Ctsg (cathepsin G) - Rat Genome Database

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Gene: Ctsg (cathepsin G) Rattus norvegicus
Analyze
Symbol: Ctsg
Name: cathepsin G
RGD ID: 1307681
Description: Predicted to enable several functions, including caspase binding activity; heparin binding activity; and serine-type endopeptidase activity. Predicted to be involved in several processes, including biofilm matrix disassembly; defense response to bacterium; and regulation of cell-cell adhesion. Predicted to act upstream of or within defense response to fungus; positive regulation of immune response; and response to bacterium. Predicted to be located in several cellular components, including cytoplasmic stress granule; lysosome; and secretory granule. Orthologous to human CTSG (cathepsin G); PARTICIPATES IN Entamoebiasis pathway; renin-angiotensin cascade pathway; systemic lupus erythematosus pathway; INTERACTS WITH anilines; bisphenol A; corn oil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290257
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,901,230 - 33,907,596 (-)NCBIGRCr8
mRatBN7.21529,930,988 - 29,937,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,931,003 - 29,937,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,780,745 - 31,783,332 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,927,946 - 32,930,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,186,079 - 31,188,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,107,333 - 35,113,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,111,091 - 35,113,678 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,994,558 - 39,000,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,622,211 - 34,624,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,637,918 - 34,648,441 (-)NCBI
Celera1529,509,460 - 29,512,047 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasmic stress granule  (IEA,ISO)
cytosol  (IEA,ISO,ISS)
extracellular space  (IEA,ISO,ISS)
lysosome  (IEA,ISO,ISS)
membrane  (ISO,ISS)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
secretory granule  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cathepsin g is required for sustained inflammation and tissue injury after reperfusion of ischemic kidneys. Shimoda N, etal., Am J Pathol. 2007 Mar;170(3):930-40.
Additional References at PubMed
PMID:1861080   PMID:1937776   PMID:2222858   PMID:8194606   PMID:8573071   PMID:10512690   PMID:10714686   PMID:11907569   PMID:12504904   PMID:16690621   PMID:17975113   PMID:19056867  
PMID:20551380   PMID:21630459   PMID:21904640   PMID:23376485   PMID:23533145   PMID:26270939   PMID:27068509   PMID:27559042  


Genomics

Comparative Map Data
Ctsg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,901,230 - 33,907,596 (-)NCBIGRCr8
mRatBN7.21529,930,988 - 29,937,353 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,931,003 - 29,937,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,780,745 - 31,783,332 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,927,946 - 32,930,533 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01531,186,079 - 31,188,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01535,107,333 - 35,113,678 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1535,111,091 - 35,113,678 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,994,558 - 39,000,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41534,622,211 - 34,624,798 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11534,637,918 - 34,648,441 (-)NCBI
Celera1529,509,460 - 29,512,047 (-)NCBICelera
Cytogenetic Map15p12NCBI
CTSG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,573,518 - 24,576,250 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,573,518 - 24,576,250 (-)EnsemblGRCh38hg38GRCh38
GRCh371425,042,724 - 25,045,456 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361424,112,564 - 24,115,306 (-)NCBINCBI36Build 36hg18NCBI36
Build 341424,112,563 - 24,115,306NCBI
Celera144,907,510 - 4,910,252 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef145,157,531 - 5,160,273 (-)NCBIHuRef
CHM1_11425,041,620 - 25,044,362 (-)NCBICHM1_1
T2T-CHM13v2.01418,772,405 - 18,775,137 (-)NCBIT2T-CHM13v2.0
Ctsg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,337,342 - 56,340,031 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,337,338 - 56,340,031 (-)EnsemblGRCm39 Ensembl
GRCm381456,099,885 - 56,102,574 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1456,099,881 - 56,102,574 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,718,718 - 56,721,411 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361455,053,952 - 55,056,645 (-)NCBIMGSCv36mm8
Celera1453,905,080 - 53,907,773 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
CTSG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,921,107 - 25,923,838 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11425,137,599 - 25,140,330 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,342,517 - 5,345,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,466,259 - 23,468,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,466,265 - 23,468,960 (-)Ensemblpanpan1.1panPan2
CTSG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,483,327 - 4,485,933 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,470,577 - 4,512,628 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,404,974 - 4,407,573 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,594,740 - 4,597,337 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,582,079 - 4,597,280 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,284,216 - 4,286,825 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,346,800 - 4,349,397 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,609,195 - 4,611,806 (-)NCBIUU_Cfam_GSD_1.0
LOC100154047
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1774,761,602 - 74,772,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2779,789,517 - 79,792,248 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,518,004 - 1,521,980 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,518,119 - 1,520,709 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,210,626 - 13,213,332 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ctsg
20 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:82
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000059677
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 16 14 4 14
Low 13 8 14 8 8 6
Below cutoff 2 4 6 3 1 3 1 1 3 6 15 1 1

Sequence


RefSeq Acc Id: ENSRNOT00000059677   ⟹   ENSRNOP00000056429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1529,931,003 - 29,937,353 (-)Ensembl
Rnor_6.0 Ensembl1535,111,091 - 35,113,678 (-)Ensembl
RefSeq Acc Id: NM_001106041   ⟹   NP_001099511
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,905,009 - 33,907,596 (-)NCBI
mRatBN7.21529,934,766 - 29,937,353 (-)NCBI
Rnor_6.01535,111,091 - 35,113,678 (-)NCBI
Rnor_5.01538,994,558 - 39,000,903 (-)NCBI
RGSC_v3.41534,622,211 - 34,624,798 (-)RGD
Celera1529,509,460 - 29,512,047 (-)RGD
Sequence:
RefSeq Acc Id: XM_006252041   ⟹   XP_006252103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,901,230 - 33,907,546 (-)NCBI
mRatBN7.21529,930,988 - 29,937,303 (-)NCBI
Rnor_6.01535,107,333 - 35,113,590 (-)NCBI
Rnor_5.01538,994,558 - 39,000,903 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093138   ⟹   XP_038949066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81533,901,230 - 33,907,546 (-)NCBI
mRatBN7.21529,930,988 - 29,937,303 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099511 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252103 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949066 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM14312 (Get FASTA)   NCBI Sequence Viewer  
  EDM14313 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056429
  ENSRNOP00000056429.3
GenBank Protein P17977 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099511   ⟸   NM_001106041
- Peptide Label: precursor
- UniProtKB: P17977 (UniProtKB/Swiss-Prot),   G3V9Q7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252103   ⟸   XM_006252041
- Peptide Label: isoform X1
- UniProtKB: A0A8I5XFF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056429   ⟸   ENSRNOT00000059677
RefSeq Acc Id: XP_038949066   ⟸   XM_039093138
- Peptide Label: isoform X2
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17977-F1-model_v2 AlphaFold P17977 1-250 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307681 AgrOrtholog
BioCyc Gene G2FUF-13662 BioCyc
Ensembl Genes ENSRNOG00000020647 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059677.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290257 UniProtKB/Swiss-Prot
NCBI Gene 290257 ENTREZGENE
PANTHER CATHEPSIN G UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KALLIKREIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CTSG RGD
PhenoGen Ctsg PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020647 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XFF7 ENTREZGENE, UniProtKB/TrEMBL
  CATG_RAT UniProtKB/Swiss-Prot
  G3V9Q7 ENTREZGENE
  P17977 ENTREZGENE
UniProt Secondary G3V9Q7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ctsg  cathepsin G   Ctsg_predicted  cathepsin G (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ctsg_predicted  cathepsin G (predicted)      Symbol and Name status set to approved 70820 APPROVED