW:KW-0418	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Papss2	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Papss2	Rat	nucleotidyltransferase activity	enables	IEA	UniProtKB-KW:KW-0548	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Papss2	Rat	protein binding	enables	ISO	RGD:1315952	1624291	UniProtKB:O43252\|UniProtKB:O75031\|UniProtKB:Q96CV9\|UniProtKB:Q96LK0 PMID:32296183, PMID:32814053, PMID:33961781	RGD	PMID:32296183\|PMID:32814053\|PMID:33961781
Papss2	Rat	selenate adenylyltransferase (ATP) activity	enables	TAS		1600115	Reactome:R-RNO-2408504	Reactome	Reactome:R-RNO-2408504
Papss2	Rat	sulfate adenylyltransferase (ATP) activity	enables	ISO	RGD:1315953	1624291	MGI:1856688 PMID:10559207, PMID:230515	RGD	PMID:10559207\|PMID:230515
Papss2	Rat	sulfate adenylyltransferase (ATP) activity	enables	IEA	InterPro:IPR002650\|InterPro:IPR024951	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Papss2	Rat	sulfate adenylyltransferase (ATP) activity	enables	IEA	EC:2.7.7.4	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Papss2	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	sulfite oxidase deficiency pathway		ISO	RGD:1315952	10402751		SMPDB	SMP:00532

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Papss2	Rat	purine metabolic pathway		IEA		6907045		KEGG	rno:00230
Papss2	Rat	selenoamino acid metabolic pathway		IEA		6907045		KEGG	rno:00450
Papss2	Rat	sulfur metabolic pathway		IEA		6907045		KEGG	rno:00920

Disease Annotations Click to see Annotation Detail View

brachyolmia (ISO)

genetic disease (ISO)

juvenile polyposis syndrome (ISO)

PTEN hamartoma tumor syndrome (ISO)

spondyloepimetaphyseal dysplasia, Pakistani type (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid (ISO)

4-octylphenol (ISO)

6-propyl-2-thiouracil (EXP)

7,12-dimethyltetraphene (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

Aroclor 1254 (EXP)

arsenite(3-) (ISO)

arsenous acid (ISO)

avobenzone (ISO)

Azoxymethane (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[ghi]perylene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

butane-2,3-dione (ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

cetrorelix (ISO)

chlordecone (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

cholic acid (ISO)

choline (ISO)

clofibrate (EXP,ISO)

clofibric acid (EXP)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

coumestrol (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cyproconazole (ISO)

decabromodiphenyl ether (ISO)

desogestrel (ISO)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

diethyl phthalate (ISO)

diethylstilbestrol (EXP)

diisobutyl phthalate (ISO)

Diisodecyl phthalate (ISO)

diisononyl phthalate (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

epoxiconazole (ISO)

ethanol (ISO)

etoposide (ISO)

flurbiprofen (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

glafenine (EXP)

glycidyl methacrylate (ISO)

glyphosate (ISO)

griseofulvin (ISO)

indole-3-methanol (EXP)

inulin (ISO)

isoprenaline (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead diacetate (EXP)

methimazole (EXP)

methyltestosterone (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (EXP)

nickel atom (ISO)

nimesulide (EXP)

okadaic acid (ISO)

paracetamol (ISO)

paraquat (EXP)

pentane-2,3-dione (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

Soman (EXP)

sulfadimethoxine (EXP)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triadimefon (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP,ISO)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

3'-phosphoadenosine 5'-phosphosulfate biosynthetic process (IBA,ISO)

biological_process (ND)

blood coagulation (ISO)

bone development (ISO)

hormone metabolic process (ISO)

purine-containing compound biosynthetic process (IEA)

sulfate assimilation (IBA,IEA,ISO)

sulfur compound metabolic process (IEA)

Cellular Component

cytosol (ISO,TAS)

nucleus (ISO)

Molecular Function

adenylylsulfate kinase activity (IBA,IEA,ISO)

