Pak1 (p21 (RAC1) activated kinase 1) - Rat Genome Database
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Gene: Pak1 (p21 (RAC1) activated kinase 1) Mus musculus
Analyze
Symbol: Pak1
Name: p21 (RAC1) activated kinase 1
RGD ID: 736234
Description: Exhibits protein kinase activity. Predicted to contribute to Rac GTPase binding activity. Involved in several processes, including nervous system development; observational learning; and trans-synaptic signaling. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1); PARTICIPATES IN adenosine signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activated protein kinase alpha; alpha-PAK; AW045634; CDC42/RAC effector kinase PAK-A; P; P21 CDKN1A-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p65-PAK; PAK; PAK-1; Paka; serine/threonine-protein kinase PAK 1
Orthologs:
Homo sapiens (human) : PAK1 (p21 (RAC1) activated kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pak1 (p21 (RAC1) activated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak1 (p21 (RAC1) activated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK1 (p21 (RAC1) activated kinase 1)
Canis lupus familiaris (dog) : PAK1 (p21 (RAC1) activated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak1 (p21 (RAC1) activated kinase 1)
Sus scrofa (pig) : PAK1 (p21 (RAC1) activated kinase 1)
Chlorocebus sabaeus (African green monkey) : PAK1 (p21 (RAC1) activated kinase 1)
Heterocephalus glaber (naked mole-rat) : Pak1 (p21 (RAC1) activated kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,437,748 - 97,561,588 (+)NCBI
GRCm38797,788,541 - 97,912,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,788,541 - 97,912,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,991,449 - 105,060,891 (+)NCBIGRCm37mm9NCBIm37
MGSCv36797,718,162 - 97,786,524 (+)NCBImm8
Celera798,163,397 - 98,233,432 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
axitinib  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP,ISO)
D-gluconic acid  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dichlorine  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP)
fonofos  (ISO)
hydrogen peroxide  (EXP,ISO)
L-methionine  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (EXP)
monosodium L-glutamate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenate  (EXP)
streptozocin  (EXP)
sulfates  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (EXP,ISO)
tebuconazole  (ISO)
terbufos  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
activation of protein kinase activity  (IBA)
amygdala development  (IGI)
apoptotic process  (IEA)
branching morphogenesis of an epithelial tube  (ISO)
cell migration  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to organic cyclic compound  (IDA)
cerebellum development  (ISO)
chromatin remodeling  (ISO)
dendrite development  (IDA)
dendritic spine development  (IGI)
establishment of cell polarity  (ISO)
exocytosis  (IEA)
gamma-aminobutyric acid secretion, neurotransmission  (IGI)
glutamate secretion, neurotransmission  (IGI)
hepatocyte growth factor receptor signaling pathway  (ISO)
MAPK cascade  (ISO)
negative regulation of cell growth involved in cardiac muscle cell development  (ISO)
negative regulation of cell proliferation involved in contact inhibition  (ISO)
neuromuscular junction development  (IGI)
neuron projection morphogenesis  (ISO)
observational learning  (IGI)
phosphorylation  (IEA)
positive regulation of axon extension  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of insulin receptor signaling pathway  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of microtubule polymerization  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein targeting to membrane  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
receptor clustering  (IGI)
regulation of actin cytoskeleton organization  (ISO)
regulation of axonogenesis  (IBA)
regulation of gene expression  (IGI)
regulation of long-term synaptic potentiation  (IGI)
regulation of MAPK cascade  (IGI)
response to hypoxia  (ISO)
response to organic substance  (ISO)
signal transduction by protein phosphorylation  (IBA)
stress-activated protein kinase signaling cascade  (IBA)
trans-synaptic signaling by endocannabinoid, modulating synaptic transmission  (EXP,IDA,IMP)
transmission of nerve impulse  (IGI)
wound healing  (ISO)

Cellular Component

Molecular Function

References

References - curated
1. Baudry D, etal., Oncogene. 2002 Aug 15;21(36):5566-73.
2. Bostner J, etal., Oncogene. 2007 Oct 25;26(49):6997-7005. Epub 2007 May 7.
3. Gadepalli R, etal., Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):2652-61. doi: 10.1161/ATVBAHA.112.253112. Epub 2012 Aug 23.
