Pak1 (p21 (RAC1) activated kinase 1) - Rat Genome Database
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Gene: Pak1 (p21 (RAC1) activated kinase 1) Rattus norvegicus
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Symbol: Pak1
Name: p21 (RAC1) activated kinase 1
RGD ID: 3250
Description: Exhibits protein kinase binding activity and protein serine/threonine kinase activity. Is predicted to contribute to small GTPase binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Localizes to several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; (S)-amphetamine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: alpha-PAK; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p68-PAK; PAK-1; protein kinase MUK2; serine/threonine-protein kinase PAK 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21152,111,172 - 152,226,390 (+)NCBI
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Celera1150,203,043 - 150,317,598 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(S)-amphetamine  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
axitinib  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
caffeine  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
dichlorine  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
folic acid  (ISO)
fonofos  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
streptozocin  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO,ISS)
activation of MAPKK activity  (IEA)
activation of protein kinase activity  (IBA)
amygdala development  (ISO)
apoptotic process  (IEA)
branching morphogenesis of an epithelial tube  (ISO,ISS)
cell migration  (ISO)
cellular response to DNA damage stimulus  (ISO,ISS)
cellular response to insulin stimulus  (IDA)
cellular response to organic cyclic compound  (ISO)
cerebellum development  (IEP)
chromatin remodeling  (ISO,ISS)
dendrite development  (ISO)
dendritic spine development  (ISO)
establishment of cell polarity  (IMP)
exocytosis  (IEA)
gamma-aminobutyric acid secretion, neurotransmission  (ISO)
glutamate secretion, neurotransmission  (ISO)
hepatocyte growth factor receptor signaling pathway  (ISO)
intracellular signal transduction  (TAS)
MAPK cascade  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (IMP)
negative regulation of cell proliferation involved in contact inhibition  (ISO,ISS)
neuromuscular junction development  (ISO)
neuron projection morphogenesis  (IMP)
observational learning  (ISO)
phosphorylation  (ISO)
positive regulation of axon extension  (IMP)
positive regulation of cell migration  (ISO,ISS)
positive regulation of cell population proliferation  (ISO)
positive regulation of fibroblast migration  (IDA)
positive regulation of insulin receptor signaling pathway  (IMP)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO,ISS)
positive regulation of JUN kinase activity  (ISO,ISS)
positive regulation of microtubule nucleation  (ISO,ISS)
positive regulation of microtubule polymerization  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IMP,ISO,ISS)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of stress fiber assembly  (ISO,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
protein autophosphorylation  (IDA,ISO,ISS)
protein phosphorylation  (IDA,ISO,ISS)
receptor clustering  (ISO)
regulation of actin cytoskeleton organization  (IMP)
regulation of axonogenesis  (IBA)
regulation of gene expression  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of MAPK cascade  (ISO)
response to hypoxia  (IDA)
response to organic substance  (IDA)
signal transduction  (IBA)
small GTPase mediated signal transduction  (TAS)
stress-activated protein kinase signaling cascade  (IBA)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (ISO)
transmission of nerve impulse  (ISO)
wound healing  (ISO,ISS)

Cellular Component

References

References - curated
1. Baudry D, etal., Oncogene. 2002 Aug 15;21(36):5566-73.
2. Bostner J, etal., Oncogene. 2007 Oct 25;26(49):6997-7005. Epub 2007 May 7.
3. Brown JL, etal., Curr Biol. 1996 May 1;6(5):598-605.
4. Clerk A and Sugden PH, FEBS Lett. 1997 Feb 10;403(1):23-5.
5. Daniels RH, etal., EMBO J. 1998 Feb 2;17(3):754-64.
6. de la Torre-Ubieta L, etal., Genes Dev. 2010 Apr 15;24(8):799-813. doi: 10.1101/gad.1880510.
7. Gadepalli R, etal., Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2652-61. doi: 10.1161/ATVBAHA.112.253112. Epub 2012 Aug 23.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Goto H, etal., Genes Cells. 2002 Feb;7(2):91-7.