ATP binding (IEA)

catalytic activity (IEA)

kinase activity (IEA)

nucleotide binding (IEA)

nucleotidyltransferase activity (IEA)

protein binding (ISO)

selenate adenylyltransferase (ATP) activity (TAS)

sulfate adenylyltransferase (ATP) activity (IEA,ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

purine metabolic pathway (IEA)

selenoamino acid metabolic pathway (IEA)

sulfite oxidase deficiency pathway (ISO)

sulfur metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:624676	PMID:8835524	PMID:10559207	PMID:12477932

Genomics

Comparative Map Data

Papss2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	239,867,597 - 239,952,614 (+)	NCBI		GRCr8
mRatBN7.2	1	230,454,314 - 230,539,332 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	230,454,426 - 230,539,331 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	238,827,264 - 238,914,193 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	245,756,967 - 245,843,895 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	238,595,075 - 238,682,007 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	251,145,264 - 251,230,716 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	251,145,253 - 251,230,715 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	258,376,054 - 258,461,337 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	236,592,414 - 236,677,379 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	236,796,239 - 236,839,791 (+)	NCBI
Celera	1	227,570,258 - 227,654,408 (+)	NCBI		Celera
Cytogenetic Map	1	q52	NCBI

PAPSS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	87,659,878 - 87,747,705 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	87,659,613 - 87,747,705 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	89,419,635 - 89,507,462 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	89,409,456 - 89,497,442 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	89,409,607 - 89,496,142	NCBI
Celera	10	83,166,000 - 83,253,966 (+)	NCBI		Celera
Cytogenetic Map	10	q23.2-q23.31	NCBI
HuRef	10	83,054,540 - 83,142,617 (+)	NCBI		HuRef
CHM1_1	10	89,701,783 - 89,789,765 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	88,543,727 - 88,631,613 (+)	NCBI		T2T-CHM13v2.0

Papss2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	32,573,072 - 32,644,587 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	32,573,190 - 32,644,587 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	32,595,669 - 32,667,187 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	32,595,790 - 32,667,187 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	32,694,495 - 32,741,677 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	32,686,002 - 32,733,184 (+)	NCBI		MGSCv36	mm8
Celera	19	33,402,870 - 33,450,031 (+)	NCBI		Celera
Cytogenetic Map	19	C1	NCBI
cM Map	19	27.46	NCBI

Papss2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	5,187,952 - 5,258,955 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	5,186,232 - 5,259,080 (-)	NCBI	ChiLan1.0	ChiLan1.0

PAPSS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	99,675,589 - 99,764,891 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	99,682,336 - 99,770,207 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	84,383,936 - 84,471,745 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	87,890,631 - 87,977,839 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	87,890,631 - 87,977,839 (+)	Ensembl	panpan1.1		panPan2

PAPSS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	37,725,205 - 37,745,103 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	37,725,616 - 37,743,928 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	37,579,442 - 37,627,983 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	39,227,070 - 39,275,831 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	39,227,159 - 39,275,846 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	37,134,164 - 37,182,464 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	36,715,608 - 36,764,348 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	37,955,064 - 38,003,810 (+)	NCBI		UU_Cfam_GSD_1.0