4. Holm C, etal., J Natl Cancer Inst. 2006 May 17;98(10):671-80.
5. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6. Liu W, etal., Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14.
7. Ma QL, etal., J Biol Chem. 2008 May 16;283(20):14132-43. Epub 2008 Mar 17.
8. Mayr D, etal., Am J Clin Pathol. 2006 Jul;126(1):101-9.
9. MGD and Homologene mouse data transfer
10. MGD data from the GO Consortium
11. Mitsios N, etal., BMC Neurosci. 2007 Nov 12;8:93.
12. O'Sullivan GC, etal., Int J Cancer. 2007 Nov 1;121(9):1930-40.
13. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
14. Osada S, etal., Oncogene 1997 May 1;14(17):2047-57.
15. Pipeline to import KEGG annotations from KEGG into RGD
16. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Pipeline to import SMPDB annotations from SMPDB into RGD
18. RGD automated import pipeline
19. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. RGD automated import pipeline for gene-chemical interactions
21. Rubio MD, etal., Biol Psychiatry. 2012 May 15;71(10):906-14. doi: 10.1016/j.biopsych.2012.02.006. Epub 2012 Mar 27.
22. Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
23. Wang D, etal., Circ Res. 2009 May 8;104(9):1066-75. doi: 10.1161/CIRCRESAHA.109.196691. Epub 2009 Apr 9.
24. Xie D, etal., Zhonghua Zhong Liu Za Zhi. 2006 Dec;28(12):911-4.
25. Zhang XQ, etal., Mol Med Rep. 2013 May;7(5):1417-24. doi: 10.3892/mmr.2013.1405. Epub 2013 Mar 28.
26. Zhang YH, etal., Zhonghua Yi Xue Za Zhi. 2007 Oct 16;87(38):2710-3.
Additional References at PubMed
PMID:7493928   PMID:8889548   PMID:10349636   PMID:10352232   PMID:10504302   PMID:10967094   PMID:11042159   PMID:11076861   PMID:11309621   PMID:11435472   PMID:11604394   PMID:11895474  
PMID:12123608   PMID:12165471   PMID:12176333   PMID:12176334   PMID:12213441   PMID:12374744   PMID:12477932   PMID:12520002   PMID:12719581   PMID:12732616   PMID:12950086   PMID:14517284  
PMID:14530270   PMID:14564011   PMID:14580336   PMID:14610273   PMID:14681479   PMID:15102471   PMID:15182717   PMID:15326355   PMID:15345747   PMID:15467718   PMID:15673687   PMID:15684429  
PMID:15761153   PMID:15775979   PMID:15800193   PMID:15814684   PMID:15849194   PMID:15996550   PMID:16061695   PMID:16141072   PMID:16141073   PMID:16331248   PMID:16368433   PMID:16602821  
PMID:17001318   PMID:17012749   PMID:17114649   PMID:17177285   PMID:17287250   PMID:17429073   PMID:17443815   PMID:17687038   PMID:17875933   PMID:17989089   PMID:18054038   PMID:18065495  
PMID:18154926   PMID:18160398   PMID:18224708   PMID:18507705   PMID:18515095   PMID:18541910   PMID:18644395   PMID:18668521   PMID:18701438   PMID:18716323   PMID:18718479   PMID:18768391  
PMID:18824165   PMID:18853424   PMID:18931661   PMID:18940914   PMID:18973680   PMID:19124833   PMID:19136554   PMID:19435845   PMID:19581924   PMID:19819308   PMID:19945391   PMID:20016102  
PMID:20067919   PMID:20383193   PMID:20400510   PMID:20534669   PMID:20729389   PMID:21072183   PMID:21093504   PMID:21115725   PMID:21267068   PMID:21645877   PMID:21828338   PMID:21873635  
PMID:21969371   PMID:21971074   PMID:22022532   PMID:22037191   PMID:22198506   PMID:22669945   PMID:22751929   PMID:22810622   PMID:22815483   PMID:22824149   PMID:22900031   PMID:22983922  
PMID:23017497   PMID:23019370   PMID:23038262   PMID:23055517   PMID:23063725   PMID:23153508   PMID:23183186   PMID:23303955   PMID:23306081   PMID:23335370   PMID:23509247   PMID:23514967  
PMID:23528453   PMID:23533177   PMID:23576562   PMID:23612118   PMID:23653349   PMID:23936510   PMID:24141051   PMID:24163148   PMID:24194600   PMID:24368667   PMID:24472646   PMID:24567357  
PMID:24684301   PMID:24952961   PMID:25074413   PMID:25199455   PMID:25215948   PMID:25217043   PMID:25242307   PMID:25379771   PMID:25446075   PMID:25456130   PMID:26025676   PMID:26036343  
PMID:26043730   PMID:26101351   PMID:26104863   PMID:26121028   PMID:26184908   PMID:26304465   PMID:26391956   PMID:26464331   PMID:26493375   PMID:26555075   PMID:26670864   PMID:26857814  
PMID:26966010   PMID:27166635   PMID:27296803   PMID:27394663   PMID:27465567   PMID:27535340   PMID:27583434   PMID:27600824   PMID:27626380   PMID:27740936   PMID:27746419   PMID:27917469  
PMID:27920252   PMID:28109008   PMID:28408623   PMID:28629331   PMID:28671696   PMID:28692051   PMID:29311744   PMID:29487189   PMID:29781585   PMID:29860311   PMID:30224799   PMID:30333726  