10. Higuchi M, etal., Nat Cell Biol. 2008 Nov;10(11):1356-64. doi: 10.1038/ncb1795. Epub 2008 Oct 19.
11. Hinoki A, etal., Hypertension. 2010 Jan;55(1):161-5. doi: 10.1161/HYPERTENSIONAHA.109.143057. Epub 2009 Nov 9.
12. Hirai S, etal., Oncogene 1996 Feb 1;12(3):641-50.
13. Holm C, etal., J Natl Cancer Inst. 2006 May 17;98(10):671-80.
14. Jacobs T, etal., J Neurosci. 2007 Aug 8;27(32):8604-15.
15. Ke Y, etal., Circ Res. 2004 Feb 6;94(2):194-200. Epub 2003 Dec 11.
16. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
17. Liu W, etal., Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14.
18. Ma QL, etal., J Biol Chem. 2008 May 16;283(20):14132-43. Epub 2008 Mar 17.
19. Manser E, etal., Mol Cell 1998 Jan;1(2):183-92.
20. Manser E, etal., Nature 1994 Jan 6;367(6458):40-6.
21. Mao K, etal., J Mol Cell Cardiol. 2008 Feb;44(2):429-34. Epub 2007 Dec 3.
22. Martin GA, etal., EMBO J 1995 May 1;14(9):1970-8.
23. Mayr D, etal., Am J Clin Pathol. 2006 Jul;126(1):101-9.
24. MGD data from the GO Consortium
25. Mitsios N, etal., BMC Neurosci. 2007 Nov 12;8:93.
26. NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. O'Sullivan GC, etal., Int J Cancer. 2007 Nov 1;121(9):1930-40.
28. Osada S, etal., FEBS Lett 1997 Mar 10;404(2-3):227-33.
29. Osada S, etal., Oncogene 1997 May 1;14(17):2047-57.
30. Park E, etal., J Biol Chem. 2003 May 23;278(21):19220-9. Epub 2003 Mar 7.
31. Parrini MC, etal., J Biol Chem. 2009 Sep 4;284(36):24133-43. doi: 10.1074/jbc.M109.015271. Epub 2009 Jul 1.
32. Pipeline to import KEGG annotations from KEGG into RGD
33. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Pipeline to import SMPDB annotations from SMPDB into RGD