Papss2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	77,276,657 - 77,356,538 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936735	1,436,153 - 1,516,378 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936735	1,437,108 - 1,516,382 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PAPSS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	99,685,578 - 99,808,381 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	99,718,299 - 99,816,346 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	108,701,055 - 108,789,588 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PAPSS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	81,102,477 - 81,191,951 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	81,102,520 - 81,190,230 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	41,763,494 - 41,853,076 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Papss2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624791	13,789,584 - 13,866,543 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624791	13,789,539 - 13,866,551 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Papss2
497 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	226
Count of miRNA genes:	142
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000014979
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8693637	Alc29	Alcohol consumption QTL 29	2.7	0.258	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	1	207987464	234238494	Rat
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	214537555	238757011	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	216255568	260522016	Rat
1600392	Bw123	Body weight QTL 123		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	223201027	260522016	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	206081677	251081677	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	228581588	259647894	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	224054293	260122809	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	225126575	260522016	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	224054293	260122809	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	221264111	259647894	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	213707201	252085212	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	224569538	260122809	Rat
734768	Niddm59	Non-insulin dependent diabetes mellitus QTL 59			body mass (VT:0001259)	body weight (CMO:0000012)	1	213843987	258843987	Rat
1358890	Bp259	Blood pressure QTL 259	3.06		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	210702053	260522016	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	218753816	256448513	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
1549910	Bw54	Body weight QTL 54		0.05	body mass (VT:0001259)	body weight (CMO:0000012)	1	214647894	259647894	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	214647894	259647894	Rat
1357399	Bw45	Body weight QTL 45	3.05		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	1	206329708	251329708	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	222363780	260522016	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228985440	245907899	Rat
1357404	Bw42	Body weight QTL 42	4.49	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	1	206329708	251329708	Rat
10053715	Scort24	Serum corticosterone level QTL 24	2.13	0.0088	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	221414816	260522016	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	210702053	240947965	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	218753689	245907899	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292216	Bw80	Body weight QTL 80	3.23	0.0019	body mass (VT:0001259)	body weight (CMO:0000012)	1	213533809	243914901	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	224054293	243747962	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	224054293	243747962	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	223262787	260522016	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	203995416	244113296	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	216255568	260522016	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	218748008	257976495	Rat

Markers in Region

D1Rat446

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	1	239,909,501 - 239,909,639 (+)	Marker Load Pipeline
mRatBN7.2	1	230,496,217 - 230,496,355 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	251,187,687 - 251,187,824	NCBI	Rnor6.0
Rnor_5.0	1	258,418,499 - 258,418,636	UniSTS	Rnor5.0
RGSC_v3.4	1	236,634,422 - 236,634,559	UniSTS	RGSC3.4
RGSC_v3.4	1	236,634,422 - 236,634,559	RGD	RGSC3.4
RGSC_v3.1	1	236,798,045 - 236,798,659	RGD
Celera	1	227,611,687 - 227,611,824	UniSTS
RH 2.0 Map	2	419.8	RGD
SHRSP x BN Map	1	127.73	RGD
Cytogenetic Map	1	q52	UniSTS

AU047720

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	230,529,290 - 230,529,505 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	251,220,677 - 251,220,891	NCBI	Rnor6.0
Rnor_5.0	1	258,451,298 - 258,451,512	UniSTS	Rnor5.0
RGSC_v3.4	1	236,667,340 - 236,667,554	UniSTS	RGSC3.4
Celera	1	227,644,369 - 227,644,583	UniSTS
Cytogenetic Map	1	q52	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006231274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC169061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000014979 ⟹ ENSRNOP00000014979

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	230,454,426 - 230,539,331 (+)	Ensembl
Rnor_6.0 Ensembl	1	251,145,363 - 251,230,715 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000083555 ⟹ ENSRNOP00000074860

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	230,454,426 - 230,539,331 (+)	Ensembl
Rnor_6.0 Ensembl	1	251,145,253 - 251,229,303 (+)	Ensembl

RefSeq Acc Id:

NM_001106375 ⟹ NP_001099845

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	239,867,713 - 239,952,614 (+)	NCBI
mRatBN7.2	1	230,454,426 - 230,539,332 (+)	NCBI
Rnor_6.0	1	251,145,363 - 251,230,716 (+)	NCBI
Rnor_5.0	1	258,376,054 - 258,461,337 (+)	NCBI
RGSC_v3.4	1	236,592,414 - 236,677,379 (+)	RGD
Celera	1	227,570,258 - 227,654,408 (+)	RGD