PMID:30718368   PMID:30791960   PMID:30814219   PMID:30891040   PMID:30992372   PMID:31399471   PMID:31402636   PMID:31857154   PMID:32325033  


Genomics

Comparative Map Data
Pak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,437,748 - 97,561,588 (+)NCBI
GRCm38797,788,541 - 97,912,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,788,541 - 97,912,381 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,991,449 - 105,060,891 (+)NCBIGRCm37mm9NCBIm37
MGSCv36797,718,162 - 97,786,524 (+)NCBImm8
Celera798,163,397 - 98,233,432 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
PAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1177,321,707 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1177,322,017 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh381177,322,017 - 77,514,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371177,033,060 - 77,185,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,710,708 - 76,862,581 (-)NCBINCBI36hg18NCBI36
Build 341176,710,708 - 76,862,581NCBI
Celera1174,340,698 - 74,492,467 (-)NCBI
Cytogenetic Map11q13.5-q14.1NCBI
HuRef1173,331,052 - 73,483,383 (-)NCBIHuRef
CHM1_11176,916,194 - 77,068,127 (-)NCBICHM1_1
Pak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01162,768,156 - 162,883,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,768,156 - 162,883,355 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,974,734 - 169,090,326 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,057,622 - 155,174,714 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,136,027 - 155,253,120 (+)NCBI
Celera1150,203,043 - 150,317,598 (+)NCBICelera
Cytogenetic Map1q32NCBI
Pak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,365,157 - 14,450,611 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541414,365,325 - 14,447,470 (+)NCBIChiLan1.0ChiLan1.0
PAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11176,014,744 - 76,166,503 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,015,998 - 76,104,197 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01172,372,577 - 72,524,817 (-)NCBI
PAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2121,265,484 - 21,408,416 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12121,341,530 - 21,409,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364986,001,126 - 6,135,663 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,830,093 - 12,113,670 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1911,830,095 - 11,973,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,979,543 - 13,123,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl168,529,571 - 68,617,092 (-)Ensembl
ChlSab1.1168,530,037 - 68,679,413 (-)NCBI
Pak1
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
AW045634  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38797,912,175 - 97,912,255UniSTSGRCm38
MGSCv377105,060,685 - 105,060,765UniSTSGRCm37
Celera798,233,226 - 98,233,306UniSTS
Cytogenetic Map7E2UniSTS
cM Map746.5UniSTS
Whitehead/MRC_RH7993.99UniSTS
D7Mit321  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38797,902,474 - 97,902,584UniSTSGRCm38
MGSCv377105,050,984 - 105,051,094UniSTSGRCm37
Celera798,223,653 - 98,223,755UniSTS
Cytogenetic Map7E2UniSTS
cM Map748.5UniSTS
Whitehead Genetic736.1UniSTS
Whitehead/MRC_RH7971.66UniSTS
Pak1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv377105,060,656 - 105,060,857UniSTSGRCm37
Celera798,233,197 - 98,233,398UniSTS
Cytogenetic Map7E2UniSTS
cM Map746.5UniSTS
cM Map746.5UniSTS
D7Dcr41  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38797,902,468 - 97,902,575UniSTSGRCm38
MGSCv377105,050,978 - 105,051,085UniSTSGRCm37
Celera798,223,647 - 98,223,746UniSTS
Cytogenetic Map7E2UniSTS
cM Map7 UniSTS
PMC140666P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38797,886,338 - 97,886,417UniSTSGRCm38
MGSCv377105,034,848 - 105,034,927UniSTSGRCm37
Celera798,207,365 - 98,207,444UniSTS
Cytogenetic Map7E2UniSTS
cM Map746.5UniSTS
Pak1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38797,912,146 - 97,912,347UniSTSGRCm38
MGSCv377105,060,656 - 105,060,857UniSTSGRCm37
Celera798,233,197 - 98,233,398UniSTS
Cytogenetic Map7E2UniSTS
cM Map746.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
1301383Aem2_manti-erythrocyte autoantibody modifier 2 (mouse)Not determined76448567698485905Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)766139778100139778Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)766139778100139778Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76680000098700000Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78650000099300000Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7a-1mmu-let-7a-5pOncomiRDBexternal_infoNANA23339187
