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Gene: PAK1 (p21 (RAC1) activated kinase 1) Homo sapiens
Symbol: PAK1
Name: p21 (RAC1) activated kinase 1
RGD ID: 1346880
Description: Exhibits collagen binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Contributes to Rac GTPase binding activity. Involved in several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of protein phosphorylation; and positive regulation of supramolecular fiber organization. Localizes to several cellular components, including actin filament; invadopodium; and ruffle. Implicated in breast cancer; renal cell carcinoma; and schizophrenia. Biomarker of Alzheimer's disease; breast cancer; carcinoma (multiple); and kidney cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-PAK; IDDMSSD; MGC130000; MGC130001; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAK-1; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
Mus musculus (house mouse) : Pak1 (p21 (RAC1) activated kinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pak1 (p21 (RAC1) activated kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak1 (p21 (RAC1) activated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK1 (p21 (RAC1) activated kinase 1)
Canis lupus familiaris (dog) : PAK1 (p21 (RAC1) activated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak1 (p21 (RAC1) activated kinase 1)
Sus scrofa (pig) : PAK1 (p21 (RAC1) activated kinase 1)
Chlorocebus sabaeus (African green monkey) : PAK1 (p21 (RAC1) activated kinase 1)
Heterocephalus glaber (naked mole-rat) : Pak1 (p21 (RAC1) activated kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1177,321,707 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1177,322,017 - 77,474,635 (-)EnsemblGRCh38hg38GRCh38
GRCh381177,322,017 - 77,514,957 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371177,033,060 - 77,185,108 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,710,708 - 76,862,581 (-)NCBINCBI36hg18NCBI36
Build 341176,710,708 - 76,862,581NCBI
Celera1174,340,698 - 74,492,467 (-)NCBI
Cytogenetic Map11q13.5-q14.1NCBI
HuRef1173,331,052 - 73,483,383 (-)NCBIHuRef
CHM1_11176,916,194 - 77,068,127 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PAK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346880
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.