35. RGD automated data pipeline
36. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
37. RGD automated import pipeline for gene-chemical interactions
38. Rubio MD, etal., Biol Psychiatry. 2012 May 15;71(10):906-14. doi: 10.1016/j.biopsych.2012.02.006. Epub 2012 Mar 27.
39. Sakurada K, etal., J Biol Chem 2002 Nov 22;277(47):45473-9.
40. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
41. Schmitz U, etal., Biochem Biophys Res Commun. 2002 Mar 1;291(3):687-91.
42. Seko Y, etal., Biochem Biophys Res Commun. 1997 Oct 29;239(3):840-4.
43. Shekarabi M, etal., J Neurosci. 2005 Mar 23;25(12):3132-41.
44. Sundberg-Smith LJ, etal., J Biol Chem. 2005 Jan 21;280(3):2055-64. Epub 2004 Nov 12.
45. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
46. Toriyama M, etal., Curr Biol. 2013 Mar 18;23(6):529-34. doi: 10.1016/j.cub.2013.02.017. Epub 2013 Feb 28.
47. Tsakiridis T, etal., J Biol Chem. 1996 Aug 16;271(33):19664-7.
48. Tunduguru R, etal., Biochem Pharmacol. 2014 Nov 15;92(2):380-8. doi: 10.1016/j.bcp.2014.08.033. Epub 2014 Sep 6.
49. Wang D, etal., Circ Res. 2009 May 8;104(9):1066-75. doi: 10.1161/CIRCRESAHA.109.196691. Epub 2009 Apr 9.
50. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
51. Xie D, etal., Zhonghua Zhong Liu Za Zhi. 2006 Dec;28(12):911-4.
52. Zhang XQ, etal., Mol Med Rep. 2013 May;7(5):1417-24. doi: 10.3892/mmr.2013.1405. Epub 2013 Mar 28.
53. Zhang YH, etal., Zhonghua Yi Xue Za Zhi. 2007 Oct 16;87(38):2710-3.
Additional References at PubMed
PMID:7559638   PMID:7592896   PMID:9032240   PMID:9395435   PMID:9418861   PMID:9601050   PMID:9852149   PMID:10075701   PMID:10559936   PMID:10802735   PMID:11278486   PMID:11604394  
PMID:11864573   PMID:11950598   PMID:12165471   PMID:12189148   PMID:12213441   PMID:12692179   PMID:12876277   PMID:12912914   PMID:12950086   PMID:14580336   PMID:14707132   PMID:15182717  
PMID:15721239   PMID:15944209   PMID:16278681   PMID:16396499   PMID:17060906   PMID:17114649   PMID:17224451   PMID:17389360   PMID:17724026   PMID:17726028   PMID:18006851   PMID:18481281  
PMID:18515110   PMID:18586681   PMID:18721488   PMID:19667065   PMID:19850129   PMID:20457839   PMID:22022532   PMID:22078298   PMID:22153498   PMID:23260667   PMID:23333386   PMID:23509247  
PMID:23528453   PMID:23633677   PMID:24859002   PMID:25198505   PMID:25242307   PMID:25766321   PMID:26255026   PMID:26483344   PMID:26670864   PMID:26700000   PMID:27121078   PMID:27296803  
PMID:27583434   PMID:27917469   PMID:28408623   PMID:28972183   PMID:31587871  


Genomics

Comparative Map Data
Pak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21152,111,172 - 152,226,390 (+)NCBI
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Celera1150,203,043 - 150,317,598 (+)NCBICelera
Cytogenetic Map1q32NCBI
PAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1177,322,017 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1177,321,707 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh381177,322,017 - 77,514,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371177,033,062 - 77,185,139 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,710,708 - 76,862,581 (-)NCBINCBI36hg18NCBI36
Build 341176,710,708 - 76,862,581NCBI
Celera1174,340,698 - 74,492,467 (-)NCBI
Cytogenetic Map11q13.5-q14.1NCBI
HuRef1173,331,052 - 73,483,383 (-)NCBIHuRef
CHM1_11176,916,194 - 77,068,127 (-)NCBICHM1_1
Pak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,437,748 - 97,561,588 (+)NCBIGRCm39mm39
GRCm39 Ensembl797,437,748 - 97,561,588 (+)Ensembl
GRCm38797,788,541 - 97,912,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,788,541 - 97,912,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,991,449 - 105,060,891 (+)NCBIGRCm37mm9NCBIm37
MGSCv36797,718,162 - 97,786,524 (+)NCBImm8
Celera798,163,397 - 98,233,432 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Pak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,365,157 - 14,450,611 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541414,365,325 - 14,447,470 (+)NCBIChiLan1.0ChiLan1.0
PAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,014,744 - 76,166,503 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,015,998 - 76,104,197 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01172,372,577 - 72,524,817 (-)NCBIMhudiblu_PPA_v0panPan3
PAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2121,265,484 - 21,408,416 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12121,341,530 - 21,409,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364986,001,126 - 6,135,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,830,093 - 12,113,670 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1911,830,095 - 11,973,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,979,543 - 13,123,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,530,037 - 68,679,413 (-)NCBI
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)Ensembl
Pak1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624863442,465 - 609,159 (-)NCBI

Position Markers
AI072234  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01162,882,082 - 162,882,287NCBIRnor6.0
Rnor_5.01169,089,052 - 169,089,257UniSTSRnor5.0
RGSC_v3.41155,174,111 - 155,174,316UniSTSRGSC3.4
Celera1150,316,995 - 150,317,200UniSTS
RH 3.4 Map11166.1UniSTS
Cytogenetic Map1q32UniSTS
PMC140666P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01162,860,538 - 162,860,617NCBIRnor6.0
Rnor_5.01169,067,508 - 169,067,587UniSTSRnor5.0
RGSC_v3.41155,152,567 - 155,152,646UniSTSRGSC3.4
Celera1150,295,462 - 150,295,541UniSTS
Cytogenetic