RGD Reference Report - Rho GTPases in insulin-stimulated glucose uptake. - Rat Genome Database

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Rho GTPases in insulin-stimulated glucose uptake.

Authors: Satoh, T 
Citation: Satoh T Small GTPases. 2014;5:e28102. doi: 10.4161/sgtp.28102. Epub 2014 Mar 10.
RGD ID: 10053654
Pubmed: PMID:24613967   (View Abstract at PubMed)
PMCID: PMC4117247   (View Article at PubMed Central)
DOI: DOI:10.4161/sgtp.28102   (Journal Full-text)

Insulin is secreted into blood vessels from beta cells of pancreatic islets in response to high blood glucose levels. Insulin stimulates an array of physiological responses in target tissues, including liver, skeletal muscle, and adipose tissue, thereby reducing the blood glucose level. Insulin-dependent glucose uptake in skeletal muscle and adipose tissue is primarily mediated by the redistribution of the glucose transporter type 4 from intracellular storage sites to the plasma membrane. Evidence for the participation of the Rho family GTPase Rac1 in glucose uptake signaling in skeletal muscle has emerged from studies using cell cultures and genetically engineered mice. Herein, recent progress in understanding the function and regulation of Rac1, especially the cross-talk with the protein kinase Akt2, is highlighted. In addition, the role for another Rho family member TC10 and its regulatory mechanism in adipocyte insulin signaling are described.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BAIAP2Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Baiap2Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOBAIAP2 (Homo sapiens) RGD 
Baiap2Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOBAIAP2 (Homo sapiens) RGD 
CBLHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
CRKHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
CYFIP1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
CblRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCBL (Homo sapiens) RGD 
CblMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCBL (Homo sapiens) RGD 
CrkMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCRK (Homo sapiens) RGD 
CrkRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCRK (Homo sapiens) RGD 
Cyfip1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCYFIP1 (Homo sapiens) RGD 
Cyfip1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOCYFIP1 (Homo sapiens) RGD 
IQGAP1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Iqgap1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOIQGAP1 (Homo sapiens) RGD 
Iqgap1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOIQGAP1 (Homo sapiens) RGD 
KIF3AHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
KIF5BHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Kif3aRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOKIF3A (Homo sapiens) RGD 
Kif3aMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOKIF3A (Homo sapiens) RGD 
Kif5bRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOKIF5B (Homo sapiens) RGD 
Kif5bMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOKIF5B (Homo sapiens) RGD 
MYO1CHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
MYO5AHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
MYO5BHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Myo1cMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO1C (Homo sapiens) RGD 
Myo1cRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO1C (Homo sapiens) RGD 
Myo5aRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO5A (Homo sapiens) RGD 
Myo5aMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO5A (Homo sapiens) RGD 
Myo5bMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO5B (Homo sapiens) RGD 
Myo5bRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO5B (Homo sapiens) RGD 
PAK1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
PLEKHG4Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
PREX1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Pak1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPAK1 (Homo sapiens) RGD 
Pak1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPAK1 (Homo sapiens) RGD 
Plekhg4Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPLEKHG4 (Homo sapiens) RGD 
Plekhg4Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPLEKHG4 (Homo sapiens) RGD 
Prex1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPREX1 (Homo sapiens) RGD 
Prex1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOPREX1 (Homo sapiens) RGD 
RAC1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
RAPGEF1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
RHOQHumaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Rac1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAC1 (Homo sapiens) RGD 
Rac1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAC1 (Homo sapiens) RGD 
Rapgef1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAPGEF1 (Homo sapiens) RGD 
Rapgef1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAPGEF1 (Homo sapiens) RGD 
RhoqRatinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORHOQ (Homo sapiens) RGD 
RhoqMouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORHOQ (Homo sapiens) RGD 
SORBS1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Sorbs1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSORBS1 (Homo sapiens) RGD 
Sorbs1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSORBS1 (Homo sapiens) RGD 
TIAM1Humaninsulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS  RGD 
Tiam1Ratinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOTIAM1 (Homo sapiens) RGD 
Tiam1Mouseinsulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOTIAM1 (Homo sapiens) RGD 
BAIAP2HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Baiap2RatRho/Rac/Cdc42 mediated signaling pathway  ISOBAIAP2 (Homo sapiens) RGD 
Baiap2MouseRho/Rac/Cdc42 mediated signaling pathway  ISOBAIAP2 (Homo sapiens) RGD 
CBLHumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
CRKHumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
CYFIP1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
CblMouseRho/Rac/Cdc42 mediated signaling pathway  ISOCBL (Homo sapiens) RGD 
CblRatRho/Rac/Cdc42 mediated signaling pathway  ISOCBL (Homo sapiens) RGD 
CrkRatRho/Rac/Cdc42 mediated signaling pathway  ISOCRK (Homo sapiens) RGD 
CrkMouseRho/Rac/Cdc42 mediated signaling pathway  ISOCRK (Homo sapiens) RGD 
Cyfip1RatRho/Rac/Cdc42 mediated signaling pathway  ISOCYFIP1 (Homo sapiens) RGD 
Cyfip1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOCYFIP1 (Homo sapiens) RGD 
IQGAP1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Iqgap1RatRho/Rac/Cdc42 mediated signaling pathway  ISOIQGAP1 (Homo sapiens) RGD 
Iqgap1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOIQGAP1 (Homo sapiens) RGD 
PAK1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
PLEKHG4HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
PREX1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Pak1RatRho/Rac/Cdc42 mediated signaling pathway  ISOPAK1 (Homo sapiens) RGD 
Pak1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOPAK1 (Homo sapiens) RGD 
Plekhg4RatRho/Rac/Cdc42 mediated signaling pathway  ISOPLEKHG4 (Homo sapiens) RGD 
Plekhg4MouseRho/Rac/Cdc42 mediated signaling pathway  ISOPLEKHG4 (Homo sapiens) RGD 
Prex1RatRho/Rac/Cdc42 mediated signaling pathway  ISOPREX1 (Homo sapiens) RGD 
Prex1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOPREX1 (Homo sapiens) RGD 
RAC1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
RAPGEF1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
RHOQHumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Rac1RatRho/Rac/Cdc42 mediated signaling pathway  ISORAC1 (Homo sapiens) RGD 
Rac1MouseRho/Rac/Cdc42 mediated signaling pathway  ISORAC1 (Homo sapiens) RGD 
Rapgef1RatRho/Rac/Cdc42 mediated signaling pathway  ISORAPGEF1 (Homo sapiens) RGD 
Rapgef1MouseRho/Rac/Cdc42 mediated signaling pathway  ISORAPGEF1 (Homo sapiens) RGD 
RhoqRatRho/Rac/Cdc42 mediated signaling pathway  ISORHOQ (Homo sapiens) RGD 
RhoqMouseRho/Rac/Cdc42 mediated signaling pathway  ISORHOQ (Homo sapiens) RGD 
SORBS1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Sorbs1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOSORBS1 (Homo sapiens) RGD 
Sorbs1RatRho/Rac/Cdc42 mediated signaling pathway  ISOSORBS1 (Homo sapiens) RGD 
TIAM1HumanRho/Rac/Cdc42 mediated signaling pathway  TAS  RGD 
Tiam1RatRho/Rac/Cdc42 mediated signaling pathway  ISOTIAM1 (Homo sapiens) RGD 
Tiam1MouseRho/Rac/Cdc42 mediated signaling pathway  ISOTIAM1 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Baiap2  (BAR/IMD domain containing adaptor protein 2)
Cbl  (Cbl proto-oncogene)
Crk  (CRK proto-oncogene, adaptor protein)
Cyfip1  (cytoplasmic FMR1 interacting protein 1)
Iqgap1  (IQ motif containing GTPase activating protein 1)
Kif3a  (kinesin family member 3a)
Kif5b  (kinesin family member 5B)
Myo1c  (myosin 1C)
Myo5a  (myosin VA)
Myo5b  (myosin Vb)
Pak1  (p21 (RAC1) activated kinase 1)
Plekhg4  (pleckstrin homology and RhoGEF domain containing G4)
Prex1  (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1)
Rac1  (Rac family small GTPase 1)
Rapgef1  (Rap guanine nucleotide exchange factor 1)
Rhoq  (ras homolog family member Q)
Sorbs1  (sorbin and SH3 domain containing 1)
Tiam1  (TIAM Rac1 associated GEF 1)