Mirlet7f-2mmu-let-7f-5pOncomiRDBexternal_infoNANA23339187
Mirlet7c-2mmu-let-7c-5pOncomiRDBexternal_infoNANA23339187
Mirlet7a-2mmu-let-7a-5pOncomiRDBexternal_infoNANA23339187
Mirlet7gmmu-let-7g-5pOncomiRDBexternal_infoNANA23339187
Mirlet7bmmu-let-7b-5pOncomiRDBexternal_infoNANA23339187
Mir465mmu-miR-465a-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI18922890
Mirlet7dmmu-let-7d-5pOncomiRDBexternal_infoNANA23339187
Mirlet7immu-let-7i-5pOncomiRDBexternal_infoNANA23339187
Mirlet7emmu-let-7e-5pOncomiRDBexternal_infoNANA23339187
Mirlet7c-1mmu-let-7c-5pOncomiRDBexternal_infoNANA23339187

Predicted Target Of
Summary Value
Count of predictions:865
Count of miRNA genes:403
Interacting mature miRNAs:443
Transcripts:ENSMUST00000033040, ENSMUST00000156637
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001357362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001357365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006507436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006507437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036152769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC125323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC151477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF082077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ133881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK078711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC055740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY630776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ905841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM027329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM027330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM027331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM027332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000033040   ⟹   ENSMUSP00000033040
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,842,935 - 97,912,381 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156637   ⟹   ENSMUSP00000138684
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,842,935 - 97,912,381 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205757
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,788,541 - 97,854,912 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206351   ⟹   ENSMUSP00000146291
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,830,928 - 97,866,126 (+)Ensembl
RefSeq Acc Id: ENSMUST00000206984   ⟹   ENSMUSP00000146055
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,788,541 - 97,911,883 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207017
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl797,893,915 - 97,911,282 (+)Ensembl
RefSeq Acc Id: NM_001357362   ⟹   NP_001344291
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,492,146 - 97,561,588 (+)NCBI
GRCm38797,842,939 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357363   ⟹   NP_001344292
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,492,146 - 97,561,588 (+)NCBI
GRCm38797,842,939 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357364   ⟹   NP_001344293
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,437,748 - 97,561,588 (+)NCBI
GRCm38797,788,541 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001357365   ⟹   NP_001344294
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,437,748 - 97,561,588 (+)NCBI
GRCm38797,788,541 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: NM_011035   ⟹   NP_035165
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,492,146 - 97,561,588 (+)NCBI
GRCm38797,842,939 - 97,912,381 (+)NCBI
MGSCv377104,991,449 - 105,060,891 (+)RGD
Celera798,163,397 - 98,233,432 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006507436   ⟹   XP_006507499
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,480,067 - 97,561,588 (+)NCBI
GRCm38797,830,934 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006507437   ⟹   XP_006507500
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,480,136 - 97,561,588 (+)NCBI
GRCm38797,830,933 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011241694   ⟹   XP_011239996
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,492,119 - 97,561,588 (+)NCBI
GRCm38797,842,912 - 97,912,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036152769   ⟹   XP_036008662