Map1q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1129208943174208943Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779148198585664Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1130779148199254774Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1130779148199254774Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1130779148199254774Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130779320219238476Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131334152176334152Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978178076978Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1133076978184188922Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1133946489178946489Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1134089429179089429Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1137787261236763528Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1137787261236763528Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1139523928170246858Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1141296374186296374Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1144395993189395993Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1144634295241482368Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144723107174343537Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1153655976198655976Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1153656062198656062Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1153834077232297227Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1154337847215828102Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1156446196214277437Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1156446196243311614Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1156446196274977688Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1156446783188289244Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1156446783189514504Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1161072673178935582Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1161321152273792054Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1161321256273791893Rat
1578778Pur4Proteinuria QTL 43.30.003total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1161321256273791893Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1161784169219232156Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1161784169219232156Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1161784169219232156Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169219232156Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1161784169278228889Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1161784169278228889Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1161784422246226103Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000049321
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 20 7 16 7 74 35 34 1
Low 40 37 34 3 34 8 11 7 10 8
Below cutoff 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049321   ⟹   ENSRNOP00000045832
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1162,768,156 - 162,882,685 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091952   ⟹   ENSRNOP00000073036
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1162,817,611 - 162,883,355 (+)Ensembl
RefSeq Acc Id: NM_017198   ⟹   NP_058894
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,111,210 - 152,225,719 (+)NCBI
Rnor_6.01162,768,156 - 162,882,685 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
RGSC_v3.41155,057,622 - 155,174,714 (+)RGD
Celera1150,203,043 - 150,317,598 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229752   ⟹   XP_006229814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,160,621 - 152,226,390 (+)NCBI
Rnor_6.01162,817,582 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229753   ⟹   XP_006229815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,160,620 - 152,226,390 (+)NCBI
Rnor_6.01162,817,582 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229754   ⟹   XP_006229816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,143,335 - 152,226,390 (+)NCBI
Rnor_6.01162,800,097 - 162,883,356 (+)NCBI
Rnor_5.01168,974,734 - 169,090,326 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109390   ⟹   XP_038965318
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,151,624 - 152,226,390 (+)NCBI
RefSeq Acc Id: XM_039109396   ⟹   XP_038965324
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21152,111,172 - 152,226,390 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058894   ⟸   NM_017198
- UniProtKB: P35465 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229816   ⟸   XM_006229754
- Peptide Label: isoform X1
- UniProtKB: P35465 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229814   ⟸   XM_006229752
- Peptide Label: isoform X1
- UniProtKB: P35465 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006229815   ⟸   XM_006229753
- Peptide Label: isoform X1
- UniProtKB: P35465 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045832   ⟸   ENSRNOT00000049321
RefSeq Acc Id: ENSRNOP00000073036   ⟸   ENSRNOT00000091952
RefSeq Acc Id: XP_038965324   ⟸   XM_039109396
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965318   ⟸   XM_039109390
- Peptide Label: isoform X1
Protein Domains
CRIB   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690212
Promoter ID:EPDNEW_R737
Type:initiation region
Name:Pak1_1
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R738  EPDNEW_R739  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,768,136 - 162,768,196EPDNEW
RGD ID:13690213
Promoter ID:EPDNEW_R738
Type:initiation region
Name:Pak1_3
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R737  EPDNEW_R739  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,768,405 - 162,768,465EPDNEW
RGD ID:13690219
Promoter ID:EPDNEW_R739
Type:initiation region
Name:Pak1_2
Description:p21 activated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R737  EPDNEW_R738  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01162,817,625 - 162,817,685EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3250 AgrOrtholog
Ensembl Genes ENSRNOG00000029784 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000045832 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000073036 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049321 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000091952 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:29431 UniProtKB/Swiss-Prot
NCBI Gene 29431 ENTREZGENE
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak1 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART PBD UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC219838
UniProt P35465 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q62934 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Pak1  p21 (RAC1) activated kinase 1  Pak1  p21 protein (Cdc42/Rac)-activated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak1  p21 protein (Cdc42/Rac)-activated kinase 1  Pak1  p21 (CDKN1A)-activated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak1  p21 (CDKN1A)-activated kinase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317
gene_product mitogen activated protein kinase kinase kinase family member 61685
gene_product mitogen activated protein kinase kinase kinase family member 70317
gene_protein 67 kDa 61685
gene_protein 67 kDa 70317
gene_regulation activated by receptor tyrosine kinases and trimeric G protein-linked receptors 70317