Genes (Mus musculus)
Baiap2  (brain-specific angiogenesis inhibitor 1-associated protein 2)
Cbl  (Casitas B-lineage lymphoma)
Crk  (v-crk avian sarcoma virus CT10 oncogene homolog)
Cyfip1  (cytoplasmic FMR1 interacting protein 1)
Iqgap1  (IQ motif containing GTPase activating protein 1)
Kif3a  (kinesin family member 3A)
Kif5b  (kinesin family member 5B)
Myo1c  (myosin IC)
Myo5a  (myosin VA)
Myo5b  (myosin VB)
Pak1  (p21 (RAC1) activated kinase 1)
Plekhg4  (pleckstrin homology domain containing, family G (with RhoGef domain) member 4)
Prex1  (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1)
Rac1  (Rac family small GTPase 1)
Rapgef1  (Rap guanine nucleotide exchange factor (GEF) 1)
Rhoq  (ras homolog family member Q)
Sorbs1  (sorbin and SH3 domain containing 1)
Tiam1  (T cell lymphoma invasion and metastasis 1)

Genes (Homo sapiens)
BAIAP2  (BAR/IMD domain containing adaptor protein 2)
CBL  (Cbl proto-oncogene)
CRK  (CRK proto-oncogene, adaptor protein)
CYFIP1  (cytoplasmic FMR1 interacting protein 1)
IQGAP1  (IQ motif containing GTPase activating protein 1)
KIF3A  (kinesin family member 3A)
KIF5B  (kinesin family member 5B)
MYO1C  (myosin IC)
MYO5A  (myosin VA)
MYO5B  (myosin VB)
PAK1  (p21 (RAC1) activated kinase 1)
PLEKHG4  (pleckstrin homology and RhoGEF domain containing G4)
PREX1  (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)
RAC1  (Rac family small GTPase 1)
RAPGEF1  (Rap guanine nucleotide exchange factor 1)
RHOQ  (ras homolog family member Q)
SORBS1  (sorbin and SH3 domain containing 1)
TIAM1  (TIAM Rac1 associated GEF 1)


Additional Information