Sequence:

show sequence

TGCACCCTGGACCCGGGCTCCGTCCCAGCCGCAGCATGTCGGAGATCAAGAAGCAGAAGACGGA
CCAGCAAAAATCCACCAATGTGGTCTACCAGGCCCATCATGTGAGCAGGAACAAGAGAGGACAG
GTGGTTGGAACCAGAGGAGGATTCAGAGGATGTACCGTGTGGCTAACAGGTCTCTCCGGCGCTG
GAAAAACAACCATAAGCTTCGCTTTGGAGGAGTACCTTGTGTCTCATGCCATCCCGTGTTACTC
CCTGGATGGAGACAATGTCCGTCATGGCCTTAACAAGAACCTGGGATTCTCTGCCGGGGACCGA
GAAGAGAATATCCGTCGAATTGCAGAGGTGGCCAAGCTCTTTGCTGATGCTGGCCTAGTGTGCA
TTACCAGTTTTATTTCTCCATTTGCAAAGGATCGTGAGAATGCCCGCAAAATCCACGAATCAGC
AGGACTCCCCTTCTTTGAGATCTTTGTAGATGCACCTTTAAATATCTGTGAAAGCCGAGATGTA
AAAGGACTCTACAAACGCGCTCGGGCAGGAGAGATTAAAGGGTTTACAGGCATCGATTCCAATT
ATGAGAAACCCGAGACTCCAGAGTGTGTGCTGAAGACCAACTTGTCCTCAGTGAGCGACTGTGT
GCAGCAGGTGGTGGAGCTTCTGCAAGAGCAGAGCATTGTTCCCCACACCACCATCAAAGGCATC
CATGAACTCTTTGTGCCGGAAAACAAAATTGATCAAATCCGAGCTGAGTTAGAGACTCTCCCAT
CACTACCAATTACCAAGCTGGATCTGCAGTGGGTGCAGATTCTGAGCGAAGGCTGGGCCACTCC
GCTCAAAGGCTTTATGAGGGAAAAGGAGTACTTGCAAACTCTGCACTTCGACACCCTACTGGAC
GATGGAGTCATCAACATGAGCATTCCCATCGTACTGCCTGTTTCTGGGGATGACAAGGCACGGC
TCGAAGGCTGCAGCAAGTTTGCCTTGATGTACGAAGGCCGGAGGGTAGCTCTCTTACAAGACCC
TGAATTCTATGAGCATAGGAAAGAGGAGCGTTGTTCTCGTGTGTGGGGAACAGCCAGTGCAAAA
CACCCCCATATCAAAATGGTGATGGAAGGTGGGGACTGGCTTGTTGGTGGAGACCTTCAGGTGC
TAGAGAGAATACGGTGGAATGATGGGCTGGACCAGTACCGCCTGACGCCTCTAGAGCTCAAACA
GAAGTGTAAAGACATGGATGCTGATGCCGTGTTTGCGTTCCAGTTACGCAATCCTGTCCACAAC
GGCCACGCTCTGCTGATGCAAGACACCCGGCGCAGGCTCCTGGAGAGGGGCTACAAGCACCCGG
TCCTCCTGCTGCACCCTCTCGGGGGCTGGACCAAGGACGATGACGTACCTCTCGACTGGAGGAT
GAAACAGCATGCGGCTGTGCTGGAGGAAGGGATCCTGGATCCCAAGTCGACTATTGTCGCCATC
TTCCCATCTCCTATGTTATACGCTGGGCCTACAGAGGTCCAGTGGCACTGCAGGTGCCGAATGA
TTGCAGGGGCCAATTTCTACATCGTGGGTAGGGATCCTGCAGGAATGCCTCACCCTGAGACAAA
GAAAGACCTATACGAACCTACCCATGGTGGTAAGGTCTTGAGCATGGCCCCTGGCCTCACCTCT
GTGGAAATCATTCCATTCCGAGTGGCTGCCTACAATAAAATTAAGAAGGCCATGGACTTTTATG
ATCCGGCAAGGCACGATGAGTTTGACTTCATCTCAGGAACTCGTATGAGGAAGCTCGCCCGGGA