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39797,480,067 - 97,561,588 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001344291 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344292 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344293 (Get FASTA)   NCBI Sequence Viewer  
  NP_001344294 (Get FASTA)   NCBI Sequence Viewer  
  NP_035165 (Get FASTA)   NCBI Sequence Viewer  
  XP_006507499 (Get FASTA)   NCBI Sequence Viewer  
  XP_006507500 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239996 (Get FASTA)   NCBI Sequence Viewer  
  XP_036008662 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC32375 (Get FASTA)   NCBI Sequence Viewer  
  ADN33266 (Get FASTA)   NCBI Sequence Viewer  
  ADN33267 (Get FASTA)   NCBI Sequence Viewer  
  ADN33268 (Get FASTA)   NCBI Sequence Viewer  
  ADN33269 (Get FASTA)   NCBI Sequence Viewer  
  ADN94725 (Get FASTA)   NCBI Sequence Viewer  
  ADN94726 (Get FASTA)   NCBI Sequence Viewer  
  ADN94728 (Get FASTA)   NCBI Sequence Viewer  
  ADN94729 (Get FASTA)   NCBI Sequence Viewer  
  ADN94730 (Get FASTA)   NCBI Sequence Viewer  
  ADN94731 (Get FASTA)   NCBI Sequence Viewer  
  CAB41618 (Get FASTA)   NCBI Sequence Viewer  
  EDL16322 (Get FASTA)   NCBI Sequence Viewer  
  EDL16323 (Get FASTA)   NCBI Sequence Viewer  
  EDL16324 (Get FASTA)   NCBI Sequence Viewer  
  EDL16325 (Get FASTA)   NCBI Sequence Viewer  
  EDL16326 (Get FASTA)   NCBI Sequence Viewer  
  O88643 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_035165   ⟸   NM_011035
- Peptide Label: isoform 1
- UniProtKB: G5E884 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006507499   ⟸   XM_006507436
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006507500   ⟸   XM_006507437
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011239996   ⟸   XM_011241694
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001344294   ⟸   NM_001357365
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001344293   ⟸   NM_001357364
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001344291   ⟸   NM_001357362
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001344292   ⟸   NM_001357363
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000146055   ⟸   ENSMUST00000206984
RefSeq Acc Id: ENSMUSP00000146291   ⟸   ENSMUST00000206351
RefSeq Acc Id: ENSMUSP00000033040   ⟸   ENSMUST00000033040
RefSeq Acc Id: ENSMUSP00000138684   ⟸   ENSMUST00000156637
RefSeq Acc Id: XP_036008662   ⟸   XM_036152769
- Peptide Label: isoform X2
Protein Domains
CRIB   Protein kinase

Promoters
RGD ID:8664825
Promoter ID:EPDNEW_M10444
Type:initiation region
Name:Pak1_2
Description:Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10445  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38797,788,543 - 97,788,603EPDNEW
RGD ID:8664827
Promoter ID:EPDNEW_M10445
Type:initiation region
Name:Pak1_1
Description:Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M10444  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38797,842,971 - 97,843,031EPDNEW
RGD ID:6841702
Promoter ID:MM_KWN:51615
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000050033,   OTTMUST00000050034
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv367104,991,306 - 104,991,806 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1339975 AgrOrtholog
Ensembl Genes ENSMUSG00000030774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000033040 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000138684 UniProtKB/TrEMBL
  ENSMUSP00000146055 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000146291 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033040 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000156637 UniProtKB/TrEMBL
  ENSMUST00000206351 UniProtKB/TrEMBL
  ENSMUST00000206984 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CRIB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRIB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAK_BD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1339975 ENTREZGENE
NCBI Gene 18479 ENTREZGENE
Pfam PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pak1 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.260227 ENTREZGENE
UniProt A0A0U1RQ87_MOUSE UniProtKB/TrEMBL
  G5E884 ENTREZGENE, UniProtKB/TrEMBL
  O88643 ENTREZGENE, UniProtKB/Swiss-Prot
  S4R2K7_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-01 Pak1  p21 (RAC1) activated kinase 1    p21 protein (Cdc42/Rac)-activated kinase 1  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.