AGGAGAAGATCCCCCAGATGGCTTCATGGCCCCCAAAGCATGGAAAGTGTTGACAGATTATTAC
AGGTCTCTGGAGAAGATCAACTAGGTGCTCCCGGCTCTGGTTTCTTTCTCAAGTGCTCTATGAC
GATTTTTTTCTATTTTTGTGATTAGCGGCTCTGTATCCAATTGCTTCTTGATGACTTTTTAAAG
TTAGTATTTTGCAATGAAGTAAAAAGTTGTGTCTATAATTTAAAACCAACTTCATTATGTCTAT
GAAACTCACACTGGAGACTAAGTCTTAGGTGAAAACATTGTTGTACATTCCAGAATGAAAGCAC
TTGTATACTACTTCATCTCAGCATATATGTCTCAGATTTCTTAAAAATGTGACTACATGTCTAG
CTGACTTGCCCAGGACAGAATCATACTTTCTGGCTTACTTTTGCCAGCCTGGAATTCTAATGTC
ACCAAACACACACACACACACACACACACACACACACACACACACACACACACACACACAGACA
CACACACACACACACACACACACACACACAGAGTCATCTTGAAGGAAATGTTTCATATCAGGAC
TTTTTACTTCGTGACTACACATGGCCTCACTGCCCAATGTATGAGATGAAGATGAATGAAACTG
GAAGGAAAATATGTGTGAAGATGCGAACTAAATCTTAAAGATGTCTGTAACGTACGTCTGCCAT
GAAAATAGAAAGAGACGTGCTAGTGGCCGTCTATGAATAGTAACTCCAGTGGGAAGGCACTTTT
CAAAAGCATGGTATGTATGCTTTGGTCAAAAGATTTCTCCCAGGGACTAAACCATCAGGGTTAC
ATTGTAGACTACTTTCCCCAGACTTGCTGTGGTCATAGTTATCTTAGAGGCACCTATTTGATCG
CTGTAGTCAAAACCAACCCACATACTAAACTAATGAGAAGCTAAAACCTGATTTCTGTAGAAAA
GATAAAGTCCAAACATCTTCATCCTAGATAAAATCTCCATTCTTCCATATCAGCTTTGAGAGCT
GCTGAGCACTGTAATACACCACACTGACATTAGCAAATACTCCTGACACTCAAAGGCTGCCCGG
ACTACCACCCTCCTAAGCTAGGTCCCTTCCTCCCCACAACACAGGAACAGGTTCTGATTCCTTG
AAGCTACTTAATGAAGCTCTCCTTGAGGATGCTAAAAGCAACCACCTTGGAGACAGAAGGTTCA
GGGCATCCTAAACTCTTGATGTTACAAGTTTCCAGAATGGACCTGTTCGACGTCCTTTGACGGT
TTATTTTCTAAGAGGGAATTTTGATATTTTATGCATGGTTCACTGTTGCCCAGGGATACGTAAA
AGAAAAAATACCTTTACATACAGGTGTCTTTGGAAGAGACCACAGACTGAAGAGAAACTGATTT
TTTTCATACTGCCACGTTTTTAGAATACTAGTAAGAGCTCTTTTGAGAGTAAGTTACATACCGT
GACCACAGCGAGTGAGTCTTCAACTGTTAGTGCCTGTGCTCACTTAGGCCGGAGTTACTCATTG
CTGCCTTTAAAACTGTGTGTTCACTGAAAACACGACAGGGCTGCAGTGCCTTACCAAATGGAGT
GAGATTCTAAAGACAGTAAAGTGCCTTTCTGCTCTAACAGTTGGTGTGACTGTTTCAGTGTCCC
GCTGATACTTGTTCTTCAATAAATCTCTCAAAGACCAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006231274 ⟹ XP_006231336

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	239,867,597 - 239,952,614 (+)	NCBI
mRatBN7.2	1	230,454,314 - 230,539,332 (+)	NCBI
Rnor_6.0	1	251,145,264 - 251,230,716 (+)	NCBI
Rnor_5.0	1	258,376,054 - 258,461,337 (+)	NCBI

Sequence:

show sequence

AGGAGAAGGGGGCCGGTCAAGGGAAGTGCGACGTGTCTGAGGAGCCTTTTTATACCTCCTTCCC
TGGAGCCGGGCAGCCACCGCCGCCATCCACGTCTCTGCACCCTGGACCCGGGCTCCGTCCCAGC
CGCAGCATGTCGGAGATCAAGAAGCAGAAGACGGACCAGCAAAAATCCACCAATGTGGTCTACC
AGGCCCATCATGTGAGCAGGAACAAGAGAGGACAGGTGGTTGGAACCAGAGGAGGATTCAGAGG
ATGTACCGTGTGGCTAACAGGTCTCTCCGGCGCTGGAAAAACAACCATAAGCTTCGCTTTGGAG
GAGTACCTTGTGTCTCATGCCATCCCGTGTTACTCCCTGGATGGAGACAATGTCCGTCATGGCC
TTAACAAGAACCTGGGATTCTCTGCCGGGGACCGAGAAGAGAATATCCGTCGAATTGCAGAGGT
GGCCAAGCTCTTTGCTGATGCTGGCCTAGTGTGCATTACCAGTTTTATTTCTCCATTTGCAAAG
GATCGTGAGAATGCCCGCAAAATCCACGAATCAGCAGGACTCCCCTTCTTTGAGATCTTTGTAG
ATGCACCTTTAAATATCTGTGAAAGCCGAGATGTAAAAGGACTCTACAAACGCGCTCGGGCAGG
AGAGATTAAAGGGTTTACAGGCATCGATTCCAATTATGAGAAACCCGAGACTCCAGAGTGTGTG
CTGAAGACCAACTTGTCCTCAGTGAGCGACTGTGTGCAGCAGGTGGTGGAGCTTCTGCAAGAGC
AGAGCATTGTTCCCCACACCACCATCAAAGGCATCCATGAACTCTTTGTGCCGGAAAACAAAAT
TGATCAAATCCGAGCTGAGTTAGAGACTCTCCCATCACTACCAATTACCAAGCTGGATCTGCAG
TGGGTGCAGATTCTGAGCGAAGGCTGGGCCACTCCGCTCAAAGGCTTTATGAGGGAAAAGGAGT
ACTTGCAAACTCTGCACTTCGACACCCTACTGGACGGCGTGATCCTCCGTGATGGAGTCATCAA
CATGAGCATTCCCATCGTACTGCCTGTTTCTGGGGATGACAAGGCACGGCTCGAAGGCTGCAGC
AAGTTTGCCTTGATGTACGAAGGCCGGAGGGTAGCTCTCTTACAAGACCCTGAATTCTATGAGC
ATAGGAAAGAGGAGCGTTGTTCTCGTGTGTGGGGAACAGCCAGTGCAAAACACCCCCATATCAA
AATGGTGATGGAAGGTGGGGACTGGCTTGTTGGTGGAGACCTTCAGGTGCTAGAGAGAATACGG
TGGAATGATGGGCTGGACCAGTACCGCCTGACGCCTCTAGAGCTCAAACAGAAGTGTAAAGACA
TGGATGCTGATGCCGTGTTTGCGTTCCAGTTACGCAATCCTGTCCACAACGGCCACGCTCTGCT
GATGCAAGACACCCGGCGCAGGCTCCTGGAGAGGGGCTACAAGCACCCGGTCCTCCTGCTGCAC
CCTCTCGGGGGCTGGACCAAGGACGATGACGTACCTCTCGACTGGAGGATGAAACAGCATGCGG
CTGTGCTGGAGGAAGGGATCCTGGATCCCAAGTCGACTATTGTCGCCATCTTCCCATCTCCTAT
GTTATACGCTGGGCCTACAGAGGTCCAGTGGCACTGCAGGTGCCGAATGATTGCAGGGGCCAAT
TTCTACATCGTGGGTAGGGATCCTGCAGGAATGCCTCACCCTGAGACAAAGAAAGACCTATACG
AACCTACCCATGGTGGTAAGGTCTTGAGCATGGCCCCTGGCCTCACCTCTGTGGAAATCATTCC
ATTCCGAGTGGCTGCCTACAATAAAATTAAGAAGGCCATGGACTTTTATGATCCGGCAAGGCAC
GATGAGTTTGACTTCATCTCAGGAACTCGTATGAGGAAGCTCGCCCGGGAAGGAGAAGATCCCC
CAGATGGCTTCATGGCCCCCAAAGCATGGAAAGTGTTGACAGATTATTACAGGTCTCTGGAGAA
GATCAACTAGGTGCTCCCGGCTCTGGTTTCTTTCTCAAGTGCTCTATGACGATTTTTTTCTATT
TTTGTGATTAGCGGCTCTGTATCCAATTGCTTCTTGATGACTTTTTAAAGTTAGTATTTTGCAA
TGAAGTAAAAAGTTGTGTCTATAATTTAAAACCAACTTCATTATGTCTATGAAACTCACACTGG
AGACTAAGTCTTAGGTGAAAACATTGTTGTACATTCCAGAATGAAAGCACTTGTATACTACTTC
ATCTCAGCATATATGTCTCAGATTTCTTAAAAATGTGACTACATGTCTAGCTGACTTGCCCAGG
ACAGAATCATACTTTCTGGCTTACTTTTGCCAGCCTGGAATTCTAATGTCACCAAACACACACA
CACACACACACACACACACACACACACACACACACACACACACAGACACACACACACACACACA
CACACACACACACAGAGTCATCTTGAAGGAAATGTTTCATATCAGGACTTTTTACTTCGTGACT
ACACATGGCCTCACTGCCCAATGTATGAGATGAAGATGAATGAAACTGGAAGGAAAATATGTGT
GAAGATGCGAACTAAATCTTAAAGATGTCTGTAACGTACGTCTGCCATGAAAATAGAAAGAGAC
GTGCTAGTGGCCGTCTATGAATAGTAACTCCAGTGGGAAGGCACTTTTCAAAAGCATGGTATGT
ATGCTTTGGTCAAAAGATTTCTCCCAGGGACTAAACCATCAGGGTTACATTGTAGACTACTTTC
CCCAGACTTGCTGTGGTCATAGTTATCTTAGAGGCACCTATTTGATCGCTGTAGTCAAAACCAA
CCCACATACTAAACTAATGAGAAGCTAAAACCTGATTTCTGTAGAAAAGATAAAGTCCAAACAT
CTTCATCCTAGATAAAATCTCCATTCTTCCATATCAGCTTTGAGAGCTGCTGAGCACTGTAATA
CACCACACTGACATTAGCAAATACTCCTGACACTCAAAGGCTGCCCGGACTACCACCCTCCTAA
GCTAGGTCCCTTCCTCCCCACAACACAGGAACAGGTTCTGATTCCTTGAAGCTACTTAATGAAG
CTCTCCTTGAGGATGCTAAAAGCAACCACCTTGGAGACAGAAGGTTCAGGGCATCCTAAACTCT
TGATGTTACAAGTTTCCAGAATGGACCTGTTCGACGTCCTTTGACGGTTTATTTTCTAAGAGGG
AATTTTGATATTTTATGCATGGTTCACTGTTGCCCAGGGATACGTAAAAGAAAAAATACCTTTA
CATACAGGTGTCTTTGGAAGAGACCACAGACTGAAGAGAAACTGATTTTTTTCATACTGCCACG
TTTTTAGAATACTAGTAAGAGCTCTTTTGAGAGTAAGTTACATACCGTGACCACAGCGAGTGAG
TCTTCAACTGTTAGTGCCTGTGCTCACTTAGGCCGGAGTTACTCATTGCTGCCTTTAAAACTGT
GTGTTCACTGAAAACACGACAGGGCTGCAGTGCCTTACCAAATGGAGTGAGATTCTAAAGACAG
TAAAGTGCCTTTCTGCTCTAACAGTTGGTGTGACTGTTTCAGTGTCCCGCTGATACTTGTTCTT
CAATAAATCTCTCAAAGACCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099845	(Get FASTA)	NCBI Sequence Viewer
	XP_006231336	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI69061	(Get FASTA)	NCBI Sequence Viewer
	EDM13139	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000014979
	ENSRNOP00000014979.4
	ENSRNOP00000074860
	ENSRNOP00000074860.1

RefSeq Acc Id:

NP_001099845 ⟸ NM_001106375

- UniProtKB:

B5DFH4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEY
LVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDR
ENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLK
TNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWV
QILSEGWATPLKGFMREKEYLQTLHFDTLLDDGVINMSIPIVLPVSGDDKARLEGCSKFALMYE
GRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWNDGLDQ
YRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTK
DDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRD
PAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDEFDFIS
GTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN

hide sequence

RefSeq Acc Id:	XP_006231336 ⟸ XM_006231274
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K950 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSEIKKQKTDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEY LVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDR ENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSNYEKPETPECVLK TNLSSVSDCVQQVVELLQEQSIVPHTTIKGIHELFVPENKIDQIRAELETLPSLPITKLDLQWV QILSEGWATPLKGFMREKEYLQTLHFDTLLDGVILRDGVINMSIPIVLPVSGDDKARLEGCSKF ALMYEGRRVALLQDPEFYEHRKEERCSRVWGTASAKHPHIKMVMEGGDWLVGGDLQVLERIRWN DGLDQYRLTPLELKQKCKDMDADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPL GGWTKDDDVPLDWRMKQHAAVLEEGILDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFY IVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHDE FDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKIN hide sequence

Ensembl Acc Id:

ENSRNOP00000014979 ⟸ ENSRNOT00000014979

Ensembl Acc Id:

ENSRNOP00000074860 ⟸ ENSRNOT00000083555

Protein Domains

ATP-sulfurylase PUA-like Sulphate adenylyltransferase catalytic

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K950-F1-model_v2	AlphaFold	A0A0G2K950	1-619	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690869

Promoter ID:

EPDNEW_R1384

Type:

multiple initiation site

Name:

Papss2_1

Description:

3'-phosphoadenosine 5'-phosphosulfate synthase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	251,145,339 - 251,145,399	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307012	AgrOrtholog
BioCyc Gene	G2FUF-55912	BioCyc
Ensembl Genes	ENSRNOG00000011068	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000014979	ENTREZGENE
	ENSRNOT00000014979.6	UniProtKB/TrEMBL
	ENSRNOT00000083555	ENTREZGENE
	ENSRNOT00000083555.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/TrEMBL
	Sulfate adenylyltransferase	UniProtKB/TrEMBL
InterPro	APS_kinase_C	UniProtKB/TrEMBL
	ATP-Sase_PUA-like_dom	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PUA-like	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	Sulfurylase_cat_dom	UniProtKB/TrEMBL
	Sulphate_adenylyltransferase	UniProtKB/TrEMBL
KEGG Report	rno:294103	UniProtKB/TrEMBL
NCBI Gene	294103	ENTREZGENE
PANTHER	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE	UniProtKB/TrEMBL
	BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2	UniProtKB/TrEMBL
Pfam	APS_kinase	UniProtKB/TrEMBL
	ATP-sulfurylase	UniProtKB/TrEMBL
	PUA_2	UniProtKB/TrEMBL
PhenoGen	Papss2	PhenoGen
RatGTEx	ENSRNOG00000011068	RatGTEx
Superfamily-SCOP	Nucleotidylyl transferase	UniProtKB/TrEMBL
	PUA-like	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0G2K950	ENTREZGENE, UniProtKB/TrEMBL
	B5DFH4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Papss2_predicted	3'-phosphoadenosine 5'-phosphosulfate synthase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Papss2_predicted	3'-phosphoadenosine 5'-phosphosulfate synthase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)